-
1
-
-
27844567142
-
Distinct sets of genetic alterations in melanoma
-
DOI 10.1056/NEJMoa050092
-
Curtin JA, Fridlyand J, Kageshita T, Patel HN, Busam KJ, Kutzner H, et al. Distinct sets of genetic alterations in melanoma. N Engl J Med. 2005;353(20):2135-47. (Pubitemid 41653105)
-
(2005)
New England Journal of Medicine
, vol.353
, Issue.20
, pp. 2135-2147
-
-
Curtin, J.A.1
Fridlyand, J.2
Kageshita, T.3
Patel, H.N.4
Busam, K.J.5
Kutzner, H.6
Cho, K.-H.7
Aiba, S.8
Brocker, E.-B.9
LeBoit, P.E.10
Pinkel, D.11
Bastian, B.C.12
-
2
-
-
84860214530
-
From genes to drugs: Targeted strategies for melanoma
-
Flaherty KT, Hodi FS, Fisher DE. From genes to drugs: targeted strategies for melanoma. Nat Rev Cancer. 2012;12(5):349-61.
-
(2012)
Nat Rev Cancer
, vol.12
, Issue.5
, pp. 349-361
-
-
Flaherty, K.T.1
Hodi, F.S.2
Fisher, D.E.3
-
3
-
-
33846465547
-
Immunostimulatory monoclonal antibodies for cancer therapy
-
DOI 10.1038/nrc2051, PII NRC2051
-
Melero I, Hervas-Stubbs S, Glennie M, Pardoll DM, Chen L. Immunostimulatory monoclonal antibodies for cancer therapy. Nat Rev Cancer. 2007;7(2):95-106. (Pubitemid 46160986)
-
(2007)
Nature Reviews Cancer
, vol.7
, Issue.2
, pp. 95-106
-
-
Melero, I.1
Hervas-Stubbs, S.2
Glennie, M.3
Pardoll, D.M.4
Chen, L.5
-
4
-
-
0348223934
-
NRAS and BRAF Mutations Arise Early during Melanoma Pathogenesis and Are Preserved throughout Tumor Progression
-
Omholt K, Platz A, Kanter L, Ringborg U, Hansson J. NRAS and BRAF mutations arise early during melanoma pathogenesis and are preserved throughout tumor progression. Clin Cancer Res. 2003;9(17):6483-8. (Pubitemid 38031837)
-
(2003)
Clinical Cancer Research
, vol.9
, Issue.17
, pp. 6483-6488
-
-
Omholt, K.1
Platz, A.2
Kanter, L.3
Ringborg, U.4
Hansson, J.5
-
5
-
-
0021258276
-
Transforming ras genes from human melanoma: A manifestation of tumour heterogeneity?
-
Albino AP, Le Strange R, Oliff AI, Furth ME, Old LJ. Transforming ras genes from human melanoma: a manifestation of tumour heterogeneity? Nature. 1984;308(5954):69-72. (Pubitemid 14130934)
-
(1984)
Nature
, vol.308
, Issue.5954
, pp. 69-72
-
-
Albino, A.P.1
Le, S.R.2
Oliff, A.I.3
-
6
-
-
0028178840
-
Ras mutations in human melanoma: A marker of malignant progression
-
Ball NJ, Yohn JJ, Morelli JG, Norris DA, Golitz LE, Hoeffler JP. Ras mutations in human melanoma: a marker of malignant progression. J Invest Dermatol. 1994;102(3):285-90.
-
(1994)
J Invest Dermatol
, vol.102
, Issue.3
, pp. 285-290
-
-
Ball, N.J.1
Yohn, J.J.2
Morelli, J.G.3
Norris, D.A.4
Golitz, L.E.5
Hoeffler, J.P.6
-
7
-
-
0028362370
-
Melanoma metastases from patients with hereditary cutaneous malignant melanoma contain a high frequency of N-ras activating mutations
-
DOI 10.1097/00008390-199406000-00005
-
Platz A, Ringborg U, Brahme EM, Lagerlof B. Melanoma metastases from patients with hereditary cutaneous malignant melanoma contain a high frequency of N-ras activating mutations. Melanoma Res. 1994;4(3):169-77. (Pubitemid 24208277)
-
(1994)
Melanoma Research
, vol.4
, Issue.3
, pp. 169-177
-
-
Platz, A.1
Ringborg, U.2
Mansson, B.E.3
Lagerlof, B.4
-
8
-
-
18144365866
-
Role of epidermal growth factor receptor signaling in RAS-driven melanoma
-
DOI 10.1128/MCB.25.10.4176-4188.2005
-
Bardeesy N, Kim M, Xu J, Kim RS, Shen Q, Bosenberg MW, et al. Role of epidermal growth factor receptor signaling in RAS-driven melanoma. Mol Cell Biol. 2005;25(10):4176-88. (Pubitemid 40617663)
-
(2005)
Molecular and Cellular Biology
, vol.25
, Issue.10
, pp. 4176-4188
-
-
Bardeesy, N.1
Kim, M.2
Xu, J.3
Kim, R.-S.4
Shen, Q.5
Bosenberg, M.W.6
Wong, W.H.7
Chin, L.8
-
9
-
-
0035845485
-
Suppression of Ras-mediated tumorigenicity and metastasis through inhibition of the Met receptor tyrosine kinase
-
DOI 10.1073/pnas.191067898
-
Furge KA, Kiewlich D, Le P, Vo MN, Faure M, Howlett AR, et al. Suppression of Ras-mediated tumorigenicity and metastasis through inhibition of the Met receptor tyrosine kinase. Proc Natl Acad Sci USA. 2001;98(19):10722-7. (Pubitemid 32878688)
-
(2001)
Proceedings of the National Academy of Sciences of the United States of America
, vol.98
, Issue.19
, pp. 10722-10727
-
-
Furge, K.A.1
Kiewlich, D.2
Le, P.3
Vo, M.N.4
Faure, M.5
Howlett, A.R.6
Lipson, K.E.7
Vande, W.G.F.8
Webb, C.P.9
-
10
-
-
74449089861
-
c-Kit mutants require hypoxia-inducible factor 1alpha to transform melanocytes
-
Monsel G, Ortonne N, Bagot M, Bensussan A, Dumaz N. c-Kit mutants require hypoxia-inducible factor 1alpha to transform melanocytes. Oncogene. 2010;29(2):227-36.
-
(2010)
Oncogene
, vol.29
, Issue.2
, pp. 227-236
-
-
Monsel, G.1
Ortonne, N.2
Bagot, M.3
Bensussan, A.4
Dumaz, N.5
-
11
-
-
27244457769
-
Raf: A strategic target for therapeutic development against cancer
-
DOI 10.1200/JCO.2005.08.036
-
Beeram M, Patnaik A, Rowinsky EK. Raf: a strategic target for therapeutic development against cancer. J Clin Oncol. 2005;23(27):6771-90. (Pubitemid 46194105)
-
(2005)
Journal of Clinical Oncology
, vol.23
, Issue.27
, pp. 6771-6790
-
-
Beeram, M.1
Patnaik, A.2
Rowinsky, E.K.3
-
12
-
-
18444374405
-
Mutations of the BRAF gene in human cancer
-
DOI 10.1038/nature00766
-
Davies H, Bignell GR, Cox C, Stephens P, Edkins S, Clegg S, et al. Mutations of the BRAF gene in human cancer. Nature. 2002;417(6892):949-54. (Pubitemid 34716871)
-
(2002)
Nature
, vol.417
, Issue.6892
, pp. 949-954
-
-
Davies, H.1
Bignell, G.R.2
Cox, C.3
Stephens, P.4
Edkins, S.5
Clegg, S.6
Teague, J.7
Woffendin, H.8
Garnett, M.J.9
Bottomley, W.10
Davis, N.11
Dicks, E.12
Ewing, R.13
Floyd, Y.14
Gray, K.15
Hall, S.16
Hawes, R.17
Hughes, J.18
Kosmidou, V.19
Menzies, A.20
Mould, C.21
Parker, A.22
Stevens, C.23
Watt, S.24
Hooper, S.25
Wilson, R.26
Jayatilake, H.27
Gusterson, B.A.28
Cooper, C.29
Shipley, J.30
Hargrave, D.31
Pritchard-Jones, K.32
Maitland, N.33
Chenevix-Trench, G.34
Riggins, G.J.35
Bigner, D.D.36
Palmleri, G.37
Cossu, A.38
Flanagan, A.39
Nicholson, A.40
Ho, J.W.C.41
Leung, S.Y.42
Yuen, S.T.43
Weber, B.L.44
Seigler, H.F.45
Darrow, T.L.46
Paterson, H.47
Marais, R.48
Marshall, C.J.49
Wooster, R.50
Stratton, M.R.51
Futreal, P.A.52
more..
