Inflammation, myocardial dysfunction, and mortality in children with septic shock: An observational study

Pediatric Cardiology

Volumn 35, Issue 3, 2014, Pages 463-470

  Carmona, Fabio ^a   Manso, Paulo H ^a   Silveira, Vanessa S ^a   Cunha, Fernando Q ^a   De Castro, Margaret ^a   Carlotti, Ana P C P ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Echocardiography; Nuclear factor kappa B; Pediatric critical care; Sepsis

Indexed keywords

BRAIN NATRIURETIC PEPTIDE; CORTICOSTEROID; HYDROCORTISONE; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 10; INTERLEUKIN 6; TROPONIN I; TUMOR NECROSIS FACTOR ALPHA;

ACUTE KIDNEY FAILURE; ADULT RESPIRATORY DISTRESS SYNDROME; ARTICLE; BRAIN HEMORRHAGE; CARDIOVASCULAR MORTALITY; CAUSE OF DEATH; CHILD; CHILDHOOD DISEASE; CLINICAL ARTICLE; COHORT ANALYSIS; DIGESTIVE SYSTEM INFECTION; DISSEMINATED INTRAVASCULAR CLOTTING; ECHOCARDIOGRAPHY; FEMALE; HEART EJECTION FRACTION; HEMODYNAMIC PARAMETERS; HUMAN; INTENSIVE CARE UNIT; LONGITUDINAL STUDY; LUNG INFECTION; MALE; MEDIASTINITIS; MULTIPLE ORGAN FAILURE; MYOCARDITIS; OBSERVATIONAL STUDY; PRESCHOOL CHILD; PROSPECTIVE STUDY; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; SECONDARY INFECTION; SEIZURE; SEPTIC SHOCK;

ADOLESCENT; BIOLOGICAL MARKERS; CARDIOMYOPATHIES; CHILD; CHILD, PRESCHOOL; ECHOCARDIOGRAPHY; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HEMODYNAMICS; HUMANS; INFANT; INFLAMMATION; INTENSIVE CARE UNITS, PEDIATRIC; INTERLEUKIN-10; LONGITUDINAL STUDIES; MALE; NATRIURETIC PEPTIDE, BRAIN; NF-KAPPA B; PROSPECTIVE STUDIES; SHOCK, SEPTIC; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84897604679     PISSN: 01720643     EISSN: 14321971     Source Type: Journal    
DOI: 10.1007/s00246-013-0801-6     Document Type: Article

References (32)

