메뉴 건너뛰기




Volumn 12, Issue 1, 2014, Pages 106-116

Cardiac side effects of chemotherapy: State of art and strategies for a correct management

Author keywords

Anthracyclines; Anti neoplastic drugs; Cancer; Cardiotoxicity; Chemotherapy; Cyclophosphamide; Fluoropirimidines; Heart failure; Oxidative stress; Taxanes; Trastuzumab

Indexed keywords

ANTHRACYCLINE; ANTINEOPLASTIC AGENT; AROMATASE INHIBITOR; BIOLOGICAL PRODUCT; CISPLATIN; CYCLOPHOSPHAMIDE; DOXORUBICIN; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE INHIBITOR; EPIRUBICINOL; ETOPOSIDE; FLUOROPIRIMIDINE DERIVATIVE; TAMOXIFEN; TAXANE DERIVATIVE; TRASTUZUMAB; UNCLASSIFIED DRUG; VINCA ALKALOID;

EID: 84897450084     PISSN: 15701611     EISSN: 18756212     Source Type: Journal    
DOI: 10.2174/157016111201140327163302     Document Type: Review
Times cited : (27)

References (120)
  • 1
  • 2
    • 64549086363 scopus 로고    scopus 로고
    • Anthracycline cardiotoxicity after breast cancer treatment
    • Hershman DL, Shao T. Anthracycline cardiotoxicity after breast cancer treatment. Oncology (Williston Park) 2009; 23: 227-34.
    • (2009) Oncology (Williston Park) , vol.23 , pp. 227-234
    • Hershman, D.L.1    Shao, T.2
  • 3
    • 34548331601 scopus 로고    scopus 로고
    • Anthracycline cardiotoxicity in long-term survivors of childhood cancer
    • Scully RE, Lipshultz SE. Anthracycline cardiotoxicity in long-term survivors of childhood cancer. Cardiovasc Toxicol 2007; 7: 122-8.
    • (2007) Cardiovasc Toxicol , vol.7 , pp. 122-128
    • Scully, R.E.1    Lipshultz, S.E.2
  • 4
    • 77249101995 scopus 로고    scopus 로고
    • Anticancer drugs and cardiotoxicity: Insights and perspectives in the era of targeted therapy
    • Raschi E, Vasina V, Ursino MG, Boriani G, Martoni A, De Ponti F. Anticancer drugs and cardiotoxicity: Insights and perspectives in the era of targeted therapy. Pharmacol Ther 2010; 125: 196-218.
    • (2010) Pharmacol Ther , vol.125 , pp. 196-218
    • Raschi, E.1    Vasina, V.2    Ursino, M.G.3    Boriani, G.4    Martoni, A.5    De Ponti, F.6
  • 5
    • 0021849385 scopus 로고
    • Cardiotoxic effect of cytostatics in patients with breast cancer
    • Nekliudova VI, Seregin GI, Shkhvatsabaia LV. Cardiotoxic effect of cytostatics in patients with breast cancer. Vopr Onkol 1985; 31: 50-7.
    • (1985) Vopr Onkol , vol.31 , pp. 50-57
    • Nekliudova, V.I.1    Seregin, G.I.2    Shkhvatsabaia, L.V.3
  • 8
    • 77953931502 scopus 로고    scopus 로고
    • Cardiotoxicity of anthracycline agents for the treatment of cancer: Systematic review and meta-analysis of randomised controlled trials
    • Smith LA, Cornelius VR, Plummer CJ, et al. Cardiotoxicity of anthracycline agents for the treatment of cancer: systematic review and meta-analysis of randomised controlled trials. BMC Cancer 2010; 10: 337.
    • (2010) BMC Cancer , vol.10 , pp. 337
    • Smith, L.A.1    Cornelius, V.R.2    Plummer, C.J.3
  • 12
    • 41149115636 scopus 로고    scopus 로고
    • Anthracycline associated cardiotoxicity in survivors of childhood cancer
    • Lipshultz SE, Alvarez JA, Scully RE. Anthracycline associated cardiotoxicity in survivors of childhood cancer. Heart 2008; 94: 525-33.
    • (2008) Heart , vol.94 , pp. 525-533
    • Lipshultz, S.E.1    Alvarez, J.A.2    Scully, R.E.3
  • 13
    • 0017354816 scopus 로고
    • Daunomycin-induced cardiotoxicity in children and adults. A review of 110 cases
    • Von Hoff DD, Rozencweig M, Layard M, Slavik M, Muggia FM. Daunomycin-induced cardiotoxicity in children and adults. A review of 110 cases. Am J Med 1977; 62: 200-8.
    • (1977) Am J Med , vol.62 , pp. 200-208
    • Von Hoff, D.D.1    Rozencweig, M.2    Layard, M.3    Slavik, M.4    Muggia, F.M.5
  • 14
    • 33847096349 scopus 로고    scopus 로고
    • Doxorubicin-induced cardiomyopathy from the cardiotoxic mechanisms to management
    • Takemura G, Fujiwara H. Doxorubicin-induced cardiomyopathy from the cardiotoxic mechanisms to management. Prog Cardiovasc Dis 2007; 49: 330-52.
    • (2007) Prog Cardiovasc Dis , vol.49 , pp. 330-352
    • Takemura, G.1    Fujiwara, H.2
  • 15
    • 0038521374 scopus 로고    scopus 로고
    • Congestive heart failure in patients treated with doxorubicin: A retrospective analysis of three trials
    • Swain SM, Whaley FS, Ewer MS. Congestive heart failure in patients treated with doxorubicin: a retrospective analysis of three trials. Cancer 2003; 97: 2869-79.
    • (2003) Cancer , vol.97 , pp. 2869-2879
    • Swain, S.M.1    Whaley, F.S.2    Ewer, M.S.3
  • 16
    • 0030904457 scopus 로고    scopus 로고
    • Clinical cardiotoxicity following anthracycline treatment for childhood cancer: The Pediatric Oncology Group experience
    • Krischer JP, Epstein S, Cuthbertson DD, Goorin AM, Epstein ML, Lipshultz SE. Clinical cardiotoxicity following anthracycline treatment for childhood cancer: the Pediatric Oncology Group experience. J Clin Oncol 1997; 15: 1544-52.
    • (1997) J Clin Oncol , vol.15 , pp. 1544-1552
    • Krischer, J.P.1    Epstein, S.2    Cuthbertson, D.D.3    Goorin, A.M.4    Epstein, M.L.5    Lipshultz, S.E.6
  • 18
    • 33644806519 scopus 로고    scopus 로고
    • Protecting against anthracycline-induced myocardial damage: A review of the most promising strategies
    • Wouters KA, Kremer LC, Miller TL, Herman EH, Lipshultz SE. Protecting against anthracycline-induced myocardial damage: a review of the most promising strategies. Br J Haematol 2005; 131: 561-78.
    • (2005) Br J Haematol , vol.131 , pp. 561-578
    • Wouters, K.A.1    Kremer, L.C.2    Miller, T.L.3    Herman, E.H.4    Lipshultz, S.E.5
  • 19
    • 34548533485 scopus 로고    scopus 로고
    • Congestive heart failure in older women treated with adjuvant anthracycline chemotherapy for breast cancer
    • Pinder MC, Duan Z, Goodwin JS, Hortobagyi GN, Giordano SH. Congestive heart failure in older women treated with adjuvant anthracycline chemotherapy for breast cancer. J Clin Oncol 2007; 25: 3808-15.
