메뉴 건너뛰기




Volumn 9, Issue 1, 2014, Pages

Alterations of epigenetic signatures in hepatocyte nuclear factor 4α deficient mouse liver determined by improved ChIP-qPCR and (h)MeDIP-qPCR assays

Author keywords

[No Author keywords available]

Indexed keywords

5 HYDROXYMETHYLCYTOSINE; 5 METHYLCYTOSINE; DNA; DNA FRAGMENT; DNA METHYLTRANSFERASE 1; HEPATOCYTE NUCLEAR FACTOR 4ALPHA; HISTONE H1; HISTONE H3; LYSINE; MESSENGER RNA; TRANSCRIPTION FACTOR EZH2;

EID: 84897491849     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0084925     Document Type: Article
Times cited : (17)

References (48)
  • 1
    • 78149496291 scopus 로고    scopus 로고
    • HNF4alpha-role in drug metabolism and potential drug target?
    • Hwang-Verslues WW, Sladek FM (2010) HNF4alpha-role in drug metabolism and potential drug target? Curr Opin Pharmacol 10: 698-705.
    • (2010) Curr Opin Pharmacol , vol.10 , pp. 698-705
    • Hwang-Verslues, W.W.1    Sladek, F.M.2
  • 2
    • 0034892164 scopus 로고    scopus 로고
    • Mutations in the human genes encoding the transcription factors of the hepatocyte nuclear factor (HNF)1 and HNF4 families: Functional and pathological consequences
    • Ryffel GU (2001) Mutations in the human genes encoding the transcription factors of the hepatocyte nuclear factor (HNF)1 and HNF4 families: functional and pathological consequences. J Mol Endocrinol 27: 11-29.
    • (2001) J Mol Endocrinol , vol.27 , pp. 11-29
    • Ryffel, G.U.1
  • 4
    • 78549256786 scopus 로고    scopus 로고
    • Alterations in hepatic mRNA expression of phase II enzymes and xenobiotic transporters after targeted disruption of hepatocyte nuclear factor 4 alpha
    • Lu H, Gonzalez FJ, Klaassen C (2010) Alterations in hepatic mRNA expression of phase II enzymes and xenobiotic transporters after targeted disruption of hepatocyte nuclear factor 4 alpha. Toxicol Sci 118: 380-390.
    • (2010) Toxicol Sci , vol.118 , pp. 380-390
    • Lu, H.1    Gonzalez, F.J.2    Klaassen, C.3
  • 5
    • 84863279150 scopus 로고    scopus 로고
    • Suppression of hepatocyte proliferation by hepatocyte nuclear factor 4alpha in adult mice
    • Bonzo JA, Ferry CH, Matsubara T, Kim JH, Gonzalez FJ (2012) Suppression of hepatocyte proliferation by hepatocyte nuclear factor 4alpha in adult mice. J Biol Chem 287: 7345-7356.
    • (2012) J Biol Chem , vol.287 , pp. 7345-7356
    • Bonzo, J.A.1    Ferry, C.H.2    Matsubara, T.3    Kim, J.H.4    Gonzalez, F.J.5
  • 7
    • 83255162659 scopus 로고    scopus 로고
    • An HNF4alpha-miRNA inflammatory feedback circuit regulates hepatocellular oncogenesis
    • Hatziapostolou M, Polytarchou C, Aggelidou E, Drakaki A, Poultsides GA, et al. (2011) An HNF4alpha-miRNA inflammatory feedback circuit regulates hepatocellular oncogenesis. Cell 147: 1233-1247.
    • (2011) Cell , vol.147 , pp. 1233-1247
    • Hatziapostolou, M.1    Polytarchou, C.2    Aggelidou, E.3    Drakaki, A.4    Poultsides, G.A.5
  • 8
    • 84879125455 scopus 로고    scopus 로고
    • Hepatocyte nuclear factor 4 alpha deletion promotes diethylnitrosamine- induced hepatocellular carcinoma in rodents
    • Walesky C, Edwards G, Borude P, Gunewardena S, O'Neil M, et al. (2013) Hepatocyte nuclear factor 4 alpha deletion promotes diethylnitrosamine-induced hepatocellular carcinoma in rodents. Hepatology 57: 2480-2490.
