A novel thromboxane A2 receptor N42S variant results in reduced surface expression and platelet dysfunction

Thrombosis and Haemostasis

Volumn 111, Issue 5, 2014, Pages 923-932

  Nisar, Shaista P ^a   Lordkipanidzé, Marie ^b   Jones, Matthew L ^a   Dawood, Ban B ^b   Murden, Sherina ^a   Cunningham, Margaret R ^a   Mumford, Andrew D ^a   Wilde, Jonathan T ^c   Watson, Steve P ^b   Mundell, Stuart J ^a   Lowe, Gillian C ^b  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

^b UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^c UNIVERSITY HOSPITALS BIRMINGHAM NHS FOUNDATION TRUST   (United Kingdom)

Author keywords

Acquired; Gene mutations; Inherited acquired platelet disorders; Platelet pathology inherited; Platelet pharmacology; Receptors

Indexed keywords

ASPARAGINE; SERINE; THROMBOXANE; THROMBOXANE A2 RECEPTOR; G PROTEIN COUPLED RECEPTOR;

ADULT; AMINO ACID METABOLISM; AMINO ACID SUBSTITUTION; ARTICLE; BINDING AFFINITY; CASE REPORT; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CRYSTALLOGRAPHY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GENE MUTATION; GENE SEQUENCE; GENETIC TRANSFECTION; GENOTYPE; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOFLUORESCENCE MICROSCOPY; LIGAND BINDING; LUCIFERASE ASSAY; MENORRHAGIA; MIDDLE AGED; MUTAGENESIS; PHENOTYPE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; SCINTILLATION COUNTING; THROMBOCYTE AGGREGATION; THROMBOCYTE COUNT; THROMBOCYTE DYSFUNCTION; BLEEDING; BLOOD; BLOOD CLOTTING PARAMETERS; CONSERVED SEQUENCE; DOWN REGULATION; GENETIC VARIATION; GENETICS; HEK293 CELL LINE; HETEROZYGOTE; METABOLISM; MUTATION; PHYSIOLOGY; RADIOASSAY; THROMBOCYTE; THROMBOCYTE ACTIVATION;

ASPARAGINE; BLOOD PLATELETS; CONSERVED SEQUENCE; DOWN-REGULATION; FEMALE; GENETIC VARIATION; HEK293 CELLS; HEMORRHAGE; HETEROZYGOTE; HUMANS; MIDDLE AGED; MUTATION; PLATELET ACTIVATION; PLATELET FUNCTION TESTS; RADIOLIGAND ASSAY; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, THROMBOXANE A2, PROSTAGLANDIN H2;

EID: 84899748419     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1160/TH13-08-0672     Document Type: Article

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