    • (2007) J Clin Oncol , vol.25 , pp. 3808-3815
    • Pinder, M.C.1    Duan, Z.2    Goodwin, J.S.3    Hortobagyi, G.N.4    Giordano, S.H.5
  • 20
    • 84864338999 scopus 로고    scopus 로고
    • Cardiovascular outcomes in women with advanced breast cancer exposed to chemotherapy
    • Mar 15
    • Yood MU, Wells KE, Alford SH, et al. Cardiovascular outcomes in women with advanced breast cancer exposed to chemotherapy. Pharmacoepidemiol Drug Saf 2012 Mar 15.
    • (2012) Pharmacoepidemiol Drug
    • Yood, M.U.1    Wells, K.E.2    Alford, S.H.3
  • 21
    • 77955290396 scopus 로고    scopus 로고
    • Cardiac function in 5-year survivors of childhood cancer: A long-term follow-up study
    • van der Pal HJ, van Dalen EC, Hauptmann M, et al. Cardiac function in 5-year survivors of childhood cancer: a long-term follow-up study. Arch Intern Med 2010; 170: 1247-55.
    • (2010) Arch Intern Med , vol.170 , pp. 1247-1255
    • van der Pal, H.J.1    van Dalen, E.C.2    Hauptmann, M.3
  • 22
    • 29844458403 scopus 로고    scopus 로고
    • Long-term cardiac toxicity after adjuvant epirubicin-based chemotherapy in early breast cancer: French Adjuvant Study Group results
    • Fumoleau P, Roche H, Kerbrat P, et al. Long-term cardiac toxicity after adjuvant epirubicin-based chemotherapy in early breast cancer: French Adjuvant Study Group results. Ann Oncol 2006; 17: 85-92.
    • (2006) Ann Oncol , vol.17 , pp. 85-92
    • Fumoleau, P.1    Roche, H.2    Kerbrat, P.3
  • 23
    • 26844503270 scopus 로고    scopus 로고
    • Trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer
    • Piccart-Gebhart MJ, Procter M, Leyland-Jones B, et al. Trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer. N Engl J Med 2005; 353: 1659-72.
    • (2005) N Engl J Med , vol.353 , pp. 1659-1672
    • Piccart-Gebhart, M.J.1    Procter, M.2    Leyland-Jones, B.3
  • 24
    • 0035869407 scopus 로고    scopus 로고
    • Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2
    • Slamon DJ, Leyland-Jones B, Shak S, et al. Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2. N Engl J Med 2001; 344: 783-92.
    • (2001) N Engl J Med , vol.344 , pp. 783-792
    • Slamon, D.J.1    Leyland-Jones, B.2    Shak, S.3
  • 25
    • 0036498781 scopus 로고    scopus 로고
    • Cardiac dysfunction in the trastuzumab clinical trials experience
    • Seidman A, Hudis C, Pierri MK, et al. Cardiac dysfunction in the trastuzumab clinical trials experience. J Clin Oncol 2002; 20: 1215-21.
    • (2002) J Clin Oncol , vol.20 , pp. 1215-1221
    • Seidman, A.1    Hudis, C.2    Pierri, M.K.3
  • 26
    • 33748300698 scopus 로고    scopus 로고
    • Enhancement of radiosensitivity by dual inhibition of the HER family with ZD1839 ("Iressa") and trastuzumab ("Herceptin")
    • Fukutome M, Maebayashi K, Nasu S, Seki K, Mitsuhashi N. Enhancement of radiosensitivity by dual inhibition of the HER family with ZD1839 ("Iressa") and trastuzumab ("Herceptin"). Int J Radiat Oncol Biol Phys 2006; 66: 528-36.
    • (2006) Int J Radiat Oncol Biol Phys , vol.66 , pp. 528-536
    • Fukutome, M.1    Maebayashi, K.2    Nasu, S.3    Seki, K.4    Mitsuhashi, N.5
  • 27
    • 66849118557 scopus 로고    scopus 로고
    • Radiotherapy and adjuvant trastuzumab in operable breast cancer: Tolerability and adverse event data from the NCCTG Phase III Trial N9831
    • Halyard MY, Pisansky TM, Dueck AC, et al. Radiotherapy and adjuvant trastuzumab in operable breast cancer: tolerability and adverse event data from the NCCTG Phase III Trial N9831. J Clin Oncol 2009; 27: 2638-44.
    • (2009) J Clin Oncol , vol.27 , pp. 2638-2644
    • Halyard, M.Y.1    Pisansky, T.M.2    Dueck, A.C.3
  • 28
    • 58149215502 scopus 로고    scopus 로고
    • Acute cardiotoxicity with concurrent trastuzumab and radiotherapy including internal mammary chain nodes: A retrospective single-institution study
    • Shaffer R, Tyldesley S, Rolles M, Chia S, Mohamed I. Acute cardiotoxicity with concurrent trastuzumab and radiotherapy including internal mammary chain nodes: a retrospective single-institution study. Radiother Oncol 2009; 90: 122-6.
    • (2009) Radiother Oncol , vol.90 , pp. 122-126
    • Shaffer, R.1    Tyldesley, S.2    Rolles, M.3    Chia, S.4    Mohamed, I.5
  • 30
    • 0028877036 scopus 로고
    • Paclitaxel by 3-hour infusion in combination with bolus doxorubicin in women with untreated metastatic breast cancer: High antitumor efficacy and cardiac effects in a dose-finding and sequence-finding study
    • Gianni L, Munzone E, Capri G, et al. Paclitaxel by 3-hour infusion in combination with bolus doxorubicin in women with untreated metastatic breast cancer: high antitumor efficacy and cardiac effects in a dose-finding and sequence-finding study. J Clin Oncol 1995; 13: 2688-99.
    • (1995) J Clin Oncol , vol.13 , pp. 2688-2699
    • Gianni, L.1    Munzone, E.2    Capri, G.3
  • 31
    • 0030977999 scopus 로고    scopus 로고
    • Human pharmacokinetic characterization and in vitro study of the interaction between doxorubicin and paclitaxel in patients with breast cancer
    • Gianni L, Vigano L, Locatelli A, et al. Human pharmacokinetic characterization and in vitro study of the interaction between doxorubicin and paclitaxel in patients with breast cancer. J Clin Oncol 1997; 15: 1906-15.
    • (1997) J Clin Oncol , vol.15 , pp. 1906-1915
    • Gianni, L.1    Vigano, L.2    Locatelli, A.3
  • 32
    • 35848950726 scopus 로고    scopus 로고
    • Cardiotoxicity of fluoropyrimidines in different schedules of administration: A prospective study
    • Kosmas C, Kallistratos MS, Kopterides P, et al. Cardiotoxicity of fluoropyrimidines in different schedules of administration: a prospective study. J Cancer Res Clin Oncol 2008; 134: 75-82.
    • (2008) J Cancer Res Clin Oncol , vol.134 , pp. 75-82
    • Kosmas, C.1    Kallistratos, M.S.2    Kopterides, P.3
  • 33
    • 79953125716 scopus 로고    scopus 로고
    • Cardiovascular effects of systemic cancer treatment
    • Senkus E, Jassem J. Cardiovascular effects of systemic cancer treatment. Cancer Treat Rev 2011; 37: 300-11.
