Cytokine profiling in chagas disease: Towards understanding the association with infecting Trypanosoma cruzi discrete typing units (A benefit trial sub-study)

PLoS ONE

Volumn 9, Issue 3, 2014, Pages

  Poveda, Cristina ^a   Fresno, Manuel ^b   Gironès, Núria ^b   Martins Filho, Olindo A ^c   Ramírez, Juan David ^a   Santi Rocca, Julien ^b   Marin Neto, José A ^d   Morillo, Carlos A ^e   Rosas, Fernando ^f   Guhl, Felipe ^a  

^a UNIVERSIDAD DE LOS ANDES   (Colombia)

^b UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

^c INSTITUTO OSWALDO CRUZ   (Brazil)

^d UNIVERSITY OF SÃO PAULO   (Brazil)

^e MCMASTER UNIVERSITY   (Canada)

^f Fundacion Clinica Abood Shaio   (Colombia)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 22;

ADULT; ARTICLE; CARDIOMYOPATHY; CHAGAS DISEASE; CONTROLLED STUDY; DISCRETE TYPING UNIT; DISEASE ASSOCIATION; FLOW CYTOMETRY; GENETIC VARIABILITY; HUMAN; IMMUNE RESPONSE; INFLAMMATION; MAJOR CLINICAL STUDY; MICROBIOLOGICAL PARAMETERS; PATHOGENESIS; PROTEIN ANALYSIS; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; TRYPANOSOMA CRUZI; CHRONIC DISEASE; CLINICAL TRIAL; DISCRIMINANT ANALYSIS; IMMUNOLOGY; METABOLISM; MIDDLE AGED; PARASITOLOGY; PHYSIOLOGY; PRINCIPAL COMPONENT ANALYSIS;

ADULT; CHAGAS CARDIOMYOPATHY; CHAGAS DISEASE; CHRONIC DISEASE; CYTOKINES; DISCRIMINANT ANALYSIS; HUMANS; MIDDLE AGED; PRINCIPAL COMPONENT ANALYSIS; TRYPANOSOMA CRUZI;

EID: 84897461338     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0091154     Document Type: Article

References (40)