-
13
-
-
34548819601
-
B- and C-RAF display essential differences in their binding to Ras: The isotype-specific N terminus of B-RAF facilitates Ras binding
-
DOI 10.1074/jbc.M607458200
-
Fischer A, Hekman M, Kuhlmann J, Rubio I, Wiese S, Rapp UR. B- and C-RAF display essential differences in their binding to Ras: the isotype-specific N terminus of B-RAF facilitates Ras binding. J Biol Chem. 2007;282(36):26503-16. (Pubitemid 47443819)
-
(2007)
Journal of Biological Chemistry
, vol.282
, Issue.36
, pp. 26503-26516
-
-
Fischer, A.1
Hekman, M.2
Kuhlmann, J.3
Rubio, I.4
Wiese, S.5
Rapp, U.R.6
-
14
-
-
29144462587
-
Wild-type and mutant B-RAF activate C-RAF through distinct mechanisms involving heterodimerization
-
DOI 10.1016/j.molcel.2005.10.022, PII S109727650501717X
-
Garnett MJ, Rana S, Paterson H, Barford D, Marais R. Wild-type and mutant B-RAF activate C-RAF through distinct mechanisms involving heterodimerization. Mol Cell. 2005;20(6):963-9. (Pubitemid 41814884)
-
(2005)
Molecular Cell
, vol.20
, Issue.6
, pp. 963-969
-
-
Garnett, M.J.1
Rana, S.2
Paterson, H.3
Barford, D.4
Marais, R.5
-
15
-
-
0037228055
-
High frequency of BRAF mutations in nevi
-
DOI 10.1038/ng1054
-
Pollock PM, Harper UL, Hansen KS, Yudt LM, Stark M, Robbins CM, et al. High frequency of BRAF mutations in nevi. Nat Genet. 2003;33(1):19-20. (Pubitemid 36068675)
-
(2003)
Nature Genetics
, vol.33
, Issue.1
, pp. 19-20
-
-
Pollock, P.M.1
Harper, U.L.2
Hansen, K.S.3
Yudt, L.M.4
Stark, M.5
Robbins, C.M.6
Moses, T.Y.7
Hostetter, G.8
Wagner, U.9
Kakareka, J.10
Salem, G.11
Pohida, T.12
Heenan, P.13
Duray, P.14
Kallioniemi, O.15
Hayward, N.K.16
Trent, J.M.17
Meltzer, P.S.18
-
16
-
-
33746263912
-
BRAF and NRAS mutations in melanoma and melanocytic nevi
-
DOI 10.1097/01.cmr.0000222600.73179.f3, PII 0000839020060800000001
-
Poynter JN, Elder JT, Fullen DR, Nair RP, Soengas MS, Johnson TM, et al. BRAF and NRAS mutations in melanoma and melanocytic nevi. Melanoma Res. 2006;16(4):267-73. (Pubitemid 44090170)
-
(2006)
Melanoma Research
, vol.16
, Issue.4
, pp. 267-273
-
-
Poynter, J.N.1
Elder, J.T.2
Fullen, D.R.3
Nair, R.P.4
Soengas, M.S.5
Johnson, T.M.6
Redman, B.7
Thomas, N.E.8
Gruber, S.B.9
-
17
-
-
16844362816
-
V599EB-Raf regulates growth and vascular development of malignant melanoma tumors
-
DOI 10.1158/0008-5472.CAN-04-2423
-
Sharma A, Trivedi NR, Zimmerman MA, Tuveson DA, Smith CD, Robertson GP. Mutant V599EB-Raf regulates growth and vascular development of malignant melanoma tumors. Cancer Res. 2005;65(6):2412-21. (Pubitemid 40490153)
-
(2005)
Cancer Research
, vol.65
, Issue.6
, pp. 2412-2421
-
-
Sharma, A.1
Trivedi, N.R.2
Zimmerman, M.A.3
Tuveson, D.A.4
Smith, C.D.5
Robertson, G.P.6
-
18
-
-
59049107421
-
Frequent somatic mutations of GNAQ in uveal melanoma and blue naevi
-
Van Raamsdonk CD, Bezrookove V, Green G, Bauer J, Gaugler L, O'Brien JM, et al. Frequent somatic mutations of GNAQ in uveal melanoma and blue naevi. Nature. 2009;457(7229):599-602.
-
(2009)
Nature
, vol.457
, Issue.7229
, pp. 599-602
-
-
Van Raamsdonk, C.D.1
Bezrookove, V.2
Green, G.3
Bauer, J.4
Gaugler, L.5
O'Brien, J.M.6
-
19
-
-
78651446131
-
Mutations in GNA11 in uveal melanoma
-
Van Raamsdonk CD, Griewank KG, Crosby MB, Garrido MC, Vemula S, Wiesner T, et al. Mutations in GNA11 in uveal melanoma. N Engl J Med. 2010;363(23):2191-9.
-
(2010)
N Engl J Med
, vol.363
, Issue.23
, pp. 2191-2199
-
-
Van Raamsdonk, C.D.1
Griewank, K.G.2
Crosby, M.B.3
Garrido, M.C.4
Vemula, S.5
Wiesner, T.6
-
20
-
-
84862657063
-
Monosomy 3 status of uveal melanoma metastases is associated with rapidly progressive tumors and short survival
-
Abdel-Rahman MH, Cebulla CM, Verma V, Christopher BN, Carson WE 3rd, Olencki T, et al. Monosomy 3 status of uveal melanoma metastases is associated with rapidly progressive tumors and short survival. Exp Eye Res. 2012;100:26-31.
-
(2012)
Exp Eye Res
, vol.100
, pp. 26-31
-
-
Abdel-Rahman, M.H.1
Cebulla, C.M.2
Verma, V.3
Christopher, B.N.4
Carson III, W.E.5
Olencki, T.6
-
21
-
-
21844478747
-
Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma
-
DOI 10.1038/nature03664
-
Garraway LA, Widlund HR, Rubin MA, Getz G, Berger AJ, Ramaswamy S, et al. Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma. Nature. 2005;436(7047):117-22. (Pubitemid 40966196)
-
(2005)
Nature
, vol.436
, Issue.7047
, pp. 117-122
-
-
Garraway, L.A.1
Widlund, H.R.2
Rubin, M.A.3
Getz, G.4
Berger, A.J.5
Ramaswamy, S.6
Beroukhim, R.7
Milner, D.A.8
Granter, S.R.9
Du, J.10
Lee, C.11
Wagner, S.N.12
Li, C.13
Golub, T.R.14
Rimm, D.L.15
Meyerson, M.L.16
Fisher, D.E.17
Sellers, W.R.18
-
22
-
-
35948985961
-
Microphthalmia-associated transcription factor gene amplification in metastatic melanoma is a prognostic marker for patient survival, but not a predictive marker for chemosensitivity and chemotherapy response
-
DOI 10.1158/1078-0432.CCR-06-2682
-
Ugurel S, Houben R, Schrama D, Voigt H, Zapatka M, Schadendorf D, et al. Microphthalmia-associated transcription factor gene amplification in metastatic melanoma is a prognostic marker for patient survival, but not a predictive marker for chemosensitivity and chemotherapy response. Clin Cancer Res. 2007;13(21):6344-50. (Pubitemid 350075023)
-
(2007)
Clinical Cancer Research
, vol.13
, Issue.21
, pp. 6344-6350
-
-
Ugurel, S.1
Houben, R.2
Schrama, D.3
Voigt, H.4
Zapatka, M.5
Schadendorf, D.6
Brocker, E.B.7
Becker, J.C.8
-
23
-
-
77954373338
-
Selective BRAFV600E inhibition enhances T-cell recognition of melanoma without affecting lymphocyte function
-
Boni A, Cogdill AP, Dang P, Udayakumar D, Njauw CN, Sloss CM, et al. Selective BRAFV600E inhibition enhances T-cell recognition of melanoma without affecting lymphocyte function. Cancer Res. 2010;70(13):5213-9.