    • (2011) Cancer Treat Rev , vol.37 , pp. 300-311
    • Senkus, E.1    Jassem, J.2
  • 35
    • 0019817511 scopus 로고
    • Mechanism of adriamycin cardiotoxicity: Evidence for oxidative stress
    • Olson RD, Boerth RC, Gerber JG, Nies AS. Mechanism of adriamycin cardiotoxicity: evidence for oxidative stress. Life Sci 1981; 29: 1393-401.
    • (1981) Life Sci , vol.29 , pp. 1393-1401
    • Olson, R.D.1    Boerth, R.C.2    Gerber, J.G.3    Nies, A.S.4
  • 36
    • 34548301536 scopus 로고    scopus 로고
    • An introduction to the metabolic determinants of anthracycline cardiotoxicity
    • Menna P, Recalcati S, Cairo G, Minotti G. An introduction to the metabolic determinants of anthracycline cardiotoxicity. Cardiovasc Toxicol 2007; 7: 80-5.
    • (2007) Cardiovasc Toxicol , vol.7 , pp. 80-85
    • Menna, P.1    Recalcati, S.2    Cairo, G.3    Minotti, G.4
  • 37
    • 1842559586 scopus 로고    scopus 로고
    • The role of nitric oxide in anthracycline toxicity and prospects for pharmacologic prevention of cardiac damage
    • Fogli S, Nieri P, Breschi MC. The role of nitric oxide in anthracycline toxicity and prospects for pharmacologic prevention of cardiac damage. FASEB J 2004; 18: 664-75.
    • (2004) FASEB J , vol.18 , pp. 664-675
    • Fogli, S.1    Nieri, P.2    Breschi, M.C.3
  • 39
    • 0036819362 scopus 로고    scopus 로고
    • Peroxynitrite-induced inhibition and nitration of cardiac myofibrillar creatine kinase
    • Mihm MJ, Bauer JA. Peroxynitrite-induced inhibition and nitration of cardiac myofibrillar creatine kinase. Biochimie 2002; 84: 1013-9.
    • (2002) Biochimie , vol.84 , pp. 1013-1019
    • Mihm, M.J.1    Bauer, J.A.2
  • 40
    • 0037102148 scopus 로고    scopus 로고
    • Doxorubicin treatment in vivo causes cytochrome C release and cardiomyocyte apoptosis, as well as increased mitochondrial efficiency, superoxide dismutase activity, and Bcl-2:Bax ratio
    • Childs AC, Phaneuf SL, Dirks AJ, Phillips T, Leeuwenburgh C. Doxorubicin treatment in vivo causes cytochrome C release and cardiomyocyte apoptosis, as well as increased mitochondrial efficiency, superoxide dismutase activity, and Bcl-2:Bax ratio. Cancer Res 2002; 62: 4592-8.
    • (2002) Cancer Res , vol.62 , pp. 4592-4598
    • Childs, A.C.1    Phaneuf, S.L.2    Dirks, A.J.3    Phillips, T.4    Leeuwenburgh, C.5
  • 41
    • 0018758732 scopus 로고
    • Chemical interactions of cardiolipin with daunorubicin and other intercalating agents
    • Schwartz HS, Kanter PM. Chemical interactions of cardiolipin with daunorubicin and other intercalating agents. Eur J Cancer 1979; 15: 923-8.
    • (1979) Eur J Cancer , vol.15 , pp. 923-928
    • Schwartz, H.S.1    Kanter, P.M.2
  • 42
  • 43
    • 1342283083 scopus 로고    scopus 로고
    • Doxorubicin cardiotoxicity and the control of iron metabolism: Quinone-dependent and independent mechanisms
    • Minotti G, Recalcati S, Menna P, Salvatorelli E, Corna G, Cairo G. Doxorubicin cardiotoxicity and the control of iron metabolism: quinone-dependent and independent mechanisms. Methods Enzymol 2004; 378: 340-61.
    • (2004) Methods Enzymol , vol.378 , pp. 340-361
    • Minotti, G.1    Recalcati, S.2    Menna, P.3    Salvatorelli, E.4    Corna, G.5    Cairo, G.6
  • 44
    • 23044447053 scopus 로고    scopus 로고
    • Molecular pharmacology of the interaction of anthracyclines with iron
    • Richardson DR, Xu XX, Persson HL. Molecular pharmacology of the interaction of anthracyclines with iron. Mol Pharmacol 2005; 68: 261-71.
    • (2005) Mol Pharmacol , vol.68 , pp. 261-271
    • Richardson, D.R.1    Xu, X.X.2    Persson, H.L.3
  • 46
    • 0031569972 scopus 로고    scopus 로고
    • Genomic organization, promoter region analysis, and chromosome localization of the mouse bcl-x gene
    • Grillot DA, Gonzalez-Garcia M, Ekhterae D, et al. Genomic organization, promoter region analysis, and chromosome localization of the mouse bcl-x gene. J Immunol 1997; 158: 4750-7.
    • (1997) J Immunol , vol.158 , pp. 4750-4757
    • Grillot, D.A.1    Gonzalez-Garcia, M.2    Ekhterae, D.3
  • 47
    • 0033070327 scopus 로고    scopus 로고
    • GATA transcription factors and cardiac development
    • Charron F, Nemer M. GATA transcription factors and cardiac development. Semin Cell Dev Biol 1999; 10: 85-91.
    • (1999) Semin Cell Dev Biol , vol.10 , pp. 85-91
    • Charron, F.1    Nemer, M.2
  • 48
    • 73649099845 scopus 로고    scopus 로고
    • Transcription factor GATA4 inhibits doxorubicin-induced autophagy and cardiomyocyte death
    • Kobayashi S, Volden P, Timm D, Mao K, Xu X, Liang Q. Transcription factor GATA4 inhibits doxorubicin-induced autophagy and cardiomyocyte death. J Biol Chem 2010; 285: 793-804.
    • (2010) J Biol Chem , vol.285 , pp. 793-804
    • Kobayashi, S.1    Volden, P.2    Timm, D.3    Mao, K.4    Xu, X.5    Liang, Q.6
  • 49
    • 77955906955 scopus 로고    scopus 로고
    • Mechanisms of anthracycline cardiac injury: Can we identify strategies for cardioprotection?
    • Sawyer DB, Peng X, Chen B, Pentassuglia L, Lim CC. Mechanisms of anthracycline cardiac injury: can we identify strategies for cardioprotection? Prog Cardiovasc Dis 2010; 53: 105-13.
    • (2010) Prog Cardiovasc Dis , vol.53 , pp. 105-113
    • Sawyer, D.B.1    Peng, X.2    Chen, B.3    Pentassuglia, L.4    Lim, C.C.5
  • 50
    • 1542349778 scopus 로고    scopus 로고
    • Anthracyclines induce calpain-dependent titin proteolysis and necrosis in cardiomyocytes
    • Lim CC, Zuppinger C, Guo X, et al. Anthracyclines induce calpain-dependent titin proteolysis and necrosis in cardiomyocytes. J Biol Chem 2004; 279: 8290-9.
    • (2004) J Biol Chem , vol.279 , pp. 8290-8299
    • Lim, C.C.1    Zuppinger, C.2    Guo, X.3
  • 52
    • 0037056083 scopus 로고    scopus 로고
    • Titin isoform switch in ischemic human heart disease
    • Neagoe C, Kulke M, del Monte F, et al. Titin isoform switch in ischemic human heart disease. Circulation 2002; 106: 1333-41.
