Catalytic mechanism of histone acetyltransferase p300: From the proton transfer to acetylation reaction

Journal of Physical Chemistry B

Volumn 118, Issue 8, 2014, Pages 2009-2019

  Zhang, Xinlei ^a,b   Ouyang, Sisheng ^b   Kong, Xiangqian ^b   Liang, Zhongjie ^e   Lu, Junyan ^b   Zhu, Kongkai ^b   Zhao, Dan ^b   Zheng, Mingyue ^b   Jiang, Hualiang ^b   Liu, Xin ^c   Marmorstein, Ronen ^d   Luo, Cheng ^b  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^b SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

^c UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^d WISTAR INSTITUTE   (United States)

^e SOOCHOW UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLATION; CELL DEATH; COMPUTATIONAL CHEMISTRY; MOLECULAR DYNAMICS; MOLECULAR MODELING; MOLECULES; PROTEINS; PROTON TRANSFER; QUANTUM CHEMISTRY;

BIOCHEMICAL STUDIES; CATALYTIC MECHANISMS; COMPUTATIONAL STRATEGY; HISTONE ACETYLTRANSFERASE P300; HISTONE ACETYLTRANSFERASES; NUCLEOPHILIC ATTACK; QUANTUM MECHANICS/MOLECULAR MECHANICS; TRANSCRIPTIONAL CO-ACTIVATORS;

CATALYSIS;

ACETYL COENZYME A; HISTONE; HISTONE ACETYLTRANSFERASE; PROTON;

ACETYLATION; ARTICLE; BIOCATALYSIS; CHEMICAL PHENOMENA; CHEMISTRY; HYDROGEN BOND; METABOLISM; MOLECULAR DYNAMICS; PROTEIN TERTIARY STRUCTURE;

ACETYL COENZYME A; ACETYLATION; BIOCATALYSIS; HISTONE ACETYLTRANSFERASES; HISTONES; HYDROGEN BONDING; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; MOLECULAR DYNAMICS SIMULATION; PROTEIN STRUCTURE, TERTIARY; PROTONS;

EID: 84897653705     PISSN: 15206106     EISSN: 15205207     Source Type: Journal    
DOI: 10.1021/jp409778e     Document Type: Article

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