Clinical features, prognostic factors, and their relationship with antiplatelet antibodies in children with immune thrombocytopenia

Journal of Pediatric Hematology/Oncology

Volumn 34, Issue 1, 2012, Pages 6-12

  Ho, Wan Ling ^a,b,c   Lee, Chin Cheng ^d   Chen, Chiung Ju ^d   Lu, Meng Yao ^c   Hu, Fu Chang ^e   Jou, Shiann Tarng ^c   Lin, Dong Tsamn ^c   Lin, Kai Hsin ^c  

^a Department of Pediatrics ^*  (Taiwan)

^b FU JEN CATHOLIC UNIVERSITY   (Taiwan)

^c NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

^d SHIN KONG WU HO SU MEMORIAL HOSPITAL   (Taiwan)

^e International Harvard Statistical Consulting Company   (Taiwan)

Author keywords

antiplatelet antibodies; glycoproteins; pediatric immune thrombocytopenia; pediatric immune thrombocytopenic purpura; thrombocytopenia; viral infection

Indexed keywords

CD36 ANTIGEN; FIBRINOGEN RECEPTOR; HLA ANTIGEN; IMMUNOGLOBULIN; PREDNISOLONE; THROMBIN RECEPTOR; THROMBOCYTE ANTIBODY; VERY LATE ACTIVATION ANTIGEN 2;

ADOLESCENT; ANTECEDENT OF PRECEDING INFECTION; ANTIBODY DETECTION; ARTICLE; CHILD; CLINICAL ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; DISEASE COURSE; DISEASE DURATION; DISEASE SEVERITY; DRUG RESPONSE; FEMALE; HUMAN; IDIOPATHIC THROMBOCYTOPENIC PURPURA; INFANT; MALE; ONSET AGE; PRESCHOOL CHILD; PRIORITY JOURNAL; PROGNOSIS; SCHOOL CHILD; THROMBOCYTE COUNT; TREATMENT OUTCOME; VACCINATION; VIRUS INFECTION;

ADOLESCENT; AGE FACTORS; AGE OF ONSET; AUTOANTIBODIES; BLOOD PLATELETS; CHILD; CHILD, PRESCHOOL; FEMALE; HUMANS; INFANT; MALE; MULTIVARIATE ANALYSIS; PROGNOSIS; PURPURA, THROMBOCYTOPENIC, IDIOPATHIC;

EID: 84855464680     PISSN: 10774114     EISSN: 15363678     Source Type: Journal    
DOI: 10.1097/MPH.0b013e3182282548     Document Type: Article

References (28)

