Doxorubicin induced apoptosis was potentiated by neferine in human lung adenocarcima, A549 cells

Food and Chemical Toxicology

Volumn 68, Issue , 2014, Pages 87-98

  Poornima, Paramasivan ^a   Kumar, Velmurugan Bharath ^b   Weng, Ching Feng ^b   Padma, Viswanadha Vijaya ^a  

^a BHARATHIAR UNIVERSITY   (India)

^b NATIONAL DONG HWA UNIVERSITY   (Taiwan)

Author keywords

Apoptosis; Doxorubicin; MAPK; Neferine; NF B; ROS

Indexed keywords

CALCIUM ION; DOXORUBICIN; GLUTATHIONE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; MULTIDRUG RESISTANCE PROTEIN; NEFERINE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P53; REACTIVE OXYGEN METABOLITE; ANTINEOPLASTIC AGENT; ANTINEOPLASTIC ANTIBIOTIC; BENZYLISOQUINOLINE DERIVATIVE; LACTATE DEHYDROGENASE; NITRIC OXIDE; TP53 PROTEIN, HUMAN;

APOPTOSIS; ARTICLE; CANCER CELL; CANCER INHIBITION; CARDIOTOXICITY; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG POTENTIATION; DRUG STRUCTURE; ENZYME ACTIVATION; ENZYME INHIBITION; HEART MUSCLE CELL; HUMAN; HUMAN CELL; INTRACELLULAR SIGNALING; LUNG ADENOCARCINOMA; MITOCHONDRIAL MEMBRANE POTENTIAL; OXIDATIVE STRESS; PROTEIN LOCALIZATION; SENSITIVITY ANALYSIS; UPREGULATION; CELL PROLIFERATION; CELL SURVIVAL; DRUG EFFECTS; GENETICS; METABOLISM; PHOSPHORYLATION; TUMOR CELL LINE;

ANTIBIOTICS, ANTINEOPLASTIC; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; APOPTOSIS; BENZYLISOQUINOLINES; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; DOXORUBICIN; GLUTATHIONE; HUMANS; L-LACTATE DEHYDROGENASE; MEMBRANE POTENTIAL, MITOCHONDRIAL; MYOCYTES, CARDIAC; NF-KAPPA B; NITRIC OXIDE; OXIDATIVE STRESS; PHOSPHORYLATION; REACTIVE OXYGEN SPECIES; TUMOR SUPPRESSOR PROTEIN P53; UP-REGULATION;

EID: 84897499604     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2014.03.008     Document Type: Article

References (52)

