Core modification of substituted piperidines as Novel inhibitors of HDM2-p53 protein-protein interaction

Bioorganic and Medicinal Chemistry Letters

Volumn 24, Issue 8, 2014, Pages 1983-1986

  Pan, Weidong ^a   Lahue, Brian R ^a   Ma, Yao ^a   Nair, Latha G ^a   Shipps, Gerald W ^a   Wang, Yaolin ^a   Doll, Ronald ^a   Bogen, Stéphane L ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Cancer; HDM2; p53; Protein protein interaction

Indexed keywords

ALLYL COMPOUND; ANTINEOPLASTIC AGENT; FUNCTIONAL GROUP; PIPERIDINE DERIVATIVE; PROTEIN MDM2; PROTEIN P53;

ANTIPROLIFERATIVE ACTIVITY; ARTICLE; BINDING AFFINITY; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG STRUCTURE; NONHUMAN; OSTEOSARCOMA CELL; PROTEIN PROTEIN INTERACTION; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION;

CANCER; HDM2; P53; PROTEIN-PROTEIN INTERACTION;

BIOLOGICAL ASSAY; CELL PROLIFERATION; HUMANS; INHIBITORY CONCENTRATION 50; MOLECULAR STRUCTURE; PIPERIDINES; PROTEIN BINDING; PROTO-ONCOGENE PROTEINS C-MDM2; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84897513391     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2014.02.055     Document Type: Article

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