Inhibition of TBK1 attenuates radiation-induced epithelial-mesenchymal transition of A549 human lung cancer cells via activation of GSK-3β and repression of ZEB1

Laboratory Investigation

Volumn 94, Issue 4, 2014, Pages 362-370

  Liu, Wen ^a   Huang, Yi Juan ^a   Liu, Cong ^a   Yang, Yan Yong ^a   Liu, Hu ^a   Cui, Jian Guo ^a   Cheng, Ying ^a   Gao, Fu ^a   Cai, Jian Ming ^a   Li, Bai Long ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

epithelial mesenchymal transition; GSK 3 ; metasatsis; radiation; TBK1; ZEB1

Indexed keywords

COBALT 60; GLYCOGEN SYNTHASE KINASE 3BETA; I KAPPA B KINASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; SMAD3 PROTEIN; TANK BINDING KINASE 1; TRANSCRIPTION FACTOR ZEB1; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; UVOMORULIN; VIMENTIN;

ARTICLE; CANCER CELL; CELL INVASION; CELL MIGRATION; CELL STRUCTURE; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME INHIBITION; EPITHELIAL MESENCHYMAL TRANSITION; EPITHELIUM CELL; GAMMA RADIATION; HUMAN; HUMAN CELL; LUNG CANCER; METASTASIS; PRIORITY JOURNAL; RADIATION CARCINOGENESIS; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

CELL LINE, TUMOR; EPITHELIAL-MESENCHYMAL TRANSITION; GAMMA RAYS; GLYCOGEN SYNTHASE KINASE 3; HOMEODOMAIN PROTEINS; HUMANS; NEOPLASM METASTASIS; NEOPLASMS; NF-KAPPA B; PROTEIN-SERINE-THREONINE KINASES; RADIOTHERAPY; SMAD PROTEINS; TRANSCRIPTION FACTORS; TRANSFORMING GROWTH FACTOR BETA;

EID: 84897410473     PISSN: 00236837     EISSN: 15300307     Source Type: Journal    
DOI: 10.1038/labinvest.2013.153     Document Type: Article

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