1. Aebi H. Catalase. Methods of Enzymatic Analysis 1974, 673-684. Academic Press, New York. H. Bergmeyer (Ed.).
2. Awasthi S., Sharma R., Singhal S.S., Zimniak P., Awasthi Y.C. RLIP76, a novel transporter catalyzing ATP-dependent efflux of xenobiotics. Drug Metab. Dispos. 2002, 30:1300-1310.
3. Boehning D., Patterson R.L., Sedaghat L., Glebova N.O., Kurosaki T., Snyder S.H. Cytochrome c binds to inositol (1,4,5) trisphosphate receptors, amplifying calcium-dependent apoptosis. Nat. Cell Biol. 2003, 5:1051-1061.
4. Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 1976, 72:248-254.
5. Bragado P., Armesilla A., Silva A., Porras A. Apoptosis by cisplatin requires p53 mediated p38alpha MAPK activation through ROS generation. Apoptosis 2007, 12:1733-1742.
6. Bubici C., Papa S., Dean K., Franzoso G. Mutual cross-talk between reactive oxygen species and nuclear factor-kappa B: molecular basis and biological significance. Oncogene 2006, 25:6731-6748.
7. Cao J.G., Tang X.Q., Shi S.H. Multidrug resistance reversal in human gastric carcinoma cells by neferine. World J. Gastroenterol. 2004, 10:3062-3064.
8. Chen L., Liu L., Huang S. Cadmium activates the mitogen-activated protein kinase (MAPK) pathway via induction of reactive oxygen species and inhibition of protein phosphatases 2A and 5. Free Radic. Biol. Med. 2008, 45:1035-1044.
9. Cheng Y., Qiu F., Tashiro S., Onodera S., Ikejima T. ERK and JNK mediate TNFalpha-induced p53 activation in apoptotic and autophagic L929 cell death. Biophys. Res. Commun. 2008, 376:483-488.
10. El-Najjar N., Chatila M., Moukadem H., Vuorela H., Ocker M., Gandesiri M., Schneider-Stock R., Gali-Muhtasib H. Reactive oxygen species mediate thymoquinone-induced apoptosis and activate ERK and JNK signaling. Apoptosis 2010, 15:183-195.
11. Feng R., Ni H.M., Wang S.Y., Tourkova I.L., Shurin M.R., Harada H., Yin X.M. Cyanidin-3-rutinoside, a natural polyphenol antioxidant, selectively kills leukemic cells by induction of oxidative stress. J. Biol. Chem. 2007, 282:13468-13476.
12. Fojo T., Bates S. Strategies for reversing drug resistance. Oncogene 2003, 22:7512-7523.
13. Gong J., Traganos F., Darzynkiewicz Z. A selective procedure for DNA extraction from apoptotic cells applicable for gel electrophoresis and flow cytometry. Anal. Biochem. 1994, 218:314-319.
14. 2+ indicators with greatly improved fluorescence properties. J. Biol. Chem. 1985, 260:3440-3450.
15. Habig W.H., Pabst M.J., Jakoby W.B. Glutathione S-transferases. The first enzymatic step in mercapturic acid formation. J. Biol. Chem. 1974, 249:7130-7139.
16. Jin X., Wu X.X., Abdel-Muneem Nouh M.A., Kakehi Y. Enhancement of death receptor 4 mediated apoptosis and cytotoxicity in renal cell carcinoma cells by subtoxic concentrations of doxorubicin. J. Urol. 2007, 177:1894-1899.
17. Johnson T.M., Yu Z.X., Ferrans V.J., Lowenstein R.A., Finkel T. Reactive oxygen species are downstream mediators of p53-dependent apoptosis. Proc. Natl. Acad. Sci. USA 1996, 93:11848-11852.
18. Karihtala P., Soini Y. Reactive oxygen species and antioxidant mechanisms in human tissues and their relation to malignancies. APMIS 2007, 115:81-103.
19. Kaufmann S.H., Hengartner M.O. Programmed cell death: alive and well in the new millennium. Trends Cell Biol. 2001, 11:526-534.
20. Lalitha G., Poornima P., Archanah A., Padma V.V. Protective effect of neferine against isoproterenol-induced cardiac toxicity. Cardiovasc. Toxicol. 2013, 13:168-179.
21. Lander H.M. An essential role for free radicals and derived species in signal transduction. FASEB J. 1997, 11:118-124.
22. Lebel C.P., Ischiropoulos H., Bondy S.C. Evaluation of the probe 2',7'-dichlorofluorescin as an indicator of reactive oxygen species formation and oxidative stress. Chem. Res. Toxicol. 1992, 5:227-231.
23. Marklund S., Marklund G. Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase. Eur. J. Biochem. 1974, 47:469-474.
24. Minotti G., Menna P., Salvatorelli E., Cairo G., Gianni L. Anthracyclines: molecular advances and pharmacologic developments in antitumor activity and cardiotoxicity. Pharmacol. Rev. 2004, 56:185-229.
25. Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J. Immunol. Meth. 1983, 65:55-63.
26. Naugler W.E., Karin M. NF-kappaB and cancer-identifying targets and mechanisms. Curr. Opin. Genet. Dev. 2008, 18:19-26.
27. Ossina N.K., Cannas A., Powers V.C., Fitzpatrick P.A., Knight J.D., Gilbert J.R., Shekhtman E.M., Tomei L.D., Umansky S.R., Kiefer M.C. Interferon-gamma modulates a p53-independent apoptotic pathway and apoptosis-related gene expression. J. Biol. Chem. 1997, 272:16351-16357.
28. Panaretakis T., Pokrovskaja K., Shoshan M.C., Grandér D. Activation of Bak, Bax, and BH3-only proteins in the apoptotic response to doxorubicin. J. Biol. Chem. 2002, 277:44317-44326.
