Comparison of human chromosome 6p25 with mouse chromosome 13 reveals a greatly expanded ov-serpin gene repertoire in the mouse

Genomics

Volumn 79, Issue 3, 2002, Pages 349-362

  Kaiserman, Dion ^a   Knaggs, Susan ^b   Scarff, Katrina L ^a   Gillard, Anneliese ^a   Mirza, Ghazala ^b   Cadman, Matthew ^c   McKeone, Richard ^c   Denny, Paul ^c   Cooley, Jessica ^d   Benarafa, Charaf ^d   Remold O'Donnell, Eileen ^d   Ragoussis, Jiannis ^b   Bird, Phillip I ^a  

^a MONASH UNIVERSITY   (Australia)

^b Div of Med and Molecular Genetics   (United Kingdom)

^c MRC MAMMALIAN GENETICS UNIT   (United Kingdom)

^d HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Gene structure; MNEI; Ov serpin; Phylogeny; PI 6; PI 9; Serpin; SPI3; SPI6

Indexed keywords

HELICASE; PROTEIN MNEI; PROTEIN PI 6; PROTEIN PI 9; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); SERINE PROTEINASE INHIBITOR; SERPIN B1; SERPIN B6; SERPIN B9; UNCLASSIFIED DRUG;

ARTICLE; CELL DEATH; CHROMOSOME 13; CHROMOSOME 18Q; CHROMOSOME 6P; CONTROLLED STUDY; EXON; GENE CLUSTER; GENE EXPRESSION; GENE MAPPING; GENE STRUCTURE; GENITAL SYSTEM; HUMAN; IMMUNE SYSTEM; INFLAMMATION; INTRON; MARKER GENE; MOUSE; NONHUMAN; PLACENTA; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; TUMOR GROWTH;

RODENTIA;

EID: 0036200071     PISSN: 08887543     EISSN: None     Source Type: Journal    
DOI: 10.1006/geno.2002.6716     Document Type: Article

References (36)

1. The serpins are an expanding superfamily of structurally similar but functionally diverse proteins
2. Structure of a serpin-protease complex shows inhibition by deformation
3. Phylogeny of the serpin superfamily: Implications of patterns of amino acid conservation for structure and function
4. Human ovalbumin serpin evolution: Phylogenic analysis, gene organization, and identification of new PI-8-related genes suggest that two interchromosomal and several intrachromosomal duplications generated the gene clusters at 18q21-q23 and 6p25
5. Vertebrate serpins: Construction of a conflict-free phylogeny by combining exon-intron and diagnostic site analyses
6. Cytoplasmic antiproteinase 2 (PI8) and bomapin (PI10) map to the serpin cluster at 18q21.3
7. Mapping the sites of putative tumor suppressor genes at 6p25 and 6p21.3 in cervical carcinoma: Occurrence of allelic deletions in precancerous lesions
8. Delineation of two distinct 6p deletion syndromes
9. Genetic, physical and phenotypic characterization of the Del(13)Svea36H mouse
10. Gene structure, chromosomal localization and expression of the murine homologue of human proteinase inhibitor 6 (PI6) suggests divergence of PI6 from the ovalbumin serpins
11. A new family of 10 murine ovalbumin serpins includes two homologs of proteinase inhibitor 8 and two homologs of the granzyme B inhibitor (proteinase inhibitor 9)
12. The plasminogen activator inhibitor-2 gene is not required for normal murine development or survival
13. Cloning and molecular characterization of a human intracellular proteinase inhibitor
14. Sequence and molecular characterisation of human monocyte/neutrophil elastase inhibitor
15. Proteinase inhibitor 6 (PI-6) expression in human skin: Induction of PI-6 and a PI-6/proteinase complex during keratinocyte differentiation
16. A cytosolic granzyme B inhibitor related to the viral apoptotic regulator cytokine response modifier A is present in cytotoxic lymphocytes
17. Structure and sequence of human M/NEI (monocyte/neutrophil elastase inhibitor), an ov-serpin family gene
18. Bacterial artificial chromosome libraries for mouse sequencing and functional analysis
19. Pleiotropic skeletal and ocular phenotypes of the mouse mutation congenital hydrocephalus (ch/Mf1) arise from a winged helix/forkhead transcription factor gene
20. Regulation of pro-apoptotic leucocyte granule serine proteinases by intracellular serpins
21. Selective regulation of apoptosis: The cytotoxic lymphocyte serpin proteinase inhibitor 9 protects against granzyme B-mediated apoptosis without perturbing the Fas cell death pathway
22. The intracellular serpin proteinase inhibitor 6 (PI-6) is expressed in monocytes and granulocytes and is a potent inhibitor of the azurophilic granule proteinase, cathepsin G
23. Serine proteinase inhibitor 3 and murinogiobulin I are potent inhibitors of neuropsin in adult mouse brain
24. The granzyme B inhibitor, PI-9, is present in endothelial and mesothelial cells, suggesting it protects bystander cells during immune responses
25. The granzyme B inhibitor, protease inhibitor 9, is mainly expressed by dendritic cells and at immune-privileged sites
26. Granzymes: Exogenous proteinases that induce target cell apoptosis
27. Multiple murine alpha 1-protease inhibitor genes show unusual evolutionary divergence
28. The murine Spi-2 proteinase inhibitor locus: A multi-gene family with a hypervariable reactive site domain
29. The expression and characterization of five recombinant murine α 1-protease inhibitor proteins
30. Basic local alignment search tool
31. Prediction of compiete gene structures in human genomic DNA
32. EST_GENOME: A program to align spliced DNA sequences to unspliced DNA
33. Contigs built with fingerprints, markers and FPC V4.7
34. A YAC-based physical map of the mouse genome
35. Evidence of a locus for orofacial clotting on human chromosome 6p24 and STS map of the region