Segmented filamentous bacteria: Commensal microbes with potential effects on research

Comparative Medicine

Volumn 64, Issue 2, 2014, Pages 90-98

  Ericsson, Aaron C ^a   Hagan, Catherine E ^a   Davis, Daniel J ^a   Franklin, Craig L ^a  

^a UNIVERSITY OF MISSOURI   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION INDUCED CYTIDINE DEAMINASE; ADHESIN; FLAGELLIN; IMMUNOGLOBULIN A; RNA 16S; TOLL LIKE RECEPTOR 5;

ACTIN POLYMERIZATION; ADAPTIVE IMMUNITY; BACTERIAL COLONIZATION; BACTERIAL SPORE; BACTERIOLOGY; BACTERIUM; BACTEROIDES THETAIOTAOMICRON; BACTEROIDETES; CROHN DISEASE; DENDRITIC CELL; DNA SEQUENCE; ENTEROPATHOGENIC ESCHERICHIA COLI; ESCHERICHIA COLI; GOBLET CELL; HOST RANGE; HUMAN; INFLAMMATORY BOWEL DISEASE; INTESTINE CELL; INTESTINE EPITHELIUM CELL; METAGENOMICS; MICROBIAL COMMUNITY; MICROFLORA; MICROSCOPY; MOLECULAR BIOLOGY; MUCOSAL IMMUNITY; NONHUMAN; PEYER PATCH; PHAGOCYTOSIS; POLYMERASE CHAIN REACTION; REVIEW; SALMONELLA ENTERITIDIS; SALMONELLA TYPHIMURIUM; SEGMENTED FILAMENTOUS BACTERIA; TYPE III SECRETION SYSTEM; ULCERATIVE COLITIS; ANIMAL; BACTERIA; BACTERIAL PHENOMENA AND FUNCTIONS; CYTOLOGY; DISEASE MODEL; GENETICS; HOST PATHOGEN INTERACTION; ILEUM; MICROBIOLOGY; MOUSE; PHYLOGENY; PHYSIOLOGY; RAT; SPECIES DIFFERENCE; SYMBIOSIS;

ANIMALS; BACTERIA; BACTERIAL PHYSIOLOGICAL PHENOMENA; DISEASE MODELS, ANIMAL; HOST-PATHOGEN INTERACTIONS; ILEUM; MICE; MICROBIOTA; PHYLOGENY; RATS; SPECIES SPECIFICITY; SYMBIOSIS;

EID: 84897407542     PISSN: 15320820     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (96)

