Clinical practice: Immune thrombocytopenia in paediatrics

European Journal of Pediatrics

Volumn 173, Issue 2, 2014, Pages 163-172

  Labarque, Veerle ^a   Van Geet, Chris ^a  

^a UNIVERSITY HOSPITALS LEUVEN   (Belgium)

Author keywords

Children; Idiopathic; Immune thrombocytopenia; ITP; Purpura

Indexed keywords

AUTOANTIBODY; CORTICOSTEROID; CYTOKINE RECEPTOR AGONIST; IMMUNOGLOBULIN G; RECOMBINANT THROMBOPOIETIN; RHESUS ANTIBODY; RITUXIMAB;

ADOLESCENT DISEASE; BONE MARROW BIOPSY; CHILDHOOD DISEASE; CLINICAL PRACTICE; DIAGNOSTIC PROCEDURE; EMERGENCY TREATMENT; HUMAN; IMMUNE THROMBOCYTOPENIA; IMMUNOPATHOLOGY; LABORATORY TEST; MEDICAL HISTORY; NOMENCLATURE; PATHOPHYSIOLOGY; PHYSICAL EXAMINATION; PRIORITY JOURNAL; REVIEW; SPLENECTOMY; THROMBOCYTOPENIA; THROMBOPOIETIN RECEPTOR AGONIST;

ADOLESCENT; ADRENAL CORTEX HORMONES; AUTOANTIBODIES; BLOOD PLATELETS; CHILD; CHILD, PRESCHOOL; HUMANS; IMMUNIZATION, PASSIVE; IMMUNOGLOBULIN G; INTRACRANIAL HEMORRHAGES; ISOANTIBODIES; PROGNOSIS; PURPURA, THROMBOCYTOPENIC, IDIOPATHIC; RESPIRATORY TRACT INFECTIONS; RISK FACTORS; WATCHFUL WAITING;

EID: 84897639764     PISSN: 03406199     EISSN: 14321076     Source Type: Journal    
DOI: 10.1007/s00431-013-2254-6     Document Type: Review

References (109)

1. Ahmad Z, Durrani NU, Hazir T (2007) Bone marrow examination in ITP in children: is it mandatory? J Coll Physicians Surg Pak 17:347-349
2. Ahmed I, Rajpurkar M, Thomas R, Chitlur M (2010) Initial lymphocyte count and the development of persistent/chronic immune thrombocytopenic purpura. Pediatr Blood Cancer 55:508-511
3. Alioglu B, Ercan S, Tapci AE, Zengin T, Yazarli E, Dallar Y (2013) A comparison of intravenous immunoglobulin (2 g/kg totally) and single doses of anti-D immunoglobulin at 50 μg/kg, 75 μg/kg in newly diagnosed children with idiopathic thrombocytopenic purpura: Ankara Hospital experience. Blood Coagul Fibrinolysis 24:505-509
4. Altintas A, Ozel A, Okur N, Okur N, Cil T, Pasa S, Ayyildiz O (2007) Prevalence and clinical significance of elevated antinuclear antibody test in children and adult patients with idiopathic thrombocytopenic purpura. J Thromb Thrombolysis 24:163-168
5. Arnold DM, Dentali F, Crowther MA, Meyer RM, Cook RJ, Sigouin C, Fraser GA, Lim W, Kelton JG (2007) Systematic review: efficacy and safety of rituximab for adults with idiopathic thrombocytopenic purpura. Ann Intern Med 146:25-33
6. Aukrust P, Frøland SS, Liabakk NB, Müller F, Nordøy I, Haug C, Espevik T (1994) Release of cytokines, soluble cytokine receptors, and interleukin-1 receptor antagonist after intravenous immunoglobulin administration in vivo. Blood 84:2136-2143
7. Ballow M (1994) Mechanisms of action of intravenous immune serum globulin therapy. Pediatr Infect Dis J 13:806-811
8. Baumann MA, Menitove JE, Aster RH, Anderson T (1986) Urgent treatment of idiopathic thrombocytopenic purpura with single-dose gammaglobulin infusion followed by platelet transfusion. Ann Intern Med 104:808-809
9. Bay A, Coskun E, Leblebisatan G, Karaoglu O, Keskin M, Yavuz S, Yilmaz F, Dai A, Coskun MY (2013) Prevalence and clinical significance of antithyroid antibodies in children with immune thrombocytopenic purpura. Pediatr Hematol Oncol 30:698-704
