Single dose of anti-D immune globulin at 75μg/kg is as effective as intravenous immune globulin at rapidly raising the platelet count in newly diagnosed immune thrombocytopenic purpura in children

Journal of Pediatrics

Volumn 148, Issue 4, 2006, Pages 489-494

  Tarantino, Michael D ^{a,b,c,d,e,f,g}   Young, Guy ^{a,b,c,d,e,f,g}   Bertolone, Salvatore J ^{a,b,c,d,e,f,g}   Kalinyak, Karen A ^{a,b,c,d,e,f,g}   Shafer, Frank E ^{a,b,c,d,e,f,g}   Kulkarni, Roshni ^{a,b,c,d,e,f,g}   Weber, Lisa C ^{a,b,c,d,e,f,g}   Davis, Mary L ^{a,b,c,d,e,f,g}   Lynn, Henry ^{a,b,c,d,e,f,g}   Nugent, Diane J ^{a,b,c,d,e,f,g}  

^a UNIVERSITY OF ILLINOIS   (United States)

^b CHILDREN S HOSPITAL OF ORANGE COUNTY   (United States)

^c UNIVERSITY OF LOUISVILLE   (United States)

^d CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

^e ST CHRISTOPHER'S HOSPITAL FOR CHILDREN   (United States)

^f MICHIGAN STATE UNIVERSITY   (United States)

^g CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN; RHESUS D ANTIBODY;

ADOLESCENT; ADULT; ARTICLE; BRAIN HEMORRHAGE; CHILD; CHILL; CLINICAL TRIAL; COMPARATIVE STUDY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFICACY; DRUG SAFETY; FEMALE; FEVER; HEADACHE; HEMATURIA; HEMOGLOBIN DETERMINATION; HEMOGLOBINURIA; HUMAN; IDIOPATHIC THROMBOCYTOPENIC PURPURA; MAJOR CLINICAL STUDY; MALE; PATIENT MONITORING; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; THROMBOCYTE COUNT;

ADOLESCENT; CHILD; CHILD, PRESCHOOL; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HUMANS; IMMUNOGLOBULINS, INTRAVENOUS; IMMUNOLOGIC FACTORS; INFANT; MALE; PLATELET COUNT; PROSPECTIVE STUDIES; PURPURA, THROMBOCYTOPENIC, IDIOPATHIC; RHO(D) IMMUNE GLOBULIN;

EID: 33646521038     PISSN: 00223476     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpeds.2005.11.019     Document Type: Article

References (32)

