Differences in clot preparation determine outcome of recombinant tissue plasminogen activator treatment in experimental thromboembolic stroke

Stroke

Volumn 34, Issue 8, 2003, Pages 2019-2024

  Niessen, Frank ^b   Hilger, Thomas ^b   Hoehn, Mathias ^b   Hossmann, Konstantin A ^a  

^a MAX PLANCK INSTITUTE FOR NEUROLOGICAL RESEARCH   (Germany)

^b NONE

Author keywords

Brain edema; Cerebral hemorrhage; Stroke, experimental; Thrombin; Thrombolysis

Indexed keywords

ADENOSINE TRIPHOSPHATE; ALTEPLASE; THROMBIN;

ACIDITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERIAL BLOOD; ARTICLE; BLOOD BRAIN BARRIER; BLOOD CLOT; BLOOD CLOT LYSIS; BLOOD CLOTTING; BRAIN EDEMA; BRAIN HEMORRHAGE; CONTROLLED STUDY; DIFFUSION COEFFICIENT; DISEASE MODEL; DRUG EFFICACY; DRUG MECHANISM; ELASTICITY; EMBOLISM; EXPERIMENTAL MODEL; FIBRINOLYTIC THERAPY; MIDDLE CEREBRAL ARTERY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PLASTICITY; PRIORITY JOURNAL; RAT; STROKE; THROMBOEMBOLISM; TREATMENT OUTCOME;

ADENOSINE TRIPHOSPHATE; ANIMALS; BLOOD-BRAIN BARRIER; BRAIN; CEREBRAL HEMORRHAGE; CEREBROVASCULAR ACCIDENT; CEREBROVASCULAR CIRCULATION; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; ELASTICITY; EXTRAVASATION OF DIAGNOSTIC AND THERAPEUTIC MATERIALS; FIBRIN; GADOLINIUM DTPA; INFARCTION, MIDDLE CEREBRAL ARTERY; INTRACRANIAL THROMBOSIS; MAGNETIC RESONANCE ANGIOGRAPHY; MALE; RATS; RATS, WISTAR; RECOMBINANT PROTEINS; REPERFUSION; THROMBIN; THROMBOLYTIC THERAPY; TIME FACTORS; TISSUE PLASMINOGEN ACTIVATOR; TREATMENT OUTCOME;

EID: 0042122367     PISSN: 00392499     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.STR.0000080941.73934.30     Document Type: Article

References (25)

