Pseudomonas aeruginosa type-3 secretion system dampens host defense by exploiting the NLRC4-coupled inflammasome

American Journal of Respiratory and Critical Care Medicine

Volumn 189, Issue 7, 2014, Pages 799-811

  Faure, Emmanuel ^a   Mear, Jean Baptiste ^a   Faure, Karine ^a   Normand, Sylvain ^a,b,c   Couturier Maillard, Aurélie ^a,b,c   Grandjean, Teddy ^a,b,c   Balloy, Viviane ^d   Ryffel, Bernhard ^e,f   Dessein, Rodrigue ^a   Chignard, Michel ^d   Uyttenhove, Catherine ^e,f   Guery, Benoit ^a   Gosset, Philippe ^a,b,c   Chamaillard, Mathias ^a,b,c   Kipnis, Eric ^a  

^a UNIV LILLE   (France)

^b INSERM U1019   (France)

^c INSERM   (France)

^d INSTITUT PASTEUR   (France)

^e Laboratoire d'Immunologie et Embryologie Moleculaires Orleans   (France)

^f UNIVERSITY OF CAPE TOWN   (South Africa)

Author keywords

Antimicrobial peptides; Inflammasome; Pseudomonas aeruginosa; Type 3 secretion system

Indexed keywords

INFLAMMASOME; INTERLEUKIN 17; INTERLEUKIN 18; NLRC4 PROTEIN; POLYPEPTIDE ANTIBIOTIC AGENT; PROTEIN; UNCLASSIFIED DRUG;

ACUTE LUNG INJURY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL CLEARANCE; BACTERIUM CULTURE; CAPILLARY PERMEABILITY; CONTROLLED STUDY; CYTOKINE RELEASE; DOWN REGULATION; FEMALE; FLOW CYTOMETRY; GAMMA DELTA T LYMPHOCYTE; HOST RESISTANCE; IMMUNE RESPONSE; IMMUNOCOMPETENT CELL; LUNG ALVEOLUS CELL; LUNG ALVEOLUS MACROPHAGE; LUNG LAVAGE; LYMPHOID CELL; MALE; MOUSE; NONHUMAN; PERITONEUM MACROPHAGE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PSEUDOMONAS AERUGINOSA; QUANTITATIVE ANALYSIS; RESPIRATORY TRACT INFECTION; SURVIVAL; TH17 CELL; TYPE III SECRETION SYSTEM;

ACUTE LUNG INJURY; ANIMALS; APOPTOSIS REGULATORY PROTEINS; BIOLOGICAL MARKERS; BRONCHOALVEOLAR LAVAGE FLUID; CALCIUM-BINDING PROTEINS; CASPASE 1; CELLS, CULTURED; FEMALE; FLOW CYTOMETRY; IMMUNITY, INNATE; INFLAMMASOMES; INTERLEUKIN-17; INTERLEUKIN-18; MACROPHAGES; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTIONS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 84897447822     PISSN: 1073449X     EISSN: 15354970     Source Type: Journal    
DOI: 10.1164/rccm.201307-1358OC     Document Type: Article

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