    • (2013) Hepatology , vol.57 , pp. 2480-2490
    • Walesky, C.1    Edwards, G.2    Borude, P.3    Gunewardena, S.4    O'Neil, M.5
  • 9
    • 84871876340 scopus 로고    scopus 로고
    • Hepatocyte-specific deletion of hepatocyte nuclear factor-4alpha in adult mice results in increased hepatocyte proliferation
    • Walesky C, Gunewardena S, Terwilliger EF, Edwards G, Borude P, et al. (2013) Hepatocyte-specific deletion of hepatocyte nuclear factor-4alpha in adult mice results in increased hepatocyte proliferation. Am J Physiol Gastrointest Liver Physiol 304: G26-37.
    • (2013) Am J Physiol Gastrointest Liver Physiol , vol.304
    • Walesky, C.1    Gunewardena, S.2    Terwilliger, E.F.3    Edwards, G.4    Borude, P.5
  • 10
    • 75449100306 scopus 로고    scopus 로고
    • Integrated approach for the identification of human hepatocyte nuclear factor 4alpha target genes using protein binding microarrays
    • Bolotin E, Liao H, Ta TC, Yang C, Hwang-Verslues W, et al. (2010) Integrated approach for the identification of human hepatocyte nuclear factor 4alpha target genes using protein binding microarrays. Hepatology 51: 642-653.
    • (2010) Hepatology , vol.51 , pp. 642-653
    • Bolotin, E.1    Liao, H.2    Ta, T.C.3    Yang, C.4    Hwang-Verslues, W.5
  • 12
    • 84883272387 scopus 로고    scopus 로고
    • Hepatocyte Nuclear Factor 4 Alpha and Farnesoid X Receptor Co-regulates Gene Transcription in Mouse Livers on a Genome-Wide Scale
    • Thomas AM, Hart SN, Li G, Lu H, Fang Y, et al. (2013) Hepatocyte Nuclear Factor 4 Alpha and Farnesoid X Receptor Co-regulates Gene Transcription in Mouse Livers on a Genome-Wide Scale. Pharm Res.
    • (2013) Pharm Res
    • Thomas, A.M.1    Hart, S.N.2    Li, G.3    Lu, H.4    Fang, Y.5
  • 13
    • 84863621527 scopus 로고    scopus 로고
    • Cancer epigenetics: From mechanism to therapy
    • Dawson MA, Kouzarides T (2012) Cancer epigenetics: from mechanism to therapy. Cell 150: 12-27.
    • (2012) Cell , vol.150 , pp. 12-27
    • Dawson, M.A.1    Kouzarides, T.2
  • 14
    • 34249337761 scopus 로고    scopus 로고
    • Perceptions of epigenetics
    • Bird A (2007) Perceptions of epigenetics. Nature 447: 396-398.
    • (2007) Nature , vol.447 , pp. 396-398
    • Bird, A.1
  • 15
    • 33847032960 scopus 로고    scopus 로고
    • The Mammalian Epigenome
    • DOI 10.1016/j.cell.2007.01.033, PII S0092867407001286
    • Bernstein BE, Meissner A, Lander ES (2007) The mammalian epigenome. Cell 128: 669-681. (Pubitemid 46273573)
    • (2007) Cell , vol.128 , Issue.4 , pp. 669-681
    • Bernstein, B.E.1    Meissner, A.2    Lander, E.S.3
  • 16
    • 84856327024 scopus 로고    scopus 로고
    • Clinical and public health research using methylated DNA immunoprecipitation (MeDIP): A comparison of commercially available kits to examine differential DNA methylation across the genome
    • Brebi-Mieville P, Ili-Gangas C, Leal-Rojas P, Noordhuis MG, Soudry E, et al. (2012) Clinical and public health research using methylated DNA immunoprecipitation (MeDIP): a comparison of commercially available kits to examine differential DNA methylation across the genome. Epigenetics 7: 106-112.