1. Arnalich F, Garcia-Palomero E, Lopez J, Jimenez M, Madero R, Renart J et al (2000) Predictive value of nuclear factor kappaB activity and plasma cytokine levels in patients with sepsis. Infect Immun 68:1942-1945
2. Barnes PJ, Karin M (1997) Nuclear factor-kappaB: A pivotal transcription factor in chronic inflammatory diseases. N Engl J Med 336:1066-1071
3. Beutler B, Milsark IW, Cerami AC (1985) Passive immunization against cachectin/tumor necrosis factor protects mice from lethal effect of endotoxin. Science 229:869-871
4. Bohrer H, Qiu F, Zimmermann T, Zhang Y, Jllmer T, Mannel D et al (1997) Role of NF kappaB in the mortality of sepsis. J Clin Invest 100:972-985
5. Bottero V, Imbert V, Frelin C, Formento JL, Peyron JF (2003) Monitoring NF-kappa B transactivation potential via real-time PCR quantification of I kappa B-alpha gene expression. Mol Diagn 7:187-194
6. Brierley J, Choong K, Cornell T, Decaen A, Deymann A, Doctor A et al (2008) 2007 American College of Critical Care Medicine clinical practice parameters for hemodynamic support of pediatric and neonatal septic shock. Crit Care Med 37:666-688
7. Ceneviva G, Paschall JA, Maffei F, Carcillo JA (1998) Hemodynamic support in fluid-refractory pediatric septic shock. Pediatrics 102:e19
8. Court O, Kumar A, Parrillo JE (2002) Clinical review: Myocardial depression in sepsis and septic shock. Crit Care 6:500-508
9. Fei Y, Wang W, Kwiecinski J, Josefsson E, Pullerits R, Jonsson IM et al (2011) The combination of a tumor necrosis factor inhibitor and antibiotic alleviates staphylococcal arthritis and sepsis in mice. J Infect Dis 204:348-357
10. Gaies MG, Gurney JG, Yen AH, Napoli ML, Gajarski RJ, Ohye RG et al (2010) Vasoactive-inotropic score as a predictor of morbidity and mortality in infants after cardiopulmonary bypass. Pediatr Crit Care Med 11:234-238
11. Goldstein B, Giroir B, Randolph A (2005) International Pediatric Sepsis Consensus Conference: definitions for sepsis and organ dysfunction in pediatrics. Pediatr Crit Care Med 6:2-8
12. Gutierrez SH, Kuri MR, del Castillo ER (2008) Cardiac role of the transcription factor NF-kappaB. Cardiovasc Hematol Disord Drug Targets 8:153-160
13. Hatherill M, Tibby SM, Turner C, Ratnavel N, Murdoch IA (2000) Procalcitonin and cytokine levels: relationship to organ failure and mortality in pediatric septic shock. Crit Care Med 28:2591-2594
14. Haudek SB, Spencer E, Bryant DD, White DJ, Maass D, Horton JW et al (2001) Overexpression of cardiac I-kappaB alpha prevents endotoxin-induced myocardial dysfunction. Am J Physiol Heart Circ Physiol 280:H962-H968
15. Hotta N, Ichiyama T, Shiraishi M, Takekawa T, Matsubara T, Furukawa S (2007) Nuclear factor-kappaB activation in peripheral blood mononuclear cells in children with sepsis. Crit Care Med 35:2395-2401
16. Joulin O, Petillot P, Labalette M, Lancel S, Neviere R (2007) Cytokine profile of human septic shock serum inducing cardiomyocyte contractile dysfunction. Physiol Res 56:291-297
17. Knuefermann P, Sakata Y, Baker JS, Huang CH, Sekiguchi K, Hardarson HS et al (2004) Toll-like receptor 2 mediates Staphylococcus aureus-induced myocardial dysfunction and cytokine production in the heart. Circulation 110:3693-3698
18. Kumar A, Thota V, Dee L, Olson J, Uretz E, Parrillo JE (1996) Tumor necrosis factor alpha and interleukin 1 beta are responsible for in vitro myocardial cell depression induced by human septic shock serum. J Exp Med 183:949-958
19. Lang RM, Bierig M, Devereux RB, Flachskampf FA, Foster E, Pellikka PA et al (2005) Recommendations for chamber quantification: a report from the American Society of Echocardiography's Guidelines and Standards Committee and the Chamber Quantification Writing Group, developed in conjunction with the European Association of Echocardiography, a branch of the European Society of Cardiology. J Am Soc Echocardiogr 18:1440-1463
20. Li Z, Bryant AE, Hamilton SM, Bayer CR, Ma Y, Stevens DL (2011) Do cardiomyocytes mount an immune response to group A streptococcus? Cytokine 54:258-265
21. Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 25:402-408
22. Morris PE, Zeno B, Bernard AC, Huang X, Das S, Edeki T et al (2012) A placebo-controlled, double-blind, dose-escalation study to assess the safety, tolerability and pharmacokinetics/pharmacodynamics of single and multiple intravenous infusions of AZD9773 in patients with severe sepsis and septic shock. Crit Care 16:R31
23. Osuchowski MF, Connett J, Welch K, Granger J, Remick DG (2009) Stratification is the key: Inflammatory biomarkers accurately direct immunomodulatory therapy in experimental sepsis. Crit Care Med 37:1567-1573
24. Parker MM, Shelhamer JH, Bacharach SL, Green MV, Natanson C, Frederick TM et al (1984) Profound but reversible myocardial depression in patients with septic shock. Ann Intern Med 100:483-490
25. Parrillo JE (1993) Pathogenetic mechanisms of septic shock. N Engl J Med 328:1471-1477
26. Pathan N, Sandiford C, Harding SE, Levin M (2002) Characterization of a myocardial depressant factor in meningococcal septicemia. Crit Care Med 30:2191-2198
27. Pathan N, Hemingway CA, Alizadeh AA, Stephens AC, Boldrick JC, Oragui EE et al (2004) Role of interleukin 6 in myocardial dysfunction of meningococcal septic shock. Lancet 363:203-209
28. Pollack MM, Ruttimann UE, Getson PR (1988) Pediatric risk of mortality (PRISM) score. Crit Care Med 16:1110-1116
29. Price S, Anning PB, Mitchell JA, Evans TW (1999) Myocardial dysfunction in sepsis: Mechanisms and therapeutic implications. Eur Heart J 20:715-724
30. Qiu P, Cui X, Barochia A, Li Y, Natanson C, Eichacker PQ (2011) The evolving experience with therapeutic TNF inhibition in sepsis: considering the potential influence of risk of death. Expert Opin Invest Drugs 20:1555-1564
31. Schaal JB, Tran D, Tran P, Osapay G, Trinh K, Roberts KD et al (2012) Rhesus macaque theta defensins suppress inflammatory cytokines and enhance survival in mouse models of bacteremic sepsis. PLoS One 7:e51337
32. Shimo T, Adachi Y, Umezawa K, Okigaki M, Takaya J, Taniuchi S et al (2011) Dehydroxymethylepoxyquinomicin (DHMEQ) can suppress tumour necrosis factor-alpha production in lipopolysaccharide-injected mice, resulting in rescuing mice from death in vivo. Clin Exp Immunol 166:299-306