10. Beck CE, Nathan PC, Parkin PC, Blanchette VS, Macarthur C (2005) Corticosteroids versus intravenous immune globulin for the treatment of acute immune thrombocytopenic purpura in children: a systematic review and meta-analysis of randomized controlled trials. J Pediatr 147:521-527
11. Bennett CM, Rogers ZR, Kinnamon DD, Bussel JB, Mahoney DH, Abshire TC, Sawaf H, Moore TB, Loh ML, Glader BE, McCarthy MC, Mueller BU, Olson TA, Lorenzana AN, Mentzer WC, Buchanan GR, Feldman HA, Neufeld EJ (2006) Prospective phase 1/2 study of rituximab in childhood and adolescent chronic immune thrombocytopenic purpura. Blood 107:2639-2642
12. Berchtold P, Müller D, Beardsley D, Fujisawa K, Kaplan C, Kekomäki R, Lipp E, Morell-Kopp MC, Kiefel V, McMillan R, von dem Borne AE, Imbach P (1997) International study to compare antigen-specific methods used for the measurement of antiplatelet autoantibodies. Br J Haematol 96:477-483
13. Black C, Kaye JA, Jick H (2003) MMR vaccine and idiopathic thrombocytopaenic purpura. Br J Clin Pharmacol 55:107-111
14. Blanchette V, Bolton-Maggs P (2010) Childhood immune thrombocytopenic purpura: diagnosis and management. Hematol Oncol Clin North Am 24:249-273
15. Blanchette VS, Carcao M (2003) Childhood acute immune thrombocytopenic purpura: 20 years later. Semin Thromb Hemost 29:605-617
16. Blanchette V, Imbach P, Andrew M, Adams M, McMillan J, Wang E, Milner R, Ali K, Barnard D, Bernstein M, Esseltine D, Chan KW, deVeber B, Israels S, Kobrinsky N, Luke B (1994) Randomised trial of intravenous immunoglobulin G, intravenous anti-D, and oral prednisone in childhood acute immune thrombocytopenic purpura. Lancet 344:703-707
17. Blanchette VS, Luke B, Andrew M, Sommerville-Nielsen S, Barnard D, de Veber B, Gent M (1993) A prospective, randomized trial of high-dose intravenous immune globulin G therapy, oral prednisone therapy, and no therapy in childhood acute immune thrombocytopenic purpura. J Pediatr 123:989-995
18. Bolton-Maggs PH (2000) Idiopathic thrombocytopenic purpura. Arch Dis Child 83:220-222
19. Borgna-Pignatti C, Rugolotto S, Nobili B, Amendola G, De Stefano P, Maccario R, Locatelli F (1997) A trial of high-dose dexamethasone therapy for chronic idiopathic thrombocytopenic purpura in childhood. J Pediatr 130:13-16
20. Breakey VR, Blanchette VS (2011) Childhood immune thrombocytopenia: a changing therapeutic landscape. Semin Thromb Hemost 37:745-755
21. Buchanan GR, Holtkamp CA (1984) Prednisone therapy for children with newly diagnosed idiopathic thrombocytopenic purpura. A randomized clinical trial. Am J Pediatr Hematol Oncol 6:355-361
22. Bussel JB, Buchanan GR, Nugent DJ, Gnarra DJ, Bomgaars LR, Blanchette VS, Wang YM, Nie K, Jun S (2011) A randomized, double-blind study of romiplostim to determine its safety and efficacy in children with immune thrombocytopenia. Blood 118:28-36
23. Bussel JB, Cheng G, Saleh MN, Psaila B, Kovaleva L, Meddeb B, Kloczko J, Hassani H, Mayer B, Stone NL, Arning M, Provan D, Jenkins JM (2007) Eltrombopag for the treatment of chronic idiopathic thrombocytopenic purpura. N Engl J Med 357:2237-2247
24. Butros LJ, Bussel JB (2003) Intracranial hemorrhage in immune thrombocytopenic purpura: a retrospective analysis. J Pediatr Hematol Oncol 25:660-664
