Characterization of multiple platelet activation pathways in patients with bleeding as a high-throughput screening option: Use of 96-well Optimul assay

Blood

Volumn 123, Issue 8, 2014, Pages

  Lordkipanidzé, Marie ^a   Lowe, Gillian C ^a   Kirkby, Nicholas S ^b   Chan, Melissa V ^b   Lundberg, Martina H ^b   Morgan, Neil V ^a   Bem, Danai ^a   Nisar, Shaista P ^c   Leo, Vincenzo C ^d   Jones, Matthew L ^c   Mundell, Stuart J ^c   Daly, Martina E ^d   Mumford, Andrew D ^c   Warner, Timothy D ^b   Watson, Steve P ^a  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^b QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^c UNIVERSITY OF BRISTOL   (United Kingdom)

^d UNIVERSITY OF SHEFFIELD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; ADENOSINE DIPHOSPHATE; ADRENALIN; ARACHIDONIC ACID; COLLAGEN; RISTOCETIN; THROMBIN RECEPTOR ACTIVATING PEPTIDE; THROMBOXANE; THROMBOXANE B2; THROMBOXANE RECEPTOR;

ADULT; ANALYTICAL EQUIPMENT; ARTICLE; BLEEDING; BLOOD LEVEL; CONCENTRATION RESPONSE; CONTROLLED STUDY; DIAGNOSTIC TEST ACCURACY STUDY; FEMALE; FUNCTION TEST; FUNCTION TEST KIT; GENOTYPE PHENOTYPE CORRELATION; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; INTERMETHOD COMPARISON; LIGHT TRANSMISSION AGGREGOMETRY; LUMIAGGREGOMETER; MAJOR CLINICAL STUDY; MALE; MICROTITER PLATE ASSAY; MIDDLE AGED; PREDICTIVE VALUE; PRIORITY JOURNAL; RECEIVER OPERATING CHARACTERISTIC; THROMBOCYTE ACTIVATION; THROMBOCYTE AGGREGATION; THROMBOCYTE ANOMALY; YOUNG ADULT;

ADULT; BLOOD PLATELET DISORDERS; BLOOD PLATELETS; DRUG MONITORING; FEMALE; GENETIC ASSOCIATION STUDIES; HEALTHY VOLUNTEERS; HEMORRHAGE; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; MALE; PLATELET ACTIVATION; PLATELET AGGREGATION INHIBITORS; PREDICTIVE VALUE OF TESTS; RECEPTORS, THROMBOXANE A2, PROSTAGLANDIN H2; SENSITIVITY AND SPECIFICITY; YOUNG ADULT;

EID: 84897875394     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2013-08-520387     Document Type: Article

References (36)

