Multiple pore conformations driven by asynchronous movements of voltage sensors in a eukaryotic sodium channel

Nature Communications

Volumn 4, Issue , 2013, Pages

  Goldschen Ohm, Marcel P ^a   Capes, Deborah L ^a,c   Oelstrom, Kevin M ^a,b   Chanda, Baron ^a  

^a UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^b UNIVERSITY OF WISCONSIN MADISON   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYSTEINE; LARGE CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL; POTASSIUM CHANNEL; SHAKER POTASSIUM CHANNEL; SODIUM CHANNEL; SODIUM CHANNEL NAV1.4; VOLTAGE GATED SODIUM CHANNEL; (2 (TRIMETHYLAMMONIUM)ETHYL)METHANETHIOSULFONATE; (2-(TRIMETHYLAMMONIUM)ETHYL)METHANETHIOSULFONATE; MESYLIC ACID DERIVATIVE; MUSCLE PROTEIN; MUTANT PROTEIN; SCN4A PROTEIN, RAT;

ASYMMETRY; CORRELATION; ELECTRIC FIELD; EUKARYOTE; FLUOROMETRY; MEMBRANE; PORE SPACE; SENSOR; SODIUM;

ANIMAL TISSUE; ARTICLE; CHANNEL GATING; CONFORMATION; DEPOLARIZATION; ELECTRIC CONDUCTIVITY; GENE MUTATION; MEMBRANE DEPOLARIZATION; MOVEMENT (PHYSIOLOGY); NONHUMAN; RAT; SENSOR; ANIMAL; BIOLOGICAL MODEL; CELL STRAIN HEK293; CHEMISTRY; DRUG EFFECT; EUKARYOTE; GENETICS; HUMAN; KINETICS; METABOLISM; MUTATION; PROTEIN TERTIARY STRUCTURE; PROTEIN TRANSPORT; TIME; XENOPUS;

ANIMALS; EUKARYOTA; HEK293 CELLS; HUMANS; ION CHANNEL GATING; KINETICS; MESYLATES; MODELS, BIOLOGICAL; MUSCLE PROTEINS; MUTANT PROTEINS; MUTATION; PROTEIN STRUCTURE, TERTIARY; PROTEIN TRANSPORT; RATS; SODIUM CHANNELS; TIME FACTORS; XENOPUS;

MLCS; MLOWN;

EID: 84879190086     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms2356     Document Type: Article

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