25. Calpin C, Dick P, Poon A, Feldman W (1998) Is bone marrow aspiration needed in acute childhood idiopathic thrombocytopenic purpura to rule out leukemia? Arch Pediatr Adolesc Med 152:345-347
26. Carcao MD, Zipursky A, Butchart S, Leaker M, Blanchette VS (1998) Short-course oral prednisone therapy in children presenting with acute immune thrombocytopenic purpura (ITP). Acta Paediatr Suppl 424:71-74
27. Cecinati V, Principi N, Brescia L, Giordano P, Esposito S (2013) Vaccine administration and the development of immune thrombocytopenic purpura in children. Hum Vaccin Immunother 9:1158-1162
28. Celik M, Bulbul A, Aydogan G, Tugcu D, Can E, Uslu S, Dursun M (2013) Comparison of anti-D immunoglobulin, methylprednisolone, or intravenous immunoglobulin therapy in newly diagnosed pediatric immune thrombocytopenic purpura. J Thromb Thrombolysis 35:228-233
29. Chandra J, Ravi R, Singh V, Narayan S, Sharma S, Dutta AK (2006) Bleeding manifestations in severely thrombocytopenic children with immune thrombocytopenic purpura. Hematology 11:131-133
30. Chang M, Nakagawa PA, Williams SA, Schwartz MR, Imfeld KL, Buzby JS, Nugent DJ (2003) Immune thrombocytopenic purpura (ITP) plasma and purified ITP monoclonal autoantibodies inhibit megakaryocytopoiesis in vitro. Blood 102:887-895
31. Chen JS, Wu JM, Chen YJ, Yeh TF (1997) Pulsed high-dose dexamethasone therapy in children with chronic idiopathic thrombocytopenic purpura. J Pediatr Hematol Oncol 19:526-529
32. Choi SI, McClure PD (1967) Idiopathic thrombocytopenic purpura in childhood. Can Med Assoc J 97:562-568
33. Choudhary DR, Naithani R, Mahapatra M, Kumar R, Mishra P, Saxena R (2009) Intracranial hemorrhage in childhood immune thrombocytopenic purpura. Pediatr Blood Cancer 52:529-531
34. Cooper N, Bussel JB (2010) The long-term impact of rituximab for childhood immune thrombocytopenia. Curr Rheumatol Rep 12:94-100
35. Dubansky AS, Boyett JM, Falletta J, Mahoney DH, Land VJ, Pullen J, Buchanan G (1989) Isolated thrombocytopenia in children with acute lymphoblastic leukemia: a rare event in a Pediatric Oncology Group study. Pediatrics 84:1068-1071
36. Duru F, Fisgin T, Yarali N, Kara A (2002) Clinical course of children with immune thrombocytopenic purpura treated with intravenous immunoglobulin G or megadose methylprednisolone or observed without therapy. Pediatr Hematol Oncol 19:219-225
37. ElAlfy M, Farid S, Abdel Maksoud A (2010) Predictors of chronic idiopathic thrombocytopenic purpura. Pediatr Blood Cancer 54:959-962
38. Elalfy MS, Abdelmaksoud AA, Eltonbary KY (2011) Romiplostim in children with chronic refractory ITP: randomized placebo controlled study. Ann Hematol 90:1341-1344
39. Edslev PW, Rosthøj S, Treutiger I, Rajantie J, Zeller B, Jonsson OG, NOPHO ITP Working Group (2007) A clinical score predicting a brief and uneventful course of newly diagnosed idiopathic thrombocytopenic purpura in children. Br J Haematol 138:513-516
40. Ephrem A, Chamat S, Miquel C, Fisson S, Mouthon L, Caligiuri G, Delignat S, Elluru S, Bayry J, Lacroix-Desmazes S, Cohen JL, Salomon BL, Kazatchkine MD, Kaveri SV, Misra N (2008) Expansion of CD4 + CD25+ regulatory T cells by intravenous immunoglobulin: a critical factor in controlling experimental autoimmune encephalomyelitis. Blood 111:715-722
