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Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 2, 2012, Pages 912-915

Pyrazolopyridine inhibitors of B-Raf V600E. Part 3: An increase in aqueous solubility via the disruption of crystal packing

(9) Wenglowsky, Steve a Moreno, David a Rudolph, Joachim b Ran, Yingqing b Ahrendt, Kateri A a Arrigo, Alisha a Colson, Ben a Gloor, Susan L a Hastings, Gregg a

a ARRAY BIOPHARMA INC (United States)

b GENENTECH INC (United States)

Author keywords

Aqueous solubility; B Raf V600E; Crystal lattice energy; Crystal packing; Single crystal X ray

Indexed keywords

B RAF KINASE; B RAF KINASE INHIBITOR; PYRAZOLOPYRIDINE INHIBITOR; SULFONAMIDE; UNCLASSIFIED DRUG;

AQUEOUS SOLUTION; ARTICLE; CRYSTAL STRUCTURE; DRUG SOLUBILITY; ENZYME INHIBITION; HYDROGEN BOND; MELTING POINT; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

CRYSTALLOGRAPHY, X-RAY; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS B-RAF; PYRAZOLES; PYRIDINES; SOLUBILITY; STRUCTURE-ACTIVITY RELATIONSHIP; WATER;

EID: 84855689766 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2011.12.030 Document Type: Article

Times cited : (39)

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