Block of human cardiac sodium channels by lacosamide: Evidence for slow drug binding along the activation pathway

Molecular Pharmacology

Volumn 85, Issue 5, 2014, Pages 692-702

  Wang, Ging Kuo ^a   Wang, Sho Ya ^b  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b STATE UNIVERSITY OF NEW YORK   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BATRACHOTOXIN; HARKOSERIDE; LACOSAMIDE RECEPTOR; LOCAL ANESTHETIC AGENT; RECEPTOR; SODIUM CHANNEL NAV1.5; UNCLASSIFIED DRUG;

ACTION POTENTIAL; ARTICLE; BINDING AFFINITY; CELL STRAIN HEK293; CONCENTRATION RESPONSE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DRUG ACTIVATION; DRUG PROTEIN BINDING; EMBRYO; HUMAN; HUMAN CELL; IC 50; PRIORITY JOURNAL; REACTION TIME; SIGNAL TRANSDUCTION; SODIUM CURRENT; WILD TYPE;

ACETAMIDES; DOSE-RESPONSE RELATIONSHIP, DRUG; HEK293 CELLS; HUMANS; MEMBRANE POTENTIALS; NAV1.5 VOLTAGE-GATED SODIUM CHANNEL; PROTEIN BINDING; SIGNAL TRANSDUCTION; SODIUM CHANNEL BLOCKERS; TIME FACTORS;

EID: 84897421326     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.113.091173     Document Type: Article

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