1. WHO (2007) World Health Organization Global health atlas. Available: http://wwwwhoint/globalatlas/Accessed 2008 Mar 2.
2. Rassi Jr A, Rassi A, Marcondes de Rezende J (2012) American Trypanosomiasis (Chagas Disease). Infectious Disease Clinics of North America 26: 275-291.
3. Schmunis GA, Yadon ZE (2010) Chagas disease: A Latin American health problem becoming a world health problem. Acta Tropica 115: 14-21.
4. Coura JR, Junqueira ACV, Fernandes O, Valente SAS, Miles MA (2002) Emerging Chagas disease in Amazonian Brazil. Trends in Parasitology 18: 171-176. (Pubitemid 34606845)
5. Pissetti CW, Correia D, de Oliveira RF, Llaguno MM, Balarin MAS, et al. (2011) Genetic and Functional Role of TNF-alpha in the Development Trypanosoma cruzi Infection. PLoS Negl Trop Dis 5: e976.
6. Macedo AM, Machado CR, Oliveira RP, Pena SDJ (2004) Trypanosoma cruzi: genetic structure of populations and relevance of genetic variability to the pathogenesis of chagas disease. Memerias do Instituto Oswaldo Cruz 99: 1-12. (Pubitemid 38406258)
7. Pissetti CW, Correia D, Braga T, Faria GEL, Oliveira RFd, et al. (2009) Associaco entre os niveis plasmaticos de TNF-α, IFN-γ, IL-10, Oxido nitrico e os isotipos de IgG especificos nas formas clinicas da doenca de Chagas cronica. Revista da Sociedade Brasileira de Medicina Tropical 42: 425-430.
8. Dutra WO, Menezes CAS, Villani FNA, Costa GCd, Silveira ABMd, et al. (2009) Cellular and genetic mechanisms involved in the generation of protective and pathogenic immune responses in human Chagas disease. Memórias do Instituto Oswaldo Cruz 104: 208-218.
9. Tarleton RL (2007) Immune system recognition of Trypanosoma cruzi. Current Opinion in Immunology 19: 430-434.
10. Vitelli-Avelar DM, Sathler-Avelar R, Massara RL, Borges JD, Lage PS, et al. (2006) Are increased frequency of macrophage-like and natural killer (NK) cells, together with high levels of NKT and CD4+CD25high T cells balancing activated CD8+ T cells, the key to control Chagas' disease morbidity? Clinical & Experimental Immunology 145: 81-92. (Pubitemid 43893936)
11. D'Ávila DA, Guedes PM, Castro AM, Gontijo ED, Chiari E, et al. (2009) Immunological imbalance between IFN-γ and IL-10 levels in the sera of patients with the cardiac form of Chagas disease. Memórias do Instituto Oswaldo Cruz 104: 100-105.
12. Ferreira RC, Ianni BM, Abel LC, Buck P, Mady C, et al. (2003) Increased plasma levels of tumor necrosis factor-α in asymptomatic/ "indeterminate" and Chagas disease cardiomyopathy patients. Memórias do Instituto Oswaldo Cruz 98: 407-412.
13. Torres OA, Calzada JE, Beraún Y, Morillo CA, González A, et al. (2010) Role of the IFNG +874T/A polymorphism in Chagas disease in a Colombian population. Infection, Genetics and Evolution 10: 682-685.
14. Armah H, Wilson N, Sarfo B, Powell M, Bond V, et al. (2007) Cerebrospinal fluid and serum biomarkers of cerebral malaria mortality in Ghanaian children. Malaria Journal 6: 147.
15. Erdman LK, Dhabangi A, Musoke C, Conroy AL, Hawkes M, et al. (2011) Combinations of Host Biomarkers Predict Mortality among Ugandan Children with Severe Malaria: A Retrospective Case-Control Study. PLoS ONE 6: e17440.
16. Boulware DR, Meya DB, Bergemann TL, Wiesner DL, Rhein J, et al. (2010) Clinical Features and Serum Biomarkers in HIV Immune Reconstitution Inflammatory Syndrome after Cryptococcal Meningitis: A Prospective Cohort Study. PLoS Med 7: e1000384.
17. Ong'echa JM, Davenport GC, Vulule JM, Hittner JB, Perkins DJ (2011) Identification of Inflammatory Biomarkers for Pediatric Malarial Anemia Severity Using Novel Statistical Methods. Infection and Immunity 79: 4674-4680.
18. Zingales B, Andrade S, Briones M, Campbell D, Chiari E, et al. (2009) A new consensus for Trypanosoma cruzi intraspecific nomenclature: second revision meeting recommends TcI to TcVI. Memórias do Instituto Oswaldo Cruz 104: 1051-1054.
19. Zingales B, Miles MA, Campbell DA, Tibayrenc M, Macedo AM, et al. (2012) The revised Trypanosoma cruzi subspecific nomenclature: Rationale, epidemiological relevance and research applications. Infection, Genetics and Evolution 12: 240-253.
20. Ramírez JD, Guhl F, Messenger L, Lewis M, Montilla M, et al. (2012) Contemporary cryptic sexuality in Trypanosoma cruzi. Molecular Ecology 21: 4216-26.
21. Añez N, Crisante G, Silva FMd, Rojas A, Carrasco H, et al. (2004) Predominance of lineage I among Trypanosoma cruzi isolates from Venezuelan patients with different clinical profiles of acute Chagas' disease. Tropical Medicine & International Health 9: 1319-1326. (Pubitemid 40037168)