    • (2002) Circulation , vol.106 , pp. 1333-1341
    • Neagoe, C.1    Kulke, M.2    del Monte, F.3
  • 53
    • 73549087024 scopus 로고    scopus 로고
    • Anthracyclineinduced cardiomyopathy: Clinical relevance and response to pharmacologic therapy
    • Cardinale D, Colombo A, Lamantia G, et al. Anthracyclineinduced cardiomyopathy: clinical relevance and response to pharmacologic therapy. J Am Coll Cardiol 2010; 55: 213-20.
    • (2010) J Am Coll Cardiol , vol.55 , pp. 213-220
    • Cardinale, D.1    Colombo, A.2    Lamantia, G.3
  • 54
    • 2342591455 scopus 로고    scopus 로고
    • The discovery of receptor tyrosine kinases: Targets for cancer therapy
    • Gschwind A, Fischer OM, Ullrich A. The discovery of receptor tyrosine kinases: targets for cancer therapy. Nat Rev Cancer 2004; 4: 361-70.
    • (2004) Nat Rev Cancer , vol.4 , pp. 361-370
    • Gschwind, A.1    Fischer, O.M.2    Ullrich, A.3
  • 55
    • 37049183697 scopus 로고
    • Human breast cancer: Correlation of relapse and survival with amplification of the HER-2/neu oncogene
    • Slamon DJ, Clark GM, Wong SG, Levin WJ, Ullrich A, McGuire WL. Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene. Science 1987; 235: 177-82.
    • (1987) Science , vol.235 , pp. 177-182
    • Slamon, D.J.1    Clark, G.M.2    Wong, S.G.3    Levin, W.J.4    Ullrich, A.5    McGuire, W.L.6
  • 57
    • 70349317477 scopus 로고    scopus 로고
    • Cardiotoxic effects, or lack thereof, of anti-Erb82 immunoagents
    • Riccio G, Esposito G, Leoncini E, et al. Cardiotoxic effects, or lack thereof, of anti-Erb82 immunoagents. FASEB J, 2009; 23: 3171-8.
    • (2009) FASEB J , vol.23 , pp. 3171-3178
    • Riccio, G.1    Esposito, G.2    Leoncini, E.3
  • 58
    • 0034533443 scopus 로고    scopus 로고
    • Differential shedding of transmembrane neuregulin isoforms by the tumor necrosis factor-alpha-converting enzyme
    • Montero JC, Yuste L, Diaz-Rodriguez E, Esparis-Ogando A, Pandiella A. Differential shedding of transmembrane neuregulin isoforms by the tumor necrosis factor-alpha-converting enzyme. Mol Cell Neurosci 2000; 16: 631-48.
    • (2000) Mol Cell Neurosci , vol.16 , pp. 631-648
    • Montero, J.C.1    Yuste, L.2    Diaz-Rodriguez, E.3    Esparis-Ogando, A.4    Pandiella, A.5
  • 59
    • 79959783092 scopus 로고    scopus 로고
    • EGFR trans-activation by urotensin II receptor is mediated by beta-arrestin recruitment and confers cardioprotection in pressure overload-induced cardiac hypertrophy
    • Esposito G, Perrino C, Cannavo A, et al. EGFR trans-activation by urotensin II receptor is mediated by beta-arrestin recruitment and confers cardioprotection in pressure overload-induced cardiac hypertrophy. Basic Res Cardiol 2011; 106: 577-89.
    • (2011) Basic Res Cardiol , vol.106 , pp. 577-589
    • Esposito, G.1    Perrino, C.2    Cannavo, A.3
  • 60
    • 33746048823 scopus 로고    scopus 로고
    • Neuregulin activates erbB2-dependent src/FAK signaling and cytoskeletal remodeling in isolated adult rat cardiac myocytes
    • Kuramochi Y, Guo X, Sawyer DB. Neuregulin activates erbB2-dependent src/FAK signaling and cytoskeletal remodeling in isolated adult rat cardiac myocytes. J Mol Cell Cardiol 2006; 41: 228-35.
    • (2006) J Mol Cell Cardiol , vol.41 , pp. 228-235
    • Kuramochi, Y.1    Guo, X.2    Sawyer, D.B.3
  • 61
    • 0028884413 scopus 로고
    • Requirement for neuregulin receptor erbB2 in neural and cardiac development
    • Lee KF, Simon H, Chen H, Bates B, Hung MC, Hauser C. Requirement for neuregulin receptor erbB2 in neural and cardiac development. Nature 1995; 378: 394-8.
    • (1995) Nature , vol.378 , pp. 394-398
    • Lee, K.F.1    Simon, H.2    Chen, H.3    Bates, B.4    Hung, M.C.5    Hauser, C.6
  • 62
    • 0028785406 scopus 로고
    • Aberrant neural and cardiac development in mice lacking the ErbB4 neuregulin receptor
    • Gassmann M, Casagranda F, Orioli D, et al. Aberrant neural and cardiac development in mice lacking the ErbB4 neuregulin receptor. Nature 1995; 378: 390-4.
    • (1995) Nature , vol.378 , pp. 390-394
    • Gassmann, M.1    Casagranda, F.2    Orioli, D.3
  • 63
    • 0028827104 scopus 로고
    • Multiple essential functions of neuregulin in development
    • Meyer D, Birchmeier C. Multiple essential functions of neuregulin in development. Nature 1995; 378: 386-90.
    • (1995) Nature , vol.378 , pp. 386-390
    • Meyer, D.1    Birchmeier, C.2
  • 64
    • 0036099675 scopus 로고    scopus 로고
    • ErbB2 is essential in the prevention of dilated cardiomyopathy
    • Crone SA, Zhao YY, Fan L, et al. ErbB2 is essential in the prevention of dilated cardiomyopathy. Nat Med 2002; 8: 459-65.
    • (2002) Nat Med , vol.8 , pp. 459-465
    • Crone, S.A.1    Zhao, Y.Y.2    Fan, L.3
  • 65
    • 22544475191 scopus 로고    scopus 로고
    • Heterozygous knockout of neuregulin-1 gene in mice exacerbates doxorubicin-induced heart failure
    • Liu FF, Stone JR, Schuldt AJ, et al. Heterozygous knockout of neuregulin-1 gene in mice exacerbates doxorubicin-induced heart failure. Am J Physiol Heart Circ Physiol 2005; 289: H660-6.
    • (2005) Am J Physiol Heart Circ Physiol , vol.289
    • Liu, F.F.1    Stone, J.R.2    Schuldt, A.J.3
  • 66
    • 0037007076 scopus 로고    scopus 로고
    • Modulation of anthracycline-induced myofibrillar disarray in rat ventricular myocytes by neuregulin-1beta and anti-erbB2: Potential mechanism for trastuzumab-induced cardiotoxicity
    • Sawyer DB, Zuppinger C, Miller TA, Eppenberger HM, Suter TM. Modulation of anthracycline-induced myofibrillar disarray in rat ventricular myocytes by neuregulin-1beta and anti-erbB2: potential mechanism for trastuzumab-induced cardiotoxicity. Circulation 2002; 105: 1551-4.