41. France EK, Glanz J, Xu S, Hambidge S, Yamasaki K, Black SB, Marcy M, Mullooly JP, Jackson LA, Nordin J, Belongia EA, Hohman K, Chen RT, Davis R, Team VSD (2008) Risk of immune thrombocytopenic purpura after measles-mumps-rubella immunization in children. Pediatrics 121:e6876-e6892
42. Fujisawa K, Iyori H, Ohkawa H, Konishi S, Bessho F, Shirahata A, Miyazaki S, Akatsuka J, Japanese Study Group on Childhood ITP (2000) A prospective, randomized trial of conventional, dose-accelerated corticosteroids and intravenous immunoglobulin in children with newly diagnosed idiopathic thrombocytopenic purpura. Int J Hematol 72:376-383
43. Gaines AR (2005) Disseminated intravascular coagulation associated with acute hemoglobinemia or hemoglobinuria following Rho(D) immune globulin intravenous administration for immune thrombocytopenic purpura. Blood 106:1532-1537
44. Geddis AE, Balduini CL (2007) Diagnosis of immune thrombocytopenic purpura in children. Curr Opin Hematol 14:520-525
45. George JN, Woolf SH, Raskob GE, Wasser JS, Aledort LM, Ballem PJ, Blanchette VS, Bussel JB, Cines DB, Kelton JG, Lichtin AE, McMillan R, Okerbloom JA, Regan DH, Warrier I (1996) Idiopathic thrombocytopenic purpura: a practice guideline developed by explicit methods for the American Society of Hematology. Blood 88:3-40
46. Gereige RS, Barrios NJ (2000) Treatment of childhood acute immune thrombocytopenic purpura with high-dose methylprednisolone, intravenous immunoglobulin, or the combination of both. P R Health Sci J 19:15-18
47. Glanz J, France E, Xu S, Hayes T, Hambidge S (2008) A population-based, multisite cohort study of the predictors of chronic idiopathic thrombocytopenic purpura in children. Pediatrics 121:e506-e512
48. Grace RF, Bennett CM, Ritchey AK, Jeng M, Thornburg CD, Lambert MP, Neier M, Recht M, Kumar M, Blanchette V, Klaassen RJ, Buchanan GR, Kurth MH, Nugent DJ, Thompson AA, Stine K, Kalish LA, Neufeld EJ (2012) Response to steroids predicts response to rituximab in pediatric chronic immune thrombocytopenia. Pediatr Blood Cancer 58:221-225
49. Halperin DS, Doyle JJ (1988) Is bone marrow examination justified in idiopathic thrombocytopenic purpura? Am J Dis Child 142:508-511
50. Harrington WJ, Minnich V, Hollingsworth JW, Moore CV (1951) Demonstration of a thrombocytopenic factor in the blood of patients with thrombocytopenic purpura. J Lab Clin Med 38:1-10
51. Hazzan R, Mukamel M, Yacobovich J, Yaniv I, Tamary H (2006) Risk factors for future development of systemic lupus erythematosus in children with idiopathic thrombocytopenic purpura. Pediatr Blood Cancer 47:657-659
52. Ho WL, Lee CC, Chen CJ, Lu MY, Hu FC, Jou ST, Lin DT, Lin KH (2012) Clinical features, prognostic factors, and their relationship with antiplatelet antibodies in children with immune thrombocytopenia. J Pediatr Hematol Oncol 34:6-12
53. Hollander LL, Leys CM, Weil BR, Rescorla FJ (2011) Predictive value of response to steroid therapy on response to splenectomy in children with immune thrombocytopenic purpura. Surgery 150:643-648
