Non-invasive fecal metabonomic detection of colorectal cancer

Cancer Biology and Therapy

Volumn 15, Issue 4, 2014, Pages 389-397

  Phua, Lee Cheng ^a   Chue, Xiu Ping ^a   Koh, Poh Koon ^b   Cheah, Peh Yean ^a,b   Ho, Han Kiat ^a   Chan, Eric Chun Yong ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b SINGAPORE GENERAL HOSPITAL   (Singapore)

Author keywords

Colorectal cancer; Feces; Gas chromatography time of flight mass spectrometry; Metabolic profiling; Metabolomics; Metabonomics

Indexed keywords

CITRIC ACID; CREATININE; FRUCTOSE; GALACTOSE; GLUCOSE; GLYCERIC ACID; INOSINE; LINOLEIC ACID; NICOTINIC ACID; PROLINE; URACIL; URIDINE; TUMOR MARKER;

ADULT; ARTICLE; CANCER CELL; CANCER DIAGNOSIS; CANCER LOCALIZATION; CLINICAL ARTICLE; COLORECTAL CANCER; CONTROLLED STUDY; DISEASE SEVERITY; FECAL METABONOMIC; FECES ANALYSIS; FEMALE; GAS CHROMATOGRAPHY; HUMAN; HUMAN TISSUE; MALE; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; METABOLITE; NON INVASIVE PROCEDURE; RECTUM; SIGMOID; TISSUE LEVEL; AGED; CASE CONTROL STUDY; CHEMISTRY; COLORECTAL TUMOR; FECES; METABOLISM; METABOLOME; MIDDLE AGED; VERY ELDERLY;

AGED; AGED, 80 AND OVER; BIOMARKERS, TUMOR; CASE-CONTROL STUDIES; COLORECTAL NEOPLASMS; FECES; FEMALE; HUMANS; MALE; METABOLOME; MIDDLE AGED;

EID: 84897549431     PISSN: 15384047     EISSN: 15558576     Source Type: Journal    
DOI: 10.4161/cbt.27625     Document Type: Article

References (42)

