-
1
-
-
0028339282
-
Phosphorylation and activation of the Jak-3 Janus kinase in response to interleukin-2
-
DOI 10.1038/370151a0
-
Johnston, JA, Kawamura, M, Kirken, RA, Chen, YQ, Blake, TB, Shibuya, K et al. (1994). Phosphorylation and activation of the Jak-3 Janus kinase in response to interleukin-2. Nature 370: 151-153. (Pubitemid 24229128)
-
(1994)
Nature
, vol.370
, Issue.6485
, pp. 151-153
-
-
Johnston, J.A.1
Kawamura, M.2
Kirken, R.A.3
Chen, Y.-Q.4
Blake, T.B.5
Shibuya, K.6
Ortaldo, J.R.7
McVicar, D.W.8
O'Shea, J.J.9
-
2
-
-
0028301958
-
Molecular cloning of L-JAK, a Janus family protein-tyrosine kinase expressed in natural killer cells and activated leukocytes
-
DOI 10.1073/pnas.91.14.6374
-
Kawamura, M, McVicar, DW, Johnston, JA, Blake, TB, Chen, YQ, Lal, BK et al. (1994). Molecular cloning of L-JAK, a Janus family protein-tyrosine kinase expressed in natural killer cells and activated leukocytes. Proc Natl Acad Sci USA 91: 6374-6378. (Pubitemid 24200663)
-
(1994)
Proceedings of the National Academy of Sciences of the United States of America
, vol.91
, Issue.14
, pp. 6374-6378
-
-
Kawamura, M.1
Mcvicar, D.W.2
Johnston, J.A.3
Blake, T.B.4
Chen, Y.-Q.5
Lal, B.K.6
Lloyd, A.R.7
Kelvin, D.J.8
Staples, J.E.9
Ortaldo, J.R.10
O'Shea, J.J.11
-
3
-
-
3543141120
-
A new modality for immunosuppression: Targeting the JAK/STAT pathway
-
O'Shea, JJ, Pesu, M, Borie, DC and Changelian, PS (2004). A new modality for immunosuppression: targeting the JAK/STAT pathway. Nat Rev Drug Discov 3: 555-564. (Pubitemid 39022985)
-
(2004)
Nature Reviews Drug Discovery
, vol.3
, Issue.7
, pp. 555-564
-
-
O'Shea, J.J.1
Pesu, M.2
Borie, D.C.3
Changelian, P.S.4
-
4
-
-
0031749260
-
T cell development and activation in Jak3-deficient mice
-
Baird, AM, Thomis, DC and Berg, LJ (1998). T cell development and activation in Jak3- deficient mice. J Leukoc Biol 63: 669-677. (Pubitemid 28274827)
-
(1998)
Journal of Leukocyte Biology
, vol.63
, Issue.6
, pp. 669-677
-
-
Baird, A.M.1
Thomis, D.C.2
Berg, L.J.3
-
5
-
-
0028840706
-
Defective lymphoid development in mice lacking Jak3
-
Nosaka, T, van Deursen, JM, Tripp, RA, Thierfelder, WE, Witthuhn, BA, McMickle, AP et al. (1995). Defective lymphoid development in mice lacking Jak3. Science 270: 800-802.
-
(1995)
Science
, vol.270
, pp. 800-802
-
-
Nosaka, T.1
Van Deursen, J.M.2
Tripp, R.A.3
Thierfelder, W.E.4
Witthuhn, B.A.5
McMickle, A.P.6
-
6
-
-
0028857954
-
Mutation of Jak3 in a patient with SCID: Essential role of Jak3 in lymphoid development
-
Russell, SM, Tayebi, N, Nakajima, H, Riedy, MC, Roberts, JL, Aman, MJ et al. (1995). Mutation of Jak3 in a patient with SCID: essential role of Jak3 in lymphoid development. Science 270: 797-800.