1. Rodeghiero F, Stasi R, Gernsheimer T, et al. Standardization of terminology, definitions and outcome criteria in immune thrombocytopenic purpura of adults and children: report from an international working group. Blood. 2009;113:2386-2393.
2. Provan D, Stasi R, Newland AC, et al. International consensus report on the investigation and management of primary immune thrombocytopenia. Blood. 2010;115:168-186.
3. Mayer JR, Beardsley DS. Varicella-associated thrombocyto-penia: Autoantibodies against platelet surface glycoprotein V. Pediatr Res. 1996;40:615-619. (Pubitemid 26332591)
4. Li Z, Nardi MA, Karpatkin S. Role of molecular mimicry to HIV-1 peptides in HIV-1 related immunologic thrombocyto-penia. Blood. 2005;106:572-576. (Pubitemid 40981253)
5. Bettaib A, Fromont P, Louache F, et al. Presence of cross-reactive antibody between human immunodeficiency virus (HIV) and platelet glycoproteins in HIV-related immune thrombocytopenic purpura. Blood. 1992;80:162-169.
6. Sevilla J, del Carmen Escudero M, Jimenez R, et al. Severe autoimmune disease associated with Epstein-Barr virus infection. J Pediatr Hematol Oncol. 2004;226:831-833. (Pubitemid 40019186)
7. Rand ML, Wright JF. Virus-associated idiopathic thrombo-cytopenic purpura. Transfus Sci. 1998;19:253-259.
8. Segal GB, Feig SA. Controversies in the diagnosis and management of childhood acute immune thrombocytopenic purpura. Pediatr Blood Cancer. 2009;53:318-324.
9. Brighton TA, Evans S, Castaldi PA, et al. Prospective evaluation of the clinical usefulness of an antigen-specific assay (MAIPA) in idiopathic thrombocytopenic purpura and other immune thrombocytopenias. Blood. 1996;88:194-201. (Pubitemid 26230687)
10. Warner MN, Moore JC, Warkentin TE, et al. A prospective study of protein-specific assays used to investigate idiopathic thrombocytopenic purpura. Br J Haematol. 1999;104:442-447. (Pubitemid 29119263)
11. Cooper N, Bussel JB. The pathogenesis of immune thrombo-cytopenic purpura. Br J Haematol. 2006;133:364-374.
12. Cines DB, Bussel JB, Liebman HA, et al. The ITP syndrome: pathogenic and clinical diversity. Blood. 2009;113:6511-6521.
13. Chang M, Nakagawa PA, Williams SA, et al. Immune thrombocytopenic purpura (ITP) plasma and purified ITP monoclonal autoantibodies inhibit megakaryocytopoiesis in vitro. Blood. 2003;102:887-895. (Pubitemid 36917780)
14. McMillan R, Wang L, Tani P. Prospective evaluation of the immunobead assay for the diagnosis of adult chronic immune thrombocytopenic purpura (ITP). J Thromb Haemost. 2003; 1:485-491.
15. Peerschke EIB, Andemariam B, Yin W, et al. Complement activation on platelets correlates with a decrease in circulating immature platelets in patients with immune thrombocytopenic purpura. Br J Haematol. 2009;148:638-645.
16. McMillan R. The pathogenesis of chronic immune (idiopathic) thrombocytopenic purpura. Semin Hematol. 2000;37:5-9. (Pubitemid 30080232)
17. Olsson B, Andersson PO, Jernas M, et al. T-cell-mediated cytotoxicity toward platelets in chronic idiopathic thrombocy-topenic purpura. Nat Med. 2003;9:1123-1124. (Pubitemid 37173694)
18. France EK, Glanz J, Xu S, et al. Risk of immune thrombocytopenic purpura after measles-mumps-rubella immunization in children. Pediatrics. 2008;121:e687-e692.
19. Wang JD, Huang FL, Chen PY, et al. Acute immune thrombocytopenic purpura in infants: associated factors, clinical features, treatment and long-term outcome. Eur J Haematol. 2006;77:334-337.
20. McMillan R. The pathogenesis of chronic immune (idiopathic) thrombocytopenic purpura. Semin Haematol. 2000;37:2-9.
21. Go RS, Johnston KL, Bruden KC. The association between platelet autoantibody specificity and response to intravenous immunoglobulin G in the treatment of patients with immune thrombocytopenia. Haematologica. 2007;92:283-284. (Pubitemid 46852445)
22. Zhang W, Nardi MA, Borkowsky W, et al. Role of molecular mimicry of HCV protein with platelet GPIIIa in hepatitis C-related immunologic thrombocytopenia. Blood. 2009;113: 4086-4093.
23. Wang CM, Sheng GY, Zou X, et al. Levels of Toll-like receptors-2,-4 on platelets in children with idiopathic throm-bocytopenic purpura. Zhongguo Dangdai Erke Zazhi. 2009; 11:797-801.
24. Black C, Kaye JA. MMR vaccine and idiopathic thrombocy-topaenic purpura. Br J Clin Pharmacol. 2003;55:107-111. (Pubitemid 36110846)
25. Mantadakis E, Farmaki E, Buchanan GR. Thrombocytopenic purpura after measles-mumps-rubella vaccination: a systematic review of the literature and guidance for management. J Pediatr. 2010;156:623-628.
26. Donato H, Picon A, Martinez M, et al. Demographic data, natural history, and prognostic factors of idiopathic thrombo-cytopenic purpura in children: a multicentered study from Argentina. Pediatr Blood Cancer. 2009;52:491-496.
27. Webster ML, Ebrahim Sayeh, Crow M, et al. Relative efficacy of intravenous immunoglobulin G in ameliorating thrombo-cytopenia induced by antiplatelet GPIIbIIIa versus GPIba antibodies. Blood. 2006;18:943-946. (Pubitemid 44154629)
28. Chanock S. The etiology of childhood immune thrombocyto-penic purpura: how complex is it? J Pediatr Hematol Oncol. 2003;25:S7-S10. (Pubitemid 37517910)