    • (2012) Epigenetics , vol.7 , pp. 106-112
    • Brebi-Mieville, P.1    Ili-Gangas, C.2    Leal-Rojas, P.3    Noordhuis, M.G.4    Soudry, E.5
  • 17
    • 0033621124 scopus 로고    scopus 로고
    • The HNF-4/HNF-1alpha transactivation cascade regulates gene activity and chromatin structure of the human serine protease inhibitor gene cluster at 14q32.1
    • DOI 10.1073/pnas.96.18.10308
    • Rollini P, Fournier RE (1999) The HNF-4/HNF-1alpha transactivation cascade regulates gene activity and chromatin structure of the human serine protease inhibitor gene cluster at 14q32.1. Proc Natl Acad Sci U S A 96: 10308-10313. (Pubitemid 29422554)
    • (1999) Proceedings of the National Academy of Sciences of the United States of America , vol.96 , Issue.18 , pp. 10308-10313
    • Rollini, P.1    Fournier, R.E.K.2
  • 18
    • 43049101096 scopus 로고    scopus 로고
    • Liver-specific hepatocyte nuclear factor-4alpha deficiency: Greater impact on gene expression in male than in female mouse liver
    • DOI 10.1210/me.2007-0564
    • Holloway MG, Miles GD, Dombkowski AA, Waxman DJ (2008) Liver-specific hepatocyte nuclear factor-4alpha deficiency: greater impact on gene expression in male than in female mouse liver. Mol Endocrinol 22: 1274-1286. (Pubitemid 351629625)
    • (2008) Molecular Endocrinology , vol.22 , Issue.5 , pp. 1274-1286
    • Holloway, M.G.1    Miles, G.D.2    Dombkowski, A.A.3    Waxman, D.J.4
  • 19
    • 0347928866 scopus 로고    scopus 로고
    • Developmentally regulated N-terminal variants of the nuclear receptor hepatocyte nuclear factor 4alpha mediate multiple interactions through coactivator and corepressor-histone deacetylase complexes
    • DOI 10.1074/jbc.M207545200
    • Torres-Padilla ME, Sladek FM, Weiss MC (2002) Developmentally regulated N-terminal variants of the nuclear receptor hepatocyte nuclear factor 4alpha mediate multiple interactions through coactivator and corepressor-histone deacetylase complexes. J Biol Chem 277: 44677-44687. (Pubitemid 36159057)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.47 , pp. 44677-44687
    • Torres-Padilla, M.E.1    Sladek, F.M.2    Weiss, M.C.3
  • 21
    • 84865266255 scopus 로고    scopus 로고
    • Modulation of histone deacetylase 6 (HDAC6) nuclear import and tubulin deacetylase activity through acetylation
    • Liu Y, Peng L, Seto E, Huang S, Qiu Y (2012) Modulation of histone deacetylase 6 (HDAC6) nuclear import and tubulin deacetylase activity through acetylation. J Biol Chem 287: 29168-29174.
    • (2012) J Biol Chem , vol.287 , pp. 29168-29174
    • Liu, Y.1    Peng, L.2    Seto, E.3    Huang, S.4    Qiu, Y.5
  • 22
    • 84861931013 scopus 로고    scopus 로고
    • Standardization and quality controls for the methylated DNA immunoprecipitation technique
    • Lisanti S, von Zglinicki T, Mathers JC (2012) Standardization and quality controls for the methylated DNA immunoprecipitation technique. Epigenetics 7: 615-625.
    • (2012) Epigenetics , vol.7 , pp. 615-625
    • Lisanti, S.1    Von Zglinicki, T.2    Mathers, J.C.3
  • 23
    • 73249152285 scopus 로고    scopus 로고
    • Immunoprecipitation of methylated DNA
    • Sorensen AL, Collas P (2009) Immunoprecipitation of methylated DNA. Methods Mol Biol 567: 249-262.
    • (2009) Methods Mol Biol , vol.567 , pp. 249-262
    • Sorensen, A.L.1    Collas, P.2
  • 24
    • 84255198348 scopus 로고    scopus 로고
    • A specific function for the histone chaperone NASP to fine-tune a reservoir of soluble H3-H4 in the histone supply chain
    • Cook AJ, Gurard-Levin ZA, Vassias I, Almouzni G (2011) A specific function for the histone chaperone NASP to fine-tune a reservoir of soluble H3-H4 in the histone supply chain. Mol Cell 44: 918-927.