-
(1995)
Science
, vol.270
, pp. 797-800
-
-
Russell, S.M.1
Tayebi, N.2
Nakajima, H.3
Riedy, M.C.4
Roberts, J.L.5
Aman, M.J.6
-
7
-
-
44849125082
-
Gene array analysis comparison between rat collagen-induced arthritis and human rheumatoid arthritis
-
DOI 10.1111/j.1365-3083.2008.02117.x
-
Soto, H, Hevezi, P, Roth, RB, Pahuja, A, Alleva, D, Acosta, HM et al. (2008). Gene array analysis comparison between rat collagen-induced arthritis and human rheumatoid arthritis. Scand J Immunol 68: 43-57. (Pubitemid 351798401)
-
(2008)
Scandinavian Journal of Immunology
, vol.68
, Issue.1
, pp. 43-57
-
-
Soto, H.1
Hevezi, P.2
Roth, R.B.3
Pahuja, A.4
Alleva, D.5
Acosta, H.M.6
Martinez, C.7
Ortega, A.8
Lopez, A.9
Araiza-Casillas, R.10
Zlotnik, A.11
-
8
-
-
34547171705
-
Characterisation of a dendritic cell subset in synovial tissue which strongly expresses Jak/STAT transcription factors from patients with rheumatoid arthritis
-
DOI 10.1136/ard.2006.060822
-
Walker, JG, Ahern, MJ, Coleman, M, Weedon, H, Papangelis, V, Beroukas, D et al. (2007). Characterisation of a dendritic cell subset in synovial tissue which strongly expresses Jak/ STAT transcription factors from patients with rheumatoid arthritis. Ann Rheum Dis 66: 992-999. (Pubitemid 47122309)
-
(2007)
Annals of the Rheumatic Diseases
, vol.66
, Issue.8
, pp. 992-999
-
-
Walker, J.G.1
Ahern, M.J.2
Coleman, M.3
Weedon, H.4
Papangelis, V.5
Beroukas, D.6
Roberts-Thomson, P.J.7
Smith, M.D.8
-
9
-
-
79961239419
-
Inhibition of JAK3 alleviates inflammation in monoarthritic rats
-
Kim, BH, Kim, M, Yin, CH, Jee, JG, Sandoval, C, Lee, H et al. (2011). Inhibition of JAK3 alleviates inflammation in monoarthritic rats. Br J Pharmacol 164: 106-118.
-
(2011)
Br J Pharmacol
, vol.164
, pp. 106-118
-
-
Kim, B.H.1
Kim, M.2
Yin, C.H.3
Jee, J.G.4
Sandoval, C.5
Lee, H.6
-
10
-
-
75749127860
-
Improved pain, physical functioning and health status in patients with rheumatoid arthritis treated with CP-690,550, an orally active Janus kinase (JAK) inhibitor: Results from a randomised, double-blind, placebo-controlled trial
-
Coombs, JH, Bloom, BJ, Breedveld, FC, Fletcher, MP, Gruben, D, Kremer, JM et al. (2010). Improved pain, physical functioning and health status in patients with rheumatoid arthritis treated with CP-690,550, an orally active Janus kinase (JAK) inhibitor: results from a randomised, double-blind, placebo-controlled trial. Ann Rheum Dis 69: 413-416.
-
(2010)
Ann Rheum Dis
, vol.69
, pp. 413-416
-
-
Coombs, J.H.1
Bloom, B.J.2
Breedveld, F.C.3
Fletcher, M.P.4
Gruben, D.5
Kremer, J.M.6
-
11
-
-
67650093218
-
The safety and efficacy of a JAK inhibitor in patients with active rheumatoid arthritis: Results of a double-blind, placebo-controlled phase IIa trial of three dosage levels of CP-690,550 versus placebo
-
Kremer, JM, Bloom, BJ, Breedveld, FC, Coombs, JH, Fletcher, MP, Gruben, D et al. (2009). The safety and efficacy of a JAK inhibitor in patients with active rheumatoid arthritis: Results of a double-blind, placebo-controlled phase IIa trial of three dosage levels of CP-690,550 versus placebo. Arthritis Rheum 60: 1895-1905.
-
(2009)
Arthritis Rheum
, vol.60
, pp. 1895-1905
-
-
Kremer, J.M.1
Bloom, B.J.2
Breedveld, F.C.3
Coombs, J.H.4
Fletcher, M.P.5
Gruben, D.6
-
12
-
-
67650938638
-
Calcineurin-inhibitor-free immunosuppression based on the JAK inhibitor CP-690,550: A pilot study in de novo kidney allograft recipients
-
Busque, S, Leventhal, J, Brennan, DC, Steinberg, S, Klintmalm, G, Shah, T et al. (2009). Calcineurin-inhibitor-free immunosuppression based on the JAK inhibitor CP-690,550: a pilot study in de novo kidney allograft recipients. Am J Transplant 9: 1936-1945.
