Hepatoprotective effect of leaves of aqueous ethanol extract of Cestrum nocturnum against paracetamol-induced hepatotoxicity

Bangladesh Journal of Pharmacology

Volumn 9, Issue 2, 2014, Pages 167-170

  Imran Qadir, M ^a   Al Murad, Muhammad Sajid ^a   Ali, Muhammad ^b   Saleem, Mohammad ^a   Ahmad Farooqi, Ammad ^c  

^a GC UNIVERSITY   (Pakistan)

^b BAHAUDDIN ZAKARIYA UNIVERSITY   (Pakistan)

^c RLMC   (Pakistan)

Author keywords

Cestrum nocturnum; Hepatoprotective; Paracetamol; Silymarin

Indexed keywords

ALANINE AMINOTRANSFERASE; ALCOHOL; ALKALINE PHOSPHATASE; ALKALOID; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; CARBOHYDRATE; CESTRUM NOCTURNUM EXTRACT; ESSENTIAL OIL; FLAVANOID; LIVER PROTECTIVE AGENT; PARACETAMOL; PHENOL DERIVATIVE; PLANT EXTRACT; SAPONIN; SILYMARIN; TERPENE; UNCLASSIFIED DRUG; WATER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOCHEMICAL COMPOSITION; CESTRUM; CESTRUM NOCTURNUM; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVITY; FEMALE; HISTOPATHOLOGY; LIVER INJURY; LIVER PROTECTION; LIVER TOXICITY; MALE; MOUSE; NONHUMAN; PHYTOCHEMISTRY; PLANT LEAF;

EID: 84897549678     PISSN: 1991007X     EISSN: 19910088     Source Type: Journal    
DOI: 10.3329/bjp.v9i2.17770     Document Type: Article

References (23)

1. Akhtar MS, Asjad HMM, Bashir S, Malik A, Khalid R, Gulzar F, Irshad N. Evaluation of antioxidant and hepatoprotective effects of Khamira Gaozaban Ambri Jadwar Ood Saleeb Wala (KGA). Bangladesh J Pharmacol. 2013; 8: 44-48.
2. Ali M, Qadir MI, Saleem M, Janbaz KH, Gul H, Hussain L, Ahmed B. Hepatoprotective potential of Convolvulus arvensis against paracetamol-induced hepatotoxicity. Bangladesh J Pharmacol. 2013; 8: 300-04.
3. Ali M, Ramachandram R, Rafiullah MRM, Singh O, Siddiqui AW, Mir SR. Prevention of carbon tetrachloride-induced hepatotoxicity by the ethanol extract of Capparis moonii fruits in rats. Pharma Bio. 2004; 42: 286-88.
4. Al-Reza SM, Rahman A, Cho YS, Kang SC. Chemical composition and antioxidant activity of essential oil and organic extracts of Cestrum nocturnum L. J Essent Oil Bearing Plants. 2010; 13: 615-24.
5. Bag AK, Mumtaz SMF. Hepatoprotective and nephroprotective activity of hydroalcoholic extract OfIpomoea staphylina leaves. Bangladesh J Pharmacol. 2013; 8: 263-68.
6. Balamurugan G, Muthusamy P. Observation of the hepatoprotective and antioxidant activities of Trianthema decandra Linn. (Vallai sharunnai) roots on carbon tetrachloride-treated rats. Bangladesh J Pharmacol. 2008; 3: 83-89.
7. Farhan H, Rammal H, Hijazi A, Badran B. Preliminary phytochemical screening and extraction of polyphenol from stems and leaves of a Lebanese plant Malva parviflora L. Int J Curr Pharm Res. 2012; 4: 55-59.
8. 4 and paracetamolinduced hepatic damage in rats. Bangladesh J Pharmacol. 2010; 5: 73-76.
9. Khan MA, Inayat H, Khan H, Saeed M, Khan I, Rahman I. Antimicrobial activities of the whole plant of Cestrum nocturnum against pathogenic microorganisms. Afr J Microbiol Res. 2011; 5: 612-16.
10. Khan YH, Mallhi TH, Sarriff A, Khan AH. Osteoporosis: are healthcare professionals missing an opportunity. Springer Plus. 2013; 2: 1-5.
11. Mazumder A, Bhatt A, Bonde VA, Shaikh A, Mazumder R. Evaluation of Cestrum Nocturnum for its anti-inflammatory and analgesic potentiality. J Herbal Med Toxicol. 2010; 4: 113-17.
12. Perez SH, Buznego MT. Behavioral and antiepileptic effects of acute administration of the extract of the plant Cestrum nocturnum Lin lady of the night. Epilepsy Behavior. 2008; 12: 366-72.
13. Prasad MP, Apoorva P, Thakur MS, Ruparel YM. Phytochemical screening, anti-oxidant potential and antimicrobial activities in three species of Cestrum plants. Int J Pharma Bio Sci. 2013; 4: 673-78.
14. Raja S, Ahamed KFH, Kumar V. Antioxidant effect of Cytisus scoparius against carbon tetrachloride treated liver injury in rats. J Ethnopharmacol. 2006; 109: 41-47.
15. Sabir MS, Rocha TBJ. Water-extractable phytochemicals from Phyllanthus niruri exhibit distinct in vitro antioxidant and in vivo hepatoprotective activity against paracetamol-induced liver damage in mice. Food Chem. 2008; 111: 845-51.
16. Saboo SS, Tapadiya G, Farooqui IA, Khadabadi SS. Free radical scavenging, in vivo antioxidant and hepatoprotective activity of folk medicine Trichodesma sedgwickianum. Bangladesh J Pharmacol. 2013; 8: 58-64.
17. Sadeque MZ, Begum ZA. Protective effect of dried fruits of Carica papaya on hepatotoxicity in rat. Bangladesh J Pharmacol. 2010; 5: 48-50.
18. Savchenko T, Whiting P, Germade A, Dinan L. Ecdysteroid agonist and antagonist activities in the species of Solanaceae. Biochem System Ecol. 2000; 28: 403-19.
19. Subramonium A, Pushpangadan P. Development of phytomedicines for liver diseases. Indian J Pharmacol. 1999; 31: 166-75.
20. Thakare SP, Jain HN, Patil SD, Upadhyay UM. Hepatoprotective effect of Cocculus hirsutus on bile duct ligation-induced liver fibrosis in albino Wistar rats. Bangladesh J Pharmacol. 2009; 4: 126-30.
21. Zeng J, Huang XH, Lai F. Study of local anesthetic effect of Cestrum nocturnum water extract. Gannan Yixueyuan Xuebao. 2002; 23: 1-3.
22. Zeng J, Li FZ, Ye HY. Study of the inhibitory effect of Cestrum nocturnum, L. n-butlalcohol extract on central nerve system. Gannan Yixueyuan Xuebao. 2003; 23: 237-39.
23. Zhong ZG, Zhao SY. Experimental studies on antitumour effect of the extract of Cestrum nocturnum invivo. Zhong Yao Cai. 2008; 31: 1709-12.