Neferine induces reactive oxygen species mediated intrinsic pathway of apoptosis in HepG2 cells

Food Chemistry

Volumn 136, Issue 2, 2013, Pages 659-667

  Poornima, Paramasivan ^a   Quency, Robin Sheeba ^a   Padma, Viswandha Vijaya ^a  

^a BHARATHIAR UNIVERSITY   (India)

Author keywords

Caspase; HepG2; Intracellular calcium; Neferine; ROS

Indexed keywords

CASPASES; HEPG2; INTRACELLULAR CALCIUM; NEFERINE; ROS;

CELL MEMBRANES; ENZYME INHIBITION; MITOCHONDRIA; OXYGEN; PROTEINS;

CELL DEATH;

CALCIUM ION; CASPASE 3; CASPASE 9; GLUTATHIONE; GLUTATHIONE PEROXIDASE; GLUTATHIONE TRANSFERASE; LACTATE DEHYDROGENASE; MANGANESE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; NEFERINE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; NITRIC OXIDE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN BAD; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P53; REACTIVE OXYGEN METABOLITE; SUPEROXIDE DISMUTASE; TUMOR NECROSIS FACTOR ALPHA;

APOPTOSIS; ARTICLE; CALCIUM CELL LEVEL; CELL MEMBRANE; CELL PROLIFERATION; CELL STRAIN HEPG2; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DNA FRAGMENTATION; DOWN REGULATION; DRUG MECHANISM; ENZYME ACTIVITY; HUMAN; HUMAN CELL; LIPID PEROXIDATION; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; OXIDATIVE STRESS; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; UPREGULATION;

ANTINEOPLASTIC AGENTS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; BENZYLISOQUINOLINES; CALCIUM; CELL SURVIVAL; DNA FRAGMENTATION; HEP G2 CELLS; HUMANS; LIVER NEOPLASMS; MITOCHONDRIA; NELUMBO; REACTIVE OXYGEN SPECIES;

NELUMBO NUCIFERA;

EID: 84866867861     PISSN: 03088146     EISSN: 18737072     Source Type: Journal    
DOI: 10.1016/j.foodchem.2012.07.112     Document Type: Article

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