-
(2009)
Am J Transplant
, vol.9
, pp. 1936-1945
-
-
Busque, S.1
Leventhal, J.2
Brennan, D.C.3
Steinberg, S.4
Klintmalm, G.5
Shah, T.6
-
13
-
-
38049018155
-
A quantitative analysis of kinase inhibitor selectivity
-
Karaman, MW, Herrgard, S, Treiber, DK, Gallant, P, Atteridge, CE, Campbell, BT et al. (2008). A quantitative analysis of kinase inhibitor selectivity. Nat Biotechnol 26: 127-132.
-
(2008)
Nat Biotechnol
, vol.26
, pp. 127-132
-
-
Karaman, M.W.1
Herrgard, S.2
Treiber, D.K.3
Gallant, P.4
Atteridge, C.E.5
Campbell, B.T.6
-
14
-
-
41349094799
-
The specificity of JAK3 kinase inhibitors
-
DOI 10.1182/blood-2007-09-115030
-
Changelian, PS, Moshinsky, D, Kuhn, CF, Flanagan, ME, Munchhof, MJ, Harris, TM et al. (2008). The specificity of JAK3 kinase inhibitors. Blood 111: 2155-2157. (Pubitemid 351451528)
-
(2008)
Blood
, vol.111
, Issue.4
, pp. 2155-2157
-
-
Changelian, P.S.1
Moshinsky, D.2
Kuhn, C.F.3
Flanagan, M.E.4
Munchhof, M.J.5
Harris, T.M.6
Doty, J.L.7
Sun, J.8
Kent, C.R.9
Magnuson, K.S.10
Perregaux, D.G.11
Sawyer, P.S.12
Kudlacz, E.M.13
-
15
-
-
58149092616
-
Examining the chirality, conformation and selective kinase inhibition of 3-((3R,4R)-4-methyl-3-(methyl(7Hpyrrolo[ 2,3-d]pyrimidin-4-yl)amino)piperidin-1- yl)-3-oxopropanenitrile (CP-690,550)
-
Jiang, JK, Ghoreschi, K, Deflorian, F, Chen, Z, Perreira, M, Pesu, M et al. (2008). Examining the chirality, conformation and selective kinase inhibition of 3-((3R,4R)-4-methyl-3-(methyl(7Hpyrrolo[ 2,3-d]pyrimidin-4-yl) amino)piperidin-1-yl)-3-oxopropanenitrile (CP-690,550). J Med Chem 51: 8012-8018.
-
(2008)
J Med Chem
, vol.51
, pp. 8012-8018
-
-
Jiang, J.K.1
Ghoreschi, K.2
Deflorian, F.3
Chen, Z.4
Perreira, M.5
Pesu, M.6
-
16
-
-
0032076542
-
Jak2 is essential for signaling through a variety of cytokine receptors
-
DOI 10.1016/S0092-8674(00)81167-8
-
Parganas, E, Wang, D, Stravopodis, D, Topham, DJ, Marine, JC, Teglund, S et al. (1998). Jak2 is essential for signaling through a variety of cytokine receptors. Cell 93: 385-395. (Pubitemid 28232083)
-
(1998)
Cell
, vol.93
, Issue.3
, pp. 385-395
-
-
Parganas, E.1
Wang, D.2
Stravopodis, D.3
Topham, D.J.4
Marine, J.-C.5
Teglund, S.6
Vanin, E.F.7
Bodner, S.8
Colamonici, O.R.9
Van Deursen, J.M.10
Grosveld, G.11
Ihle, J.N.12
-
17
-
-
0032076183
-
Disruption of the Jak1 gene demonstrates obligatory and nonredundant roles of the Jaks in cytokine-induced biologic responses
-
DOI 10.1016/S0092-8674(00)81166-6
-
Rodig, SJ, Meraz, MA, White, JM, Lampe, PA, Riley, JK, Arthur, CD et al. (1998). Disruption of the Jak1 gene demonstrates obligatory and nonredundant roles of the Jaks in cytokine-induced biologic responses. Cell 93: 373-383. (Pubitemid 28232082)
-
(1998)
Cell
, vol.93
, Issue.3
, pp. 373-383
-
-
Rodig, S.J.1
Meraz, M.A.2
White, J.M.3
Lampe, P.A.4
Riley, J.K.5
Arthur, C.D.6
King, K.L.7
Sheehan, K.C.F.8
Yin, L.9
Pennica, D.10
Johnson Jr., E.M.11
Schreiber, R.D.12
-
18
-
-
48349097976
-
Phase 1 dose-escalation study of CP-690 550 in stable renal allograft recipients: Preliminary findings of safety, tolerability, effects on lymphocyte subsets and pharmacokinetics
-
van Gurp, E, Weimar, W, Gaston, R, Brennan, D, Mendez, R, Pirsch, J et al. (2008). Phase 1 dose-escalation study of CP-690 550 in stable renal allograft recipients: preliminary findings of safety, tolerability, effects on lymphocyte subsets and pharmacokinetics. Am J Transplant 8: 1711-1718.