-
(2010)
Cancer Res
, vol.70
, Issue.13
, pp. 5213-5219
-
-
Boni, A.1
Cogdill, A.P.2
Dang, P.3
Udayakumar, D.4
Njauw, C.N.5
Sloss, C.M.6
-
24
-
-
77949685981
-
RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth
-
Hatzivassiliou G, Song K, Yen I, Brandhuber BJ, Anderson DJ, Alvarado R, et al. RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth. Nature. 2010;464(7287):431-5.
-
(2010)
Nature
, vol.464
, Issue.7287
, pp. 431-435
-
-
Hatzivassiliou, G.1
Song, K.2
Yen, I.3
Brandhuber, B.J.4
Anderson, D.J.5
Alvarado, R.6
-
25
-
-
74849109743
-
Kinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAF
-
Heidorn SJ, Milagre C, Whittaker S, Nourry A, Niculescu-Duvas I, Dhomen N, et al. Kinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAF. Cell. 2010;140(2):209-21.
-
(2010)
Cell
, vol.140
, Issue.2
, pp. 209-221
-
-
Heidorn, S.J.1
Milagre, C.2
Whittaker, S.3
Nourry, A.4
Niculescu-Duvas, I.5
Dhomen, N.6
-
26
-
-
77949732073
-
RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF
-
Poulikakos PI, Zhang C, Bollag G, Shokat KM, Rosen N. RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF. Nature. 2010;464(7287):427-30.
-
(2010)
Nature
, vol.464
, Issue.7287
, pp. 427-430
-
-
Poulikakos, P.I.1
Zhang, C.2
Bollag, G.3
Shokat, K.M.4
Rosen, N.5
-
27
-
-
78650309875
-
COT drives resistance to RAF inhibition through MAP kinase pathway reactivation
-
Johannessen CM, Boehm JS, Kim SY, Thomas SR, Wardwell L, Johnson LA, et al. COT drives resistance to RAF inhibition through MAP kinase pathway reactivation. Nature. 2010;468(7326):968-72.
-
(2010)
Nature
, vol.468
, Issue.7326
, pp. 968-972
-
-
Johannessen, C.M.1
Boehm, J.S.2
Kim, S.Y.3
Thomas, S.R.4
Wardwell, L.5
Johnson, L.A.6
-
28
-
-
78650303507
-
Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation
-
Nazarian R, Shi H, Wang Q, Kong X, Koya RC, Lee H, et al. Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation. Nature. 2010;468(7326):973-7.
-
(2010)
Nature
, vol.468
, Issue.7326
, pp. 973-977
-
-
Nazarian, R.1
Shi, H.2
Wang, Q.3
Kong, X.4
Koya, R.C.5
Lee, H.6
-
29
-
-
77956029013
-
Pharmacodynamic characterization of the efficacy signals due to selective BRAF inhibition with PLX4032 in malignant melanoma
-
Tap WD, Gong KW, Dering J, Tseng Y, Ginther C, Pauletti G, et al. Pharmacodynamic characterization of the efficacy signals due to selective BRAF inhibition with PLX4032 in malignant melanoma. Neoplasia. 2010; 12(8):637-49.
-
(2010)
Neoplasia
, vol.12
, Issue.8
, pp. 637-649
-
-
Tap, W.D.1
Gong, K.W.2
Dering, J.3
Tseng, Y.4
Ginther, C.5
Pauletti, G.6
-
30
-
-
49649118852
-
Elevated CRAF as a potential mechanism of acquired resistance to BRAF inhibition in melanoma
-
Montagut C, Sharma SV, Shioda T, McDermott U, Ulman M, Ulkus LE, et al. Elevated CRAF as a potential mechanism of acquired resistance to BRAF inhibition in melanoma. Cancer Res. 2008;68(12):4853-61.
-
(2008)
Cancer Res
, vol.68
, Issue.12
, pp. 4853-4861
-
-
Montagut, C.1
Sharma, S.V.2
Shioda, T.3
McDermott, U.4
Ulman, M.5
Ulkus, L.E.6
-
31
-
-
80051625929
-
Dissecting therapeutic resistance to RAF inhibition in melanoma by tumor genomic profiling
-
Wagle N, Emery C, Berger MF, Davis MJ, Sawyer A, Pochanard P, et al. Dissecting therapeutic resistance to RAF inhibition in melanoma by tumor genomic profiling. J Clin Oncol. 2011;29(22):3085-96.
-
(2011)
J Clin Oncol
, vol.29
, Issue.22
, pp. 3085-3096
-
-
Wagle, N.1
Emery, C.2
Berger, M.F.3
Davis, M.J.4
Sawyer, A.5
Pochanard, P.6
-
32
-
-
80051687428
-
Identification of the MEK1(F129L) activating mutation as a potential mechanism of acquired resistance to MEK inhibition in human cancers carrying the B-RafV600E mutation
-
Wang H, Daouti S, Li WH, Wen Y, Rizzo C, Higgins B, et al. Identification of the MEK1(F129L) activating mutation as a potential mechanism of acquired resistance to MEK inhibition in human cancers carrying the B-RafV600E mutation. Cancer Res. 2011;71(16):5535-45.
-
(2011)
Cancer Res
, vol.71
, Issue.16
, pp. 5535-5545
-
-
Wang, H.1
Daouti, S.2
Li, W.H.3
Wen, Y.4
Rizzo, C.5
Higgins, B.6
-
33
-
-
83455254767
-
RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E)
-
Poulikakos PI, Persaud Y, Janakiraman M, Kong X, Ng C, Moriceau G, et al. RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E). Nature. 2011;480(7377):387-90.
-
(2011)
Nature
, vol.480
, Issue.7377
, pp. 387-390
-
-
Poulikakos, P.I.1
Persaud, Y.2
Janakiraman, M.3
Kong, X.4
Ng, C.5
Moriceau, G.6
-
34
-
-
78650008177
-
Acquired resistance to BRAF inhibitors mediated by a RAF kinase switch in melanoma can be overcome by cotargeting MEK and IGF-1R/PI3K
-
Villanueva J, Vultur A, Lee JT, Somasundaram R, Fukunaga-Kalabis M, Cipolla AK, et al. Acquired resistance to BRAF inhibitors mediated by a RAF kinase switch in melanoma can be overcome by cotargeting MEK and IGF-1R/PI3K. Cancer Cell. 2010;18(6):683-95.
-
(2010)
Cancer Cell
, vol.18
, Issue.6
, pp. 683-695
-
-
Villanueva, J.1
Vultur, A.2
Lee, J.T.3
Somasundaram, R.4
Fukunaga-Kalabis, M.5
Cipolla, A.K.6
-
35
-
-
0035180866
-
Estimation of genetic and environmental components in colorectal and lung cancer and melanoma
-
Hemminki K, Lonnstedt I, Vaittinen P, Lichtenstein P. Estimation of genetic and environmental components in colorectal and lung cancer and melanoma. Genet Epidemiol. 2001;20(1):107-16.
