Mitochondrial DNA copy numbers in pyramidal neurons are decreased and mitochondrial biogenesis transcriptome signaling is disrupted in Alzheimer's disease hippocampi

Journal of Alzheimer's Disease

Volumn 40, Issue 2, 2014, Pages 319-330

  Rice, Ann C ^a,b   Keeney, Paula M ^a   Algarzae, Norah K ^a   Ladd, Amy C ^a   Thomas, Ravindar R ^a   Bennett Jr , James P ^a,b  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^b VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Laser capture microdissection; neural stem cells; PGC1 alpha; real time PCR; TFAM

Indexed keywords

AMYLOID BETA PROTEIN[1-42]; AMYLOID BETA PROTEIN[25-35]; COMPLEMENTARY DNA; MITOCHONDRIAL DNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; TRANSCRIPTOME; AMYLOID BETA PROTEIN; AMYLOID BETA-PROTEIN (1-42); DIPHTHERIA TOXIN; DIPHTHERIA TOXIN FRAGMENT A; GLIAL FIBRILLARY ACIDIC PROTEIN; PEPTIDE FRAGMENT;

AGED; ALZHEIMER DISEASE; ARTICLE; ASTROCYTE; AUTOPSY; BIOGENESIS; BRAIN MITOCHONDRION; BRAIN NERVE CELL; CLINICAL ARTICLE; CONTROLLED STUDY; DENTATE GRANULE NEURON; FEMALE; GENE DOSAGE; HIPPOCAMPUS; HUMAN; HUMAN CELL; HUMAN TISSUE; LASER CAPTURE MICRODISSECTION; MALE; MITOBIOGENESIS; MULTIPLEX POLYMERASE CHAIN REACTION; NEURAL STEM CELL; PRIORITY JOURNAL; PYRAMIDAL NERVE CELL; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; DRUG EFFECTS; GENETICS; GLIA; METABOLISM; PATHOLOGY; PHYSIOLOGY; STATISTICS; VERY ELDERLY;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; BIOGENESIS; DIPHTHERIA TOXIN; DNA, MITOCHONDRIAL; FEMALE; GENE DOSAGE; GLIAL FIBRILLARY ACIDIC PROTEIN; HIPPOCAMPUS; HUMANS; LASER CAPTURE MICRODISSECTION; MALE; NEURAL STEM CELLS; NEUROGLIA; PEPTIDE FRAGMENTS; PYRAMIDAL CELLS; SIGNAL TRANSDUCTION; STATISTICS AS TOPIC; TRANSCRIPTOME;

EID: 84897879235     PISSN: 13872877     EISSN: 18758908     Source Type: Journal    
DOI: 10.3233/JAD-131715     Document Type: Article

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