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Volumn 23, Issue 21, 2013, Pages 5896-5899

Imidazo[4,5-b]pyridine inhibitors of B-Raf kinase

Author keywords

C helix out; B Raf; DFG in; Imidazopyridine Scaffold hopping

Indexed keywords

B RAF KINASE INHIBITOR; CHIR 265; DABRAFENIB; IMIDAZO[4,5 B]PYRIDINE INHIBITOR; UNCLASSIFIED DRUG; VEMURAFENIB; XL 281;

EID: 84885178969     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2013.08.086     Document Type: Article
Times cited : (29)

References (31)
  • 12
    • 84885184861 scopus 로고    scopus 로고
    • August 7th, 2013
    • http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm268241.htm, August 7th, 2013
  • 16
    • 84885183719 scopus 로고    scopus 로고
    • August 7th, 2013
    • http://clinicaltrials.gov/ct2/results?term=XL-281, August 7th, 2013.
  • 17
    • 84885176787 scopus 로고    scopus 로고
    • August 7th, 2013
    • http://clinicaltrials.gov/ct2/results?term=GSK2118436&Search=Search, August 7th, 2013.
  • 23
    • 84885172004 scopus 로고    scopus 로고
    • PDB accession code
    • PDB accession code 4MBJ.
  • 25
    • 84885188830 scopus 로고    scopus 로고
    • Inhibitor enzyme activity was determined utilizing full-length B-RafV600E. Inhibition of basal ERK phosphorylation in Malme-3M cells was used as the mechanistic cellular assay
    • Inhibitor enzyme activity was determined utilizing full-length B-RafV600E. Inhibition of basal ERK phosphorylation in Malme-3M cells was used as the mechanistic cellular assay.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.