Water-extractable phytochemicals from Phyllanthus niruri exhibit distinct in vitro antioxidant and in vivo hepatoprotective activity against paracetamol-induced liver damage in mice

Food Chemistry

Volumn 111, Issue 4, 2008, Pages 845-851

  Sabir, S M ^a,b   Rocha, J B T ^b  

^a UNIVERSITY OF AZAD JAMMU AND KASHMIR   (Pakistan)

^b CCNE   (Brazil)

Author keywords

Antioxidant; Lipid peroxidation; Paracetamol; Phyllanthus niruri; Pro oxidants; Serum enzymes

Indexed keywords

1,1 DIPHENYL 2 PICRYLHYDRAZYL; ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CATALASE; FERROUS SULFATE; NITROPRUSSIDE SODIUM; PARACETAMOL; PHOSPHOLIPID; PHYLLANTHUS NIRURI EXTRACT; PLANT MEDICINAL PRODUCT; THIOBARBITURIC ACID REACTIVE SUBSTANCE;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BRAIN HOMOGENATE; CONTROLLED STUDY; DRUG ISOLATION; ENZYME ACTIVITY; IC 50; IN VITRO STUDY; IN VIVO STUDY; IRON CHELATION; KIDNEY HOMOGENATE; LIPID PEROXIDATION; LIVER HOMOGENATE; LIVER INJURY; LIVER PROTECTION; MOUSE; NONHUMAN; RAT;

MUS; PHYLLANTHUS NIRURI; RATTUS;

EID: 84984585914     PISSN: 03088146     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.foodchem.2008.04.060     Document Type: Article

References (31)