22. Burgos JM, Diez M, Vigliano C, Bisio M, Risso M, et al. (2010) Molecular Identification of Trypanosoma cruzi Discrete Typing Units in End-Stage Chronic Chagas Heart Disease and Reactivation after Heart Transplantation. Clinical Infectious Diseases 51: 485-495.
23. Ramírez JD, Guhl F, Rendón LM, Rosas F, Marin-Neto JA, et al. (2010) Chagas Cardiomyopathy Manifestations and Trypanosoma cruzi Genotypes Circulating in Chronic Chagasic Patients. PLoS Negl Trop Dis 4: e899.
24. Zafra G, Mantilla J, Valadares H, Macedo A, González C (2008) Evidence of Trypanosoma cruzi II infection in Colombian chagasic patients. Parasitology Research 103: 731-734.
25. Miguel BJ, Diez M, Vigliano C, Duffy T, Bisio M, et al. (2008) Molecular Diagnosis, Follow-up and Identification of Natural Trypanosoma cruzi Populations in Chagas Heart Disease Patients Undergoing Clinical Reactivation after Heart Transplantation. International Journal of Infectious Diseases 12, Supplement 2: S11-S12.
26. Diosque P, Barnabé, Padilla AM, Marco JD, Cardozo RnM, et al. (2003) Multilocus enzyme electrophoresis analysis of Trypanosoma cruzi isolates from a geographically restricted endemic area for Chagas disease in Argentina. International Journal for Parasitology 33: 997-1003.
27. Cura CI, Mejía-Jaramillo AM, Duffy Ts, Burgos JM, Rodriguero M, et al. (2010) Trypanosoma cruzi I genotypes in different geographical regions and transmission cycles based on a microsatellite motif of the intergenic spacer of spliced-leader genes. International Journal for Parasitology 40: 1599-1607.
28. Marcili A, Lima L, Valente VC, Valente SoA, Batista JS, et al. (2009) Comparative phylogeography of Trypanosoma cruzi TCIIc: New hosts, association with terrestrial ecotopes, and spatial clustering. Infection, Genetics and Evolution 9: 1265-1274.
29. Ramírez JD, Montilla M, Cucunubá ZM, Floréz AC, Zambrano P, et al. (2013) Molecular Epidemiology of Human Oral Chagas Disease Outbreaks in Colombia. PLoS Negl Trop Dis 7: e2041.
30. Bautista-López NL, Morillo CA, López-Jaramillo P, Quiroz R, Luengas C, et al. (2013) Matrix metalloproteinases 2 and 9 as diagnostic markers in the progression to Chagas cardiomyopathy. American heart journal 165: 558-566.
31. Gomes JAS, Bahia-Oliveira LMG, Rocha MOC, Martins-Filho OA, Gazzinelli G, et al. (2003) Evidence that Development of Severe Cardiomyopathy in Human Chagas' Disease Is Due to a Th1-Specific Immune Response. Infection and Immunity 71: 1185-1193. (Pubitemid 36254300)
32. Corrêa-Oliveira R, Gomes JdAS, Lemos EM, Cardoso GM, Reis DDÁ, et al. (1999) The role of the immune response on the development of severe clinical forms of human Chagas disease. Memórias do Instituto Oswaldo Cruz 94: 253-255. (Pubitemid 129584504)
33. López L, Arai K, Giménez E, Jiménez M, Pascuzo C, et al. (2006) C-Reactive Protein and Interleukin-6 Serum Levels Increase as Chagas Disease Progresses Towards Cardiac Failure. Revista Española de Cardiología 59: 50-56. (Pubitemid 43285631)
34. Zafra G, Morillo C, Martín J, González A, González CI (2007) Polymorphism in the 3′ UTR of the IL12B gene is associated with Chagas disease cardiomyopathy. Microbes and Infection 9: 1049-1052. (Pubitemid 47299211)
35. Dutra WO, Rocha MOC, Teixeira MM (2005) The clinical immunology of human Chagas disease. Trends in Parasitology 21: 581-587. (Pubitemid 41572271)
36. Costa GC, da Costa Rocha MO, Moreira PR, Menezes AS, Silva MR, et al. (2009) Functional IL-10 Gene Polymorphism Is Associated with Chagas Disease Cardiomyopathy. Journal of Infectious Diseases 199: 451-454.
37. Satthaporn S, Eremin O (2001) Dendritic cells (I): Biological functions. J R Coll Surg Edinb 46: 9-19.
38. Campos MAS, Almeida IC, Takeuchi O, Akira S, Valente EP, et al. (2001) Activation of Toll-Like Receptor-2 by Glycosylphosphatidylinositol Anchors from a Protozoan Parasite. The Journal of Immunology 167: 416-423. (Pubitemid 32567807)
39. Guedes PMM, Gutierrez FRS, Silva GK, Dellalibera-Joviliano R, Rodrigues GJ, et al. (2012) Deficient Regulatory T Cell Activity and Low Frequency of IL-17-Producing T Cells Correlate with the Extent of Cardiomyopathy in Human Chagas' Disease. PLoS Negl Trop Dis 6: e1630.
40. Luiza-Silva M, Campi-Azevedo AC, Batista MA, Martins MA, Avelar RS, et al. (2011) Cytokine Signatures of Innate and Adaptive Immunity in 17DD Yellow Fever Vaccinated Children and Its Association With the Level of Neutralizing Antibody. Journal of Infectious Diseases 204: 873-883.