-
(2008)
Am J Transplant
, vol.8
, pp. 1711-1718
-
-
Van Gurp, E.1
Weimar, W.2
Gaston, R.3
Brennan, D.4
Mendez, R.5
Pirsch, J.6
-
19
-
-
77955363826
-
Selective functional inhibition of JAK-3 is sufficient for efficacy in collagen-induced arthritis in mice
-
Lin, TH, Hegen, M, Quadros, E, Nickerson-Nutter, CL, Appell, KC, Cole, AG et al. (2010). Selective functional inhibition of JAK-3 is sufficient for efficacy in collagen-induced arthritis in mice. Arthritis Rheum 62: 2283-2293.
-
(2010)
Arthritis Rheum
, vol.62
, pp. 2283-2293
-
-
Lin, T.H.1
Hegen, M.2
Quadros, E.3
Nickerson-Nutter, C.L.4
Appell, K.C.5
Cole, A.G.6
-
20
-
-
79953043687
-
Jak1 has a dominant role over Jak3 in signal transduction through ?c-containing cytokine receptors
-
Haan, C, Rolvering, C, Raulf, F, Kapp, M, Drückes, P, Thoma, G et al. (2011). Jak1 has a dominant role over Jak3 in signal transduction through ?c-containing cytokine receptors. Chem Biol 18: 314-323.
-
(2011)
Chem Biol
, vol.18
, pp. 314-323
-
-
Haan, C.1
Rolvering, C.2
Raulf, F.3
Kapp, M.4
Drückes, P.5
Thoma, G.6
-
21
-
-
36849044732
-
Nonviral delivery of synthetic siRNAs in vivo
-
DOI 10.1172/JCI33494
-
Akhtar, S and Benter, IF (2007). Nonviral delivery of synthetic siRNAs in vivo. J Clin Invest 117: 3623-3632. (Pubitemid 350224068)
-
(2007)
Journal of Clinical Investigation
, vol.117
, Issue.12
, pp. 3623-3632
-
-
Akhtar, S.1
Benter, I.F.2
-
22
-
-
77952385213
-
RNAi nanomedicines: Challenges and opportunities within the immune system
-
Weinstein, S and Peer, D (2010). RNAi nanomedicines: challenges and opportunities within the immune system. Nanotechnology 21: 232001.
-
(2010)
Nanotechnology
, vol.21
, pp. 232001
-
-
Weinstein, S.1
Peer, D.2
-
23
-
-
18144393469
-
Efficiency of RNA interference in the mouse hematopoietic system varies between cell types and developmental stages
-
DOI 10.1128/MCB.25.10.3896-3905.2005
-
Oberdoerffer, P, Kanellopoulou, C, Heissmeyer, V, Paeper, C, Borowski, C, Aifantis, I et al. (2005). Efficiency of RNA interference in the mouse hematopoietic system varies between cell types and developmental stages. Mol Cell Biol 25: 3896-3905. (Pubitemid 40617641)
-
(2005)
Molecular and Cellular Biology
, vol.25
, Issue.10
, pp. 3896-3905
-
-
Oberdoerffer, P.1
Kanellopoulou, C.2
Heissmeyer, V.3
Paeper, C.4
Borowski, C.5
Aifantis, I.6
Rao, A.7
Rajewsky, K.8
-
24
-
-
0037708570
-
Suppression of early T-cell-receptor-triggered cellular activation by the Janus kinase 3 inhibitor WHI-P-154
-
DOI 10.1097/01.TP.0000065738.58742.A9
-
Säemann, MD, Zeyda, M, Diakos, C, Szekeres, A, Böhmig, GA, Kelemen, P et al. (2003). Suppression of early T-cell-receptor-triggered cellular activation by the Janus kinase 3 inhibitor WHI-P-154. Transplantation 75: 1864-1872. (Pubitemid 36734644)
-
(2003)
Transplantation
, vol.75
, Issue.11
, pp. 1864-1872
-
-
Saemann, M.D.1
Zeyda, M.2
Diakos, C.3
Szekeres, A.4
Bohmig, G.A.5
Kelemen, P.6
Parolini, O.7
Stockinger, H.8
Prieschl, E.E.9
Stulnig, T.M.10
Baumruker, T.11
Zlabinger, G.J.12
-
25
-
-
0035816692
-
Cytokineindependent Jak3 activation upon T cell receptor (TCR) stimulation through direct association of Jak3 and the TCR complex
-
Tomita, K, Saijo, K, Yamasaki, S, Iida, T, Nakatsu, F, Arase, H et al. (2001). Cytokineindependent Jak3 activation upon T cell receptor (TCR) stimulation through direct association of Jak3 and the TCR complex. J Biol Chem 276: 25378-25385.
