Procalcitonin and cytokine levels: Relationship to organ failure and mortality in pediatric septic shock

Critical Care Medicine

Volumn 28, Issue 7, 2000, Pages 2591-2594

  Hatherill, Mark ^a   Tibby, Shane M ^a   Turner, Charles ^a   Ratnavel, Nandiran ^a   Murdoch, Ian A ^a  

^a GUY S HOSPITAL   (United Kingdom)

Author keywords

Child; Interleukin 10; Mortality; Organ failure; Pediatric; Procalcitonin; Sepsis; Tumor necrosis factor

Indexed keywords

CYTOKINE; INTERLEUKIN 10; PROCALCITONIN; TUMOR NECROSIS FACTOR;

ANTIBIOTIC THERAPY; ARTICLE; ARTIFICIAL VENTILATION; CLINICAL TRIAL; HUMAN; INFANT; INFECTION; INFLAMMATION; INTENSIVE CARE; LENGTH OF STAY; MAJOR CLINICAL STUDY; MENINGOCOCCOSIS; MORTALITY; MULTIPLE ORGAN FAILURE; PRESCHOOL CHILD; PRIORITY JOURNAL; PROGNOSIS; SEPTIC SHOCK;

EID: 0033862536     PISSN: 00903493     EISSN: None     Source Type: Journal    
DOI: 10.1097/00003246-200007000-00068     Document Type: Article

References (21)

1. 1. Assicot M, Gendrel D, Carsin H, et al: High serum procalcitonin concentrations in patients with sepsis and infection. Lancet 1993; 341:515-518
2. 2. Gendrel D, Assicot M, Raymond J, et al: Procalcitonin as a marker for the early diagnosis of neonatal infection. J Pediatr 1996; 128: 570-573
3. 3. Monneret G, Labaune JM, Isaac C, et al: Procalcitonin and C-reactive protein levels in neonatal infections. Acta Paediatr 1997; 86: 209-212
4. 4. Braithwaite S: Procalcitonin - Marker, or mediator? Crit Care Med 1998; 26:977-978
5. 5. Nylen ES, Whang KT, Snider RH, et al: Mortality is increased by procalcitonin and decreased by an antiserum reactive to procalcitonin in experimental sepsis. Crit Care Med 1998; 26:1001-1006
6. 6. Meisner M, Tschaikowsky K, Spieβl C, et al: Procalcitonin - A marker or modulator of the acute immune response? Intensive Care Med 1996; 22:S14
7. 7. Oberhoffer M, Bogel D, Meier-Hellman A, et al: ACCP/SCCM consensus conference definitions correlate better with procalcitonin than tumor necrosis factor alpha and interleukin 6. Intensive Care Med 1996; 22:S15
8. 8. Smith MD, Suputtamongkol Y, Chaowagul W, et al: Elevated serum procalcitonin levels in patients with melioidosis. Clin Infect Dis 1995; 20:641-645
9. 9. Dandona P, Nix D, Wilson MF, et al: Procalcitonin increase after endotoxin injection in normal subjects. J Clin Endocrinol Metab 1994; 79:1605-1608
10. 10. De Werra I, Jaccard C, Corradin SB, et al: Cytokines, nitrate/nitrite, soluble tumor necrosis factor receptors, and procalcitonin concentrations: Comparisons in patients with septic shock, cardiogenic shock, and bacterial pneumonia. Crit Care Med 1997; 25:607-613
11. 11. Brunkhorst FM, Heinz U, Forycki ZF: Kinetics of procalcitonin in iatrogenic sepsis. Intensive Care Med 1998; 24:888-889
12. 12. Saez-Llorens X, McCracken GH: Sepsis syndrome and septic shock in pediatrics: Current concepts of terminology, pathophysiology, and management. J Pediatr 1993; 123: 497-508
13. 13. Pollack MM, Ruttiman UE, Getson PR: Pediatric risk of mortality (PRISM) score. Crit Care Med 1988; 16:1110-1116
14. 14. Wilkinson JD, Pollack MM, Glass NL, et al: Mortality associated with multiple organ system failure and sepsis in the pediatric intensive care unit. J Pediatr 1987; 111:324-328
15. 15. Meisner M, Tschaikowsky K, Palmaers T, et al: Procalcitonin and CRP in septic shock: Inflammatory parameters with different kinetics. Intensive Care Med 1996; 22:S13
16. 16. Sullivan JS, Kilpatrick L, Costarino AT, et al: Correlation of plasma cytokine elevations with mortality rate in children with sepsis. J Pediatr 1992; 120:510-515
17. 17. Moscovitz H, Shofer F, Mignott H, et al: Plasma cytokine determinations in emergency department patients as a predictor of bacteremia and infectious disease severity. Crit Care Med 1994; 22:1102-1107
18. 18. Calandra T, Gerain J, Heumann D, et al: High circulating levels of interleukin-6 in patients with septic shock: Evolution during sepsis, prognostic value, and interplay with other cytokines. Am J Med 1991; 91:23-29
19. 19. Friedland JS, Porter JC, Daryanani S, et al: Plasma proinflammatory cytokine concentrations, Acute Physiology and Chronic Health Evaluation (APACHE) III scores and survival in patients in an intensive care unit. Crit Care Med 1996; 24:1775-1781
20. 20. Van Dissel JT, Van Langevelde P, Westendorp RGJ, et al: Anti-inflammatory cytokine profile and mortality in febrile patients. Lancet 1998; 351:950-953
21. 21. Kirschenbaum L, Astiz M, Rackow EC: Antibodies to TNF-alpha: Too little, too late? Crit Care Med 1998; 26:1625-1626