-
(2001)
Genet Epidemiol
, vol.20
, Issue.1
, pp. 107-116
-
-
Hemminki, K.1
Lonnstedt, I.2
Vaittinen, P.3
Lichtenstein, P.4
-
36
-
-
34548074394
-
Etiology of familial aggregation in melanoma and squamous cell carcinoma of the skin
-
DOI 10.1158/1055-9965.EPI-07-0047
-
Lindstrom LS, Yip B, Lichtenstein P, Pawitan Y, Czene K. Etiology of familial aggregation in melanoma and squamous cell carcinoma of the skin. Cancer Epidemiol Biomarkers Prev. 2007;16(8):1639-43. (Pubitemid 47294831)
-
(2007)
Cancer Epidemiology Biomarkers and Prevention
, vol.16
, Issue.8
, pp. 1639-1643
-
-
Lindstrom, L.S.1
Yip, B.2
Lichtenstein, P.3
Pawitan, Y.4
Czene, K.5
-
37
-
-
0141961836
-
Familial melanoma: A complex disorder leading to controversy on DNA testing
-
DOI 10.1023/A:1025758527675
-
de Snoo FA, Bergman W, Gruis NA. Familial melanoma: a complex disorder leading to controversy on DNA testing. Fam Cancer. 2003;2(2):109-16. (Pubitemid 37247983)
-
(2003)
Familial Cancer
, vol.2
, Issue.2
, pp. 109-116
-
-
De Snoo, F.A.1
Bergman, W.2
Gruis, N.A.3
-
38
-
-
77955878053
-
Familial cutaneous melanoma
-
Hansson J. Familial cutaneous melanoma. Adv Exp Med Biol. 2010;685:134-45.
-
(2010)
Adv Exp Med Biol
, vol.685
, pp. 134-145
-
-
Hansson, J.1
-
39
-
-
33847282821
-
Features associated with germline CDKN2A mutations: A GenoMEL study of melanoma-prone families from three continents
-
Goldstein AM, Chan M, Harland M, Hayward NK, Demenais F, Bishop DT, et al. Features associated with germline CDKN2A mutations: a GenoMEL study of melanoma-prone families from three continents. J Med Genet. 2007;44(2):99-106.
-
(2007)
J Med Genet
, vol.44
, Issue.2
, pp. 99-106
-
-
Goldstein, A.M.1
Chan, M.2
Harland, M.3
Hayward, N.K.4
Demenais, F.5
Bishop, D.T.6
-
40
-
-
27144522283
-
Lifetime risk of melanoma in CDKN2A mutation carriers in a population-based sample
-
DOI 10.1093/jnci/dji312
-
Begg CB, Orlow I, Hummer AJ, Armstrong BK, Kricker A, Marrett LD, et al. Lifetime risk of melanoma in CDKN2A mutation carriers in a population-based sample. J Natl Cancer Inst. 2005;97(20):1507-15. (Pubitemid 41631950)
-
(2005)
Journal of the National Cancer Institute
, vol.97
, Issue.20
, pp. 1507-1515
-
-
Begg, C.B.1
Orlow, I.2
Hummer, A.J.3
Armstrong, B.K.4
Kricker, A.5
Marrett, L.D.6
Millikan, R.C.7
Gruber, S.B.8
Anton-Culver, H.9
Zanetti, R.10
Gallagher, R.P.11
Dwyer, T.12
Rebbeck, T.R.13
Mitra, N.14
Busam, K.15
From, L.16
Berwick, M.17
Litchfield, M.18
Tucker, P.19
Stephens, N.20
Switzer, T.21
Theis, E.22
Chowdhury, N.23
Vanasse, L.24
Purdue, M.25
Northrup, D.26
Rosso, S.27
Sacerdote, C.28
Leighton, N.29
Gildea, M.30
Bonner, J.31
Jeter, J.32
Klotz, J.33
Wilcox, H.34
Weiss, H.35
Mattingly, D.36
Player, J.37
Tse, C.-K.38
Kanetsky, P.39
Walker, A.40
Panossian, S.41
Mohrenweiser, H.42
Setlow, R.43
more..
-
41
-
-
70249098475
-
Selection criteria for genetic assessment of patients with familial melanoma
-
Leachman SA, Carucci J, Kohlmann W, Banks KC, Asgari MM, Bergman W, et al. Selection criteria for genetic assessment of patients with familial melanoma. J Am Acad Dermatol. 2009;61(4):677.e1-14.
-
(2009)
J Am Acad Dermatol
, vol.61
, Issue.4
-
-
Leachman, S.A.1
Carucci, J.2
Kohlmann, W.3
Banks, K.C.4
Asgari, M.M.5
Bergman, W.6
-
42
-
-
56149102515
-
Low prevalence of CDKN2A/ARF mutations among early-onset cancers of breast, pancreas and malignant melanoma in Poland
-
Debniak T, van de Wetering T, Scott R, Nagay L, Cybulski C, Gorski B, et al. Low prevalence of CDKN2A/ARF mutations among early-onset cancers of breast, pancreas and malignant melanoma in Poland. Eur J Cancer Prev. 2008;17(5):389-91.
-
(2008)
Eur J Cancer Prev
, vol.17
, Issue.5
, pp. 389-391
-
-
Debniak, T.1
Van De Wetering, T.2
Scott, R.3
Nagay, L.4
Cybulski, C.5
Gorski, B.6
-
43
-
-
33845592531
-
NRAS and BRAF mutations in melanoma tumours in relation to clinical characteristics: A study based on mutation screening by pyrosequencing
-
DOI 10.1097/01.cmr.0000232300.22032.86, PII 0000839020061200000001
-
Edlundh-Rose E, Egyhazi S, Omholt K, Mansson-Brahme E, Platz A, Hansson J, et al. NRAS and BRAF mutations in melanoma tumours in relation to clinical characteristics: a study based on mutation screening by pyrosequencing. Melanoma Res. 2006;16(6):471-8. (Pubitemid 44934704)
-
(2006)
Melanoma Research
, vol.16
, Issue.6
, pp. 471-478
-
-
Edlundh-Rose, E.1
Egyhazi, S.2
Omholt, K.3
Mansson-Brahme, E.4
Platz, A.5
Hansson, J.6
Lundeberg, J.7
-
44
-
-
70349565251
-
Small molecules and targeted therapies in distant metastatic disease
-
Hersey P, Bastholt L, Chiarion-Sileni V, Cinat G, Dummer R, Eggermont AM, et al. Small molecules and targeted therapies in distant metastatic disease. Ann Oncol. 2009;20(Suppl 6):vi35-40.
-
(2009)
Ann Oncol
, vol.20
, Issue.SUPPL. 6
-
-
Hersey, P.1
Bastholt, L.2
Chiarion-Sileni, V.3
Cinat, G.4
Dummer, R.5
Eggermont, A.M.6
-
45
-
-
77956030786
-
Inhibition of mutated, activated BRAF in metastatic melanoma
-
Flaherty KT, Puzanov I, Kim KB, Ribas A, McArthur GA, Sosman JA, et al. Inhibition of mutated, activated BRAF in metastatic melanoma. N Engl J Med. 2010;363(9):809-19.
-
(2010)
N Engl J Med
, vol.363
, Issue.9
, pp. 809-819
-
-
Flaherty, K.T.1
Puzanov, I.2
Kim, K.B.3
Ribas, A.4
McArthur, G.A.5
Sosman, J.A.6
-
46
-
-
84865068182
-
Updated overall survival (OS) results for BRIM-3, a phase III randomized, open-label, multicenter trial comparing BRAF inhibitor vemurafenib (vem) with dacarbazine (DTIC) in previously untreated patients with BRAFV600E-mutated melanoma
-
Chapman PB, Hauschild A, Robert C, Larkin JMG, Haanen JBAG, Ribas A, et al. Updated overall survival (OS) results for BRIM-3, a phase III randomized, open-label, multicenter trial comparing BRAF inhibitor vemurafenib (vem) with dacarbazine (DTIC) in previously untreated patients with BRAFV600E-mutated melanoma. ASCO Meet Abstr. 2012;30(15-suppl):8502.
-
(2012)
ASCO Meet Abstr
, vol.30
, Issue.15 SUPPL.
, pp. 8502
-
-
Chapman, P.B.1
Hauschild, A.2
Robert, C.3
Larkin, J.M.G.4
Haanen, J.B.A.G.5
Ribas, A.6
-
47
-
-
84864297421
-
Phase III, randomized, open-label, multicenter trial (BREAK-3) comparing the BRAF kinase inhibitor dabrafenib (GSK2118436) with dacarbazine (DTIC) in patients with BRAFV600E-mutated melanoma
-
Hauschild A, Grob JJ, Demidov LV, Jouary T, Gutzmer R, Millward M, et al. Phase III, randomized, open-label, multicenter trial (BREAK-3) comparing the BRAF kinase inhibitor dabrafenib (GSK2118436) with dacarbazine (DTIC) in patients with BRAFV600E-mutated melanoma. ASCO Meet Abstr. 2012;30(18-suppl): LBA8500.