54. Imbach P, Akatsuka J, Blanchette V, Burek-Kozlowska A, Bussel J, Gaedicke G, Gianella-Borradori A, Gugler E, Hirt A, Imholz B, McMillan R, Morell A, Newland A, Nugent D, Schöni MH, Wagner HP (1995) Immune thrombocytopenic purpura as a model for pathogenesis and treatment of autoimmunity. Eur J Pediatr 154:S60-S64
55. Imbach P, Barandun S, d'Apuzzo V, Baumgartner C, Hirt A, Morell A, Rossi E, Schöni M, Vest M, Wagner HP (1981) High-dose intravenous gammaglobulin for idiopathic thrombocytopenic purpura in childhood. Lancet 1:1228-1231
56. Imbach P, Kühne T, Müller D, Berchtold W, Zimmerman S, Elalfy M, Buchanan GR (2006) Childhood ITP: 12 months follow-up data from the prospective registry I of the Intercontinental Childhood ITP Study Group (ICIS). Pediatr Blood Cancer 46:351-356
57. Imbach P, Wagner HP, Berchtold W, Gaedicke G, Hirt A, Joller P, Mueller-Eckhardt C, Müller B, Rossi E, Barandun S (1985) Intravenous immunoglobulin versus oral corticosteroids in acute immune thrombocytopenic purpura in childhood. Lancet 2:464-468
58. Iyori H, Bessho F, Ookawa H, Konishi S, Shirahata A, Miyazaki S, Fujisawa K, Akatsuka J, Japanese Study Group on Childhood ITP (2000) Intracranial hemorrhage in children with immune thrombocytopenic purpura. Japanese Study Group on childhood ITP. Ann Hematol 79:691-695
59. Jayabose S, Patel P, Inamdar S, Brilliant R, Mamtani R (1987) Use of intravenous methylprednisolone in acute idiopathic thrombocytopenic purpura. Am J Pediatr Hematol Oncol 9:133-135
60. Kane I, Ragucci D, Shatat IF, Bussel J, Kalpatthi R (2010) Comparison of intravenous immune globulin and high dose anti-D immune globulin as initial therapy for childhood immune thrombocytopenic purpura. Br J Haematol 149:79-83
61. Kees-Folts D, Abt AB, Domen RE, Freiberg AS (2002) Renal failure after anti-D globulin treatment of idiopathic thrombocytopenic purpura. Pediatr Nephrol 17:91-96
62. Kessel A, Ammuri H, Peri R, Pavlotzky ER, Blank M, Shoenfeld Y, Toubi E (2007) Intravenous immunoglobulin therapy affects T regulatory cells by increasing their suppressive function. J Immunol 179:5571-5575
63. Klaassen RJ, Mathias SD, Buchanan G, Bussel J, Deuson R, Young NL, Collier A, Bomgaars L, Blanchette V (2012) Pilot study of the effect of romiplostim on child health-related quality of life (HRQoL) and parental burden in immune thrombocytopenia (ITP). Pediatr Blood Cancer 58:395-398
64. Koçak U, Aral YZ, Kaya Z, Oztürk G, Gürsel T (2007) Evaluation of clinical characteristics, diagnosis and management in childhood immune thrombocytopenic purpura: a single center's experience. Turk J Pediatr 49:250-255
65. Kubota M, Usami I, Kobayashi K, Tsutsui T, Matsubara K (2003) Serum immunoglobulin levels at onset: association with the prognosis of childhood idiopathic thrombocytopenic purpura. Int J Hematol 77:304-307
66. Kühne T, Buchanan GR, Zimmerman S, Michaels LA, Kohan R, Berchtold W, Imbach P (2003) A prospective comparative study of 2540 infants and children with newly diagnosed idiopathic thrombocytopenic purpura (ITP) from the Intercontinental Childhood ITP Study Group. J Pediatr 14:605-608
67. Kühne T, Freedman J, Semple JW, Doyle J, Butchart S, Blanchette VS (1997) Platelet and immune responses to oral cyclic dexamethasone therapy in childhood chronic immune thrombocytopenic purpura. J Pediatr 130:17-24