    • (2011) Mol Cell , vol.44 , pp. 918-927
    • Cook, A.J.1    Gurard-Levin, Z.A.2    Vassias, I.3    Almouzni, G.4
  • 25
    • 84876404522 scopus 로고    scopus 로고
    • Replication-independent nucleosome exchange is enhanced by local and specific acetylation of histone H4
    • Elliott GO, Murphy KJ, Hayes JJ, Thiriet C (2013) Replication-independent nucleosome exchange is enhanced by local and specific acetylation of histone H4. Nucleic Acids Res 41: 2228-2238.
    • (2013) Nucleic Acids Res , vol.41 , pp. 2228-2238
    • Elliott, G.O.1    Murphy, K.J.2    Hayes, J.J.3    Thiriet, C.4
  • 26
    • 62149137376 scopus 로고    scopus 로고
    • Analysis of DNA methylation and histone modification profiles of liver-specific transporters
    • Imai S, Kikuchi R, Kusuhara H, Yagi S, Shiota K, et al. (2009) Analysis of DNA methylation and histone modification profiles of liver-specific transporters. Mol Pharmacol 75: 568-576.
    • (2009) Mol Pharmacol , vol.75 , pp. 568-576
    • Imai, S.1    Kikuchi, R.2    Kusuhara, H.3    Yagi, S.4    Shiota, K.5
  • 27
    • 79955777417 scopus 로고    scopus 로고
    • Genome-wide survey reveals dynamic widespread tissue-specific changes in DNA methylation during development
    • Liang P, Song F, Ghosh S, Morien E, Qin M, et al. (2011) Genome-wide survey reveals dynamic widespread tissue-specific changes in DNA methylation during development. BMC Genomics 12: 231.
    • (2011) BMC Genomics , vol.12 , pp. 231
    • Liang, P.1    Song, F.2    Ghosh, S.3    Morien, E.4    Qin, M.5
  • 28
    • 0142212154 scopus 로고    scopus 로고
    • Constitutive expression of various xenobiotic and endobiotic transporter mRNAs in the choroid plexus of rats
    • DOI 10.1124/dmd.31.11.1337
    • Choudhuri S, Cherrington NJ, Li N, Klaassen CD (2003) Constitutive expression of various xenobiotic and endobiotic transporter mRNAs in the choroid plexus of rats. Drug Metab Dispos 31: 1337-1345. (Pubitemid 37310322)
    • (2003) Drug Metabolism and Disposition , vol.31 , Issue.11 , pp. 1337-1345
    • Choudhuri, S.1    Cherrington, N.J.2    Li, N.3    Klaassen, C.D.4
  • 29
    • 79551581840 scopus 로고    scopus 로고
    • The phosphorylation of the androgen receptor by TFIIH directs the ubiquitin/proteasome process
    • Chymkowitch P, Le May N, Charneau P, Compe E, Egly JM (2011) The phosphorylation of the androgen receptor by TFIIH directs the ubiquitin/proteasome process. EMBO J 30: 468-479.
    • (2011) EMBO J , vol.30 , pp. 468-479
    • Chymkowitch, P.1    Le May, N.2    Charneau, P.3    Compe, E.4    Egly, J.M.5
  • 30
    • 84866419591 scopus 로고    scopus 로고
    • Loss of 5-hydroxymethylcytosine is an epigenetic hallmark of melanoma
    • Lian CG, Xu Y, Ceol C, Wu F, Larson A, et al. (2012) Loss of 5-hydroxymethylcytosine is an epigenetic hallmark of melanoma. Cell 150: 1135-1146.
    • (2012) Cell , vol.150 , pp. 1135-1146
    • Lian, C.G.1    Xu, Y.2    Ceol, C.3    Wu, F.4    Larson, A.5
  • 32
    • 84859893371 scopus 로고    scopus 로고
    • Histone methylation: A dynamic mark in health, disease and inheritance
    • Greer EL, Shi Y (2012) Histone methylation: a dynamic mark in health, disease and inheritance. Nat Rev Genet 13: 343-357.
    • (2012) Nat Rev Genet , vol.13 , pp. 343-357
    • Greer, E.L.1    Shi, Y.2
  • 33
    • 84872531591 scopus 로고    scopus 로고
    • High-Affinity, Small-Molecule Peptidomimetic Inhibitors of MLL1/WDR5 Protein-Protein Interaction
    • Karatas H, Townsend EC, Cao F, Chen Y, Bernard D, et al. (2013) High-Affinity, Small-Molecule Peptidomimetic Inhibitors of MLL1/WDR5 Protein-Protein Interaction. J Am Chem Soc 135: 669-682.