-
(2012)
ASCO Meet Abstr
, vol.3018
, Issue.SUPPL.
-
-
Hauschild, A.1
Grob, J.J.2
Demidov, L.V.3
Jouary, T.4
Gutzmer, R.5
Millward, M.6
-
48
-
-
84872002685
-
Analysis of molecular mechanisms of response and resistance to vemurafenib (vem) in BRAFV600E melanoma
-
Sosman JA, Pavlick AC, Schuchter LM, Lewis KD, McArthur GA, Cowey CL, et al. Analysis of molecular mechanisms of response and resistance to vemurafenib (vem) in BRAFV600E melanoma. ASCO Meet Abstr. 2012;30(15-suppl):8503.
-
(2012)
ASCO Meet Abstr
, vol.30
, Issue.15 SUPPL.
, pp. 8503
-
-
Sosman, J.A.1
Pavlick, A.C.2
Schuchter, L.M.3
Lewis, K.D.4
McArthur, G.A.5
Cowey, C.L.6
-
49
-
-
33749021085
-
Somatic activation of KIT in distinct subtypes of melanoma
-
DOI 10.1200/JCO.2006.06.2984
-
Curtin JA, Busam K, Pinkel D, Bastian BC. Somatic activation of KIT in distinct subtypes of melanoma. J Clin Oncol. 2006;24(26):4340-6. (Pubitemid 46630793)
-
(2006)
Journal of Clinical Oncology
, vol.24
, Issue.26
, pp. 4340-4346
-
-
Curtin, J.A.1
Busam, K.2
Pinkel, D.3
Bastian, B.C.4
-
50
-
-
2742529418
-
Human proto-oncogene c-kit: A new cell surface receptor tyrosine kinase for an unidentified ligand
-
Yarden Y, Kuang WJ, Yang-Feng T, Coussens L, Munemitsu S, Dull TJ, et al. Human proto-oncogene c-kit: a new cell surface receptor tyrosine kinase for an unidentified ligand. EMBO J. 1987;6(11):3341-51.
-
(1987)
EMBO J
, vol.6
, Issue.11
, pp. 3341-3351
-
-
Yarden, Y.1
Kuang, W.J.2
Yang-Feng, T.3
Coussens, L.4
Munemitsu, S.5
Dull, T.J.6
-
51
-
-
58149260596
-
KIT gene mutations and copy number in melanoma subtypes
-
Beadling C, Jacobson-Dunlop E, Hodi FS, Le C, Warrick A, Patterson J, et al. KIT gene mutations and copy number in melanoma subtypes. Clin Cancer Res. 2008;14(21):6821-8.
-
(2008)
Clin Cancer Res
, vol.14
, Issue.21
, pp. 6821-6828
-
-
Beadling, C.1
Jacobson-Dunlop, E.2
Hodi, F.S.3
Le, C.4
Warrick, A.5
Patterson, J.6
-
52
-
-
79958066836
-
KIT as a therapeutic target in metastatic melanoma
-
Carvajal RD, Antonescu CR, Wolchok JD, Chapman PB, Roman RA, Teitcher J, et al. KIT as a therapeutic target in metastatic melanoma. JAMA. 2011;305(22):2327-34.
-
(2011)
JAMA
, vol.305
, Issue.22
, pp. 2327-2334
-
-
Carvajal, R.D.1
Antonescu, C.R.2
Wolchok, J.D.3
Chapman, P.B.4
Roman, R.A.5
Teitcher, J.6
-
53
-
-
79960708519
-
Phase II, open-label, single-arm trial of imatinib mesylate in patients with metastatic melanoma harboring c-Kit mutation or amplification
-
Guo J, Si L, Kong Y, Flaherty KT, Xu X, Zhu Y, et al. Phase II, open-label, single-arm trial of imatinib mesylate in patients with metastatic melanoma harboring c-Kit mutation or amplification. J Clin Oncol. 2011;29(21):2904-9.
-
(2011)
J Clin Oncol
, vol.29
, Issue.21
, pp. 2904-2909
-
-
Guo, J.1
Si, L.2
Kong, Y.3
Flaherty, K.T.4
Xu, X.5
Zhu, Y.6
-
54
-
-
79953324920
-
Large-scale analysis of KIT aberrations in Chinese patients with melanoma
-
Kong Y, Si L, Zhu Y, Xu X, Corless CL, Flaherty KT, et al. Large-scale analysis of KIT aberrations in Chinese patients with melanoma. Clin Cancer Res. 2011;17(7):1684-91.
-
(2011)
Clin Cancer Res
, vol.17
, Issue.7
, pp. 1684-1691
-
-
Kong, Y.1
Si, L.2
Zhu, Y.3
Xu, X.4
Corless, C.L.5
Flaherty, K.T.6
-
55
-
-
79959195681
-
KIT pathway alterations in mucosal melanomas of the vulva and other sites
-
Omholt K, Grafstrom E, Kanter-Lewensohn L, Hansson J, Ragnarsson-Olding BK. KIT pathway alterations in mucosal melanomas of the vulva and other sites. Clin Cancer Res. 2011;17(12):3933-42.
-
(2011)
Clin Cancer Res
, vol.17
, Issue.12
, pp. 3933-3942
-
-
Omholt, K.1
Grafstrom, E.2
Kanter-Lewensohn, L.3
Hansson, J.4
Ragnarsson-Olding, B.K.5
-
56
-
-
77951620399
-
Dissection of RAS downstream pathways in melanomagenesis: A role for Ral in transformation
-
Mishra PJ, Ha L, Rieker J, Sviderskaya EV, Bennett DC, Oberst MD, et al. Dissection of RAS downstream pathways in melanomagenesis: a role for Ral in transformation. Oncogene. 2010;29(16):2449-56.
-
(2010)
Oncogene
, vol.29
, Issue.16
, pp. 2449-2456
-
-
Mishra, P.J.1
Ha, L.2
Rieker, J.3
Sviderskaya, E.V.4
Bennett, D.C.5
Oberst, M.D.6
-
58
-
-
33644774541
-
Examination of mutations in BRAF, NRAS, and PTEN in primary cutaneous melanoma
-
DOI 10.1038/sj.jid.5700026, PII 5700026
-
Goel VK, Lazar AJ, Warneke CL, Redston MS, Haluska FG. Examination of mutations in BRAF, NRAS, and PTEN in primary cutaneous melanoma. J Invest Dermatol. 2006;126(1):154-60. (Pubitemid 43336107)
-
(2006)
Journal of Investigative Dermatology
, vol.126
, Issue.1
, pp. 154-160
-
-
Goel, V.K.1
Lazar, A.J.F.2
Warneke, C.L.3
Redston, M.S.4
Haluska, F.G.5
-
59
-
-
33947390695
-
Phase II study of the farnesyltransferase inhibitor R115777 in advanced melanoma: CALGB 500104
-
Gajewski TF, Niedzwiecki D, Johnson J, Linette G, Bucher C, Blaskovich M, et al. Phase II study of the farnesyltransferase inhibitor R115777 in advanced melanoma: CALGB 500104. ASCO Meet Abstr. 2006;24(18-suppl):8014.
-
(2006)
ASCO Meet Abstr
, vol.24
, Issue.18 SUPPL.
, pp. 8014
-
-
Gajewski, T.F.1
Niedzwiecki, D.2
Johnson, J.3
Linette, G.4
Bucher, C.5
Blaskovich, M.6
-
60
-
-
84875235432
-
MEK162 for patients with advanced melanoma harbouring NRAS or Val600 BRAF mutations: A non-randomised, open-label phase 2 study
-
Ascierto PA, Schadendorf D, Berking C, Agarwala SS, van Herpen CM, Queirolo P, et al. MEK162 for patients with advanced melanoma harbouring NRAS or Val600 BRAF mutations: a non-randomised, open-label phase 2 study. Lancet Oncol. 2013;14(3):249-56.
