Comparative bioinformatics, temporal and spatial expression analyses of Ixodes scapularis organic anion transporting polypeptides

Ticks and Tick-borne Diseases

Volumn 5, Issue 3, 2014, Pages 287-298

  Radulović, Željko ^a   Porter, Lindsay M ^a   Kim, Tae K ^a   Mulenga, Albert ^a  

^a TEXAS A AND M UNIVERSITY   (United States)

Author keywords

Expression analyses; Ixodes scapularis; Organic anion transporting polypeptides

Indexed keywords

MESSENGER RNA; DNA; ORGANIC ANION TRANSPORTER;

ACTIN GENE; ADULT; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOINFORMATICS; CELL SURFACE; COMPARATIVE STUDY; FEEDING BEHAVIOR; FEMALE; GENE; GENE EXPRESSION; GENOME; HOMEOSTASIS; ISOATP0726 GENE; ISOATP2114 GENE; ISOATP2116 GENE; ISOATP4056 GENE; ISOATP4134 GENE; ISOATP4548 GENE; ISOATP4550 GENE; ISOATP5126 GENE; ISOATP5621 GENE; IXODES SCAPULARIS; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; OVARY; PHYLOGENETIC TREE; PRIORITY JOURNAL; PROTEIN MOTIF; REAL TIME POLYMERASE CHAIN REACTION; SALIVARY GLAND; UNINDEXED SEQUENCE; AMINO ACID SEQUENCE; ANIMAL; ANTIBODY SPECIFICITY; BIOLOGY; CHEMISTRY; DNA SEQUENCE; GENE EXPRESSION REGULATION; GENETICS; IXODES; METABOLISM; MOLECULAR GENETICS; MULTIGENE FAMILY; PHYLOGENY; PROTEIN TERTIARY STRUCTURE; SEQUENCE ALIGNMENT; TIME;

INVERTEBRATA; IXODES SCAPULARIS; IXODIDA; PEDICULUS HUMANUS; VERTEBRATA;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; COMPUTATIONAL BIOLOGY; DNA; FEEDING BEHAVIOR; FEMALE; GENE EXPRESSION REGULATION; GENOME; IXODES; MALE; MOLECULAR SEQUENCE DATA; MULTIGENE FAMILY; ORGAN SPECIFICITY; ORGANIC ANION TRANSPORTERS; PHYLOGENY; PROTEIN STRUCTURE, TERTIARY; SALIVARY GLANDS; SEQUENCE ALIGNMENT; SEQUENCE ANALYSIS, DNA; TIME FACTORS;

EID: 84897416269     PISSN: 1877959X     EISSN: 18779603     Source Type: Journal    
DOI: 10.1016/j.ttbdis.2013.12.002     Document Type: Article

References (71)

