Assaying the efficacy of dual-antiplatelet therapy: Use of a controlled-shear-rate microfluidic device with a well-defined collagen surface to track dynamic platelet adhesion

Analytical and Bioanalytical Chemistry

Volumn 405, Issue 14, 2013, Pages 4823-4834

  Lucitt, Margaret B ^a,d,g   O'Brien, Sinead ^a   Cowman, Jonathan ^a   Meade, Gerardene ^a   Basabe Desmonts, Lourdes ^b,c,e   Somers, Martin ^b   Kent, Nigel ^b,f   Ricco, Antonio J ^b   Kenny, Dermot ^a,b  

^a ROYAL COLLEGE OF SURGEONS IN IRELAND   (Ireland)

^b DUBLIN CITY UNIVERSITY   (Ireland)

^c BASQUE FOUNDATION FOR SCIENCE   (Spain)

^d TRINITY COLLEGE DUBLIN   (Ireland)

^e CIC MICROGUNE   (Spain)

^f DUBLIN INSTITUTE OF TECHNOLOGY   (Ireland)

^g ST JAMES S HOSPITAL   (Ireland)

Author keywords

Antiplatelet therapy; Collagen platelet interactions; Microfluidics; Parallel plate flow chamber; Thrombosis

Indexed keywords

AGGREGATES; ATOMIC FORCE MICROSCOPY; COLLAGEN; FLUIDIC DEVICES; MICROFLUIDICS; PARALLEL FLOW; PLATELETS; SURFACE TREATMENT;

ANTIPLATELET THERAPY; CLINICAL SETTINGS; CONTROL MEASUREMENTS; MICRO-FLUIDIC DEVICES; PARALLEL PLATE FLOW CHAMBER; PHARMACOLOGICAL EFFECTS; PLATELET ADHESION; THROMBOSIS;

PATIENT TREATMENT;

ACETYLSALICYLIC ACID; ANTITHROMBOCYTIC AGENT; CLOPIDOGREL; COLLAGEN; DRUG COMBINATION; TICLOPIDINE; DRUG DERIVATIVE;

ANALOGS AND DERIVATIVES; BIOASSAY; CELL CULTURE; CHEMISTRY; DEVICES; DOSE RESPONSE; DRUG COMBINATION; DRUG EFFECTS; DRUG SCREENING; FLOW INJECTION ANALYSIS; HUMAN; PHYSIOLOGY; SHEAR STRENGTH; SURFACE PROPERTY; THROMBOCYTE; THROMBOCYTE ADHESION; TREATMENT OUTCOME; ARTICLE; DRUG EFFECT; EQUIPMENT;

ASPIRIN; BIOLOGICAL ASSAY; BLOOD PLATELETS; CELLS, CULTURED; COLLAGEN; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG COMBINATIONS; DRUG EVALUATION, PRECLINICAL; FLOW INJECTION ANALYSIS; HUMANS; PLATELET ADHESIVENESS; PLATELET AGGREGATION INHIBITORS; SHEAR STRENGTH; SURFACE PROPERTIES; TICLOPIDINE; TREATMENT OUTCOME;

EID: 84891689267     PISSN: 16182642     EISSN: 16182650     Source Type: Journal    
DOI: 10.1007/s00216-013-6897-y     Document Type: Article

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