-
(2001)
J Biol Chem
, vol.276
, pp. 25378-25385
-
-
Tomita, K.1
Saijo, K.2
Yamasaki, S.3
Iida, T.4
Nakatsu, F.5
Arase, H.6
-
26
-
-
0031054442
-
Peripheral expression of Jak3 is required to maintain T lymphocyte function
-
DOI 10.1084/jem.185.2.197
-
Thomis, DC and Berg, LJ (1997). Peripheral expression of Jak3 is required to maintain T lymphocyte function. J Exp Med 185: 197-206. (Pubitemid 27078277)
-
(1997)
Journal of Experimental Medicine
, vol.185
, Issue.2
, pp. 197-206
-
-
Thomis, D.C.1
Berg, L.J.2
-
27
-
-
0031563948
-
Manipulation of Th1/Th2 balance in vivo by adoptive transfer of antigen- specific Th1 or Th2 cells
-
DOI 10.1016/S0022-1759(97)00152-X, PII S002217599700152X
-
Ohta, A, Sato, N, Yahata, T, Ohmi, Y, Santa, K, Sato, T et al. (1997). Manipulation of Th1/ Th2 balance in vivo by adoptive transfer of antigen-specific Th1 or Th2 cells. J Immunol Methods 209: 85-92. (Pubitemid 28032147)
-
(1997)
Journal of Immunological Methods
, vol.209
, Issue.1
, pp. 85-92
-
-
Ohta, A.1
Sato, N.2
Yahata, T.3
Ohmi, Y.4
Santa, K.5
Sato, T.6
Tashiro, H.7
Habu, S.8
Nishimura, T.9
-
28
-
-
33644519308
-
Self-limitation of Th1-mediated inflammation by IFN-gamma
-
Feuerer, M, Eulenburg, K, Loddenkemper, C, Hamann, A and Huehn, J (2006). Self-limitation of Th1-mediated inflammation by IFN-gamma. J Immunol 176: 2857-2863.
-
(2006)
J Immunol
, vol.176
, pp. 2857-2863
-
-
Feuerer, M.1
Eulenburg, K.2
Loddenkemper, C.3
Hamann, A.4
Huehn, J.5
-
29
-
-
55649098807
-
RNA interference-mediated gene silencing in murine T cells: In vitro and in vivo validation of proinflammatory target genes
-
Gust, TC, Neubrandt, L, Merz, C, Asadullah, K, Zügel, U and von Bonin, A (2008). RNA interference-mediated gene silencing in murine T cells: in vitro and in vivo validation of proinflammatory target genes. Cell Commun Signal 6: 3.