    • (2002) Circulation , vol.105 , pp. 1551-1554
    • Sawyer, D.B.1    Zuppinger, C.2    Miller, T.A.3    Eppenberger, H.M.4    Suter, T.M.5
  • 67
    • 0344924865 scopus 로고    scopus 로고
    • Neuregulin-1 protects ventricular myocytes from anthracycline-induced apoptosis via erbB4-dependent activation of PI3-kinase/Akt
    • Fukazawa R, Miller TA, Kuramochi Y, et al. Neuregulin-1 protects ventricular myocytes from anthracycline-induced apoptosis via erbB4-dependent activation of PI3-kinase/Akt. J Mol Cell Cardiol 2003; 35: 1473-9.
    • (2003) J Mol Cell Cardiol , vol.35 , pp. 1473-1479
    • Fukazawa, R.1    Miller, T.A.2    Kuramochi, Y.3
  • 68
    • 33750347979 scopus 로고    scopus 로고
    • Neuregulin-1 beta attenuates doxorubicin-induced alterations of excitation-contraction coupling and reduces oxidative stress in adult rat cardiomyocytes
    • Timolati F, Ott D, Pentassuglia L, et al. Neuregulin-1 beta attenuates doxorubicin-induced alterations of excitation-contraction coupling and reduces oxidative stress in adult rat cardiomyocytes. J Mol Cell Cardiol 2006; 41: 845-54.
    • (2006) J Mol Cell Cardiol , vol.41 , pp. 845-854
    • Timolati, F.1    Ott, D.2    Pentassuglia, L.3
  • 69
    • 3843074548 scopus 로고    scopus 로고
    • Distinctive regulation and function of PI 3K/Akt and MAPKs in doxorubicin-induced apoptosis of human lung adenocarcinoma cells
    • Zhao Y, You H, Yang Y, et al. Distinctive regulation and function of PI 3K/Akt and MAPKs in doxorubicin-induced apoptosis of human lung adenocarcinoma cells. J Cell Biochem 2004; 91: 621-32.
    • (2004) J Cell Biochem , vol.91 , pp. 621-632
    • Zhao, Y.1    You, H.2    Yang, Y.3
  • 70
    • 0037445247 scopus 로고    scopus 로고
    • Docetaxel and doxorubicin compared with doxorubicin and cyclophosphamide as first-line chemotherapy for metastatic breast cancer: Results of a randomized, multicenter, phase III trial
    • Nabholtz JM, Falkson C, Campos D, et al. Docetaxel and doxorubicin compared with doxorubicin and cyclophosphamide as first-line chemotherapy for metastatic breast cancer: results of a randomized, multicenter, phase III trial. J Clin Oncol 2003; 21: 968-75.
    • (2003) J Clin Oncol , vol.21 , pp. 968-975
    • Nabholtz, J.M.1    Falkson, C.2    Campos, D.3
  • 71
    • 0031647550 scopus 로고    scopus 로고
    • Taxoids in combination with anthracyclines and other agents: Pharmacokinetic considerations
    • D'Incalci M, Schuller J, Colombo T, Zucchetti M, Riva A. Taxoids in combination with anthracyclines and other agents: pharmacokinetic considerations. Semin Oncol 1998; 25(Suppl 13): 16-20.
    • (1998) Semin Oncol , vol.25 , Issue.SUPPL. 13 , pp. 16-20
    • D'Incalci, M.1    Schuller, J.2    Colombo, T.3    Zucchetti, M.4    Riva, A.5
  • 72
    • 33745263272 scopus 로고    scopus 로고
    • Paclitaxel and docetaxel stimulation of doxorubicinol formation in the human heart: Implications for cardiotoxicity of doxorubicin-taxane chemotherapies
    • Salvatorelli E, Menna P, Cascegna S, et al. Paclitaxel and docetaxel stimulation of doxorubicinol formation in the human heart: implications for cardiotoxicity of doxorubicin-taxane chemotherapies. J Pharmacol Exp Ther 2006; 318: 424-33.
    • (2006) J Pharmacol Exp Ther , vol.318 , pp. 424-433
    • Salvatorelli, E.1    Menna, P.2    Cascegna, S.3
  • 73
    • 0018217372 scopus 로고
    • Use of the myocardial biopsy to monitor cardiotoxicity
    • Billingham M. Use of the myocardial biopsy to monitor cardiotoxicity. Cancer Treat Rep 1978; 62: 1607.
    • (1978) Cancer Treat Rep , vol.62 , pp. 1607
    • Billingham, M.1
  • 74
    • 84862526571 scopus 로고    scopus 로고
    • Current and proposed biomarkers of anthracycline cardiotoxicity in cancer: Emerging opportunities in oxidative damage and autophagy
    • Jan 27
    • Dickey JS, Rao VA. Current and proposed biomarkers of anthracycline cardiotoxicity in cancer: emerging opportunities in oxidative damage and autophagy. Curr Mol Med 2012 Jan 27.
    • (2012) Curr Mol Med
    • Dickey, J.S.1    Rao, V.A.2
  • 75
    • 24744439974 scopus 로고    scopus 로고
    • Plasma concentrations of NT-pro-BNP and cardiac troponin-I in relation to doxorubicin-induced cardiomyopathy and cardiac function in childhood malignancy
    • Soker M, Kervancioglu M. Plasma concentrations of NT-pro-BNP and cardiac troponin-I in relation to doxorubicin-induced cardiomyopathy and cardiac function in childhood malignancy. Saudi Medical J 2005; 26: 1197-202.
    • (2005) Saudi Medical J , vol.26 , pp. 1197-1202
    • Soker, M.1    Kervancioglu, M.2
  • 76
    • 33845402341 scopus 로고    scopus 로고
    • Prevention of highdose chemotherapy-induced cardiotoxicity in high-risk patients by angiotensin-converting enzyme inhibition
    • Cardinale D, Colombo A, Sandri MT, et al. Prevention of highdose chemotherapy-induced cardiotoxicity in high-risk patients by angiotensin-converting enzyme inhibition. Circulation 2006; 114: 2474-81.
    • (2006) Circulation , vol.114 , pp. 2474-2481
    • Cardinale, D.1    Colombo, A.2    Sandri, M.T.3
  • 77
    • 78650383580 scopus 로고    scopus 로고
    • Cardiovascular side effects of cancer therapies: A position statement from the Heart Failure Association of the European Society of Cardiology
    • Eschenhagen T, Force T, Ewer MS, et al. Cardiovascular side effects of cancer therapies: a position statement from the Heart Failure Association of the European Society of Cardiology. Eur J Heart Fail 2011; 13: 1-10.
    • (2011) Eur J Heart Fail , vol.13 , pp. 1-10
    • Eschenhagen, T.1    Force, T.2    Ewer, M.S.3
  • 78
    • 79955035031 scopus 로고    scopus 로고
    • Assessing adriamycin-induced early cardiotoxicity by estimating left ventricular ejection fraction using technetium-99m multiple-gated acquisition scan and echocardiography
    • Fatima N, Zaman MU, Hashmi A, Kamal S, Hameed A. Assessing adriamycin-induced early cardiotoxicity by estimating left ventricular ejection fraction using technetium-99m multiple-gated acquisition scan and echocardiography. Nucl Med Commun 2011; 32: 381-5.