-
(2013)
Lancet Oncol
, vol.14
, Issue.3
, pp. 249-256
-
-
Ascierto, P.A.1
Schadendorf, D.2
Berking, C.3
Agarwala, S.S.4
Van Herpen, C.M.5
Queirolo, P.6
-
61
-
-
0037205055
-
G protein pathways
-
DOI 10.1126/science.1071550
-
Neves SR, Ram PT, Iyengar R. G protein pathways. Science. 2002;296(5573):1636-9. (Pubitemid 34579147)
-
(2002)
Science
, vol.296
, Issue.5573
, pp. 1636-1639
-
-
Neves, S.R.1
Ram, P.T.2
Iyengar, R.3
-
62
-
-
70249134535
-
Oncogenic GNAQ mutations are not correlated with disease-free survival in uveal melanoma
-
Bauer J, Kilic E, Vaarwater J, Bastian BC, Garbe C, de Klein A. Oncogenic GNAQ mutations are not correlated with disease-free survival in uveal melanoma. Br J Cancer. 2009;101(5):813-5.
-
(2009)
Br J Cancer
, vol.101
, Issue.5
, pp. 813-815
-
-
Bauer, J.1
Kilic, E.2
Vaarwater, J.3
Bastian, B.C.4
Garbe, C.5
De Klein, A.6
-
63
-
-
79954997817
-
What hope for the future? GNAQ and uveal melanoma
-
Sisley K, Doherty R, Cross NA. What hope for the future? GNAQ and uveal melanoma. Br J Ophthalmol. 2011;95(5):620-3.
-
(2011)
Br J Ophthalmol
, vol.95
, Issue.5
, pp. 620-623
-
-
Sisley, K.1
Doherty, R.2
Cross, N.A.3
-
64
-
-
77949452524
-
The PKB/AKT pathway in cancer
-
Carnero A. The PKB/AKT pathway in cancer. Curr Pharm Des. 2010;16(1):34-44.
-
(2010)
Curr Pharm des
, vol.16
, Issue.1
, pp. 34-44
-
-
Carnero, A.1
-
65
-
-
25844522712
-
Expression of activated Akt and PTEN in malignant Melanomas: Relationship with clinical outcome
-
DOI 10.1309/YT58-WWMT-A6YR-1PRV
-
Slipicevic A, Holm R, Nguyen MT, Bohler PJ, Davidson B, Florenes VA. Expression of activated Akt and PTEN in malignant melanomas: relationship with clinical outcome. Am J Clin Pathol. 2005;124(4):528-36. (Pubitemid 41395633)
-
(2005)
American Journal of Clinical Pathology
, vol.124
, Issue.4
, pp. 528-536
-
-
Slipicevic, A.1
Holm, R.2
Nguyen, M.T.P.3
Bohler, P.J.4
Davidson, B.5
Florenes, V.A.6
-
66
-
-
53949103143
-
Melanoma genetics and therapeutic approaches in the 21st century: Moving from the benchside to the bedside
-
Hocker TL, Singh MK, Tsao H. Melanoma genetics and therapeutic approaches in the 21st century: moving from the benchside to the bedside. J Invest Dermatol. 2008;128(11):2575-95.
-
(2008)
J Invest Dermatol
, vol.128
, Issue.11
, pp. 2575-2595
-
-
Hocker, T.L.1
Singh, M.K.2
Tsao, H.3
-
67
-
-
21344456180
-
The Ras/Raf/MEK/ERK and PI3K/AKT signaling pathways present molecular targets for the effective treatment of advanced melanoma
-
Meier F, Schittek B, Busch S, Garbe C, Smalley K, Satyamoorthy K, et al. The RAS/RAF/MEK/ERK and PI3K/AKT signaling pathways present molecular targets for the effective treatment of advanced melanoma. Front Biosci. 2005;10:2986-3001. (Pubitemid 40910537)
-
(2005)
Frontiers in Bioscience
, vol.10
, Issue.SUPPL. 3
, pp. 2986-3001
-
-
Meier, F.1
Schittek, B.2
Busch, S.3
Garbe, C.4
Smalley, K.5
Satyamoorthy, K.6
Li, G.7
Herlyn, M.8
-
68
-
-
36849065072
-
Assessment of PI3Kinase as a druggable target in melanoma
-
Aziz SA, Pick-Golan E, McCarthy MM, Flaherty KT, Camp RL, Rimm DL, et al. Assessment of PI3Kinase as a druggable target in melanoma. ASCO Meet Abstr. 2007;25(18-suppl):8521.
-
(2007)
ASCO Meet Abstr
, vol.25
, Issue.18 SUPPL.
, pp. 8521
-
-
Aziz, S.A.1
Pick-Golan, E.2
McCarthy, M.M.3
Flaherty, K.T.4
Camp, R.L.5
Rimm, D.L.6
-
69
-
-
65649147543
-
Braf(V600E) cooperates with Pten loss to induce metastatic melanoma
-
Dankort D, Curley DP, Cartlidge RA, Nelson B, Karnezis AN, Damsky WE Jr, et al. Braf(V600E) cooperates with Pten loss to induce metastatic melanoma. Nat Genet. 2009;41(5):544-52.
-
(2009)
Nat Genet
, vol.41
, Issue.5
, pp. 544-552
-
-
Dankort, D.1
Curley, D.P.2
Cartlidge, R.A.3
Nelson, B.4
Karnezis, A.N.5
Damsky Jr., W.E.6
-
70
-
-
33745075558
-
Multiple signaling pathways must be targeted to overcome drug resistance in cell lines derived from melanoma metastases
-
DOI 10.1158/1535-7163.MCT-06-0084
-
Smalley KS, Haass NK, Brafford PA, Lioni M, Flaherty KT, Herlyn M. Multiple signaling pathways must be targeted to overcome drug resistance in cell lines derived from melanoma metastases. Mol Cancer Ther. 2006;5(5):1136-44. (Pubitemid 43881305)
-
(2006)
Molecular Cancer Therapeutics
, vol.5
, Issue.5
, pp. 1136-1144
-
-
Smalley, K.S.M.1
Haass, N.K.2
Brafford, P.A.3
Lioni, M.4
Flaherty, K.T.5
Herlyn, M.6
-
71
-
-
47349099502
-
Combined inhibition of MAPK and mTOR signaling inhibits growth, induces cell death, and abrogates invasive growth of melanoma cells
-
DOI 10.1038/jid.2008.44, PII JID200844
-
Lasithiotakis KG, Sinnberg TW, Schittek B, Flaherty KT, Kulms D, Maczey E, et al. Combined inhibition of MAPK and mTOR signaling inhibits growth, induces cell death, and abrogates invasive growth of melanoma cells. J Invest Dermatol. 2008;128(8):2013-23. (Pubitemid 352001225)
-
(2008)
Journal of Investigative Dermatology
, vol.128
, Issue.8
, pp. 2013-2023
-
-
Lasithiotakis, K.G.1
Sinnberg, T.W.2
Schittek, B.3
Flaherty, K.T.4
Kulms, D.5
MacZey, E.6
Garbe, C.7
Meier, F.E.8
-
72
-
-
34447104362
-
Combined targeting of MAPK and AKT signalling pathways is a promising strategy for melanoma treatment
-
DOI 10.1111/j.1365-2133.2007.07821.x
-
Meier F, Busch S, Lasithiotakis K, Kulms D, Garbe C, Maczey E, et al. Combined targeting of MAPK and AKT signalling pathways is a promising strategy for melanoma treatment. Br J Dermatol. 2007;156(6):1204-13. (Pubitemid 47029801)
-
(2007)
British Journal of Dermatology
, vol.156
, Issue.6
, pp. 1204-1213
-
-
Meier, F.1
Busch, S.2
Lasithiotakis, K.3
Kulms, D.4
Garbe, C.5
Maczey, E.6
Herlyn, M.7
Schittek, B.8
-
73
-
-
18444418797
-
Bcl2 regulation by the melanocyte master regulator Mitf modulates lineage survival and melanoma cell viability
-
DOI 10.1016/S0092-8674(02)00762-6
-
McGill GG, Horstmann M, Widlund HR, Du J, Motyckova G, Nishimura EK, et al. Bcl2 regulation by the melanocyte master regulator Mitf modulates lineage survival and melanoma cell viability. Cell. 2002;109(6):707-18. (Pubitemid 34722267)
-
(2002)
Cell
, vol.109
, Issue.6
, pp. 707-718
-
-
McGill, G.G.1
Horstmann, M.2
Widlund, H.R.3
Du, J.4
Motyckova, G.5
Nishimura, E.K.6
Lin, Y.-L.7
Ramaswamy, S.8
Avery, W.9
Ding, H.-F.10
Jordan, S.A.11
Jackson, I.J.12
Korsmeyer, S.J.13
Golub, T.R.14
Fisher, D.E.15
-
74
-
-
41049114747
-
How to make a melanoma: What do we know of the primary clonal events?
