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Bioorganic and Medicinal Chemistry Letters

Volumn 24, Issue 8, 2014, Pages 1875-1879

In vivo optimization of 2,3-diaminopyrazine Rho Kinase inhibitors for the treatment of glaucoma

(15) Chen, Hwang Hsing a Namil, Abdelmoulah a Severns, Bryon a Ward, Jennifer a Kelly, Curtis a Drace, Colene a McLaughlin, Marsha A a Yacoub, Shenouda a Li, Byron a Patil, Raj a Sharif, Naj a Hellberg, Mark R a Rusinko, Andrew a Pang, Iok Hou a Combrink, Keith D a

a ALCON RESEARCH LTD (United States)

Author keywords

Glaucoma; IOP reduction; Pyrazine; Rho Kinase

Indexed keywords

2,3 DIAMINOPYRAZINE DERIVATIVE; PIPERAZINE DERIVATIVE; RHO KINASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL MODIFICATION; CONTROLLED STUDY; DRUG POTENCY; DRUG SOLUBILITY; GLAUCOMA; IN VITRO STUDY; IN VIVO STUDY; INTRAOCULAR PRESSURE; NONHUMAN; PHYSICAL CHEMISTRY; PRIMATE; STRUCTURE ACTIVITY RELATION;

PRIMATES;

GLAUCOMA; IOP REDUCTION; PYRAZINE; RHO KINASE;

ANIMALS; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; GLAUCOMA; GUINEA PIGS; HUMANS; INHIBITORY CONCENTRATION 50; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PROTEIN KINASE INHIBITORS; PYRAZINES; PYRIDINES; RHO-ASSOCIATED KINASES;

EID: 84897520919 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2014.03.017 Document Type: Article

Times cited : (15)

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