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Bioorganic and Medicinal Chemistry Letters

Volumn 24, Issue 8, 2014, Pages 1923-1927

Highly potent and selective 3-N-methylquinazoline-4(3H)-one based inhibitors of B-RafV600E kinase

(17) Wenglowsky, Steve a Ren, Li a Grina, Jonas a Hansen, Joshua D a Laird, Ellen R a Moreno, David a Dinkel, Victoria a Gloor, Susan L a Hastings, Gregg a Rana, Sumeet a Rasor, Kevin a Sturgis, Hillary L a Voegtli, Walter C a Vigers, Guy a Willis, Brandon a Mathieu, Simon b Rudolph, Joachim b

a ARRAY BIOPHARMA INC (United States)

b GENENTECH INC (United States)

Author keywords

B Raf inhibitors; Kinase drug discovery; Melonoma; Type IIB inhibitor

Indexed keywords

ADENOSINE TRIPHOSPHATE; AMIDE; AZ 628; B RAF KINASE; B RAF KINASE INHIBITOR; KETONE DERIVATIVE; PHOSPHOTRANSFERASE INHIBITOR; POLYCYCLIC AROMATIC HYDROCARBON DERIVATIVE; QUINAZOLINE DERIVATIVE; SULFONAMIDE; UNCLASSIFIED DRUG;

ARTICLE; CANCER INHIBITION; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG DESIGN; DRUG POTENCY; DRUG SELECTIVITY; MOUSE; NONHUMAN; STRUCTURE ACTIVITY RELATION; TUMOR XENOGRAFT;

B-RAF INHIBITORS; KINASE DRUG DISCOVERY; MELONOMA; TYPE IIB INHIBITOR;

ANIMALS; ANTINEOPLASTIC AGENTS; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; ENZYME ACTIVATION; HUMANS; INHIBITORY CONCENTRATION 50; MOLECULAR STRUCTURE; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS B-RAF; QUINAZOLINES; TUMOR BURDEN; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84897535510 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2014.03.007 Document Type: Article

Times cited : (20)

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