-
DOI 10.1111/j.1755-148X.2007.00433.x
-
Bennett DC. How to make a melanoma: what do we know of the primary clonal events? Pigment Cell Melanoma Res. 2008;21(1):27-38. (Pubitemid 351421467)
-
(2008)
Pigment Cell and Melanoma Research
, vol.21
, Issue.1
, pp. 27-38
-
-
Bennett, D.C.1
-
75
-
-
33644659012
-
Epigenetic inactivation of tumor suppressor genes in serum of patients with cutaneous melanoma
-
DOI 10.1038/sj.jid.5700073, PII 5700073
-
Marini A, Mirmohammadsadegh A, Nambiar S, Gustrau A, Ruzicka T, Hengge UR. Epigenetic inactivation of tumor suppressor genes in serum of patients with cutaneous melanoma. J Invest Dermatol. 2006;126(2):422-31. (Pubitemid 43323180)
-
(2006)
Journal of Investigative Dermatology
, vol.126
, Issue.2
, pp. 422-431
-
-
Marini, A.1
Mirmohammadsadegh, A.2
Nambiar, S.3
Gustrau, A.4
Ruzicka, T.5
Hengge, U.R.6
-
76
-
-
74949143594
-
Final version of 2009 AJCC melanoma staging and classification
-
Balch CM, Gershenwald JE, Soong SJ, Thompson JF, Atkins MB, Byrd DR, et al. Final version of 2009 AJCC melanoma staging and classification. J Clin Oncol. 2009;27(36):6199-206.
-
(2009)
J Clin Oncol
, vol.27
, Issue.36
, pp. 6199-6206
-
-
Balch, C.M.1
Gershenwald, J.E.2
Soong, S.J.3
Thompson, J.F.4
Atkins, M.B.5
Byrd, D.R.6
-
77
-
-
79957929511
-
Prognostic significance of mitotic rate in localized primary cutaneous melanoma: An analysis of patients in the multi-institutional American Joint Committee on Cancer melanoma staging database
-
Thompson JF, Soong SJ, Balch CM, Gershenwald JE, Ding S, Coit DG, et al. Prognostic significance of mitotic rate in localized primary cutaneous melanoma: an analysis of patients in the multi-institutional American Joint Committee on Cancer melanoma staging database. J Clin Oncol. 2011;29(16):2199-205.
-
(2011)
J Clin Oncol
, vol.29
, Issue.16
, pp. 2199-2205
-
-
Thompson, J.F.1
Soong, S.J.2
Balch, C.M.3
Gershenwald, J.E.4
Ding, S.5
Coit, D.G.6
-
78
-
-
74149089083
-
But...was there ever a Clark classification of melanomas?
-
Sanchez Yus E, Herrera M, Simon RS, Requena L. But...was there ever a Clark classification of melanomas? Actas Dermosifiliogr. 2010;101(1):19-30.
-
(2010)
Actas Dermosifiliogr
, vol.101
, Issue.1
, pp. 19-30
-
-
Sanchez Yus, E.1
Herrera, M.2
Simon, R.S.3
Requena, L.4
-
79
-
-
84859384253
-
Recent advances in pathologic evaluation and reporting of melanoma
-
Mathew R, Messina JL. Recent advances in pathologic evaluation and reporting of melanoma. Semin Oncol. 2012;39(2):184-91.
-
(2012)
Semin Oncol
, vol.39
, Issue.2
, pp. 184-191
-
-
Mathew, R.1
Messina, J.L.2
-
80
-
-
46349084183
-
Improving melanoma classification by integrating genetic and morphologic features
-
Viros A, Fridlyand J, Bauer J, Lasithiotakis K, Garbe C, Pinkel D, et al. Improving melanoma classification by integrating genetic and morphologic features. PLoS Med. 2008;5(6):e120.
-
(2008)
PLoS Med
, vol.5
, Issue.6
-
-
Viros, A.1
Fridlyand, J.2
Bauer, J.3
Lasithiotakis, K.4
Garbe, C.5
Pinkel, D.6
-
81
-
-
71149108914
-
Cutting a sentinel lymph node into slices is the optimal first step for examination of sentinel lymph nodes in melanoma patients
-
Mitteldorf C, Bertsch HP, Zapf A, Neumann C, Kretschmer L. Cutting a sentinel lymph node into slices is the optimal first step for examination of sentinel lymph nodes in melanoma patients. Mod Pathol. 2009;22(12):1622-7.
-
(2009)
Mod Pathol
, vol.22
, Issue.12
, pp. 1622-1627
-
-
Mitteldorf, C.1
Bertsch, H.P.2
Zapf, A.3
Neumann, C.4
Kretschmer, L.5
-
82
-
-
79957970164
-
Prognosis in patients with sentinel node-positive melanoma is accurately defined by the combined Rotterdam tumor load and Dewar topography criteria
-
van der Ploeg AP, van Akkooi AC, Rutkowski P, Nowecki ZI, Michej W, Mitra A, et al. Prognosis in patients with sentinel node-positive melanoma is accurately defined by the combined Rotterdam tumor load and Dewar topography criteria. J Clin Oncol. 2011;29(16):2206-14.
-
(2011)
J Clin Oncol
, vol.29
, Issue.16
, pp. 2206-2214
-
-
Van Der Ploeg, A.P.1
Van Akkooi, A.C.2
Rutkowski, P.3
Nowecki, Z.I.4
Michej, W.5
Mitra, A.6
-
83
-
-
84896700038
-
Feasibility and reliability of the assessment of BRAF and c-KIT mutations in cytologic samples from metastatic melanoma
-
Lozano MD, Labiano T, Echeveste JI, Montana M, Gomez N, Sanmamed MF, et al. Feasibility and reliability of the assessment of BRAF and c-KIT mutations in cytologic samples from metastatic melanoma. ASCO Meet Abstr. 2011;29(15-suppl):8575.
-
(2011)
ASCO Meet Abstr
, vol.29
, Issue.15 SUPPL.
, pp. 8575
-
-
Lozano, M.D.1
Labiano, T.2
Echeveste, J.I.3
Montana, M.4
Gomez, N.5
Sanmamed, M.F.6
-
84
-
-
84857232726
-
Analytical performance of a real-time PCR-based assay for V600 mutations in the BRAF gene, used as the companion diagnostic test for the novel BRAF inhibitor vemurafenib in metastatic melanoma
-
Halait H, Demartin K, Shah S, Soviero S, Langland R, Cheng S, et al. Analytical performance of a real-time PCR-based assay for V600 mutations in the BRAF gene, used as the companion diagnostic test for the novel BRAF inhibitor vemurafenib in metastatic melanoma. Diagn Mol Pathol. 2012;21(1):1-8.
-
(2012)
Diagn Mol Pathol
, vol.21
, Issue.1
, pp. 1-8
-
-
Halait, H.1
Demartin, K.2
Shah, S.3
Soviero, S.4
Langland, R.5
Cheng, S.6
-
85
-
-
77951725120
-
A commercial real-time PCR kit provides greater sensitivity than direct a sequencing to detect KRAS mutations: A morphology-based approach in colorectal carcinoma
-
Angulo B, García-García E, Martínez R, Suárez-Gauthier A, Conde E, Hidalgo M, et al. A commercial real-time PCR kit provides greater sensitivity than direct a sequencing to detect KRAS mutations: a morphology-based approach in colorectal carcinoma. J Mol Diagn. 2010;12(3):292-9.