    • (2011) Nucl Med Commun , vol.32 , pp. 381-385
    • Fatima, N.1    Zaman, M.U.2    Hashmi, A.3    Kamal, S.4    Hameed, A.5
  • 79
    • 79955501818 scopus 로고    scopus 로고
    • Radionuclide ventriculography detects early anthracycline cardiotoxicity in children with Hodgkin lymphoma
    • Tantawy AA, Elmasry OA, Shaaban M, Toaima DN, El Shahat AM. Radionuclide ventriculography detects early anthracycline cardiotoxicity in children with Hodgkin lymphoma. J Pediatr Hematol Oncol 2011; 33: e132-7.
    • (2011) J Pediatr Hematol Oncol , vol.33
    • Tantawy, A.A.1    Elmasry, O.A.2    Shaaban, M.3    Toaima, D.N.4    El Shahat, A.M.5
  • 80
    • 82255174926 scopus 로고    scopus 로고
    • Baseline diastolic dysfunction as a predictive factor of trastuzumab-mediated cardiotoxicity after adjuvant anthracycline therapy in breast cancer
    • Cochet A, Quilichini G, Dygai-Cochet I, et al. Baseline diastolic dysfunction as a predictive factor of trastuzumab-mediated cardiotoxicity after adjuvant anthracycline therapy in breast cancer. Breast Cancer Res Treat 2011; 130: 845-54.
    • (2011) Breast Cancer Res Treat , vol.130 , pp. 845-854
    • Cochet, A.1    Quilichini, G.2    Dygai-Cochet, I.3
  • 81
    • 0037148438 scopus 로고    scopus 로고
    • Clinical and economic impact of multiple gated acquisition scan monitoring during anthracycline therapy
    • Shureiqi I, Cantor SB, Lippman SM, Brenner DE, Chernew ME, Fendrick AM. Clinical and economic impact of multiple gated acquisition scan monitoring during anthracycline therapy. Br J Cancer 2002; 86: 226-32.
    • (2002) Br J Cancer , vol.86 , pp. 226-232
    • Shureiqi, I.1    Cantor, S.B.2    Lippman, S.M.3    Brenner, D.E.4    Chernew, M.E.5    Fendrick, A.M.6
  • 82
    • 77957367762 scopus 로고    scopus 로고
    • Novel approach to early detection of doxorubicin cardiotoxicity by gadolinium-enhanced cardiovascular magnetic resonance imaging in an experimental model
    • Lightfoot JC, D'Agostino RB, Jr., Hamilton CA, et al. Novel approach to early detection of doxorubicin cardiotoxicity by gadolinium-enhanced cardiovascular magnetic resonance imaging in an experimental model. Circ Cardiovasc Imaging 2010; 3: 550-8.
    • (2010) Circ Cardiovasc Imaging , vol.3 , pp. 550-558
    • Lightfoot, J.C.1    D'Agostino Jr., R.B.2    Hamilton, C.A.3
  • 83
    • 82555176568 scopus 로고    scopus 로고
    • A prospective comparison of cardiac magnetic resonance imaging and radionuclide ventriculography in the assessment of cardiac function in patients treated with anthracycline-based chemotherapy
    • Petri S, Esko V, Esa J, et al. A prospective comparison of cardiac magnetic resonance imaging and radionuclide ventriculography in the assessment of cardiac function in patients treated with anthracycline-based chemotherapy. Nucl Med Commun 2012; 33: 51-9.
    • (2012) Nucl Med Commun , vol.33 , pp. 51-59
    • Petri, S.1    Esko, V.2    Esa, J.3
  • 84
    • 0020038042 scopus 로고
    • Reduction of doxorubicin cardiotoxicity by prolonged continuous intravenous infusion
    • Legha SS, Benjamin RS, Mackay B, et al. Reduction of doxorubicin cardiotoxicity by prolonged continuous intravenous infusion. Ann Intern Med 1982; 96: 133-9.
    • (1982) Ann Intern Med , vol.96 , pp. 133-139
    • Legha, S.S.1    Benjamin, R.S.2    McKay, B.3
  • 85
    • 0024546425 scopus 로고
    • Decreased cardiac toxicity of doxorubicin administered by continuous intravenous infusion in combination chemotherapy for metastatic breast carcinoma
    • Hortobagyi GN, Frye D, Buzdar AU, et al. Decreased cardiac toxicity of doxorubicin administered by continuous intravenous infusion in combination chemotherapy for metastatic breast carcinoma. Cancer 1989; 63: 37-45.
    • (1989) Cancer , vol.63 , pp. 37-45
    • Hortobagyi, G.N.1    Frye, D.2    Buzdar, A.U.3
  • 86
    • 0037087687 scopus 로고    scopus 로고
    • Doxorubicin administration by continuous infusion is not cardioprotective: The Dana-Farber 91-01 Acute Lymphoblastic Leukemia protocol
    • Lipshultz SE, Giantris AL, Lipsitz SR, et al. Doxorubicin administration by continuous infusion is not cardioprotective: the Dana-Farber 91-01 Acute Lymphoblastic Leukemia protocol. J Clin Oncol 2002; 20: 1677-82.
    • (2002) J Clin Oncol , vol.20 , pp. 1677-1682
    • Lipshultz, S.E.1    Giantris, A.L.2    Lipsitz, S.R.3
  • 87
    • 0024343537 scopus 로고
    • Doxorubicin: Effect of different schedules on toxicity and anti-tumor efficacy
    • Bielack SS, Erttmann R, Winkler K, Landbeck G. Doxorubicin: effect of different schedules on toxicity and anti-tumor efficacy. Eur J Cancer Clin Oncol 1989; 25: 873-82.
    • (1989) Eur J Cancer Clin Oncol , vol.25 , pp. 873-882
    • Bielack, S.S.1    Erttmann, R.2    Winkler, K.3    Landbeck, G.4
  • 88
    • 33744959330 scopus 로고    scopus 로고
    • Defective one-or twoelectron reduction of the anticancer anthracycline epirubicin in human heart. Relative importance of vesicular sequestration and impaired efficiency of electron addition
    • Salvatorelli E, Guarnieri S, Menna P, et al. Defective one-or twoelectron reduction of the anticancer anthracycline epirubicin in human heart. Relative importance of vesicular sequestration and impaired efficiency of electron addition. J Biol Chem 2006; 281: 10990-1001.
    • (2006) J Biol Chem , vol.281 , pp. 10990-11001
    • Salvatorelli, E.1    Guarnieri, S.2    Menna, P.3
  • 89
    • 33846425322 scopus 로고    scopus 로고
    • Defective taxane stimulation of epirubicinol formation in the human heart: Insight into the cardiac tolerability of epirubicin-taxane chemotherapies
    • Salvatorelli E, Menna P, Gianni L, Minotti G. Defective taxane stimulation of epirubicinol formation in the human heart: insight into the cardiac tolerability of epirubicin-taxane chemotherapies. J Pharmacol Exp Ther 2007; 320: 790-800.
    • (2007) J Pharmacol Exp Ther , vol.320 , pp. 790-800
    • Salvatorelli, E.1    Menna, P.2    Gianni, L.3    Minotti, G.4
  • 90
    • 63849177199 scopus 로고    scopus 로고
    • Doxorubicinolone formation and efflux: A salvage pathway against epirubicin accumulation in human heart
    • Salvatorelli E, Menna P, Lusini M, Covino E, Minotti G. Doxorubicinolone formation and efflux: a salvage pathway against epirubicin accumulation in human heart. J Pharmacol Exp Ther 2009; 329: 175-84.
