Identification of serpinb6b as a species-specific mouse granzyme A inhibitor suggests functional divergence between human and mouse granzyme A

Journal of Biological Chemistry

Volumn 289, Issue 13, 2014, Pages 9408-9417

  Kaiserman, Dion ^a   Stewart, Sarah E ^a   Plasman, Kim ^b,c   Gevaert, Kris ^b,c   Van Damme, Petra ^b,c   Bird, Phillip I ^a  

^a MONASH UNIVERSITY   (Australia)

^b DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

^c GHENT UNIVERSITY   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CYTOTOXICITY; ENZYME ACTIVITY; MOLECULAR BIOLOGY;

ASSOCIATION CONSTANT; PHYSIOLOGICAL ROLES; POTENT INHIBITOR; POTENTIAL INHIBITORS; SERINE PROTEASE; STOICHIOMETRY OF INHIBITIONS; STREPTOLYSIN O; SUBSTRATE SPECIFICITY;

MAMMALS;

COMPLEMENTARY DNA; ENZYME INHIBITOR; GRANZYME A; PROTEIN SERPINB6B; RECOMBINANT PROTEIN; STREPTOLYSIN O; UNCLASSIFIED DRUG; GRANZYME; PROTEINASE INHIBITOR; SERINE PROTEINASE INHIBITOR;

ANIMAL CELL; ARTICLE; CELL STRAIN COS1; CONTROLLED STUDY; CYTOTOXICITY; ENZYME SPECIFICITY; GENETIC TRANSFECTION; HUMAN; MOLECULAR CLONING; MOUSE; NONHUMAN; PHAGE DISPLAY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FAMILY; PROTEIN INTERACTION; PROTEOMICS; STOICHIOMETRY; AMINO ACID SEQUENCE; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL DEATH; CHEMICAL STRUCTURE; CHEMISTRY; CHLOROCEBUS AETHIOPS; COS 1 CELL LINE; INTRACELLULAR SPACE; JURKAT CELL LINE; METABOLISM; MOLECULAR EVOLUTION; MOLECULAR GENETICS; PROTEIN MULTIMERIZATION; PROTEIN QUATERNARY STRUCTURE; SPECIES DIFFERENCE;

AMINO ACID SEQUENCE; ANIMALS; CELL DEATH; CERCOPITHECUS AETHIOPS; COS CELLS; EVOLUTION, MOLECULAR; GRANZYMES; HUMANS; INTRACELLULAR SPACE; JURKAT CELLS; MICE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEASE INHIBITORS; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, QUATERNARY; PROTEOMICS; SERPINS; SPECIES SPECIFICITY; SUBSTRATE SPECIFICITY;

EID: 84897437189     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.525808     Document Type: Article

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