1. Abe T., Kakyo M., Sakagami H., Tokui T., Nishio T., Tanemoto M., Nomura H., Hebert S.C., Matsuno S., Kondo H., Yawo H. Molecular characterization and tissue distribution of a new organic anion transporter subtype (oatp3) that transports thyroid hormones and taurocholate and comparison with oatp2. J. Biol. Chem. 1998, 273:22395-22401.
2. Abe T., Kakyo M., Tokui T., Nagakomi R., Nishio T., Nakai D., Nomura H., Unno M., Suzuki M., Naitoh T., Matsuno S., Yawo H. Identification of a novel gene family encoding human liver-specific organic anion transporter LST-1. J. Biol. Chem. 1999, 274:17159-17163.
3. Alekseev A.N., Semenov A.V., Dubinina H.V. Evidence of Babesia microti infection in multi-infected Ixodes persulcatus ticks in Russia. Exp. Appl. Acarol. 2003, 29:345-353.
4. Briz O., Serrano M.A., Rebollo N., Hagenbuch B., Meier P.J., Koepsell H., Marin J.J. Carriers involved in targeting the cytostatic bile acid-cisplatin derivatives cis-diammine-chloro-cholylglycinate-platinum(II) and cis-diammine-bisursodeoxycholate-platinum(II) toward liver cells. Mol. Pharmacol. 2002, 61:853-860.
5. Charrel R.N., Attoui H., Butenko A.M., Clegg J.C., Deubel V., Frolova T.V., Gould E.A., Gritsun T.S., Heinz F.X., Labuda M., Lashkevich V.A., Loktev V., Lundkvist A., Lvov D.V., Mandl C.W., Niedrig M., Papa A., Petrov V.S., Plysnin A., Randolph S., Süss J., Zlobin V.I., De Lamballerie X. Tick-borne virus diseases of human interest in Europe. Clin. Microbiol. Infect. 2004, 10:1040-1055.
6. Chausov E.V., Ternovoi V.A., Protopopova E.V., Kononova J.V., Konovalova S.N., Pershikova N.L., Romanenko V.N., Ivanova N.V., Bolshakova N.P., Moskvitina N.S., Loktev V.B. Variability of the tick-borne encephalitis virus genome in the 5' noncoding region derived from ticks Ixodes persulcatus and Ixodes pavlovskyi in western Siberia. Vector Borne Zoonot. Dis. 2010, 10:365-375.
7. Cheng X., Maher J., Chen C., Klaassen C.D. Tissue distribution and ontogeny of mouse organic anion transporting polypeptides (Oatps). Drug Metab. Dispos. 2005, 33:1062-1073.
8. Cui Y., König J., Leier I., Buchholz U., Keppler D. Hepatic uptake of bilirubin and its conjugates by the human organic anion transporter SLC21A6. J. Biol. Chem. 2001, 276:9626-9630.
9. Dantas-Torres F., Chomel B.B., Otranto D. Ticks and tick-borne diseases: a one health perspective. Trends Parasitol. 2012, 28:437-446.
10. Dereeper A., Guignon V., Blanc G., Audic S., Buffet S., Chevenet F., Dufayard J.-F., Guindon S., Lefort V., Lescot M., Claverie J.M., Gascuel O. Phylogeny.fr: robust phylogenetic analysis for the non-specialists. Nucl. Acids Res. 2008, 36:W465-W469.
11. Florea L., Di Francesco V., Miller J., Turner R., Yao A., Harris M., Walenz B., Mobarry C., Merkulov G.V., Charlab R., Dew I., Deng Z., Istrail S., Li P., Sutton G. Gene and alternative splicing annotation with AIR. Genome Res. 2005, 15:54-66.
12. Franta Z., Sojka D., Frantova H., Dvorak J., Horn M., Srba J., Talacko P., Mares M., Schneider E., Craik C.S., McKerrow J.H., Caffrey C.R., Kopacek P. IrCL1 - the haemoglobinolytic cathepsin L of the hard tick Ixodes ricinus. Int. J. Parasitol. 2011, 41:1253-1262.
13. Fujiwara K., Adachi H., Nishio T., Unno M., Tokui T., Okabe M., Onogawa T., Suzuki T., Asano N., Tanemoto M., Seki M., Shiiba K., Suzuki M., Kondo Y., Nunoki K., Shimosegawa T., Iinuma K., Ito S., Matsuno S., Abe T. Identification of thyroid hormone transporters in humans: different molecules are involved in tissue-specific manner. Endocrinology 2001, 142:2005-2012.