29. Pereira-Caro G., Mateos R., Sarria B., Cert R., Goya L., Bravo L. Hydroxytyrosyl acetate contributes to the protective effects against oxidative stress of virgin olive oil. Food Chem. 2012, 131:869-878.
30. Poornima P., Quency R.S., Padma V.V. Neferine induces reactive oxygen species mediated intrinsic pathway of apoptosis in HepG2 cells. Food Chem. 2013, 136:659-667.
31. Poornima P., Weng C.F., Vijaya Padma V. Neferine, an alkaloid from lotus seed embryo inhibits human lung cancer cell growth by MAPK activation and cell cycle arrest. Biofactors 2013, 10.1002/biof.1115.
32. Qian J.Q. Cardiovascular pharmacological effects of bisbenzylisoquinoline alkaloid derivatives. Acta Pharmacol. Sinica 2002, 23:1086-1092.
33. Rotruck J.T., Pope A.L., Ganther H.E., Swanson A.B., Hafeman D.G., Hoekstra W.G. Selenium: biochemical role as a component of glutathione peroxidase. Science 1973, 179:588-590.
34. Samejima K., Tone S., Earnshaw W.C. CAD/DFF40 nuclease is dispensable for high molecular weight DNA cleavage and stage I chromatin condensation in apoptosis. J. Biol. Chem. 2001, 276:45427-45432.
35. Sasazuki T., Okazaki T., Tada K., Sakon-Komazawa S., Katano M., Tanaka M., Yagita H., Okumura K., Tominaga N., Hayashizaki Y., Okazaki Y., Nakano H. Genome wide analysis of TNF-inducible genes reveals that antioxidant enzymes are induced by TNF and responsible for elimination of ROS. Mol. Immunol. 2004, 41:547-551.
36. Scherz-Shouval R., Shvets E., Fass E., Shorer H., Gil L., Elazar Z. Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4. EMBO J. 2007, 26:1749-1760.
37. Sen G.S., Mohanty S., Hossain D.M., Bhattacharyya S., Banerjee S., Chakraborty J., Saha S., Ray P., Bhattacharjee P., Mandal D., Bhattacharya A., Chattopadhyay S., Das T., Sa G. Curcumin enhances the efficacy of chemotherapy by tailoring p65NFkappaB-p300 cross-talk in favor of p53-p300 in breast cancer. J. Biol. Chem. 2011, 286:42232-42247.
38. Siu W.Y., Yam C.H., Poon R.Y. G1 versus G2 cell cycle arrest after adriamycin-induced damage in mouse Swiss3T3 cells. FEBS Lett. 1999, 461:299-305.
39. Stuehr D.J., Marletta M.A. Induction of nitrite/nitrate synthesis in murine macrophages by BCG infection, lymphokines, or interferon-gamma. J. Immunol. 1987, 139:518-525.
40. Tang X.Q., Cao J.G. Enhancement of cytotoxicity of anticancer drugs in vitro by neferine in MCF-7 cells. Chin. J. Modern Appl. Pharm. 2001, 18:345-347.
41. Torres M., Forman H.J. Redox signaling and the MAP kinase pathways. Biofactors 2003, 17:287-296.
42. Ulmer D.D., Vallee B.L., Wacker W.E. Metalloenzymes and myocardial infarction. II. Malic and lactic dehydrogenase activities and zinc concentrations in serum. N. Engl. J. Med. 1956, 255:450-456.
43. van Wijngaarden J., van Beek E., van Rossum G., van der Bent C., Hoekman K., van der Pluijm G., van der Pol M.A., Broxterman H.J., van Hinsbergh V.W., Lowik C.W. Celecoxib enhances doxorubicin-induced cytotoxicity in MDA-MB231 cells by NF-kappaB-mediated increase of intracellular doxorubicin accumulation. Eur. J. Cancer 2007, 43:433-442.
44. Wang Q.E., Milum K., Han C., Huang Y.W., Wani G., Thomale J., Wani A.A. Differential contributory roles of nucleotide excision and homologous recombination repair for enhancing cisplatin sensitivity in human ovarian cancer cells. Mol. Cancer 2011, 10:24.
45. Weiss R.B. The anthracyclines: will we ever find a better doxorubicin?. Seminars Oncol. 1992, 19:670-686.
46. Wolf B.B., Green D.R. Suicidal tendencies: apoptotic cell death by caspase family proteinases. J. Biol. Chem. 1999, 274:20049-20052.
47. Wu S., Sun C., Cao X., Zhou H., Hong Z., Pan Y. Preparative counter-current chromatography isolation of liensinine and its analogues from embryo of the seed of Nelumbo nucifera GAERTN. using upright coil planet centrifuge with four multilayer coils connected in series. J. Chromatogr. A 2004, 1041:153-162.
48. Wyllie A.H., Kerr J.F., Currie A.R. Cell death: the significance of apoptosis. Int. Rev. Cytol. 1980, 68:251-306.
49. Yang J., Zhou K. NMR spectroscopic analysis of neferine and isoliensinine. Magn. Reson. Chem. 2004, 42:994-997.
50. Yu J., Hu W.S. Effects of neferine on platelet aggregation in rabbits. Yao Xue Xue Bao 1997, 32:1-4.
51. Zhang X., Liu Z., Xu B., Sun Z., Gong Y., Shao C. Neferine, an alkaloid ingredient in lotus seed embryo, inhibits proliferation of human osteosarcoma cells by promoting p38 MAPK-mediated p21 stabilization. Eur. J. Pharmacol. 2012, 677:47-54.
52. Zhao L., Wang X., Chang Q., Xu J., Huang Y., Guo Q., Zhang S., Wang W., Chen X., Wang J. Neferine, a bisbenzylisoquinline alkaloid attenuates bleomycin-induced pulmonary fibrosis. Eur. J. Pharmacol. 2010, 627:304-312.