-
(2008)
Cell Commun Signal
, vol.6
, pp. 3
-
-
Gust, T.C.1
Neubrandt, L.2
Merz, C.3
Asadullah, K.4
Zügel, U.5
Von Bonin, A.6
-
30
-
-
0032545933
-
Potent and specific genetic interference by double-stranded RNA in caenorhabditis elegans
-
DOI 10.1038/35888
-
Fire, A, Xu, S, Montgomery, MK, Kostas, SA, Driver, SE and Mello, CC (1998). Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature 391: 806-811. (Pubitemid 28099681)
-
(1998)
Nature
, vol.391
, Issue.6669
, pp. 806-811
-
-
Fire, A.1
Xu, S.2
Montgomery, M.K.3
Kostas, S.A.4
Driver, S.E.5
Mello, C.C.6
-
31
-
-
39549101284
-
Delivering silence: Advancements in developing siRNA therapeutics
-
Novobrantseva, TI, Akinc, A, Borodovsky, A and de Fougerolles, A (2008). Delivering silence: advancements in developing siRNA therapeutics. Curr Opin Drug Discov Devel 11: 217-224. (Pubitemid 351281061)
-
(2008)
Current Opinion in Drug Discovery and Development
, vol.11
, Issue.2
, pp. 217-224
-
-
Novobrantseva, T.I.1
Akinc, A.2
Borodovsky, A.3
De Fougerolles, A.4
-
32
-
-
22344454846
-
Sequence-dependent stimulation of the mammalian innate immune response by synthetic siRNA
-
DOI 10.1038/nbt1081
-
Judge, AD, Sood, V, Shaw, JR, Fang, D, McClintock, K and MacLachlan, I (2005). Sequence- dependent stimulation of the mammalian innate immune response by synthetic siRNA. Nat Biotechnol 23: 457-462. (Pubitemid 41724921)
-
(2005)
Nature Biotechnology
, vol.23
, Issue.4
, pp. 457-462
-
-
Judge, A.D.1
Sood, V.2
Shaw, J.R.3
Fang, D.4
McClintock, K.5
MacLachlan, I.6
-
33
-
-
0042972933
-
Activation of the interferon system by short-interfering RNAs
-
DOI 10.1038/ncb1038
-
Sledz, CA, Holko, M, de Veer, MJ, Silverman, RH and Williams, BR (2003). Activation of the interferon system by short-interfering RNAs. Nat Cell Biol 5: 834-839. (Pubitemid 37087172)
-
(2003)
Nature Cell Biology
, vol.5
, Issue.9
, pp. 834-839
-
-
Sledz, C.A.1
Holko, M.2
De Veer, M.J.3
Silverman, R.H.4
Williams, B.R.G.5
-
34
-
-
33748069824
-
SiRNA and isRNA: Two edges of one sword
-
DOI 10.1016/j.ymthe.2006.06.001, PII S1525001606002176
-
Schlee, M, Hornung, V and Hartmann, G (2006). siRNA and isRNA: two edges of one sword. Mol Ther 14: 463-470. (Pubitemid 44296098)
-
(2006)
Molecular Therapy
, vol.14
, Issue.4
, pp. 463-470
-
-
Schlee, M.1
Hornung, V.2
Hartmann, G.3
-
35
-
-
0033037268
-
SOCS-3 is tyrosine phosphorylated in response to interleukin-2 and suppresses STAT5 phosphorylation and lymphocyte proliferation
-
Cohney, SJ, Sanden, D, Cacalano, NA, Yoshimura, A, Mui, A, Migone, TS et al. (1999). SOCS-3 is tyrosine phosphorylated in response to interleukin-2 and suppresses STAT5 phosphorylation and lymphocyte proliferation. Mol Cell Biol 19: 4980-4988. (Pubitemid 29289537)
-
(1999)
Molecular and Cellular Biology
, vol.19
, Issue.7
, pp. 4980-4988
-
-
Cohney, S.J.1
Sanden, D.2
Cacalano, N.A.3
Yoshimura, A.4
Mui, A.5
Migone, T.S.6
Johnston, J.A.7
-
36
-
-
84857414096
-
Suppression of cytokine signaling by SOCS3: Characterization of the mode of inhibition and the basis of its specificity
-
Jeffrey, JB, Nadia, JK, James, MM, Leila, NV, Artem L et al. (2012). Suppression of cytokine signaling by SOCS3: Characterization of the mode of inhibition and the basis of its specificity. Immunity 36: 239-250.
-
(2012)
Immunity
, vol.36
, pp. 239-250
-
-
Jeffrey, J.B.1
Nadia, J.K.2
James, M.M.3
Leila, N.V.4
Artem, L.5
-
37
-
-
55849095891
-
Evidence that cytokines play a role in rheumatoid arthritis
-
Brennan, FM and McInnes, IB (2008). Evidence that cytokines play a role in rheumatoid arthritis. J Clin Invest 118: 3537-3545.
-
(2008)
J Clin Invest
, vol.118
, pp. 3537-3545
-
-
Brennan, F.M.1
McInnes, I.B.2
-
38
-
-
51549096629
-
Targeting CpG oligonucleotides to the lymph node by nanoparticles elicits efficient antitumoral immunity
-
Bourquin, C, Anz, D, Zwiorek, K, Lanz, AL, Fuchs, S, Weigel, S et al. (2008). Targeting CpG oligonucleotides to the lymph node by nanoparticles elicits efficient antitumoral immunity. J Immunol 181: 2990-2998.