1. Patterson C, Stouffer GA, Madamanchi N, Runge MS. New tricks for old dogs: nonthrombotic effects of thrombin in vessel wall biology. Circ Res. 2001;88:987-997.
2. Figueroa BE, Keep RF, Betz AL, Hoff JT. Plasminogen activators potentiate thrombin-induced brain injury. Stroke. 1998;29:1202-1207.
3. Andrew M, Schmidt B, Mitchell L, Paes B, Ofosu F. Thrombin generation in newborn plasma is critically dependent on the concentration of prothrombin. Thromb Haemost. 1990;63:27-30.
4. Smiles AM, Macy EM, Sakkinen PA, Bovill EG, Mann KG, Tracy RP. Variability in plasma prothrombin concentration: implications for use in epidemiology. Blood Coagul Fibrinolysis. 1998;9:525-531.
5. Overgaard K. Thrombolytic therapy in experimental embolic stroke. Cerebrovasc Brain Metab Rev. 1994;6:257-286.
6. Niessen F, Hilger T, Hoehn M, Hossmann KA. Thrombolytic treatment of clot embolism in rat: comparison of intra arterial and intravenous application of recombinant tissue plasminogen activator. Stroke. 2002;33:2999-3005.
7. Hilger T, Niessen F, Diedenhofen M, Hossmann KA, Hoehn M. Magnetic resonance angiography of thromboembolic stroke in rats: indicator of recanalization probability and tissue survival after recombinant tissue plasminogen activator treatment. J Cereb Blood Flow Metab. 2002;22:652-662.
8. Hochn-Berlage M, Norris DC, Kohno K, Mies G, Leibfritz D, Hossmann KA. Evolution of regional changes in apparent diffusion coefficient during focal ischemia of rat brain: the relationship of quantitative diffusion NMR imaging to reduction in cerebral blood flow and metabolic disturbances. J Cereb Blood Flow Metab. 1995;15:1002-1011.
9. Kirchhof K, Welzel T, Zoubaa S, Lichy C, Sikinger M, Lorbacher de Ruiz H, Sartor K. New method of embolus preparation for standardized embolic stroke in rabbits. Stroke. 2002;33:2329-2333.
10. Hossmann KA. Reperfusion of the brain after global ischemia: hemodynamic disturbances. Shock. 1997;8:95-101.
11. Francis CW, Markham RE Jr, Barlow GH, Florack TM, Dobrzynski DM, Marder VJ. Thrombin activity of fibrin thrombi and soluble plasmic derivatives. J Lab Clin Med. 1983;102:220-230.
12. Trumbo TA, Maurer MC. Thrombin hydrolysis of v29f and v341 mutants of factor XIII (28-41) reveals roles of the p(9) and p(4) positions in factor XIII activation. Biochemistry. 2002;41:2859-2868.
13. Collet JP, Park D, Lesty C, Soria J, Soria C, Montalescot G, Weisel JW. Influence of fibrin network conformation and fibrin fiber diameter on fibrinolysis speed: dynamic and structural approaches by confocal microscopy. Arterioscler Thromb Vasc Biol. 2000;20:1354-1361.
14. Calandre L, Grau M, Cabello A. Lysis rates with rt-PA vary between different human emboli in a rat model of cerebral embolism. Fibrinolysis Proteolysis. 1998;12:107-111.
15. Kumar R, Beguin S, Hemker HC. The effect of fibrin clots and clot-bound thrombin on the development of platelet procoagulant activity. Thromb Haemost. 1995;74:962-968.
16. Gruber A, Mori E, del Zoppo GJ, Waxman L, Griffin JH. Alteration of fibrin network by activated protein C. Blood. 1994;83:2541-2548.
17. Shibata M, Kumar SR, Amar A, Fernandez JA, Hofman F, Griffin JH, Zlokovic BV. Anti-inflammatory, antithrombotic, and neuroprotective effects of activated protein C in a murine model of focal ischemic stroke. Circulation. 2001;103:1799-1805.
18. Griffin JH. Blood coagulation: the thrombin paradox. Nature. 1995;378:337-338.
19. Lee KR, Betz AL, Keep RF, Chenevert TL, Kim S, Hoff JT. Intracerebral infusion of thrombin as a cause of brain edema. J Neurosurg. 1995;83:1045-1050.
20. Busch E, Krüger K, Fritze K, Allegrini PR, Hoehn-Berlage M, Hossmann KA. Blood-brain barrier disturbances after rt-PA treatment of thromboembolic stroke in the rat. Acta Neurochir Suppl. 1997;70:206-208.
21. Neumann-Haefelin C, Brinker G, Uhlenküken U, Pillekamp F, Hossmann KA, Hoehn M. Prediction of hemorrhagic transformation after thrombolytic therapy of clot embolism: an MRI investigation in rat brain. Stroke. 2002;33:1392-1398.
22. Dijkhuizen RM, Asahi M, Wu O, Rosen BR, Lo EH. Rapid breakdown of microvascular barriers and subsequent hemorrhagic transformation after delayed recombinant tissue plasminogen activator treatment in a rat embolic stroke model. Stroke. 2002;33:2100-2104.
23. Nakamura K, Hatano Y, Mori K. Thrombin-induced vasoconstriction in isolated cerebral arteries and the influence of a synthetic thrombin inhibitor. Thromb Res. 1985;40:715-720.
24. Turgeon VL, Houenou LJ. The role of thrombin-like (serine) proteases in the development, plasticity and pathology of the nervous system. Brain Res Rev. 1997;25:85-95.
25. Striggow F, Riek M, Breder J, Henrich-Noack P, Reymann KG, Reiser G. The protease thrombin is an endogenous mediator of hippocampal neuroprotection against ischemia at low concentrations but causes degeneration at high concentrations. Proc Natl Acad Sci USA. 2000;97:2264-2269.