    • (2009) J Pharmacol Exp Ther , vol.329 , pp. 175-184
    • Salvatorelli, E.1    Menna, P.2    Lusini, M.3    Covino, E.4    Minotti, G.5
  • 92
    • 0033802643 scopus 로고    scopus 로고
    • Pegylated liposomal doxorubicin (doxil): Reduced clinical cardiotoxicity in patients reaching or exceeding cumulative doses of 500 mg/m2
    • Safra T, Muggia F, Jeffers S, et al. Pegylated liposomal doxorubicin (doxil): reduced clinical cardiotoxicity in patients reaching or exceeding cumulative doses of 500 mg/m2. Ann Oncol 2000; 11: 1029-33.
    • (2000) Ann Oncol , vol.11 , pp. 1029-1033
    • Safra, T.1    Muggia, F.2    Jeffers, S.3
  • 94
    • 11144357506 scopus 로고    scopus 로고
    • Reduced cardiotoxicity and comparable efficacy in a phase III trial of pegylated liposomal doxorubicin HCl (CAELYX/Doxil) vs. conventional doxorubicin for first-line treatment of metastatic breast cancer
    • O'Brien ME, Wigler N, Inbar M, et al. Reduced cardiotoxicity and comparable efficacy in a phase III trial of pegylated liposomal doxorubicin HCl (CAELYX/Doxil) vs. conventional doxorubicin for first-line treatment of metastatic breast cancer. Ann Oncol 2004; 15: 440-9.
    • (2004) Ann Oncol , vol.15 , pp. 440-449
    • O'Brien, M.E.1    Wigler, N.2    Inbar, M.3
  • 95
    • 0018403626 scopus 로고
    • Reduction of daunorubicin lethality and myocardial cellular alterations by pretreatment with ICRF-187 in Syrian golden hamsters
    • Herman E, Ardalan B, Bier C, Waravdekar V, Krop S. Reduction of daunorubicin lethality and myocardial cellular alterations by pretreatment with ICRF-187 in Syrian golden hamsters. Cancer Treat Rep 1979; 63: 89-92.
    • (1979) Cancer Treat Rep , vol.63 , pp. 89-92
    • Herman, E.1    Ardalan, B.2    Bier, C.3    Waravdekar, V.4    Krop, S.5
  • 96
    • 0030904096 scopus 로고    scopus 로고
    • Cardioprotection with dexrazoxane for doxorubicin-containing therapy in advanced breast cancer
    • Swain SM, Whaley FS, Gerber MC, et al. Cardioprotection with dexrazoxane for doxorubicin-containing therapy in advanced breast cancer. J Clin Oncol 1997; 15: 1318-32.
    • (1997) J Clin Oncol , vol.15 , pp. 1318-1332
    • Swain, S.M.1    Whaley, F.S.2    Gerber, M.C.3
  • 97
    • 0037096826 scopus 로고    scopus 로고
    • 2002 update of recommendations for the use of chemotherapy and radiotherapy protectants: Clinical practice guidelines of the American Society of Clinical Oncology
    • Schuchter LM, Hensley ML, Meropol NJ, Winer EP. 2002 update of recommendations for the use of chemotherapy and radiotherapy protectants: clinical practice guidelines of the American Society of Clinical Oncology. J Clin Oncol 2002; 20: 2895-903.
    • (2002) J Clin Oncol , vol.20 , pp. 2895-2903
    • Schuchter, L.M.1    Hensley, M.L.2    Meropol, N.J.3    Winer, E.P.4
  • 98
    • 0742269397 scopus 로고    scopus 로고
    • The current and future role of dexrazoxane as a cardioprotectant in anthracycline treatment: Expert panel review
    • Swain SM, Vici P. The current and future role of dexrazoxane as a cardioprotectant in anthracycline treatment: expert panel review. J Cancer Res Clin Oncol 2004; 130: 1-7.
    • (2004) J Cancer Res Clin Oncol , vol.130 , pp. 1-7
    • Swain, S.M.1    Vici, P.2
  • 99
    • 0031860862 scopus 로고    scopus 로고
    • Dexrazoxane cardioprotection in advanced breast cancer patients undergoing high-dose epirubicin treatment
    • Vici P, Ferraironi A, Di Lauro L, et al. Dexrazoxane cardioprotection in advanced breast cancer patients undergoing high-dose epirubicin treatment. Clin Ter 1998; 149: 15-20.
    • (1998) Clin Ter , vol.149 , pp. 15-20
    • Vici, P.1    Ferraironi, A.2    Di Lauro, L.3
  • 100
    • 77957375770 scopus 로고    scopus 로고
    • Dexrazoxane for preventing anthracycline cardiotoxicity in children with solid tumors
    • Choi HS, Park ES, Kang HJ, et al. Dexrazoxane for preventing anthracycline cardiotoxicity in children with solid tumors. J Korean Med Sci 2010; 25: 1336-42.
    • (2010) J Korean Med Sci , vol.25 , pp. 1336-1342
    • Choi, H.S.1    Park, E.S.2    Kang, H.J.3
  • 101
    • 0028025390 scopus 로고
    • Comparison of different iron chelators as protective agents against acute doxorubicin-induced cardiotoxicity
    • Voest EE, van Acker SA, van der Vijgh WJ, van Asbeck BS, Bast A. Comparison of different iron chelators as protective agents against acute doxorubicin-induced cardiotoxicity. J Mol Cell Cardiol 1994; 26: 1179-85.
    • (1994) J Mol Cell Cardiol , vol.26 , pp. 1179-1185
    • Voest, E.E.1    van Acker, S.A.2    van der Vijgh, W.J.3    van Asbeck, B.S.4    Bast, A.5
  • 102
    • 0028080144 scopus 로고
    • Comparison of the protective effects of desferrioxamine and ICRF-187 against doxorubicininduced toxicity in spontaneously hypertensive rats
    • Herman EH, Zhang J, Ferrans VJ. Comparison of the protective effects of desferrioxamine and ICRF-187 against doxorubicininduced toxicity in spontaneously hypertensive rats. Cancer Chemother Pharmacol 1994; 35: 93-100.
    • (1994) Cancer Chemother Pharmacol , vol.35 , pp. 93-100
    • Herman, E.H.1    Zhang, J.2    Ferrans, V.J.3
  • 103
    • 0018761073 scopus 로고
    • The effects of alpha-tocopherol on the toxicity, disposition, and metabolism of adriamycin in mice
    • Mimnaugh EG, Siddik ZH, Drew R, Sikic BI, Gram TE. The effects of alpha-tocopherol on the toxicity, disposition, and metabolism of adriamycin in mice. Toxicol Appl Pharmacol 1979; 49: 119-26.
    • (1979) Toxicol Appl Pharmacol , vol.49 , pp. 119-126
    • Mimnaugh, E.G.1    Siddik, Z.H.2    Drew, R.3    Sikic, B.I.4    Gram, T.E.5
  • 104
    • 0022644948 scopus 로고
    • The effect of vitamin E and selenium on doxorubicin (Adriamycin) induced delayed toxicity in mice
    • Hermansen K, Wassermann K. The effect of vitamin E and selenium on doxorubicin (Adriamycin) induced delayed toxicity in mice. Acta Pharmacol Toxicol (Copenh) 1986; 58: 31-7.