68. Kühne T, Michaels LA (2008) Helicobacter pylori in children with chronic idiopathic thrombocytopenic purpura: are the obstacles in the way typical in pediatric hematology? J Pediatr Hematol Oncol 30:2-3
69. Kuter DJ, Rummel M, Boccia R, Macik BG, Pabinger I, Selleslag D, Rodeghiero F, Chong BH, Wang X, Berger DP (2010) Romiplostim or standard of care in patients with immune thrombocytopenia. N Engl J Med 363:1889-1899
70. Liang Y, Zhang L, Gao J, Hu D, Ai Y (2012) Rituximab for children with immune thrombocytopenia: a systematic review. PLoS One 7:e36698
71. Lowe EJ, Buchanan GR (2002) Idiopathic thrombocytopenic purpura diagnosed during the second decade of life. J Pediatr 141:253-258
72. Lusher JM, Zuelzer WW (1966) Idiopathic thrombocytopenic purpura in childhood. J Pediatr 68:971-979
73. Mantadakis E, Farmaki E, Buchanan GR (2010) Thrombocytopenic purpura after measles-mumps-rubella vaccination: a systematic review of the literature and guidance for management. J Pediatr 156:623-628
74. Mantadakis E, Farmaki E, Thomaidis S, Tsalkidis A, Chatzimichael A (2010) A case of immune thrombocytopenic purpura after influenza vaccination: consequence or coincidence? J Pediatr Hematol Oncol 32:e227-e229
75. McMillan R, Wang L, Tomer A, Nichol J, Pistillo J (2004) Suppression of in vitro megakaryocyte production by antiplatelet autoantibodies from adult patients with chronic ITP. Blood 103:1364-1369
76. Medeiros D, Buchanan GR (1998) Major hemorrhage in children with idiopathic thrombocytopenic purpura: immediate response to therapy and long-term outcome. J Pediatr 133:334-339
77. Medeiros D, Buchanan GR (2000) Idiopathic thrombocytopenic purpura: beyond consensus. Curr Opin Pediatr 12:4-9
78. Mueller BU, Bennett CM, Feldman HA, Bussel JB, Abshire TC, Moore TB, Sawaf H, Loh ML, Rogers ZR, Glader BE, McCarthy MC, Mahoney DH, Olson TA, Feig SA, Lorenzana AN, Mentzer WC, Buchanan GR, Neufeld EJ, Pediatric Rituximab/ITP Study Group; Glaser Pediatric Research Network (2009) One year follow-up of children and adolescents with chronic immune thrombocytopenic purpura (ITP) treated with rituximab. Pediatr Blood Cancer 52:259-262
79. Murawski M, Patkowski D, Korlacki W, Czauderna P, Sroka M, Makarewicz W, Czernik J, Dzielicki J (2008) Laparoscopic splenectomy in children - a multicenter experience. J Pediatr Surg 43:951-954
80. Neunert CE, Buchanan GR, Imbach P, Bolton-Maggs PH, Bennett CM, Neufeld EJ, Vesely SK, Adix L, Blanchette VS, Kühne T, Intercontinental Childhood ITP Study Group Registry II Participants (2008) Severe hemorrhage in children with newly diagnosed immune thrombocytopenic purpura. Blood 112:4003-4008
81. Neunert CE, Buchanan GR, Imbach P, Bolton-Maggs PH, Bennett CM, Neufeld E, Vesely SK, Adix L, Blanchette VS, Kühne T, Intercontinental Cooperative ITP Study Group Registry II Participants (2013) Bleeding manifestations and management of children with persistent and chronic immune thrombocytopenia: data from the Intercontinental Cooperative ITP Study Group (ICIS). Blood 121:4457-4462
