Pyrazolopyridine inhibitors of B-Raf V600E. Part 2: Structure-activity relationships

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 18, 2011, Pages 5533-5537

  Wenglowsky, Steve ^a   Ahrendt, Kateri A ^a   Buckmelter, Alex J ^a   Feng, Bainian ^b   Gloor, Susan L ^a   Gradl, Stefan ^b   Grina, Jonas ^a   Hansen, Joshua D ^a   Laird, Ellen R ^a   Lunghofer, Paul ^a   Mathieu, Simon ^b   Moreno, David ^a   Newhouse, Brad ^a   Ren, Li ^a   Risom, Tyler ^a   Rudolph, Joachim ^b   Seo, Jeongbeob ^a   Sturgis, Hillary L ^a   Voegtli, Walter C ^a   Wen, Zhaoyang ^b  

^a ARRAY BIOPHARMA INC   (United States)

^b GENENTECH INC   (United States)

Author keywords

B Raf V600E; Pyrazolopyridine; Pyrrolopyridine; Structure activity relationship

Indexed keywords

3 METHOXYPYRAZOLOPYRIDINE; B RAF KINASE; B RAF KINASE INHIBITOR; PYRAZOLOPYRIDINE; SULFONAMIDE; UNCLASSIFIED DRUG;

ALPHA HELIX; ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL; DRUG ABSORPTION; DRUG POTENCY; LIPOPHILICITY; NONHUMAN; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

CRYSTALLOGRAPHY, X-RAY; DOSE-RESPONSE RELATIONSHIP, DRUG; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS B-RAF; PYRAZOLES; PYRIDINES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 80051951259     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.06.097     Document Type: Article

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