1. Nugent D.J. Immune thrombocytopenic purpura. why treat?. J Pediatr 134 (1999) 3-4
2. Bolton-Maggs P.H.B., Dickeroff R., and Vora A.J. The nontreatment of childhood ITP (or "the art of medicine consists of amusing the patient until nature cures the disease"). Semin Thromb Hemost 27 (2001) 269-275
3. de Alarcon P.A. Immune or idiopathic thrombocytopenic purpura (ITP) in childhood. what are the risks and who should be treated?. J Pediatr 143 (2003) 287-289
4. Buchanan G.R. Childhood acute thrombocytopenic purpura. how many tests and how much treatment required?. J Pediatr 106 (1985) 928-932
5. Lilleyman J. Medical nemesis and childhood ITP. Br J Haematol 123 (2003) 586-589
6. Buchanan G.R., de Alarcon P.A., Feig S.A., Gilchrist G.S., Lukens J.N., Moertel C.L., et al. Acute idiopathic thrombocytopenic purpura-management in childhood. [letter]. Blood 89 (1997) 1464-1465
7. Dickerhoff R., and von Ruecker A. The clinical course of immune thrombocytopenic purpura in children who did not receive intravenous immunoglobulins or sustained prednisone treatment. J Pediatr 137 (2000) 629-632
8. Tarantino M.D. On the conservative management of acute immune thrombocytopenia in children. J Pediatr 138 (2001) 787-788
9. Bolton-Maggs P., Tarantino M.D., Buchannan G., Bussel J., and George J.N. The child with immune thrombocytopenic purpura. is pharmacotherapy or watchful waiting the best initial management? A panel discussion from the 2002 meeting of the American Society of Pediatric Hematology/Oncology. J Pediatric Hematol/Oncol 26 (2004) 146-151
10. Vesely S.K., Buchanan G.R., Adix L., George J.N., Cohen A.R., Blanchette V.S., et al. Self-reported initial management of childhood idiopathic thrombocytopenic purpura. results of a survey of members of the American Society of Pediatric Hematology/Oncology, 2001. J Pediatr Hematol/Oncol 25 (2003) 130-133
11. Blanchette V., Imbach P., Andrew M., Adams M., McMillan J., Wang E., et al. Randomised trial of intravenous immunoglobulin G, intravenous anti-D, and oral prednisone in childhood acute immune thrombocytopenic purpura. Lancet 344 (1994) 703-707
12. Scaradavou A., Woo B., Woloski B.M., Cunningham-Rundles S., Ettinger L.J., Aledort L.M., et al. Intravenous anti-D treatment of immune thrombocytopenic purpura. experience in 272 patients. Blood 89 (1997) 2689-2700
13. Tarantino M.D., Madden R.M., Fennewald D.L., Patel C.C., and Bertolone S.J. Efficacy of anti-D immunoglobulin vs. intravenous pooled immunoglobulin G in the initial treatment of acute immune thrombocytopenic purpura in children. J Pediatr 134 (1999) 21-26
14. Newman G.C., Novoa M.V., Fodero E.M., Lesser M.L., Woloski B.M., and Bussel J.B. A dose of 75 microg/kg/d of i.v. anti-D increases the platelet count more rapidly and for a longer period of time than 50 microg/kg/d in adults with immune thrombocytopenic purpura. Br J Haematol 112 (2001) 1076-1078
15. Andrew M., Blanchette V.S., Adams M., Ali K., Barnard D., Chan K.W., et al. A multicenter study of the treatment of childhood chronic idiopathic thrombocytopenic purpura with anti-D. J Pediatr 120 (1992) 522-527
16. Bussel J.B., Goldman A., Imbach P., Schulman I., and Hilgartner M.W. Treatment of acute idiopathic thrombocytopenic purpura of childhood with intravenous infusions of gammaglobulin. J Pediatr 106 (1985) 886-890
17. Imbach P., Wagner H.P., Berchtold W., Gaedicke G., Hirt A., Joller P., et al. Intravenous Immunoglobulin versus oral corticosteroids in acute immune thrombocytopenic purpura in childhood. Lancet 2 (1985) 464-468
18. Warrier I., Bussel J.B., Valdez L., Barbosa J., and Beardsley D.S. Safety and efficacy of low-dose intravenous immune globulin (IVIG) treatment for infants and children with immune thrombocytopenic purpura. J Pediatr Hematol/Oncol 19 (1997) 197-201
19. Benesch M., Kerbl R., Lackner H., Berghold A., Schwinger W., Triebl-Roth K., et al. Low-dose versus high-dose immunoglobulin for primary treatment of acute immune thrombocytopenic purpura in children. results of a prospective, randomized single-center trial. J Pediatr Hematol/Oncol 25 (2003) 797-800
20. Bieri D., Reeve R.A., Champion G.D., Addicoat L., and Ziegler J.B. The faces pain scale for the self-assessment of the severity of pain experienced by children. development, initial validation, and preliminary investigation for ratio scale properties. Pain 41 (1990) 139-150
21. Beyer J.E., Denyes M.J., and Villarruel A.M. The creation, validation, and continuing development of the Oucher. a measure of pain intensity in children. J Pediatr Nurs 7 (1992) 335-346
22. Blanchette V.S., Luke B., Andrew M., Sommerville-Nielsen S., Barnard D., de Veber B., et al. A prospective, randomized trial of high-dose intravenous gammaglobulin G therapy, oral prednisone therapy and no therapy in childhood acute immune thrombocytopenic purpura. J Pediatr 123 (1993) 989-995
23. Butros L.J., and Bussel J.B. Intracranial hemorrhage in immune thrombocytopenic purpura. a retrospective analysis. J Pediatr Hematol/Oncol 25 (2003) 660-664
24. Kirovski A., Gregoire-Bottex M., Harris M.E., and Bussel J.B. Intracranial hemorrhage in children with acute and chronic immune thrombocytopenic purpura. Blood 100 (2002) 480a-481a
25. Kuhne T., Buchanan G.R., Zimmerman S., Michaels L.A., Kohan R., Berchtold W., et al. A prospective comparative study of 2540 infants and children with newly diagnosed idiopathic thrombocytopenic purpura (ITP) from the intercontinental childhood ITP study group. J Pediatr 143 (2003) 605-608
26. Medeiros D., and Buchanan G.R. Major hemorrhage in children with idiopathic thrombocytopenic purpura. immediate response to therapy and long-term outcome. J Pediatr 133 (1998) 334-339
27. Buchanan G.R., and Adix L. Grading of hemorrhage in children with idiopathic thrombocytopenic purpura. J Pediatr 141 (2002) 683-688
28. Monteleone P.M., Vander Heyden M.A., Steele D.A., and Kelleher J.F. Anti-D immunoglobulin in children with newly diagnosed immune thrombocytopenic purpura. a pilot study. Haematologica 85 (2000) 887-888
29. Kees-Folts D., Abt A.B., Domen R.E., and Freiberg A.S. Renal failure after anti-D globulin treatment of idiopathic thrombocytopenic purpura. Pediatr Nephrol 17 (2002) 91-96
30. Levendoglu-Tugal O., and Jayabose S. Intravenous anti-D immune globulin-induced intravascular hemolysis in Epstein-Barr virus-related thrombocytopenia. J Pediatr Hematol/Oncol 23 (2001) 460-463
31. Olofinboba K.A., and Greenberg B.R. Successful treatment of infectious mononucleosis-associated immune thrombocytopenia with WinRho anti-D immunoglobulin complicated by severe hemolysis. Am J Hematol 65 (2000) 178
32. Gaines A.R. Acute onset hemoglobinemia and/or hemoglobinuria and sequelae following Rh(o)(D) immune globulin intravenous administration in immune thrombocytopenic purpura patients. Blood 95 (2000) 2523-2529