14. Fukunaga M., Takahashi Y., Tsuruta Y., Matsushita O., Ralph D., McClelland M., Nakao M. Genetic and phenotypic analysis of Borrelia miyamotoi sp. nov., isolated from the ixodid tick Ixodes persulcatus, the vector for Lyme disease in Japan. Int. J. Syst. Bacteriol. 1995, 45:804-810.
15. Gee J.D. Fluid secretion by the malpighian tubules of tsetse fly Glossina morsitans: the effects of ouabain, ethacrynic acid and amiloride. J. Exp. Biol. 1976, 65:323-332.
16. Ghedin E., Wang S., Spiro D., Caler E., Zhao Q., Crabtree J., Allen J.E., Delcher A.L., Guiliano D.B., Miranda-Saavedra D., Angiuoli S.V., Creasy T., Amedeo P., Haas B., El-Sayed N.M., Wortman J.R., Feldblyum T., Tallon L., Schatz M., Shumway M., Koo H., Salzberg S.L., Schobel S., Pertea M., Pop M., White O., Barton G.J., Carlow C.K., Crawford M.J., Daub J., Dimmic M.W., Estes C.F., Foster J.M., Ganatra M., Gregory W.F., Johnson N.M., Jin J., Komuniecki R., Korf I., Kumar S., Laney S., Li B.W., Li W., Lindblom T.H., Lustigman S., Ma D., Maina C.V., Martin D.M., McCarter J.P., McReynolds L., Mitreva M., Nutman T.B., Parkinson J., Peregrín-Alvarez J.M., Poole C., Ren Q., Saunders L., Sluder A.E., Smith K., Stanke M., Unnasch T.R., Ware J., Wei A.D., Weil G., Williams D.J., Zhang Y., Williams S.A., Fraser-Liggett C., Slatko B., Blaxter M.L., Scott A.L. Draft genome of the filarial nematode parasite Brugia malayi. Science 2007, 317:1756-1760.
17. Gould E.A., De Lamballerie X., Zanotto P.M.A., Holmes E.C. Evolution, epidemiology and dispersal of flaviviruses revealed by molecular phylogenies. Adv. Virus Res. 2001, 57:71-103.
18. Hagenbuch B., Meier P.J. The superfamily of organic anion transporting polypeptides. Biochim. Biophys. Acta 2003, 1609:1-18.
19. Hagenbuch B., Meier P.J. Organic anion transporting polypeptides of the OATP/SLC21 family: phylogenetic classification as OATP/SLCO superfamily, new nomenclature and molecular/functional properties. Pflügers Arch. 2004, 447:653-665.
20. Hagenbuch B., Gao B., Meier P.J. Transport of xenobiotics across the blood-brain barrier. News Physiol. Sci. 2002, 17:231-234.
21. Hall T.A. BiEdit: a user-friendly biological sequence alignment editor and analysis program for Windows 95/98/NT. Nucl. Acids Symp. Ser. 1999, 41:95-98.
22. Hänggi E., Grundschober A.F., Leuthold S., Meier P.J., St-Pierre M.V. Functional analysis of the extracellular cysteine residues in the human organic anion transporting polypeptide, OATP2B1. Mol. Pharmacol. 2006, 70:806-817.
23. Heyman P., Cochez C., Hofhuis A., Van Der Giessen J., Sprong H., Porter S.R., Losson B., Saegerman C., Donoso-Mantke O., Niedrig M., Papa A. A clear and present danger: tick-borne diseases in Europe. Expert Rev. Anti Infect. Ther. 2010, 8:33-50.
24. Hill C.A., Wikel S.K. The Ixodes scapularis genome project: an opportunity for advancing tick research. Trends Parasitol. 2005, 21:151-153.
25. Huber R.D., Gao B., Sidler Pfändler M.A., Zhang-Fu W., Leuthold S., Hagenbuch B., Folkers G., Meier P.J., Stieger B. Characterization of two splice variants of human organic anion transporting polypeptide 3A1 isolated from human brain. Am. J. Physiol. Cell Physiol. 2007, 292:C795-C806.
26. Inokuma H., Ohashi M., Jilintai, Tanabe S., Miyahara K. Prevalence of tick-borne Rickettsia and Ehrlichia in Ixodes persulcatus and Ixodes ovatus in Tokachi district, eastern Hokkaido, Japan. J. Vet. Med. Sci. 2007, 69:661-664.
27. +-independent organic anion transporter. P. Natl. Acad. Sci. USA 1994, 91:133-137.
28. Kakyo M., Unno M., Tokui T., Nakagomi R., Nishio T., Iwasashi H., Nakai D., Seki M., Suzuki M., Naitoh T., Matsuno S., Yawo H., Abe T. Molecular characterization and functional regulation of a novel rat liver-specific organic anion transporter rlst-1. Gastroenterology 1999, 117:770-775.