    • (2013) J Am Chem Soc , vol.135 , pp. 669-682
    • Karatas, H.1    Townsend, E.C.2    Cao, F.3    Chen, Y.4    Bernard, D.5
  • 34
    • 84864715917 scopus 로고    scopus 로고
    • Hepatic ontogeny and tissue distribution of mRNAs of epigenetic modifiers in mice using RNA-sequencing
    • Lu H, Cui JY, Gunewardena S, Yoo B, Zhong XB, et al. (2012) Hepatic ontogeny and tissue distribution of mRNAs of epigenetic modifiers in mice using RNA-sequencing. Epigenetics 7: 914-929.
    • (2012) Epigenetics , vol.7 , pp. 914-929
    • Lu, H.1    Cui, J.Y.2    Gunewardena, S.3    Yoo, B.4    Zhong, X.B.5
  • 35
    • 0036431018 scopus 로고    scopus 로고
    • A novel endogenous retrovirus-related element in the human genome resembles a DNA transposon: Evidence for an evolutionary link?
    • DOI 10.1016/S0888-7543(02)96856-4
    • Hughes JF, Coffin JM (2002) A novel endogenous retrovirus-related element in the human genome resembles a DNA transposon: evidence for an evolutionary link? Genomics 80: 453-455. (Pubitemid 35333785)
    • (2002) Genomics , vol.80 , Issue.5 , pp. 453-455
    • Hughes, J.F.1    Coffin, J.M.2
  • 36
    • 84873181931 scopus 로고    scopus 로고
    • Optimal histone H3 to linker histone H1 chromatin ratio is vital for mesodermal competence in Xenopus
    • Lim CY, Reversade B, Knowles BB, Solter D (2013) Optimal histone H3 to linker histone H1 chromatin ratio is vital for mesodermal competence in Xenopus. Development.
    • (2013) Development
    • Lim, C.Y.1    Reversade, B.2    Knowles, B.B.3    Solter, D.4
  • 37
    • 77954367690 scopus 로고    scopus 로고
    • A new fractionation assay, based on the size of formaldehyde-crosslinked, mildly sheared chromatin, delineates the chromatin structure at promoter regions
    • Ishihara S, Varma R, Schwartz RH (2010) A new fractionation assay, based on the size of formaldehyde-crosslinked, mildly sheared chromatin, delineates the chromatin structure at promoter regions. Nucleic Acids Res 38: e124.
    • (2010) Nucleic Acids Res , vol.38
    • Ishihara, S.1    Varma, R.2    Schwartz, R.H.3
  • 38
    • 33847070442 scopus 로고    scopus 로고
    • The Role of Chromatin during Transcription
    • DOI 10.1016/j.cell.2007.01.015, PII S0092867407001092
    • Li B, Carey M, Workman JL (2007) The role of chromatin during transcription. Cell 128: 707-719. (Pubitemid 46273570)
    • (2007) Cell , vol.128 , Issue.4 , pp. 707-719
    • Li, B.1    Carey, M.2    Workman, J.L.3
  • 39
    • 79953760389 scopus 로고    scopus 로고
    • H3 lysine 4 is acetylated at active gene promoters and is regulated by H3 lysine 4 methylation
    • Guillemette B, Drogaris P, Lin HH, Armstrong H, Hiragami-Hamada K, et al. (2011) H3 lysine 4 is acetylated at active gene promoters and is regulated by H3 lysine 4 methylation. PLoS Genet 7: e1001354.
    • (2011) PLoS Genet , vol.7
    • Guillemette, B.1    Drogaris, P.2    Lin, H.H.3    Armstrong, H.4    Hiragami-Hamada, K.5
  • 40
    • 84858986637 scopus 로고    scopus 로고
    • Identification and characterization of nardilysin as a novel dimethyl H3K4-binding protein involved in transcriptional regulation
    • Li J, Chu M, Wang S, Chan D, Qi S, et al. (2012) Identification and characterization of nardilysin as a novel dimethyl H3K4-binding protein involved in transcriptional regulation. J Biol Chem 287: 10089-10098.