82. Neunert C, Lim W, Crowther M, Cohen A, Solberg L Jr, Crowther MA, American Society of Hematology (2011) The American Society of Hematology 2011 evidence-based practice guideline for immune thrombocytopenia. Blood 117:4190-4207
83. O'Leary ST, Glanz JM, McClure DL, Akhtar A, Daley MF, Nakasato C, Baxter R, Davis RL, Izurieta HS, Lieu TA, Ball R (2012) The risk of immune thrombocytopenic purpura after vaccination in children and adolescents. Pediatrics 129:248-255
84. Olsson B, Andersson PO, Jernås M, Jacobsson S, Carlsson B, Carlsson LM, Wadenvik H (2003) T-cell-mediated cytotoxicity toward platelets in chronic idiopathic thrombocytopenic purpura. Nat Med 9:1123-1124
85. Ozsoylu S, Sayli TR, Oztürk G (1993) Oral megadose methylprednisolone versus intravenous immunoglobulin for acute childhood idiopathic thrombocytopenic purpura. Pediatr Hematol Oncol 10:317-321
86. Patel VL, Mahévas M, Lee SY, Stasi R, Cunningham-Rundles S, Godeau B, Kanter J, Neufeld E, Taube T, Ramenghi U, Shenoy S, Ward MJ, Mihatov N, Patel VL, Bierling P, Lesser M, Cooper N, Bussel JB (2012) Outcomes 5 years after response to rituximab therapy in children and adults with immune thrombocytopenia. Blood 119:5989-5995
87. Pratt EL, Tarantino MD, Wagner D, Hirsch Pescovitz O, Bowyer S, Shapiro AD (2005) Prevalence of elevated antithyroid antibodies and antinuclear antibodies in children with immune thrombocytopenic purpura. Am J Hematol 79:175-179
88. Provan D, Stasi R, Newland AC, Blanchette VS, Bolton-Maggs P, Bussel JB, Chong BH, Cines DB, Gernsheimer TB, Godeau B, Grainger J, Greer I, Hunt BJ, Imbach PA, Lyons G, McMillan R, Rodeghiero F, Sanz MA, Tarantino M, Watson S, Young J, Kuter DJ (2010) International consensus report on the investigation and management of primary immune thrombocytopenia. Blood 115:168-186
89. Psaila B, Petrovic A, Page LK, Menell J, Schonholz M, Bussel JB (2009) Intracranial hemorrhage (ICH) in children with immune thrombocytopenia (ITP): study of 40 cases. Blood 114:4777-4783
90. Rajantie J, Zeller B, Treutiger I, Rosthöj S, NOPHO ITP working group and five national study groups (2007) Vaccination associated thrombocytopenic purpura in children. Vaccine 25:1838-1840
91. Rescorla FJ, West KW, Engum SA, Grosfeld JL (2007) Laparoscopic splenic procedures in children: experience in 231 children. Ann Surg 246:683-687, discussion 687-688
92. Revel-Vilk S, Yacobovich J, Frank S, Ben-Ami T, Yechieli M, Shkalim V, Lebel A, Semo-Oz R, Tamary H (2013) Age and duration of bleeding symptoms at diagnosis best predict resolution of childhood immune thrombocytopenia at 3, 6, and 12 months. J Pediatr. doi: 10.1016/j.jpeds.2013.06.018
93. Rodeghiero F, Stasi R, Gernsheimer T, Michel M, Provan D, Arnold DM, Bussel JB, Cines DB, Chong BH, Cooper N, Godeau B, Lechner K, Mazzucconi MG, McMillan R, Sanz MA, Imbach P, Blanchette V, Kühne T, Ruggeri M, George JN (2009) Standardization of terminology, definitions and outcome criteria in immune thrombocytopenic purpura of adults and children: report from an international working group. Blood 113:2386-2393
94. Romero-Guzmán LT, López-Karpovitch X, Paredes R, Barrales-Benitez O, Piedras J (2000) Detection of platelet-associated immunoglobulins by flow cytometry for the diagnosis of immune thrombocytopenia: a prospective study and critical review. Haematologica 85:627-631