29. Kalliokoski A., Niemi M. Impact of OATP transporters on pharmacokinetics. Br. J. Pharmacol. 2009, 158:693-705.
30. König J. Uptake transporters of the human OATP family: molecular characteristics, substrates, their role in drug-drug interactions, and functional consequences of polymorphisms. Handb. Exp. Pharmacol. 2011, 201:1-28.
31. König J., Cui Y., Nies A.T., Keppler D. Localization and genomic organization of a new hepatocellular organic anion transporting polypeptide. J. Biol. Chem. 2000, 275:23161-23168.
32. König J., Seithel A., Gradhand U., Fromm M.F. Pharmacogenomics of human OATP transporters. Naunyn Schmiedebergs Arch. Pharmacol. 2006, 372:432-443.
33. Kullak-Ublick G.A., Hagenbuch B., Stieger B., Schteingart C.D., Hofmann A.F., Wolkoff A.W., Meier P.J. Molecular and functional characterization of an organic anion transporting polypeptide cloned from human liver. Gastroenterology 1995, 109:1274-1282.
34. Labuda M., Randolph S.E. Survival of tick-borne encephalitis virus: cellular basis and environmental determinants. Zentralbl. Bakteriol. 1999, 291(S33):513-524.
35. Li J.Y., Boado R.J., Pardridge W.M. Blood-brain barrier genomics. J. Cereb. Blood Flow Metab. 2001, 21:61-68.
36. Lu R., Kanai N., Bao Y., Schuster V.L. Cloning, in vitro expression, and tissue distribution of a human prostaglandin transporter cDNA (hPGT). J. Clin. Invest. 1996, 98:1142-1149.
37. Lu H., Choudhuri S., Ogura K., Csanaky I.L., Lei X., Cheng X., Song P., Klaassen C.D. Characterization of organic anion transporting polypeptide 1b2-null mice: essential role in hepatic uptake/toxicity of phalloidin and microcystin-LR. Toxicol. Sci. 2008, 103:35-45.
38. McNally K.L., Mitzel D.N., Anderson J.M., Ribeiro J.M., Valenzuela J.G., Myers T.G., Godinez A., Wolfinbarger J.B., Best S.M., Bloom M.E. Differential salivary gland transcript expression profile in Ixodes scapularis nymphs upon feeding or flavivirus infection. Ticks Tick-Borne Dis. 2012, 3:18-26.
39. Mehlhorn H. Encyclopedia of Parasitology 2008, Springer Reference. Third edition.
40. Meier-Abt F., Mokrab Y., Mizuguchi K. Organic anion transporting polypeptides of the OATP/SLCO superfamily: identification of new members in nonmammalian species, comparative modeling and a potential transport mode. J. Membrane Biol. 2005, 208:213-227.
41. Mikkaichi T., Suzuki T., Onogawa T., Tanemoto M., Mizutamari H., Okada M., Chaki T., Masuda S., Tokui T., Eto N., Abe M., Satoh F., Unno M., Hishinuma T., Inui K., Ito S., Goto J., Abe T. Isolation and characterization of a digoxin transporter and its rat homologue expressed in the kidney. P. Natl. Acad. Sci. USA 2004, 101:3569-3574.
42. Mikkaichi T., Suzuki T., Tanemoto M., Ito S., Abe T. The organic anion transporter (OATP) family. Drug Metab. Pharmacokin. 2004, 19:171-179.
43. Mitreva M., Jasmer D.P., Zarlenga D.S., Wang Z., Abubucker S., Martin J., Taylor C.M., Yin Y., Fulton L., Minx P., Yang S.P., Warren W.C., Fulton R.S., Bhonagiri V., Zhang X., Hallsworth-Pepin K., Clifton S.W., McCarter J.P., Appelton J., Mardis E.R., Wilson R.K. The draft genome of the parasitic nematode Trichinella spiralis. Nat. Genet. 2011, 43:228-235.
44. Mongin E., Louis C., Holt R.A., Birney E., Collins F.H. The Anopheles gambiae genome: an update. Trends Parasitol. 2004, 20:49-52.
45. Mulenga A., Macaluso K.R., Simser J.A., Azad A.F. The American dog tick, Dermacentor variabilis, encodes a functional histamine release factor homolog. Insect Biochem. Mol. Biol. 2003, 33:911-919.
46. Mulenga A., Khumthong R., Chalaire K.C., Strey O., Teel P. Molecular and biological characterization of the Amblyomma americanum organic anion transporter polypeptide. J. Exp. Biol. 2008, 211:3401-3408.