1. Ferlay J, Shin HR, Bray F, Forman D, Mathers C, Parkin DM. GLOBOCAN 2008 v2.0, Cancer Incidence and Mortality Worldwide: IARC CancerBase No. 10 Lyon, France: International Agency for Research on Cancer, 2010.
2. American Cancer Society Cancer Facts and Figures. American Cancer Society, 2012.
3. Ouyang DL, Chen JJ, Getzenberg RH, Schoen RE. Noninvasive testing for colorectal cancer: a review. Am J Gastroenterol 2005; 100:1393-403; PMID:15929776; http://dx.doi.org/10.1111/j.1572-0241.2005.41427.x
4. Ransohoff DF, Sandler RS. Clinical practice. Screening for colorectal cancer. N Engl J Med 2002; 346:40-4; PMID:11778002; http://dx.doi.org/10.1056/ NEJMcp010886
5. Osborn NK, Ahlquist DA. Stool screening for colorectal cancer: molecular approaches. Gastroenterology 2005; 128:192-206; PMID:15633136; http://dx.doi.org/10.1053/j.gastro.2004.10.041
6. Takai T, Kanaoka S, Yoshida K, Hamaya Y, Ikuma M, Miura N, Sugimura H, Kajimura M, Hishida A. Fecal cyclooxygenase 2 plus matrix metalloproteinase 7 mRNA assays as a marker for colorectal cancer screening. Cancer Epidemiol Biomarkers Prev 2009; 18:1888-93; PMID:19505922; http://dx.doi.org/10.1158/1055- 9965.EPI-08-0937
7. Kroemer G, Pouyssegur J. Tumor cell metabolism: cancer's Achilles' heel. Cancer Cell 2008; 13:472-82; PMID:18538731; http://dx.doi.org/10.1016/j.ccr. 2008.05.005
8. Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell 2011; 144:646-74; PMID:21376230; http://dx.doi.org/10.1016/j.cell.2011.02.013
9. Vander Heiden MG, Cantley LC, Thompson CB. Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science 2009; 324:1029-33; PMID:19460998; http://dx.doi.org/10.1126/science.1160809
10. Benjamin DI, Cravatt BF, Nomura DK. Global profiling strategies for mapping dysregulated metabolic pathways in cancer. Cell Metab 2012; 16:565-77; PMID:23063552; http://dx.doi.org/10.1016/j.cmet.2012.09.013
11. Chan EC, Koh PK, Mal M, Cheah PY, Eu KW, Backshall A, Cavill R, Nicholson JK, Keun HC. Metabolic profiling of human colorectal cancer using high-resolution magic angle spinning nuclear magnetic resonance (HR-MAS NMR) spectroscopy and gas chromatography mass spectrometry (GC/MS). J Proteome Res 2009; 8:352-61; PMID:19063642; http://dx.doi.org/10.1021/pr8006232
12. Mal M, Koh PK, Cheah PY, Chan EC. Metabotyping of human colorectal cancer using two-dimensional gas chromatography mass spectrometry. Anal Bioanal Chem 2012; 403:483-93; PMID:22374317; http://dx.doi.org/10.1007/s00216-012-5870-5
13. Mal M, Koh PK, Cheah PY, Chan ECY. Development and validation of a gas chromatography/mass spectrometry method for the metabolic profiling of human colon tissue. Rapid Commun Mass Spectrom 2009; 23:487-94; PMID:19140133; http://dx.doi.org/10.1002/rcm.3898
14. Ong ES, Zou L, Li S, Cheah PY, Eu KW, Ong CN. Metabolic profiling in colorectal cancer reveals signature metabolic shifts during tumorigenesis. Mol Cell Proteomics 2010; (Forthcoming); PMID:20147338; http://dx.doi.org/10.1074/ mcp. M900551-MCP200
15. Piotto M, Moussallieh FM, Dillmann B, Imperiale A, Neuville A, Brigand C, Bellocq JP, Elbayed K, Namer IJ. Metabolic characterization of primary human colorectal cancers using high resolution magic angle spinning 1H magnetic resonance spectroscopy. Metabolomics 2009; 5:292-301; http://dx.doi. org/10.1007/s11306-008-0151-1
16. Denkert C, Budczies J, Weichert W, Wohlgemuth G, Scholz M, Kind T, Niesporek S, Noske A, Buckendahl A, Dietel M, et al. Metabolite profiling of human colon carcinoma - deregulation of TCA cycle and amino acid turnover. Mol Cancer 2008; 7:72; PMID:18799019; http://dx.doi. org/10.1186/1476-4598-7-72
17. Lean CL, Newland RC, Ende DA, Bokey EL, Smith IC, Mountford CE. Assessment of human colorectal biopsies by 1H MRS: correlation with histopathology. Magn Reson Med 1993; 30:525-33; PMID:8259052; http://dx.doi.org/10.1002/mrm.1910300502
18. Balamurugan R, Rajendiran E, George S, Samuel GV, Ramakrishna BS. Real-time polymerase chain reaction quantification of specific butyrate-producing bacteria, Desulfovibrio and Enterococcus faecalis in the feces of patients with colorectal cancer. J Gastroenterol Hepatol 2008; 23:1298-303; PMID:18624900; http://dx.doi.org/10.1111/j.1440-1746.2008.05490.x
19. Wang T, Cai G, Qiu Y, Fei N, Zhang M, Pang X, Jia W, Cai S, Zhao L. Structural segregation of gut microbiota between colorectal cancer patients and healthy volunteers. ISME J 2012; 6:320-9; PMID:21850056; http://dx.doi.org/10. 1038/ ismej.2011.109
20. Monleón D, Morales JM, Barrasa A, López JA, Vázquez C, Celda B. Metabolite profiling of fecal water extracts from human colorectal cancer. NMR Biomed 2009; 22:342-8; PMID:19006102; http:// dx.doi.org/10.1002/ nbm.1345
21. Bezabeh T, Somorjai R, Dolenko B, Bryskina N, Levin B, Bernstein CN, Jeyarajah E, Steinhart AH, Rubin DT, Smith IC. Detecting colorectal cancer by 1H magnetic resonance spectroscopy of fecal extracts. NMR Biomed 2009; 22:593-600; PMID:19259992; http://dx.doi.org/10.1002/nbm.1372
22. Pasikanti KK, Ho PC, Chan EC. Gas chromatography/mass spectrometry in metabolic profiling of biological fluids. J Chromatogr B Analyt Technol Biomed Life Sci 2008; 871:202- 11; PMID:18479983; http://dx.doi.org/10.1016/j. jchromb.2008.04.033