    • (1986) Acta Pharmacol Toxicol (Copenh) , vol.58 , pp. 31-37
    • Hermansen, K.1    Wassermann, K.2
  • 105
    • 0020583667 scopus 로고
    • A randomized controlled trial assessing the prevention of doxorubicin cardiomyopathy by Nacetylcysteine
    • Myers C, Bonow R, Palmeri S, et al. A randomized controlled trial assessing the prevention of doxorubicin cardiomyopathy by Nacetylcysteine. Semin Oncol 1983; 10(Suppl 1): 53-5.
    • (1983) Semin Oncol , vol.10 , Issue.SUPPL. 1 , pp. 53-55
    • Myers, C.1    Bonow, R.2    Palmeri, S.3
  • 106
    • 0024679488 scopus 로고
    • Probucol. A reappraisal of its pharmacological properties and therapeutic use in hypercholesterolaemia
    • Buckley MM, Goa KL, Price AH, Brogden RN. Probucol. A reappraisal of its pharmacological properties and therapeutic use in hypercholesterolaemia. Drugs 1989; 37: 761-800.
    • (1989) Drugs , vol.37 , pp. 761-800
    • Buckley, M.M.1    Goa, K.L.2    Price, A.H.3    Brogden, R.N.4
  • 107
    • 0028275840 scopus 로고
    • Probucol promotes endogenous antioxidants and provides protection against adriamycininduced cardiomyopathy in rats
    • Siveski-Iliskovic N, Kaul N, Singal PK. Probucol promotes endogenous antioxidants and provides protection against adriamycininduced cardiomyopathy in rats. Circulation 1994; 89: 2829-35.
    • (1994) Circulation , vol.89 , pp. 2829-2835
    • Siveski-Iliskovic, N.1    Kaul, N.2    Singal, P.K.3
  • 108
    • 0028888378 scopus 로고
    • Probucol protects against adriamycin cardiomyopathy without interfering with its antitumor effect
    • Siveski-Iliskovic N, Hill M, Chow DA, Singal PK. Probucol protects against adriamycin cardiomyopathy without interfering with its antitumor effect. Circulation 1995; 91: 10-5.
    • (1995) Circulation , vol.91 , pp. 10-15
    • Siveski-Iliskovic, N.1    Hill, M.2    Chow, D.A.3    Singal, P.K.4
  • 110
    • 58349097915 scopus 로고    scopus 로고
    • Pretreatment with statin attenuates the cardiotoxicity of Doxorubicin in mice
    • Riad A, Bien S, Westermann D, et al. Pretreatment with statin attenuates the cardiotoxicity of Doxorubicin in mice. Cancer Res 2009; 69: 695-9.
    • (2009) Cancer Res , vol.69 , pp. 695-699
    • Riad, A.1    Bien, S.2    Westermann, D.3
  • 111
    • 70349734337 scopus 로고    scopus 로고
    • Chronic doxorubicin cardiotoxicity is mediated by oxidative DNA damage-ATM-p53-apoptosis pathway and attenuated by pitavastatin through the inhibition of Rac1 activity
    • Yoshida M, Shiojima I, Ikeda H, Komuro I. Chronic doxorubicin cardiotoxicity is mediated by oxidative DNA damage-ATM-p53-apoptosis pathway and attenuated by pitavastatin through the inhibition of Rac1 activity. J Mol Cell Cardiol 2009; 47: 698-705.
    • (2009) J Mol Cell Cardiol , vol.47 , pp. 698-705
    • Yoshida, M.1    Shiojima, I.2    Ikeda, H.3    Komuro, I.4
  • 113
    • 33644871048 scopus 로고    scopus 로고
    • Preventive effect of erythropoietin on cardiac dysfunction in doxorubicin-induced cardiomyopathy
    • Li L, Takemura G, Li Y, et al. Preventive effect of erythropoietin on cardiac dysfunction in doxorubicin-induced cardiomyopathy. Circulation 2006; 113: 535-43.
    • (2006) Circulation , vol.113 , pp. 535-543
    • Li, L.1    Takemura, G.2    Li, Y.3
  • 114
    • 33745018358 scopus 로고    scopus 로고
    • Granulocyte colony-stimulating factor reduces cardiomyocyte apoptosis and improves cardiac function in adriamycin-induced cardiomyopathy in rats
    • Hou XW, Son J, Wang Y, et al. Granulocyte colony-stimulating factor reduces cardiomyocyte apoptosis and improves cardiac function in adriamycin-induced cardiomyopathy in rats. Cardiovasc Drugs Ther 2006; 20: 85-91.
    • (2006) Cardiovasc Drugs Ther , vol.20 , pp. 85-91
    • Hou, X.W.1    Son, J.2    Wang, Y.3
  • 115
    • 33646819975 scopus 로고    scopus 로고
    • Thrombopoietin protects against in vitro and in vivo cardiotoxicity induced by doxorubicin
    • Li K, Sung RY, Huang WZ, et al. Thrombopoietin protects against in vitro and in vivo cardiotoxicity induced by doxorubicin. Circulation 2006; 113: 2211-20.
    • (2006) Circulation , vol.113 , pp. 2211-2220
    • Li, K.1    Sung, R.Y.2    Huang, W.Z.3
  • 116
    • 3142678666 scopus 로고    scopus 로고
    • Cardiotoxicity associated with trastuzumab (Herceptin) therapy in the treatment of metastatic breast cancer
    • Suter TM, Cook-Bruns N, Barton C. Cardiotoxicity associated with trastuzumab (Herceptin) therapy in the treatment of metastatic breast cancer. Breast 2004; 13: 173-83.
    • (2004) Breast , vol.13 , pp. 173-183
    • Suter, T.M.1    Cook-Bruns, N.2    Barton, C.3
  • 117
    • 51649092308 scopus 로고    scopus 로고
    • Cardiac management during adjuvant trastuzumab therapy: Recommendations of the Canadian Trastuzumab Working Group
    • Mackey JR, Clemons M, Cote MA, et al. Cardiac management during adjuvant trastuzumab therapy: recommendations of the Canadian Trastuzumab Working Group. Curr Oncol 2008; 15: 24-35.
    • (2008) Curr Oncol , vol.15 , pp. 24-35
    • McKey, J.R.1    Clemons, M.2    Cote, M.A.3
  • 118
    • 77957306355 scopus 로고    scopus 로고
    • Cardiotoxicity of anticancer treatments: What the cardiologist needs to know
    • Ewer MS, Ewer SM. Cardiotoxicity of anticancer treatments: what the cardiologist needs to know. Nat Rev Cardiol 2010; 7: 564-75.
    • (2010) Nat Rev Cardiol , vol.7 , pp. 564-575
    • Ewer, M.S.1    Ewer, S.M.2
  • 120
    • 0032721964 scopus 로고    scopus 로고
    • Cardiotoxicity of epirubicin/ paclitaxel-containing regimens: Role of cardiac risk factors
    • Gennari A, Salvadori B, Donati S, et al. Cardiotoxicity of epirubicin/ paclitaxel-containing regimens: role of cardiac risk factors. J Clin Oncol 1999; 17: 3596-602.
    • (1999) J Clin Oncol , vol.17 , pp. 3596-3602
    • Gennari, A.1    Salvadori, B.2    Donati, S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.