-
(2008)
J Immunol
, vol.181
, pp. 2990-2998
-
-
Bourquin, C.1
Anz, D.2
Zwiorek, K.3
Lanz, A.L.4
Fuchs, S.5
Weigel, S.6
-
39
-
-
33751511117
-
Gene Expression Analysis in Blood Cells in Response to Unmodified and 2′-Modified siRNAs Reveals TLR-dependent and Independent Effects
-
DOI 10.1016/j.jmb.2006.09.034, PII S0022283606012253
-
Cekaite, L, Furset, G, Hovig, E and Sioud, M (2007). Gene expression analysis in blood cells in response to unmodified and 2?-modified siRNAs reveals TLR-dependent and independent effects. J Mol Biol 365: 90-108. (Pubitemid 44830036)
-
(2007)
Journal of Molecular Biology
, vol.365
, Issue.1
, pp. 90-108
-
-
Cekaite, L.1
Furset, G.2
Hovig, E.3
Sioud, M.4
-
40
-
-
54349089048
-
Utility of animal models for identification of potential therapeutics for rheumatoid arthritis
-
Hegen, M, Keith, JC Jr, Collins, M and Nickerson-Nutter, CL (2008). Utility of animal models for identification of potential therapeutics for rheumatoid arthritis. Ann Rheum Dis 67: 1505-1515.
-
(2008)
Ann Rheum Dis
, vol.67
, pp. 1505-1515
-
-
Hegen, M.1
Keith Jr., J.C.2
Collins, M.3
Nickerson-Nutter, C.L.4
-
41
-
-
0028889726
-
Activation of JAK3, but not JAK1, is critical for IL-2-induced proliferation and STAT5 recruitment by a COOH-terminal region of the IL-2 receptor beta-chain
-
Kirken, RA, Rui, H, Malabarba, MG, Howard, OM, Kawamura, M, O'Shea, JJ et al. (1995). Activation of JAK3, but not JAK1, is critical for IL-2-induced proliferation and STAT5 recruitment by a COOH-terminal region of the IL-2 receptor beta-chain. Cytokine 7: 689-700.
-
(1995)
Cytokine
, vol.7
, pp. 689-700
-
-
Kirken, R.A.1
Rui, H.2
Malabarba, M.G.3
Howard, O.M.4
Kawamura, M.5
O'Shea, J.J.6
-
42
-
-
0034088346
-
Hierarchy of protein tyrosine kinases in interleukin-2 (IL-2) signaling: Activation of Syk depends on Jak3; however, neither Syk nor Lck is required for IL-2-mediated STAT activation
-
DOI 10.1128/MCB.20.12.4371-4380.2000
-
Zhou, YJ, Magnuson, KS, Cheng, TP, Gadina, M, Frucht, DM, Galon, J et al. (2000). Hierarchy of protein tyrosine kinases in interleukin-2 (IL-2) signaling: activation of syk depends on Jak3; however, neither Syk nor Lck is required for IL-2-mediated STAT activation. Mol Cell Biol 20: 4371-4380. (Pubitemid 30346631)
-
(2000)
Molecular and Cellular Biology
, vol.20
, Issue.12
, pp. 4371-4380
-
-
Zhou, Y.-J.1
Magnuson, K.S.2
Cheng, T.P.3
Gadina, M.4
Frucht, D.M.5
Galon, J.6
Candotti, F.7
Geahlen, R.L.8
Changelian, P.S.9
O'Shea, J.J.10
-
43
-
-
41349095906
-
RNAi screening of the tyrosine kinome identifies therapeutic targets in acute myeloid leukemia
-
DOI 10.1182/blood-2007-06-097253
-
Tyner, JW, Walters, DK, Willis, SG, Luttropp, M, Oost, J, Loriaux, M et al. (2008). RNAi screening of the tyrosine kinome identifies therapeutic targets in acute myeloid leukemia. Blood 111: 2238-2245. (Pubitemid 351451431)
-
(2008)
Blood
, vol.111
, Issue.4
, pp. 2238-2245
-
-
Tyner, J.W.1
Walters, D.K.2
Willis, S.G.3
Luttropp, M.4
Oost, J.5
Loriaux, M.6
Erickson, H.7
Corbin, A.S.8
O'Hare, T.9
Heinrich, M.C.10
Deininger, M.W.11
Druker, B.J.12
-
44
-
-
33846577821
-
Cell type-specific roles of Jak3 in IL-2-induced proliferative signal transduction
-
DOI 10.1016/j.bbrc.2007.01.067, PII S0006291X07001192
-
Fujii, H (2007). Cell type-specific roles of Jak3 in IL-2-induced proliferative signal transduction. Biochem Biophys Res Commun 354: 825-829. (Pubitemid 46186261)
-
(2007)
Biochemical and Biophysical Research Communications
, vol.354
, Issue.3
, pp. 825-829
-
-
Fujii, H.1
-
45
-
-
0028901042
-
Activation of JAK3, but not JAK1, is critical to interleukin-4 (IL4) stimulated proliferation and requires a membrane-proximal region of IL4 receptor alpha
-
Malabarba, MG, Kirken, RA, Rui, H, Koettnitz, K, Kawamura, M, O'Shea, JJ et al. (1995). Activation of JAK3, but not JAK1, is critical to interleukin-4 (IL4) stimulated proliferation and requires a membrane-proximal region of IL4 receptor alpha. J Biol Chem 270: 9630-9637.