23. Lu J, Zhou J, Bao Y, Chen T, Zhang Y, Zhao A, Qiu Y, Xie G, Wang C, Jia W, et al. Serum metabolic signatures of fulminant type 1 diabetes. J Proteome Res 2012; 11:4705-11; PMID:22894710; http://dx.doi.org/10.1021/pr300523x
24. Li X, Xu Z, Lu X, Yang X, Yin P, Kong H, Yu Y, Xu G. Comprehensive two-dimensional gas chromatography/time-of-flight mass spectrometry for metabonomics: Biomarker discovery for diabetes mellitus. Anal Chim Acta 2009; 633:257-62; PMID:19166731; http://dx.doi.org/10.1016/j. aca.2008.11.058
25. Ye G, Zhu B, Yao Z, Yin P, Lu X, Kong H, Fan F, Jiao B, Xu G. Analysis of urinary metabolic signatures of early hepatocellular carcinoma recurrence after surgical removal using gas chromatography-mass spectrometry. J Proteome Res 2012; 11:4361-72; PMID:22768978; http://dx.doi.org/10.1021/pr300502v
26. Pasikanti KK, Esuvaranathan K, Ho PC, Mahendran R, Kamaraj R, Wu QH, Chiong E, Chan EC. Noninvasive urinary metabonomic diagnosis of human bladder cancer. J Proteome Res 2010; 9:2988-95; PMID:20337499; http://dx.doi.org/10. 1021/ pr901173v
27. Caldeira M, Perestrelo R, Barros AS, Bilelo MJ, Morête A, Câmara JS, Rocha SM. Allergic asthma exhaled breath metabolome: a challenge for comprehensive two-dimensional gas chromatography. J Chromatogr A 2012; 1254:87-97; PMID:22835687; http://dx.doi.org/10.1016/j.chroma.2012.07.023
28. Trygg J, Holmes E, Lundstedt T. Chemometrics in metabonomics. J Proteome Res 2007; 6:469-79; PMID:17269704; http://dx.doi.org/10.1021/ pr060594q
29. Wiklund S, Johansson E, Sjöström L, Mellerowicz EJ, Edlund U, Shockcor JP, Gottfries J, Moritz T, Trygg J. Visualization of GC/TOF-MS-based metabolomics data for identification of biochemically interesting compounds using OPLS class models. Anal Chem 2008; 80:115-22; PMID:18027910; http://dx.doi. org/10.1021/ac0713510
30. Calvani R, Miccheli A, Capuani G, Tomassini Miccheli A, Puccetti C, Delfini M, Iaconelli A, Nanni G, Mingrone G. Gut microbiome-derived metabolites characterize a peculiar obese urinary metabotype. Int J Obes (Lond) 2010; 34:1095-8; PMID:20212498; http://dx.doi.org/10.1038/ijo.2010.44
31. Vallejo M, García A, Tuñón J, García- Martínez D, Angulo S, Martin-Ventura JL, Blanco-Colio LM, Almeida P, Egido J, Barbas C. Plasma fingerprinting with GC-MS in acute coronary syndrome. Anal Bioanal Chem 2009; 394:1517-24; PMID:19172251; http://dx.doi.org/10.1007/ s00216-009-2610-6
32. Sharif AW, Williams HR, Lampejo T, Khan SA, Bansi DS, Westaby D, Thillainayagam AV, Thomas HC, Cox IJ, Taylor-Robinson SD. Metabolic profiling of bile in cholangiocarcinoma using in vitro magnetic resonance spectroscopy. HPB (Oxford) 2010; 12:396-402; PMID:20662790; http://dx.doi. org/10.1111/j.1477- 2574.2010.00185.x
33. Phua LC, Koh PK, Cheah PY, Ho HK, Chan ECY. Global gas chromatography/time-of-flight mass spectrometry (GC/TOFMS)-based metabonomic profiling of lyophilized human feces. J Chromatogr B Analyt Technol Biomed Life Sci 2013; 937:103-13; PMID:24029555; http://dx.doi.org/10.1016/j. jchromb.2013.08.025
34. Jiménez B, Mirnezami R, Kinross J, Cloarec O, Keun HC, Holmes E, Goldin RD, Ziprin P, Darzi A, Nicholson JK. 1H HR-MAS NMR spectroscopy of tumor-induced local metabolic "field-effects" enables colorectal cancer staging and prognostication. J Proteome Res 2013; 12:959-68; PMID:23240862; http://dx.doi.org/10.1021/pr3010106
35. Weir TL, Manter DK, Sheflin AM, Barnett BA, Heuberger AL, Ryan EP. Stool microbiome and metabolome differences between colorectal cancer patients and healthy adults. PLoS One 2013; 8:e70803; PMID:23940645; http://dx.doi.org/10. 1371/journal.pone.0070803
36. Godoy A, Ulloa V, Rodríguez F, Reinicke K, Yañez AJ, García MdeL, Medina RA, Carrasco M, Barberis S, Castro T, et al. Differential subcellular distribution of glucose transporters GLUT1-6 and GLUT9 in human cancer: ultrastructural localization of GLUT1 and GLUT5 in breast tumor tissues. J Cell Physiol 2006; 207:614-27; PMID:16523487; http://dx.doi. org/10.1002/jcp.20606
37. Zlobec I, Bihl MP, Schwarb H, Terracciano L, Lugli A. Clinicopathological and protein characterization of BRAF- and K-RAS-mutated colorectal cancer and implications for prognosis. Int J Cancer 2010; 127:367-80; PMID:19908233
38. Kirkland JB. Niacin requirements for genomic stability. Mutat Res 2012; 733:14-20; PMID:22138132; http://dx.doi.org/10.1016/j. mrfmmm.2011.11.008
39. Mayo B, van Sinderen D. Bifidobacteria: Genomics and Molecular Aspects. Caister Acad. Press, 2010.
40. Vandendool H, Kratz PD. A Generalization of the Retention Index System Including Linear Temperature Programmed Gas-Liquid Partition Chromatography. J Chromatogr 1963; 11:463- 71; PMID:14062605; http://dx.doi.org/10.1016/ S0021-9673(01)80947-X
41. Verner P. Separation, quantification and identification of non-volatile organic acids in body fluids by gas chromatography. J Pharm Biomed Anal 1988; 6:131-50; PMID:16867427; http://dx.doi. org/10.1016/0731-7085(88)80040-2
42. van den Berg RA, Hoefsloot HC, Westerhuis JA, Smilde AK, van der Werf MJ. Centering, scaling, and transformations: improving the biological information content of metabolomics data. BMC Genomics 2006; 7:142; PMID:16762068; http://dx.doi.org/10.1186/1471-2164-7-142