95. Sartorius JA (1984) Steroid treatment of idiopathic thrombocytopenic purpura in children. Preliminary results of a randomized cooperative study. Am J Pediatr Hematol Oncol 6:165-169
96. Shahgholi E, Vosough P, Sotoudeh K, Arjomandi K, Ansari S, Salehi S, Faranoush M, Ehsani MA (2008) Intravenous immune globulin versus intravenous anti-D immune globulin for the treatment of acute immune thrombocytopenic purpura. Indian J Pediatr 75:1231-1235
97. Stasi R, Amadori S, Osborn J, Newland AC, Provan D (2006) Long-term outcome of otherwise healthy individuals with incidentally discovered borderline thrombocytopenia. PLoS Med 3:e24
98. Takahashi R, Sekine N, Nakatake T (1999) Influence of monoclonal antiplatelet glycoprotein antibodies on in vitro human megakaryocyte colony formation and proplatelet formation. Blood 93:1951-1958
99. Tamminga R, Berchtold W, Bruin M, Buchanan GR, Kühne T (2009) Possible lower rate of chronic ITP after IVIG for acute childhood ITP an analysis from registry I of the Intercontinental Cooperative ITP Study Group (ICIS). Br J Haematol 146:180-184
100. Tancabelic J, Stout LA, Wetering J (2005) Acute immune thrombocytopenic purpura in children and adolescents in South Dakota 1998-2004. S D J Med 58:465-468
101. Tarantino MD, Young G, Bertolone SJ, Kalinyak KA, Shafer FE, Kulkarni R, Weber LC, Davis ML, Lynn H, Nugent DJ, Acute ITP Study Group (2006) Single dose of anti-D immune globulin at 75 microg/kg is as effective as intravenous immune globulin at rapidly raising the platelet count in newly diagnosed immune thrombocytopenic purpura in children. J Pediatr 148:489-494
102. Terrell DR, Beebe LA, Vesely SK, Neas BR, Segal JB, George JN (2010) The incidence of immune thrombocytopenic purpura in children and adults: a critical review of published reports. Am J Hematol 85:174-180
103. van Hoff J, Ritchey AK (1998) Pulse methylprednisolone therapy for acute childhood idiopathic thrombocytopenic purpura. J Pediatr 113:563-566
104. Vilaplana VE, Aragonés JH, Fernández-Llamazares CM, Bieler CB, Rodríguez SM, Sáez MS (2012) Use of romiplostim for primary immune thrombocytopenia in children. Pediatr Hematol Oncol 29:197-205
105. Wali YA, Al Lamki Z, Shah W, Zacharia M, Hassan A (2002) Pulsed high-dose dexamethasone therapy in children with chronic idiopathic thrombocytopenic purpura. Pediatr Hematol Oncol 19:329-335
106. Woerner SJ, Abildgaard CF, French BN (1981) Intracranial hemorrhage in children with idiopathic thrombocytopenic purpura. Pediatrics 67:453-460
107. Yacobovich J, Revel-Vilk S, Tamary H (2013) Childhood immune thrombocytopenia - who will spontaneously recover? Semin Hematol 50:S71-S74
108. Yong M, Schoonen WM, Li L, Kanas G, Coalson J, Mowat F, Fryzek J, Kaye JA (2010) Epidemiology of paediatric immune thrombocytopenia in the General Practice Research Database. Br J Haematol 149:855-864
109. Zeller B, Rajantie J, Hedlund-Treutiger I, Tedgård U, Wesenberg F, Jonsson OG, Henter JI, NOPHO ITP (2005) Childhood idiopathic thrombocytopenic purpura in the Nordic countries: epidemiology and predictors of chronic disease. Acta Paediatr 94:178-184