Monosomy 3 status of uveal melanoma metastases is associated with rapidly progressive tumors and short survival

Experimental Eye Research

Volumn 100, Issue , 2012, Pages 26-31

  Abdel Rahman, Mohamed H ^a,b   Cebulla, Colleen M ^a   Verma, Vishal ^a   Christopher, Benjamin N ^a   Carson, William E ^a   Olencki, Thomas ^a   Davidorf, Frederick H ^a  

^a OHIO STATE UNIVERSITY   (United States)

^b MENOUFIA UNIVERSITY   (Egypt)

Author keywords

Eye neoplasms; Molecular genetics; Uveal melanoma

Indexed keywords

ADULT; AGED; ARTICLE; CANCER GENETICS; CANCER GROWTH; CANCER SURVIVAL; CELL PROLIFERATION; CHROMOSOME 1P; CHROMOSOME 6P; CHROMOSOME 8Q; CLINICAL ARTICLE; CODON; CONTROLLED STUDY; DISOMY; FEMALE; GENE FREQUENCY; GENE MUTATION; GENETIC ASSOCIATION; GENOTYPE; HETEROZYGOSITY; HUMAN; HUMAN TISSUE; INFLAMMATORY INFILTRATE; MALE; MELANOMA METASTASIS; MONOSOMY; MONOSOMY 3; PRIORITY JOURNAL; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; TUMOR NECROSIS; TUMOR VASCULARIZATION; UVEA MELANOMA;

ADULT; AGED; CHROMOSOMES, HUMAN, PAIR 3; CODON; DISEASE PROGRESSION; DNA MUTATIONAL ANALYSIS; DNA, NEOPLASM; FEMALE; GENOTYPE; GTP-BINDING PROTEIN ALPHA SUBUNITS; HUMANS; LIVER NEOPLASMS; LUNG NEOPLASMS; MALE; MELANOMA; MICROSATELLITE REPEATS; MIDDLE AGED; MOLECULAR BIOLOGY; MONOSOMY; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; SURVIVAL RATE; UVEAL NEOPLASMS;

EID: 84862657063     PISSN: 00144835     EISSN: 10960007     Source Type: Journal    
DOI: 10.1016/j.exer.2012.04.010     Document Type: Article

References (24)

