Substituted piperidines as HDM2 inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 24, Issue 4, 2014, Pages 1026-1030

  Ma, Yao ^a   Lahue, Brian R ^a   Shipps, Gerald W ^a   Brookes, Jeseca ^a   Wang, Yaolin ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Cancer; HDM2; MDM2; Oncology; p53; Small molecule inhibitor; Substituted piperidine

Indexed keywords

PIPERIDINE DERIVATIVE; PROTEIN INHIBITOR; PROTEIN P53;

ARTICLE; BIOAVAILABILITY; CANCER CELL; CELL PROLIFERATION; DRUG IDENTIFICATION; DRUG POTENCY; HUMAN; HUMAN CELL; STRUCTURE ACTIVITY RELATION;

CANCER; HDM2; MDM2; ONCOLOGY; P53; SMALL MOLECULE INHIBITOR; SUBSTITUTED PIPERIDINE;

DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; MOLECULAR STRUCTURE; PIPERIDINES; PROTO-ONCOGENE PROTEINS C-MDM2; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84893715429     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2014.01.026     Document Type: Article

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