1. Watson SP, Lowe GC, Lordkipanidzé M, Morgan NV; GAPP consortium. Genotyping and phenotyping of platelet function disorders. J Thromb Haemost. 2013;11(Suppl 1):351-363.
2. Michelson AD. Platelet function testing in cardiovascular diseases. Circulation. 2004;110(19):e489-e493.
3. Rollini F, Tello-Montoliu A, Angiolillo DJ. Advances in platelet function testing assessing bleeding complications in patients with coronary artery disease. Platelets. 2012;23(7):537-551.
4. Harrison P, Lordkipanidzé M. Testing platelet function. Hematol Oncol Clin North Am. 2013;27(3):411-441.
5. Würtz M, Hvas AM, Wulff LN, Kristensen SD, Grove EL. Shear-induced platelet aggregation in aspirin-treated patients: initial experience with the novel PlaCor PRT device. Thromb Res. 2012;130(5):753-758.
6. Westein E, de Witt S, Lamers M, Cosemans JM, Heemskerk JW. Monitoring in vitro thrombus formation with novel microfluidic devices. Platelets. 2012;23(7):501-509.
7. Conant CG, Schwartz MA, Beecher JE, Rudoff RC, Ionescu-Zanetti C, Nevill JT. Well plate microfluidic system for investigation of dynamic platelet behavior under variable shear loads. Biotechnol Bioeng. 2011;108(12):2978-2987.
8. Lucitt MB, O'Brien S, Cowman J, et al. Assaying the efficacy of dual-antiplatelet therapy: use of a controlled-shear-rate microfluidic device with a well-defined collagen surface to track dynamic platelet adhesion. Anal Bioanal Chem. 2013;405(14):4823-4834.
9. Liu EC, Abell LM. Development and validation of a platelet calcium flux assay using a fluorescent imaging plate reader. Anal Biochem. 2006;357(2):216-224. (Pubitemid 44415686)
10. Salles I, Broos K, Fontayne A, et al. Development of a high-throughput ELISA assay for platelet function testing using platelet-rich plasma or whole blood. Thromb Haemost. 2010;104(2):392-401.
11. Sun B, Tandon NN, Yamamoto N, Yoshitake M, Kambayashi J. Luminometric assay of platelet activation in 96-well microplate. Biotechniques. 2001;31(5):1174, 1176, 1178 passim.
12. De Cuyper IM, Meinders M, van de Vijver E, et al. A novel flow cytometry-based platelet aggregation assay. Blood. 2013;121(10):e70-e80.
13. Chan MV, Warner TD. Standardised optical multichannel (optimul) platelet aggregometry using high-speed shaking and fixed time point readings. Platelets. 2012;23(5):404-408.
14. Chan MV, Armstrong PC, Papalia F, Kirkby NS, Warner TD. Optical multichannel (optimul) platelet aggregometry in 96-well plates as an additional method of platelet reactivity testing. Platelets. 2011;22(7):485-494.
15. Cattaneo M, Cerletti C, Harrison P, et al. Recommendations for the Standardization of Light Transmission Aggregometry: A Consensus of the Working Party from the Platelet Physiology Subcommittee of SSC/ISTH. J Thromb Haemost. 2013;11(6):1183-1189.
16. Dawood BB, Lowe GC, Lordkipanidzé M, et al. Evaluation of participants with suspected heritable platelet function disorders including recommendation and validation of a streamlined agonist panel. Blood. 2012;120(25):5041-5049.
17. Armstrong PC, Dhanji AR, Truss NJ, et al. Utility of 96-well plate aggregometry and measurement of thrombi adhesion to determine aspirin and clopidogrel effectiveness. Thromb Haemost. 2009;102(4):772-778.
18. FitzGerald GA. Mechanisms of platelet activation: thromboxane A2 as an amplifying signal for other agonists. Am J Cardiol. 1991;68(7):11B-15B.
19. Kamae T, Shiraga M, Kashiwagi H, et al. Critical role of ADP interaction with P2Y12 receptor in the maintenance of alpha(IIb)beta3 activation: association with Rap1B activation. J Thromb Haemost. 2006;4(6):1379-1387.
20. Rodeghiero F, Tosetto A, Abshire T, et al; ISTH/SSC joint VWF and Perinatal/Pediatric Hemostasis Subcommittees Working Group. ISTH/SSC bleeding assessment tool: a standardized questionnaire and a proposal for a new bleeding score for inherited bleeding disorders. J Thromb Haemost. 2010;8(9):2063-2065.
21. Lowe GC, Lordkipanidzé M, Watson SP; UK GAPP study group. Utility of the ISTH bleeding assessment tool in predicting platelet defects in participants with suspected inherited platelet function disorders. J Thromb Haemost. 2013;11(9):1663-1668.
22. Nisar S, Lordkipanidzé M, Jones M, et al, on behalf of the UK GAPP study group. A novel thromboxane A2 receptor N42S variant results in reduced surface expression and platelet dysfunction. Thromb Haemost. In press. doi: 10.1160/TH13-08-0672.
23. Rovati GE, Capra V, Neubig RR. The highly conserved DRY motif of class A G protein-coupled receptors: beyond the ground state. Mol Pharmacol. 2007;71(4):959-964. (Pubitemid 46456999)
24. Patel YM, Lordkipanidzé M, Lowe GC, et al. A novel mutation in the P2Y12 receptor and a function-reducing polymorphism in PAR-1 in a patient with chronic bleeding. J Thromb Haemost. In press.
25. Cox K, Price V, Kahr WH. Inherited platelet disorders: a clinical approach to diagnosis and management. Expert Rev Hematol. 2011;4(4):455-472.
26. Harrison P, Mackie I, Mumford A, et al British Committee for Standards in Haematology. Guidelines for the laboratory investigation of heritable disorders of platelet function. Br J Haematol. 2011;155(1):30-44.
27. Rodeghiero F, Castaman G. Congenital von Willebrand disease type I: definition, phenotypes, clinical and laboratory assessment. Best Pract Res Clin Haematol. 2001;14(2):321-335. (Pubitemid 32677082)
28. Pai M, Wang G, Moffat KA, et al. Diagnostic usefulness of a lumi-aggregometer adenosine triphosphate release assay for the assessment of platelet function disorders. Am J Clin Pathol. 2011;136(3):350-358.
29. Nieuwenhuis HK, Akkerman JW, Sixma JJ. Patients with a prolonged bleeding time and normal aggregation tests may have storage pool deficiency: studies on one hundred six patients. Blood. 1987;70(3):620-623.
30. Cattaneo M. Light transmission aggregometry and ATP release for the diagnostic assessment of platelet function. Semin Thromb Hemost. 2009;35(2):158-167.
31. Moffat KA, Ledford-Kraemer MR, Nichols WL, Hayward CP; North American Specialized Coagulation Laboratory Association. Variability in clinical laboratory practice in testing for disorders of platelet function: results of two surveys of the North American Specialized Coagulation Laboratory Association. Thromb Haemost. 2005;93(3):549-553. (Pubitemid 40392545)
32. Jennings I, Woods TA, Kitchen S, Walker ID. Platelet function testing: practice among UK National External Quality Assessment Scheme for Blood Coagulation participants, 2006. J Clin Pathol. 2008;61(8):950-954.
33. Cattaneo M, Hayward CP, Moffat KA, Pugliano MT, Liu Y, Michelson AD. Results of a worldwide survey on the assessment of platelet function by light transmission aggregometry: a report from the platelet physiology subcommittee of the SSC of the ISTH. J Thromb Haemost. 2009;7(6):1029.
34. Rodeghiero F, Tosetto A, Castaman G. How to estimate bleeding risk in mild bleeding disorders. J Thromb Haemost. 2007;5(Suppl 1):157-166. (Pubitemid 46958829)
35. Menkis AH, Martin J, Cheng DC, et al. Drug, devices, technologies, and techniques for blood management in minimally invasive and conventional cardiothoracic surgery: a consensus statement from the International Society for Minimally Invasive Cardiothoracic Surgery (ISMICS) 2011. Innovations (Phila). 2012;7(4):229-241.
36. Ranucci M, Baryshnikova E, Colella D. Monitoring prohemostatic treatment in bleeding patients. Semin Thromb Hemost. 2012;38(3):282-291.