1. Abdel-Rahman M.H., Christopher B.N., Faramawi M.F., Said-Ahmed K., Cole C., McFaddin A., Ray-Chaudhury A., Heerema N., Davidorf F.H. Frequency, molecular pathology and potential clinical significance of partial chromosome 3 aberrations in uveal melanoma. Mod. Pathol. 2011, 24:954-962.
2. Ahmad T., Satsangi J., McGovern D., Bunce M., Jewell D.P. Review article: the genetics of inflammatory bowel disease. Aliment. Pharmacol. Ther. 2001, 15:731-748.
3. Bedikian A.Y., Legha S.S., Mavligit G., Carrasco C.H., Khorana S., Plager C., Papadopoulos N., Benjamin R.S. Treatment of uveal melanoma metastatic to the liver: a review of the M. D. Anderson Cancer Center experience and prognostic factors. Cancer 1995, 76:1665-1670.
4. Cawkwell L., Bell S.M., Lewis F.A., Dixon M.F., Taylor G.R., Quirke P. Rapid detection of allele loss in colorectal tumours using microsatellites and fluorescent DNA technology. Br. J. Cancer 1993, 67:1262-1267.
5. Damato B., Coupland S.E. Translating uveal melanoma cytogenetics into clinical care. Arch. Ophthalmol. 2009, 127:423-429.
6. Harbour J.W. Molecular prognostic testing and individualized patient care in uveal melanoma. Am. J. Ophthalmol. 2009, 148:823-829. e1.
7. Harbour J.W., Onken M.D., Roberson E.D., Duan S., Cao L., Worley L.A., Council M.L., Matatall K.A., Helms C., Bowcock A.M. Frequent mutation of BAP1 in metastasizing uveal melanomas. Science 2010, 330:1410-1413.
8. Hausler T., Stang A., Anastassiou G., Jockel K.H., Mrzyk S., Horsthemke B., Lohmann D.R., Zeschnigk M. Loss of heterozygosity of 1p in uveal melanomas with monosomy 3. Int. J. Cancer 2005, 116:909-913.
9. Maat W., Ly L.V., Jordanova E.S., de Wolff-Rouendaal D., Schalij-Delfos N.E., Jager M.J. Monosomy of chromosome 3 and an inflammatory phenotype occur together in uveal melanoma. Invest. Ophthalmol. Vis. Sci. 2008, 49:505-510.
10. Niederkorn J.Y. Immune escape mechanisms of intraocular tumors. Prog. Retin. Eye Res. 2009, 28:329-347.
11. Onken M.D., Worley L.A., Ehlers J.P., Harbour J.W. Gene expression profiling in uveal melanoma reveals two molecular classes and predicts metastatic death. Cancer Res. 2004, 64:7205-7209.
12. Parrella P., Fazio V.M., Gallo A.P., Sidransky D., Merbs S.L. Fine mapping of chromosome 3 in uveal melanoma: identification of a minimal region of deletion on chromosomal arm 3p25.1-p25.2. Cancer Res. 2003, 63:8507-8510.
13. Prescher G., Bornfeld N., Hirche H., Horsthemke B., Jockel K.H., Becher R. Prognostic implications of monosomy 3 in uveal melanoma. Lancet 1996, 347:1222-1225.
14. Rietschel P., Panageas K.S., Hanlon C., Patel A., Abramson D.H., Chapman P.B. Variates of survival in metastatic uveal melanoma. J. Clin. Oncol. 2005, 23:8076-8080.
15. Shields C.L., Ganguly A., Bianciotto C.G., Turaka K., Tavallali A., Shields J.A. Prognosis of uveal melanoma in 500 cases using genetic testing of fine-needle aspiration biopsy specimens. Ophthalmology 2011, 118:396-401.
16. Shields J.A., Shields C.L., Materin M., Sato T., Ganguly A. Role of cytogenetics in management of uveal melanoma. Arch. Ophthalmol. 2008, 126:416-419.
17. Singh A.D., Topham A. Incidence of uveal melanoma in the United States: 1973-1997. Ophthalmology 2003, 110:956-961.
18. Singh A.D., Tubbs R., Biscotti C., Schoenfield L., Trizzoi P. Chromosomal 3 and 8 status within hepatic metastasis of uveal melanoma. Arch. Pathol. Lab. Med. 2009, 133:1223-1227.
19. Skotheim R.I., Diep C.B., Kraggerud S.M., Jakobsen K.S., Lothe R.A. Evaluation of loss of heterozygosity/allelic imbalance scoring in tumor DNA. Cancer Genet. Cytogenet. 2001, 127:64-70.
20. Trolet J., Hupe P., Huon I., Lebigot I., Decraene C., Delattre O., Sastre-Garau X., Saule S., Thiery J.P., Plancher C., Asselain B., Desjardins L., Mariani P., Piperno-Neumann S., Barillot E., Couturier J. Genomic profiling and identification of high-risk uveal melanoma by array CGH analysis of primary tumors and liver metastases. Invest. Ophthalmol. Vis. Sci. 2009, 50:2572-2580.
21. Tschentscher F., Prescher G., Horsman D.E., White V.A., Rieder H., Anastassiou G., Schilling H., Bornfeld N., Bartz-Schmidt K.U., Horsthemke B., Lohmann D.R., Zeschnigk M. Partial deletions of the long and short arm of chromosome 3 point to two tumor suppressor genes in uveal melanoma. Cancer Res. 2001, 61:3439-3442.
22. Van Raamsdonk C.D., Bezrookove V., Green G., Bauer J., Gaugler L., O'Brien J.M., Simpson E.M., Barsh G.S., Bastian B.C. Frequent somatic mutations of GNAQ in uveal melanoma and blue naevi. Nature 2009, 457:599-602.
23. Van Raamsdonk C.D., Griewank K.G., Crosby M.B., Garrido M.C., Vemula S., Wiesner T., Obenauf A.C., Wackernagel W., Green G., Bouvier N., Sozen M.M., Baimukanova G., Roy R., Heguy A., Dolgalev I., Khanin R., Busam K., Speicher M.R., O'Brien J., Bastian B.C. Mutations in GNA11 in uveal melanoma. N. Engl. J. Med. 2010, 363:2191-2199.
24. Verbik D.J., Murray T.G., Tran J.M., Ksander B.R. Melanomas that develop within the eye inhibit lymphocyte proliferation. Int. J. Cancer 1997, 73:470-478.