Hepatoprotective effect of Cocculus hirsutus on bile duct ligation-induced liver fibrosis in Albino Wistar rats

Bangladesh Journal of Pharmacology

Volumn 4, Issue 2, 2009, Pages 126-130

  Thakare, Sagar P ^a   Jain, Hitesh N ^a   Patil, Savita D ^b   Upadhyay, Umesh M ^a  

^a Sigma Institute of Pharmacy   (India)

^b R C PATEL INSTITUTE OF PHARMACEUTICAL EDUCATION AND RESEARCH   (India)

Author keywords

Bile duct ligation; Cocculus hirsutus; Glutathione; Hepatoprotective activity; Oxidative stress

Indexed keywords

BILE ACID; COCCULUS HIRSUTUS EXTRACT; GLUTATHIONE REDUCTASE; HYDROXYPROLINE; PLANT EXTRACT; REACTIVE OXYGEN METABOLITE; SILYMARIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BILE DUCT LIGATION; BIOCHEMISTRY; BLOOD SAMPLING; COCCULUS HIRSUTUS; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME BLOOD LEVEL; FEMALE; HISTOPATHOLOGY; IN VIVO STUDY; LIPID LIVER LEVEL; LIPID PEROXIDATION; LIVER; LIVER FIBROSIS; LIVER PROTECTION; MALE; MEDICINAL PLANT; NONHUMAN; OXIDATIVE STRESS; RAT; WISTAR RAT;

EID: 85090372583     PISSN: 1991007X     EISSN: None     Source Type: Journal    
DOI: 10.3329/bjp.v4i2.2980     Document Type: Article

References (25)

1. Balamurugan G, Muthusamy P. Observation of the hepatoprotective and antioxidant activities of Trianthema decandra Linn. (Vallai sharunnai) roots on carbon tetrachloride-treated rats. Bangladesh J Pharmacol. 2008; 3: 83-89. doi:10.3329/bjp.v3i2.890
2. Buetler E, Duron O, Kelly BM. Proved method for determination of blood glutathione. J Lab Clin Med. 1963; 61: 882-87.
3. D'SOUZA M. Tribal Medicine. Social center, Ahmednagar, 1st ed. India, 1998, pp 143-144.
4. Ganapaty S, Dash GK, Suresh P. Diuretic, laxative and toxicity studies of Cocculus hirsutus aerial parts. Fitoterapia 2002; 73: 28-31. doi:10.1016/S0367-326X(01)00345-8
5. Ganapaty S, Vijay K. Hypoglycemic activity of aerial parts of Cocculus hirsutus on alloxan-induced diabetes. Indian J Nat Prod. 2006; 22: 17-20.
6. Iqbal MJ, Dewan ZF, Choudhury SAR, Mamun MIR, Mashiuzzaman M, Begum M. Pre-treatment by hexane extract of Phyllanthus niruri can alleviate paracetamolinduced damage of the rat liver. Bangladesh J Pharmacol. 2007; 2: 43-48. doi.10.3329/bjp.v2i1.499
7. Jayakar B, Sangameswaran B. Anti-diabetic and spermatogenic activity of Cocculus hirsutus (L) diels. African J Biotech. 2007; 6: 1212-16.
8. Kirtikar KR, Basu BD. Indian medicinal plants. 2nd ed. India, International Book Publishers, 1987, pp 86-87.
9. Kokate CK, Purohit AP, Gokhale SB. Pharmacognosy, 26th ed. India, Nirali Prakashan, 2004, pp 101-10.
10. Lee TY, Chang HH, Chenjenn H. Herb medicine ameliorates hepatic fibrosis in bile duct ligation rats. J Ethnopharmacol. 2007; 109: 318-24. doi:10.1016/j.jep.2006.07.042
11. Lin CC, Yen MH, Lo TS, Lin JM. Evaluation of the hepatoprotective and antioxidant activity of Boehmeria nivea var. nivea and B. nivea var. tenacissima. J Ethnopharmacol. 1998; 60: 9-17. doi:10.1016/S0378-8741(97) 00122-0
12. OECD Guidelines for the testing of chemicals revised draft guideline 425: Acute oral toxicity - 2001. Acute toxic class method.
13. Palsamy P, Malathi R. Evaluation of hypoglycemic and hypolipidemic activity of methanolic extract of Cocculus hirsutus (L) diels leves in streptozotocin-induced diabetes mellitus rats. Int J Biol Chem. 2007; 1: 205-12. doi:10.3923/ijbc.2007.205.212
14. Panda BK, Mishra US. Antibacterial activity of the leaves of Cocculus hirsutus. Indian Drugs 2007; 44: 108-10.
15. Rao VN, Patil N, Shalam MD. Hepatoprotective activity of alcoholic and aqueous extracts of leaves of Tylophora indica (Linn) in rats. Indian J Pharmacol. 2007; 39: 43-47. doi:10.4103/0253-7613.30763
16. Sanmugapriya E, Venkataraman S. Studies on hepatoprotective and antioxidant actions of Strychnos potatoram Linn. seeds on CCl4 induced acute hepatic injury in experimental rats. J Ethnopharmacol. 2006; 105: 154-60. doi:10.1016/j.jep.2005.10.028
17. Saraswat B, Visen PKS, Patnaik GK, Dhawan BN. Ex vivo and in vivo investigations of picroliv from Picrorhiza kurrooa and in alcohol intoxication model in rats. J Ethnopharmacol. 1999; 66: 263-69. doi:10.1016/S0378-8741(99)00007-0
18. Saxena AK, Singh B, Anand KK. Hepatoprotective effects of Eclipta alba on subcellular levels in rats. J Ethnopharmacol. 1993; 40: 155-16. doi:10.1016/0378-8741(93)90063-B
19. Tieppo J, Vercelino R, Dias AS, Marroni CA, Marroni N. Common bile duct ligation as a model of hepatopulmonary syndrome and oxidative stress. Arq Gastroenterol. 2005; 42: 244-48. doi:10.1590/S0004-28032005000400010
20. Torres-Durain PV, Miranda-Zamora R, Paredes Carbajal MC, Mascher D, Bie-Castillo J, Diaz-Zagoya JC. Studies on the preventive effect of Spirulina maxima on fatty liver development by carbon tetrachloride in the rat. J Ethnopharmacol. 1999; 64: 141-47. doi:10.1016/S0378-8741(98)00120-2
21. Vogel GH, Vogel WH. Drug discovery and evaluation. Pharmacological Assays. 2nd ed. Germany. Springer. 2002, pp 936-44. doi:10.1007/3-540-29837-1
22. Wang G, Shen H, Rajaraman G, Roberts MS, Gong Y, Jiang P, Burczynsk F. Expression and antioxidant function of liver fatty acid binding protein in normal and bile-duct ligated rats. Eur J Pharmacol. 2007; 560: 61-68. doi:10.1016/j.ejphar.2007.01.015
23. Wardi J, Reifen R, Aeed H., Zadel L, Avni Y, Bruck R. Beta carotene attenuates experimentally induced liver cirrhosis in rats. Isr Med Assoc J. 2001; 3: 151-54.
24. Yoshioka K, Mori A, Taniguchi K, Mutoh K. Cell proliferation activity of proliferating bile duct after bile duct ligation in rats. Vet Pathol. 2005; 42: 382-85. doi:10.1354/vp.42-3-382
25. Zafar R, Ali SM. Anti-hepatotoxic effects of root and root callus of Cichorium intybus. J Ethnopharmacol. 1998: 63: 227-31. doi:10.1016/S0378-8741(98)00087-7