1. In: Aebi H.E., and Bergmeyer H.O. (Eds). Catalase, methods enzymology (1983), Academic Press, New York 2
2. Amar P.J., and Schiff E.R. Acetaminophen safety and hepatotoxicity where do we go from here?. Expert Opinion on Drug Safety 6 (2007) 341-355
3. Angela B.R., Richard C.K., Sandra S.M., Robert W.B., and Jack A.H. Mechanism of acetaminophen-induced hepatotoxicity: Role of oxidative stress and mitochondrial permeability transition in freshly isolated mouse hepatocytes. The Journal of Pharmacology and Experimental Therapeutics 312 (2005) 509-516
4. Bates J.N., Baker M.T., Guerra R., and Harrison D.G. Nitric oxide generation from nitroprusside by vascular tissue. Biochemical Pharmacology 42 (1990) S157-S165
5. Chen H.J., Wu C.F., and Huang J.L. Measurement of urinary excretion of 5-hydroxymethyluracil in human by GC/NICI/MS: Correlation with cigarette smoking, urinary TBARS and etheno DNA adduct. Toxicology Letters 155 (2005) 403-4102
6. Calliste C.A., Trouillas P., Allais D.P., Simon A., and Duroux J.L. Free radical scavenging activities measured by electron spin resonance spectroscopy and B16 cell antiproliferative behaviours of seven plants. Journal of Agriculture and Food Chemistry 49 (2001) 3321-3327
7. Elise A.M., and James R.C. The case of iron chelation and or antioxidant therapy in Alzheimer's disease. Drug Development Research 56 (2002) 520-526
8. Fraga C.G., and Oteiza P.I. Iron toxicity and antioxidant nutrients. Toxicology 80 (2002) 23-32
9. Ghasanfari G., Minaie B., Yasa N., Leilu A.N., and Azadeh M. Biochemical and histopathological evidences for beneficial effects of Satureja Khuzestanica Jamzad essential oil on the mouse model of inflammatory bowel diseases. Toxicology Mechanism and Methods 16 (2006) 365-372
10. Groote D.J., and Steenbergen V.W. Paracetamol intoxication and N-acetyl-cysteine treatment. Acta Gastro-Enterologica Bélgica 58 (1995) 326-334
11. Gulcum I., Oktay M., Krreccr E.O., and Kufrevioglu I. Screening of antioxidant and antimicrobial activities of anise (Pimpinella anisum L.) seed extracts. Food Chemistry 83 (2003) 371-382
12. Houglum K., Filip M., Witztum J.L., and Chojkier M. Malondialdehyde and 4-hydroxynonenal protein adducts in plasma and liver of rats with iron overload. Journal of Clinical Investigation 86 (1990) 1991-1998
13. Harish R., and Shivanandappa T. Antioxidative and hepatoprotective potential of Phyllanthus niruri. Food Chemistry 95 (2005) 180-185
14. Halliwell B., Gutteridge J.M.C., and Cross C.E. Free radicals, antioxidants and human disease: Where are we now?. Journal of Laboratory and Clinical Medicine 119 (1992) 598-620
15. Hatano T., Kagawa H., Yasuhara T., and Okuda T. Two new flavonoids and other constituents in licorice root; their relative astringency and radical scavenging effects. Chemical and Pharmaceutical Bulletin 36 (1988) 2090-2097
16. Hertog M.G.L., Hollman P.C.H., and Van P.B. Content of potentially anticarcinogenic flavonoids of tea infusions, wines and fruit juices. Journal of Agriculture and Food Chemistry 41 (1993) 1242-1246
17. Kosalec I., Bakmaz M., Pepeliniak S., and Vladimir-Knezevic S. Quantitative analysis of the flavonoids in raw propolis from northern Croatia. Acta Pharmaceutica 54 (2004) 65-72
18. 4 induced hepatotoxicity in rodents. Fitoterapia 73 (2002) 557-563
19. Micali C., Sighinolfi M.C., Celia A., Stefani S.D., Grande M., Cicero A.F., and Bianchi G. Can Phyllanthus niruri affect the efficacy of extracorporeal shock wave lithotripsy for renal stones? A randomized, prospective, long-term study. The Journal of Urology 176 (2006) 1020-1022
20. Nicolaou A., Waterfield C.J., Kenyon S.H., and Gibbons W.A. The inactivation of methionine synthase in isolated rat hepatocytes by sodium nitroprusside. European Journal of Biochemistry 244 (1997) 876-882
21. Ohkawa H., Ohishi N., and Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Analytical Biochemistry 95 (1979) 351-358
22. Puntel R.L., Nogueira C.W., and Rocha J.B.T. Krebs cycle intermediates modulate thiobarbituric acid reactive species (TBARS) production in rat brain in vitro. Neurochemical Research 30 (2005) 225-235
23. Qian-Cutrone J. Niruriside, a new HIV REV/RRE binding inhibitor from Phyllanthus niruri. Journal of Natural Products 59 (1996) 196-199
24. Rajeshkumar N.V., Joy K.L., Girija K., Ramsewak R.S., Nair M.G., and Ramadasan K. Antitumour and anticarcinogenic activity of Phyllanthus amarus extract. Journal of Ethnopharmacology 81 (2002) 17-22
25. Schidt F.V., Rochling F.V., Cassey D.L., and Lee W.M. Acetaminophen toxicity in an urban country hospital. New England Journal of Medicine 337 (1997) 1112-1117
26. Singleton V.L., Orthofer R., and Lamuela-Raventos R.M. Analysis of total phenols and other oxidation substrates and antioxidants by means of Folin-Ciocalteu Reagent. Methods of Enzymology 299 (1999) 152-178
27. Shamasundar K.V., Singh B., Thakur R.S., Hussain A., Kiso Y., and Hikino H. Antihepatoprotective principles of Phyllanthus niruri herbs. Journal of Ethnopharmacology 14 (1985) 41-44
28. Vieira R.F. Conservation of medicinal and aromatic plants in Brazil. In: Janick J. (Ed). Perspective in new crops and new uses (1999), AHS press, Alexandria, VA 152-159
29. Whittaker B.S., Berlett E.R., and Stadtman R.R. Protein oxidation in aging diseases and oxidative stress. Journal of Biological Chemistry 272 (1997) 20313-20316
30. Yeh S.F., Hong C.Y., Huang Y.L., Liu T.Y., Choo K.B., and Chou C.K. Effect of an extract from Phyllanthus amarus on hepatitis B surface antigen gene expression in human hepatoma cells. Antiviral Research 20 (1993) 185-192
31. Zimmerman H.J., and Seeff L.B. Enzymes in hepatic disease. In: Goodly E.L. (Ed). Diagnostic enzymology (1970), Lea & Febiger, Philadelphia, USA 1-38