-
(2010)
J Mol Diagn
, vol.12
, Issue.3
, pp. 292-299
-
-
Angulo, B.1
García-García, E.2
Martínez, R.3
Suárez-Gauthier, A.4
Conde, E.5
Hidalgo, M.6
-
86
-
-
27644599364
-
Preponderance of the oncogenic V599E and V599K mutations in the B-raf kinase domain is enhanced in melanoma lymph node metastases
-
DOI 10.1097/00008390-200510000-00011
-
Kirschner M, Helmke B, Starz H, Benner A, Thome M, Deichmann M. Preponderance of the oncogenic V599E and V599K mutations in the B-raf kinase domain is enhanced in melanoma lymph node metastases. Melanoma Res. 2005;15(5):427-34. (Pubitemid 41558953)
-
(2005)
Melanoma Research
, vol.15
, Issue.5
, pp. 427-434
-
-
Kirschner, M.1
Helmke, B.2
Starz, H.3
Benner, A.4
Thome, M.5
Deichmann, M.6
-
87
-
-
84978034236
-
Prognostic and clinicopathologic associations of oncogenic BRAF in metastatic melanoma
-
Long GV, Menzies AM, Nagrial AM, Haydu LE, Hamilton AL, Mann GJ, et al. Prognostic and clinicopathologic associations of oncogenic BRAF in metastatic melanoma. J Clin Oncol. 2011;29(10):1239-46.
-
(2011)
J Clin Oncol
, vol.29
, Issue.10
, pp. 1239-1246
-
-
Long, G.V.1
Menzies, A.M.2
Nagrial, A.M.3
Haydu, L.E.4
Hamilton, A.L.5
Mann, G.J.6
-
88
-
-
34250307902
-
Number of nevi and early-life ambient UV exposure are associated with BRAF-mutant melanoma
-
DOI 10.1158/1055-9965.EPI-06-1038
-
Thomas NE, Edmiston SN, Alexander A, Millikan RC, Groben PA, Hao H, et al. Number of nevi and early-life ambient UV exposure are associated with BRAFmutant melanoma. Cancer Epidemiol Biomarkers Prev. 2007;16(5):991-7. (Pubitemid 46910102)
-
(2007)
Cancer Epidemiology Biomarkers and Prevention
, vol.16
, Issue.5
, pp. 991-997
-
-
Thomas, N.E.1
Edmiston, S.N.2
Alexander, A.3
Millikan, R.C.4
Groben, P.A.5
Hao, H.6
Tolbert, D.7
Berwick, M.8
Busam, K.9
Begg, C.B.10
Mattingly, D.11
Ollila, D.W.12
Chiu, K.T.13
Hummer, A.14
Lee-Taylor, J.15
Conway, K.16
-
89
-
-
84867555830
-
Multisite Analytic performance studies of a real-time polymerase chain reaction assay for the detection of BRAF V600E mutations in formalin-fixed paraffin-embedded tissue specimens of malignant melanoma
-
Anderson S, Bloom KJ, Vallera DU, Rueschoff J, Meldrum C, Schilling R, et al. Multisite Analytic performance studies of a real-time polymerase chain reaction assay for the detection of BRAF V600E mutations in formalin-fixed paraffin-embedded tissue specimens of malignant melanoma. Arch Pathol Lab Med. 2012;136(11):1385-91.
-
(2012)
Arch Pathol Lab Med
, vol.136
, Issue.11
, pp. 1385-1391
-
-
Anderson, S.1
Bloom, K.J.2
Vallera, D.U.3
Rueschoff, J.4
Meldrum, C.5
Schilling, R.6
-
90
-
-
79960799905
-
NRAS and BRAF mutation frequency in primary oral mucosal melanoma
-
Buery RR, Siar CH, Katase N, Gunduz M, Lefeuvre M, Fujii M, et al. NRAS and BRAF mutation frequency in primary oral mucosal melanoma. Oncol Rep. 2011;26(4):783-7.
-
(2011)
Oncol Rep
, vol.26
, Issue.4
, pp. 783-787
-
-
Buery, R.R.1
Siar, C.H.2
Katase, N.3
Gunduz, M.4
Lefeuvre, M.5
Fujii, M.6
-
91
-
-
84860324493
-
KIT gene mutations and patterns of protein expression in mucosal and acral melanoma
-
Abu-Abed S, Pennell N, Petrella T, Wright F, Seth A, Hanna W. KIT gene mutations and patterns of protein expression in mucosal and acral melanoma. J Cutan Med Surg. 2012;16(2):135-42.
-
(2012)
J Cutan Med Surg
, vol.16
, Issue.2
, pp. 135-142
-
-
Abu-Abed, S.1
Pennell, N.2
Petrella, T.3
Wright, F.4
Seth, A.5
Hanna, W.6
-
92
-
-
79959795786
-
Improved survival with vemurafenib in melanoma with BRAF V600E mutation
-
Chapman PB, Hauschild A, Robert C, Haanen JB, Ascierto P, Larkin J, et al. Improved survival with vemurafenib in melanoma with BRAF V600E mutation. N Engl J Med. 2011;364(26):2507-16.
-
(2011)
N Engl J Med
, vol.364
, Issue.26
, pp. 2507-2516
-
-
Chapman, P.B.1
Hauschild, A.2
Robert, C.3
Haanen, J.B.4
Ascierto, P.5
Larkin, J.6
-
93
-
-
84864285704
-
Dabrafenib in BRAF-mutated metastatic melanoma: A multicentre, open-label, phase 3 randomised controlled trial
-
Hauschild A, Grob JJ, Demidov LV, Jouary T, Gutzmer R, Millward M, et al. Dabrafenib in BRAF-mutated metastatic melanoma: a multicentre, open-label, phase 3 randomised controlled trial. Lancet. 2012;380(9839):358-65.
-
(2012)
Lancet
, vol.380
, Issue.9839
, pp. 358-365
-
-
Hauschild, A.1
Grob, J.J.2
Demidov, L.V.3
Jouary, T.4
Gutzmer, R.5
Millward, M.6
-
94
-
-
84861845490
-
Melanoma: From mutations to medicine
-
Tsao H, Chin L, Garraway LA, Fisher DE. Melanoma: from mutations to medicine. Genes Dev. 2012;26(11):1131-55.
-
(2012)
Genes Dev
, vol.26
, Issue.11
, pp. 1131-1155
-
-
Tsao, H.1
Chin, L.2
Garraway, L.A.3
Fisher, D.E.4
-
95
-
-
84873383423
-
A focus on PD-L1 in human melanoma
-
Hersey P, Gallagher S. A focus on PD-L1 in human melanoma. Clin Cancer Res. 2013;19(3):514-6.
-
(2013)
Clin Cancer Res
, vol.19
, Issue.3
, pp. 514-516
-
-
Hersey, P.1
Gallagher, S.2
-
96
-
-
84897414353
-
-
[cited 2013 7th February]; Available from
-
EMA-Vemurafenib product characteristic. [cited 2013 7th February]; Available from: http://www.ema.europa.eu/docs/en-GB/document-library/EPAR--- Product-Information/human/002409/WC500124317.pdf.
-
EMA-Vemurafenib Product Characteristic
-
-
-
97
-
-
84897428303
-
-
[cited 2013 7th February]; Available from
-
FDA-Vemurafenib prescribing information. [cited 2013 7th February]; Available from: http://www.accessdata.fda.gov/drugsatfda-docs/label/2011/ 202429s000lbl.pdf.
-
FDA-Vemurafenib Prescribing Information
-
-
-
98
-
-
0014884119
-
Thickness, cross-sectional areas and depth of invasion in the prognosis of cutaneous melanoma
-
Breslow A. Thickness, cross-sectional areas and depth of invasion in the prognosis of cutaneous melanoma. Ann Surg. 1970;172(5):902-8.
-
(1970)
Ann Surg
, vol.172
, Issue.5
, pp. 902-908
-
-
Breslow, A.1
|