Clot injection technique affects thrombolytic efficacy in a rat embolic stroke model: Implications for translaboratory collaborations

Journal of Cerebral Blood Flow and Metabolism

Volumn 34, Issue 4, 2014, Pages 677-682

  Marinescu, Marilena ^a   Bouley, James ^a   Chueh, Juyu ^a   Fisher, Marc ^a   Henninger, Nils ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

Animal model; Embolic stroke; Thrombolysis; Tissue plasminogen activator

Indexed keywords

ALTEPLASE; SODIUM CHLORIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD CLOT LYSIS; BRAIN BLOOD FLOW; BRAIN CIRCULUS ARTERIOSUS; BRAIN EDEMA; BRAIN INFARCTION SIZE; BRAIN PERFUSION; CONTROLLED STUDY; DRUG EFFICACY; EMBOLIC STROKE; EXPERIMENTAL STROKE; FLOW RATE; LASER DOPPLER FLOWMETRY; MALE; MORTALITY; NONHUMAN; PRIORITY JOURNAL; RAT; REPERFUSION INJURY; RETROSPECTIVE STUDY;

ANIMALS; CEREBROVASCULAR CIRCULATION; CLINICAL LABORATORY TECHNIQUES; COOPERATIVE BEHAVIOR; DISEASE MODELS, ANIMAL; FIBRINOLYTIC AGENTS; INFARCTION, MIDDLE CEREBRAL ARTERY; INJECTIONS, INTRA-ARTERIAL; INTRACRANIAL EMBOLISM; MALE; RATS; RATS, INBRED WKY; STROKE; TISSUE PLASMINOGEN ACTIVATOR; TREATMENT OUTCOME;

EID: 84897574851     PISSN: 0271678X     EISSN: 15597016     Source Type: Journal    
DOI: 10.1038/jcbfm.2014.1     Document Type: Article

References (22)

1. Zhu H, Fan X, Yu Z, Liu J, Murata Y, Lu J et al. Annexin A2 combined with low-dose tPA improves thrombolytic therapy in a rat model of focal embolic stroke. J Cereb Blood Flow Metab 2012; 30: 1137-1146.
2. Fan X, Lo EH, Wang X. Effects of minocycline plus tissue plasminogen activator combination therapy after focal embolic stroke in type 1 diabetic rats. Stroke 2013; 44: 745-752.
3. Henninger N, Sicard KM, Fisher M. Spectacular shrinking deficit: insights from multimodal magnetic resonance imaging after embolic middle cerebral artery occlusion in Sprague-Dawley rats. J Cereb Blood Flow Metab 2007b; 27: 1756-1763.
4. Lam CK, Yoo T, Hiner B, Liu Z, Grutzendler J. Embolus extravasation is an alternative mechanism for cerebral microvascular recanalization. Nature 2010; 465: 478-482.
5. Krueger M, Hartig W, Reichenbach A, Bechmann I, Michalski D. Blood-brain barrier breakdown after embolic stroke in rats occurs without ultrastructural evidence for disrupting tight junctions. PLoS ONE 2013; 8: e56419.
6. Strom JO, Ingberg E, Theodorsson A, Theodorsson E. Method parameters' impact on mortality and variability in rat stroke experiments: a meta-analysis. BMC Neurosci 2013; 14: 41.
7. Niessen F, Hilger T, Hoehn M, Hossmann KA. Differences in clot preparation determine outcome of recombinant tissue plasminogen activator treatment in experimental thromboembolic stroke. Stroke 2003; 34: 2019-2024.
8. Overgaard K, Rasmussen RS, Johansen FF. The site of embolization related to infarct size, oedema and clinical outcome in a rat stroke model - further translational stroke research. Exp Transl Stroke Med 2010; 2: 17.
9. Henninger N, Bouley J, Bratane BT, Bastan B, Shea M, Fisher M. Laser Doppler flowmetry predicts occlusion but not tPA-mediated reperfusion success after rat embolic stroke. Exp Neurol 2009; 215: 290-297.
10. Asahi M, Asahi K, Wang X, Lo EH. Reduction of tissue plasminogen activatorinduced hemorrhage and brain injury by free radical spin trapping after embolic focal cerebral ischemia in rats. J Cereb Blood Flow Metab 2000; 20: 452-457.
11. Dijkhuizen RM, Asahi M, Wu O, Rosen BR, Lo EH. Delayed rt-PA treatment in a rat embolic stroke model: diagnosis and prognosis of ischemic injury and hemorrhagic transformation with magnetic resonance imaging. J Cereb Blood Flow Metab 2001; 21: 964-971.
12. Tiebosch IA, Crielaard BJ, Bouts MJ, Zwartbol R, Salas-Perdomo A, Lammers T et al. Combined treatment with recombinant tissue plasminogen activator and dexamethasone phosphate-containing liposomes improves neurological outcome and restricts lesion progression after embolic stroke in rats. J Neurochem 2012; 123(Suppl 2): 65-74.
13. Fisher M, Feuerstein G, Howells DW, Hurn PD, Kent TA, Savitz SI et al. Update of the stroke therapy academic industry roundtable preclinical recommendations. Stroke 2009; 40: 2244-2250.
14. Dirnagl U, Hakim A, Macleod M, Fisher M, Howells D, Alan SM et al. A concerted appeal for international cooperation in preclinical stroke research. Stroke 2013; 44: 1754-1760.
15. Li F, Irie K, Anwer MS, Fisher M. Delayed triphenyltetrazolium chloride staining remains useful for evaluating cerebral infarct volume in a rat stroke model. J Cereb Blood Flow Metab 1997; 17: 1132-1135.
16. Henninger N, Sicard KM, Schmidt KF, Bardutzky J, Fisher M. Comparison of ischemic lesion evolution in embolic versus mechanical middle cerebral artery occlusion in Sprague Dawley rats using diffusion and perfusion imaging. Stroke 2006; 37: 1283-1287.
17. Walvick RP, Bratane BT, Henninger N, Sicard KM, Bouley J, Yu Z et al. Visualization of clot lysis in a rat embolic stroke model: application to comparative lytic efficacy. Stroke 2011; 42: 1110-1115.
18. Chueh JY, Kuhn AL, Puri AS, Wilson SD, Wakhloo AK, Gounis MJ. Reduction in distal emboli with proximal flow control during mechanical thrombectomy: a quantitative in vitro study. Stroke 2013; 44: 1396-1401.
19. Menzies SA, Hoff JT, Betz AL. Middle cerebral artery occlusion in rats: a neurological and pathological evaluation of a reproducible model. Neurosurgery 1992; 31: 100-106.
20. Gerriets T, Stolz E, Walberer M, Muller C, Kluge A, Bachmann A et al. Noninvasive quantification of brain edema and the space-occupying effect in rat stroke models using magnetic resonance imaging. Stroke 2004; 35: 566-571.
21. Henninger N, Bratane BT, Bastan B, Bouley J, Fisher M. Normobaric hyperoxia and delayed tPA treatment in a rat embolic stroke model. J Cereb Blood Flow Metab 2009; 29: 119-129.
22. Chen H, Yoshioka H, Kim GS, Jung JE, Okami N, Sakata H et al. Oxidative stress in ischemic brain damage: mechanisms of cell death and potential molecular targets for neuroprotection. Antioxid Redox Signal 2011; 14: 1505-1517.