47. Nene V., Wortman J.R., Lawson D., Haas B., Kodira C., Tu Z.J., Loftus B., Xi Z., Megy K., Grabherr M., Ren Q., Zdobnov E.M., Lobo N.F., Campbell K.S., Brown S.E., Bonaldo M.F., Zhu J., Sinkins S.P., Hogenkamp D.G., Amedeo P., Arensburger P., Atkinson P.W., Bidwell S., Biedler J., Birney E., Bruggner R.V., Costas J., Coy M.R., Crabtree J., Crawford M., Debruyn B., Decaprio D., Eiglmeier K., Eisenstadt E., El-Dorry H., Gelbart W.M., Gomes S.L., Hammond M., Hannick L.I., Hogan J.R., Holmes M.H., Jaffe D., Johnston J.S., Kennedy R.C., Koo H., Kravitz S., Kriventseva E.V., Kulp D., Labutti K., Lee E., Li S., Lovin D.D., Mao C., Mauceli E., Menck C.F., Miller J.R., Montgomery P., Mori A., Nascimento A.L., Naceira H.F., Nusbaum C., O'leary S., Orvis J., Pertea M., Quesneville H., Reidenbach K.R., Rogers Y.H., Roth C.W., Schneider J.R., Schatz M., Shumway M., Stanke M., Stinson E.O., Tubio J.M., Vanzee J.P., Verjovski-Almeida S., Werner D., White O., Wyder S., Zeng Q., Zhao Y., Hill C.A., Raikhel A.S., Soares M.B., Knudson D.L., Lee N.H., Galagan J., Salzberg S.L., Paulsen I.T., Dimopoulos G., Collins F.H., Birren B., Fraser-Liggett C.M., Severson D.W. Genome sequence of Aedes aegypti, a major arbovirus vector. Science 2007, 316:1718-1723.
48. Neufeld D.S., Leader J.P. Electrochemical characteristics of ion secretion in malpighian tubules of the New Zealand alpine weta (Hemideina maori). J. Insect Physiol. 1997, 44:39-48.
49. Niemi M. Role of OATP transporters in the disposition of drugs. Pharmacogenomics 2007, 8:787-802.
50. Nishio T., Adachi H., Nakagomi R., Tokui T., Sato E., Tanemoto M., Fujiwara K., Okabe M., Onogawa T., Suzuki T., Nakai D., Shiiba K., Suzuki M., Ohtani H., Kondo Y., Unno M., Ito S., Iinuma K., Nunoki K., Matsuno S., Abe T. Molecular identification of a rat novel organic anion transporter moat1, which transports prostaglandin D(2), leukotriene C(4), and taurocholate. Biochem. Biophys. Res. Commun. 2000, 275:831-838.
51. Noe B., Hagenbuch B., Stieger B., Meier P.J. Isolation of a multispecific organic anion and cardiac glycoside transporter from rat brain. P. Natl. Acad. Sci. USA 1997, 94:10346-10350.
52. Pizzagalli F., Hagenbuch B., Stieger B., Klenk U., Folkers G., Meier P.J. Identification of a novel human organic anion transporting polypeptide as a high affinity thyroxine transporter. Mol. Endocrinol. 2002, 16:2283-2296.
53. Popović M., Zaja R., Smital T. Organic anion transporting polypeptides (OATP) in zebrafish (Danio rerio): phylogenetic analysis and tissue distribution. Comp. Biochem. Phys. A 2010, 155:327-335.
54. Rehse-Küpper B., Casals J., Rehse E., Ackermann R. Eyach, an arthropod-borne virus related to Colorado tick fever virus in the Federal Republic of Germany. Acta Virol. 1976, 20:339-342.
55. Roth M., Obaidat A., Hagenbuch B. OATPs, OATs and OCTs: the organic anion and cation transporters of the SLCO and SLC22A gene superfamilies. Br. J. Pharmacol. 2012, 165:1260-1287.
56. Rudenko N., Golovchenko M., Edwards M.J., Grubhoffer L. Differential expression of Ixodes ricinus tick genes induced by blood feeding or Borrelia burgdorferi infection. J. Med. Entomol. 2005, 42:36-41.
57. Shpynov S., Fournier P.E., Rudakov N., Tarasevich I., Raoult D. Detection of members of the genera Rickettsia, Anaplasma, and Ehrlichia in ticks collected in the Asiatic part of Russia. Ann. N. Y. Acad. Sci. 2006, 1078:378-383.
58. Sonenshine D.E. Biology of Ticks 1993, Oxford University Press, USA.
59. Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G., Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D., Altschul S.F., Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K., Hopkins R.F., Jordan H., Moore T., Max S.I., Wang J., Hsieh F., Diatchenko L., Marusina K., Farmer A.A., Rubin G.M., Hong L., Stapleton M., Soares M.B., Bonaldo M.F., Casavant T.L., Scheetz T.E., Brownstein M.J., Usdin T.B., Toshiyuki S., Carninci P., Prange C., Raha S.S., Loquellano N.A., Peters G.J., Abramson R.D., Mullahy S.J., Bosak S.A., McEwan P.J., McKernan K.J., Malek J.A., Gunaratne P.H., Richards S., Worley K.C., Hale S., Garcia A.M., Gay L.J., Hulyk S.W., Villalon D.K., Muzny D.M., Sodergren E.J., Lu X., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madan A., Young A.C., Shevchenko Y., Bouffard G.G., Blakesley R.W., Touchman J.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Krzywinski M.I., Skalska U., Smailus D.E., Schnerch A., Schein J.E., Jones S.J., Marra M.A. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. P. Natl. Acad. Sci. USA 2002, 99:16899-16903.
60. Suzuki T., Onogawa T., Asano N., Mizutamari H., Mikkaichi T., Tanemoto M., Abe M., Satoh F., Unno M., Nunoki K., Suzuki M., Hishinuma T., Goto J., Shimosegawa T., Matsuno S., Ito S., Abe T. Identification and characterization of novel rat and human gonad-specific organic anion transporters. Mol. Endocrinol. 2003, 17:1203-1215.
61. Tamai I., Nezu J., Uchino H., Sai Y., Oku A., Shimane M., Tsuji A. Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family. Biochem. Biophys. Res. Commun. 2000, 273:251-260.
62. Teng X., Zhang Z., He G., Yang L., Li F. Validation of reference genes for quantitative expression analysis by real-time RT-PCR in four lepidopteran insects. J. Insect Sci. 2012, 12:60.
63. Thellin O., Zorzi W., Lakaye B., De Borman B., Coumans B., Hennen G., Grisar T., Igout A., Heinen E. Housekeeping genes as internal standards: use and limits. J. Biotech. 1999, 75:291-295.
64. Tomanović S., Chochlakis D., Radulović Ž., Milutinović M., Ćakić S., Mihaljica D., Tselentis Y., Psaroulaki A. Analysis of pathogen co-occurrence in host-seeking adult hard ticks from Serbia. Exp. Appl. Acarol. 2013, 59:367-376.
65. Torrie L.S., Radford J.C., Southall T.D., Kean L., Dinsmore A.J., Davies S.A., Dow J.A.T. Resolution of the insect ouabain paradox. Proc. Natl. Acad. Sci. USA 2004, 101:13689-13693.
66. Trivedi S., Arasu P. Evaluation of endogenous reference genes for real-time PCR quantification of gene expression in Ancylostoma caninum. Mol. Biochem. Parasitol. 2005, 143:241-244.
67. Van Monfort J.E., Hagenbuch B., Fattinger K.E., Müller M., Groothuis G.M., Meijer D.K., Meier P.J. Polyspecific organic anion transporting polypeptides mediate hepatic uptake of amphipathic type II organic cations. J. Pharmacol. Exp. Ther. 1999, 291:147-152.
68. Van Zee P.J., Geraci N.S., Guerrero F.D., Wikel S.K., Stuart J.J., Nene V.M., Hill C.A. Tick genomics: the Ixodes genome project and beyond. Int. J. Parasitol. 2007, 37:1297-1305.
69. Wang J., Czech B., Crunk A., Wallace A., Mitreva M., Hannon G.J., Davis R.E. Deep small RNA sequencing from the nematode Ascaris reveals conservation, functional diversification, and novel developmental profiles. Genome Res. 2011, 21:1462-1477.
70. Westholm D.E., Marold J.D., Viken K.J., Duerst A.H., Anderson G.W., Rumbley J.N. Evidence of evolutionary conservation of function between the thyroxine transporter Oatp1c1 and major facilitator superfamily members. Endocrinology 2010, 151:5941-5951.
71. Yao J., Hong W., Huang J., Zhan K., Huang H., Hong M. N-glycosylation dictates proper processing of organic anion transporting polypeptide 1B1. PLOS One 2012, 7:e52563.