-
(1995)
J Biol Chem
, vol.270
, pp. 9630-9637
-
-
Malabarba, M.G.1
Kirken, R.A.2
Rui, H.3
Koettnitz, K.4
Kawamura, M.5
O'Shea, J.J.6
-
46
-
-
33750008991
-
Transcriptional and phenotypic comparisons of Ppara knockout and siRNA knockdown mice
-
DOI 10.1093/nar/gkl609
-
De Souza, AT, Dai, X, Spencer, AG, Reppen, T, Menzie, A, Roesch, PL et al. (2006). Transcriptional and phenotypic comparisons of Ppara knockout and siRNA knockdown mice. Nucleic Acids Res 34: 4486-4494. (Pubitemid 44567048)
-
(2006)
Nucleic Acids Research
, vol.34
, Issue.16
, pp. 4486-4494
-
-
De Souza, A.T.1
Dai, X.2
Spencer, A.G.3
Reppen, T.4
Menzie, A.5
Roesch, P.L.6
He, Y.7
Caguyong, M.J.8
Bloomer, S.9
Herweijer, H.10
Wolff, J.A.11
Hagstrom, J.E.12
Lewis, D.L.13
Linsley, P.S.14
Ulrich, R.G.15
-
47
-
-
44649178270
-
Janus-kinase-3-dependent signals induce chromatin remodeling at the ifng locus during t helper 1 cell differentiation
-
DOI 10.1016/j.immuni.2008.04.016, PII S1074761308002331
-
Shi, M, Lin, TH, Appell, KC and Berg, LJ (2008). Janus-kinase-3-dependent signals induce chromatin remodeling at the Ifng locus during T helper 1 cell differentiation. Immunity 28: 763-773. (Pubitemid 351778407)
-
(2008)
Immunity
, vol.28
, Issue.6
, pp. 763-773
-
-
Shi, M.1
Lin, T.H.2
Appell, K.C.3
Berg, L.J.4
-
48
-
-
72249115144
-
MS-1020 is a novel small molecule that selectively inhibits JAK3 activity
-
Kim, BH, Oh, SR, Yin, CH, Lee, S, Kim, EA, Kim, MS et al. (2010). MS-1020 is a novel small molecule that selectively inhibits JAK3 activity. Br J Haematol 148: 132-143.
-
(2010)
Br J Haematol
, vol.148
, pp. 132-143
-
-
Kim, B.H.1
Oh, S.R.2
Yin, C.H.3
Lee, S.4
Kim, E.A.5
Kim, M.S.6
-
49
-
-
38849166053
-
Systemic leukocyte-directed siRNA delivery revealing cyclin D1 as an anti-inflammatory target
-
DOI 10.1126/science.1149859
-
Peer, D, Park, EJ, Morishita, Y, Carman, CV and Shimaoka, M (2008). Systemic leukocytedirected siRNA delivery revealing cyclin D1 as an anti-inflammatory target. Science 319: 627-630. (Pubitemid 351197066)
-
(2008)
Science
, vol.319
, Issue.5863
, pp. 627-630
-
-
Peer, D.1
Eun, J.P.2
Morishita, Y.3
Carman, C.V.4
Shimaoka, M.5
-
50
-
-
0025697469
-
lo thymocytes in vivo
-
Murphy, KM, Heimberger, AB and Loh, DY (1990). Induction by antigen of intrathymic apoptosis of CD4+CD8+TCRlo thymocytes in vivo. Science 250: 1720-1723. (Pubitemid 120031881)
-
(1990)
Science
, vol.250
, Issue.4988
, pp. 1720-1723
-
-
Murphy, K.M.1
Heimberger, A.B.2
Loh, D.Y.3
|