    • (2012) J Biol Chem , vol.287 , pp. 10089-10098
    • Li, J.1    Chu, M.2    Wang, S.3    Chan, D.4    Qi, S.5
  • 41
    • 84865687580 scopus 로고    scopus 로고
    • Step-wise methylation of histone H3K9 positions heterochromatin at the nuclear periphery
    • Towbin BD, Gonzalez-Aguilera C, Sack R, Gaidatzis D, Kalck V, et al. (2012) Step-wise methylation of histone H3K9 positions heterochromatin at the nuclear periphery. Cell 150: 934-947.
    • (2012) Cell , vol.150 , pp. 934-947
    • Towbin, B.D.1    Gonzalez-Aguilera, C.2    Sack, R.3    Gaidatzis, D.4    Kalck, V.5
  • 43
    • 77950473704 scopus 로고    scopus 로고
    • A chromodomain switch mediated by histone H3 Lys 4 acetylation regulates heterochromatin assembly
    • Xhemalce B, Kouzarides T (2010) A chromodomain switch mediated by histone H3 Lys 4 acetylation regulates heterochromatin assembly. Genes Dev 24: 647-652.
    • (2010) Genes Dev , vol.24 , pp. 647-652
    • Xhemalce, B.1    Kouzarides, T.2
  • 44
    • 33646848438 scopus 로고    scopus 로고
    • Substrate preferences of the EZH2 histone methyltransferase complex
    • DOI 10.1074/jbc.M513425200
    • Martin C, Cao R, Zhang Y (2006) Substrate preferences of the EZH2 histone methyltransferase complex. J Biol Chem 281: 8365-8370. (Pubitemid 43847937)
    • (2006) Journal of Biological Chemistry , vol.281 , Issue.13 , pp. 8365-8370
    • Martin, C.1    Cao, R.2    Zhang, Y.3
  • 45
    • 29244449333 scopus 로고    scopus 로고
    • Histone H1 depletion in mammals alters global chromatin structure but causes specific changes in gene regulation
    • DOI 10.1016/j.cell.2005.10.028, PII S0092867405011724
    • Fan Y, Nikitina T, Zhao J, Fleury TJ, Bhattacharyya R, et al. (2005) Histone H1 depletion in mammals alters global chromatin structure but causes specific changes in gene regulation. Cell 123: 1199-1212. (Pubitemid 41821779)
    • (2005) Cell , vol.123 , Issue.7 , pp. 1199-1212
    • Fan, Y.1    Nikitina, T.2    Zhao, J.3    Fleury, T.J.4    Bhattacharyya, R.5    Bouhassira, E.E.6    Stein, A.7    Woodcock, C.L.8    Skoultchi, A.I.9
  • 46
    • 79952536146 scopus 로고    scopus 로고
    • The double face of the histone variant H3.3
    • Szenker E, Ray-Gallet D, Almouzni G (2011) The double face of the histone variant H3.3. Cell Res 21: 421-434.
    • (2011) Cell Res , vol.21 , pp. 421-434
    • Szenker, E.1    Ray-Gallet, D.2    Almouzni, G.3
  • 47
    • 84871743304 scopus 로고    scopus 로고
    • Crosstalk between SET7/9-dependent methylation and ARTD1-mediated ADP-ribosylation of histone H1.4
    • Kassner I, Barandun M, Fey M, Rosenthal F, Hottiger MO (2013) Crosstalk between SET7/9-dependent methylation and ARTD1-mediated ADP-ribosylation of histone H1.4. Epigenetics Chromatin 6: 1.
    • (2013) Epigenetics Chromatin , vol.6 , pp. 1
    • Kassner, I.1    Barandun, M.2    Fey, M.3    Rosenthal, F.4    Hottiger, M.O.5
  • 48
    • 84874763341 scopus 로고    scopus 로고
    • H3K4me3 Interactions with TAF3 Regulate Preinitiation Complex Assembly and Selective Gene Activation
    • Lauberth SM, Nakayama T, Wu X, Ferris AL, Tang Z, et al. (2013) H3K4me3 Interactions with TAF3 Regulate Preinitiation Complex Assembly and Selective Gene Activation. Cell 152: 1021-1036.
    • (2013) Cell , vol.152 , pp. 1021-1036
    • Lauberth, S.M.1    Nakayama, T.2    Wu, X.3    Ferris, A.L.4    Tang, Z.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.