1. Allen PC. 1992. Comparative study of long, segmented, filamentous organisms in chickens and mice. Lab Anim Sci 42:542-547. (Pubitemid 23016707)
2. Angel CR, Sell JL, Fagerland JA, Reynolds DL, Trampel DW. 1990. Long-segmented filamentous organisms observed in poults experimentally infected with stunting syndrome agent. Avian Dis 34:994-1001.
3. Barrangou R, Fremaux C, Deveau H, Richards M, Boyaval P, Moineau S, Romero DA, Horvath P. 2007. CRISPR provides acquired resistance against viruses in prokaryotes. Science 315:1709-1712. (Pubitemid 46515624)
4. Blumershine RV, Savage DC. 1977. Filamentous microbes indigenous to the murine small bowel: a scanning-electron microscopic study of their morphology and attachment to the epithelium. Microb Ecol 4:95-103. (Pubitemid 9120006)
5. Bohorquez DV, Bohorquez NE, Ferket PR. 2011. Ultrastructural development of the small intestinal mucosa in the embryo and turkey poult: a light- and electron-microscopy study. Poult Sci 90:842-855.
6. Bruorton MR, Davis CL, Perrin MR. 1991. Gut microflora of vervet and samango monkeys in relation to diet. Appl Environ Microbiol 57:573-578.
7. Caselli M, Holton J, Boldrini P, Vaira D, Calo G. 2010. Morphology of segmented filamentous bacteria and their patterns of contact with the follicle-associated epithelium of the mouse terminal ileum: implications for the relationship with the immune system. Gut Microbes 1:367-372.
8. Caselli M, Tosini D, Gafa R, Gasbarrini A, Lanza G. 2013. Segmented filamentous bacteria-like organisms in histological slides of ileocecal valves in patients with ulcerative colitis. Am J Gastroenterol 108:860-861.
9. Cebra JJ. 1999. Influences of microbiota on intestinal immune system development. Am J Clin Nutr 69:1046S-1051S. (Pubitemid 29205083)
10. Chase DG, Erlandsen SL. 1976. Evidence for a complex life cycle and endospore formation in the attached, filamentous, segmented bacterium from murine ileum. J Bacteriol 127:572-583.
11. Chung H, Pamp SJ, Hill JA, Surana NK, Edelman SM, Troy EB, Reading NC, Villablanca EJ, Wang S, Mora JR, Umesaki Y, Mathis D, Benoist C, Relman DA, Kasper DL. 2012. Gut immune maturation depends on colonization with a host-specific microbiota. Cell 149:1578-1593.
12. Davis CP, Cleven D, Balish E, Yale CE. 1977. Bacterial association in the gastrointestinal tract of beagle dogs. Appl Environ Microbiol 34:194-206. (Pubitemid 8178140)
13. Davis CP, Savage DC. 1974. Habitat, succession, attachment, and morphology of segmented, filamentous microbes indigenous to the murine gastrointestinal tract. Infect Immun 10:948-956.
14. Davis CP, Savage DC. 1976. Effect of penicillin on the succession, attachment, and morphology of segmented, filamentous microbes in the murine small bowel. Infect Immun 13:180-188.
15. Del-Pozo J, Crumlish M, Ferguson HW, Green DM, Turnbull JF. 2010. A prospective longitudinal study of 'Candidatus arthromitus'-associated rainbow trout gastroenteritis in the UK. Prev Vet Med 94:289-300.
16. Del- Pozo J, Crumlish M, Turnbull JF, Ferguson HW. 2010. Histopathology and ultrastructure of segmented filamentous bacteria-associated rainbow trout gastroenteritis. Vet Pathol 47: 220-230.
17. Del-Pozo J, Turnbull J, Ferguson H, Crumlish M. 2010. A comparative molecular study of the presence of 'Candidatus arthromitus' in the digestive system of rainbow trout, Oncorhynchus mykiss (Walbaum), healthy and affected with rainbow trout gastroenteritis. J Fish Dis 33:241-250.
18. Del-Pozo J, Turnbull JF, Crumlish M, Ferguson HW. 2010. A study of gross, histological, and blood biochemical changes in rainbow trout, Oncorhynchus mykiss (Walbaum), with rainbow trout gastroenteritis (RTGE). J Fish Dis 33:301-310.
19. Denning TL, Norris BA, Medina-Contreras O, Manicassamy S, Geem D, Madan R, Karp CL, Pulendran B. 2011. Functional specializations of intestinal dendritic cell and macrophage subsets that control Th17 and regulatory T cell responses are dependent on the T cell:APC ratio, source of mouse strain, and regional localization. J Immunol 187:733-747.
20. Eckburg PB, Bik EM, Bernstein CN, Purdom E, Dethlefsen L, Sargent M, Gill SR, Nelson KE, Relman DA. 2005. Diversity of the human intestinal microbial flora. Science 308:1635-1638. (Pubitemid 40807514)
21. Erlandsen SL, Chase DG. 1974. Morphological alterations in the microvillous border of villous epithelial cells produced by intestinal microorganisms. Am J Clin Nutr 27:1277-1286.
22. Finlay BB, Rosenshine I, Donnenberg MS, Kaper JB. 1992. Cytoskeletal composition of attaching and effacing lesions associated with enteropathogenic Escherichia coli adherence to HeLa cells. Infect Immun 60:2541-2543.
23. Finlay BB, Ruschkowski S, Dedhar S. 1991. Cytoskeletal rearrangements accompanying Salmonella entry into epithelial cells. J Cell Sci 99:283-296. (Pubitemid 21925017)
24. Fuentes S, Egert M, Jimenez-Valera M, Monteoliva-Sanchez M, Ruiz-Bravo A, Smidt H. 2008. A strain of Lactobacillus plantarum affects segmented filamentous bacteria in the intestine of immuno-suppressed mice. FEMS Microbiol Ecol 63:65-72. (Pubitemid 350233292)
25. Fuller R, Turvey A. 1971. Bacteria associated with the intestinal wall of the fowl (Gallus domesticus). J Appl Bacteriol 34:617-622.
26. Gaboriau-Routhiau V, Rakotobe S, Lecuyer E, Mulder I, Lan A, Bridonneau C, Rochet V, Pisi A, De Paepe M, Brandi G, Eberl G, Snel J, Kelly D, Cerf-Bensussan N. 2009. The key role of segmented filamentous bacteria in the coordinated maturation of gut helper T-cell responses. Immunity 31:677-689.
27. Garland CD, Lee A, Dickson MR. 1982. Segmented filamentous bacteria in the rodent small intestine: their colonization of growing animals and possible role in host resistance to Salmonella. Microb Ecol 8:181-190. (Pubitemid 13207833)
28. Glick B, Holbrook KA, Olah I, Perkins WD, Stinson R. 1978. A scanning-electron microscope study of the caecal tonsil: the identification of a bacterial attachment to the villi of the caecal tonsil and the possible presence of lymphatics in the caecal tonsil. Poult Sci 57:1408-1416.
29. Goodwin MA, Cooper GL, Brown J, Bickford AA, Waltman WD, Dickson TG. 1991. Clinical, pathological, and epizootiological features of long-segmented filamentous organisms (bacteria, LSFOs) in the small intestines of chickens, turkeys, and quails. Avian Dis 35:872-876.
30. Goto Y, Umesaki Y, Benno Y, Kiyono H. 2011. Specific commensal bacteria modulate epithelial glycosylation. J Immunol 186:59.5.
31. Hajishengallis G, Darveau RP, Curtis MA. 2012. The keystone-pathogen hypothesis. Nat Rev Microbiol 10:717-725.
32. Hampton JC, Rosario B. 1965. The attachment of microorganisms to epithelial cells in the distal ileum of the mouse. Lab Invest 14:1464-1481.
33. Heczko U, Abe A, Finlay BB. 2000. Segmented filamentous bacteria prevent colonization of enteropathogenic Escherichia coli O103 in rabbits. J Infect Dis 181:1027-1033. (Pubitemid 30194488)
34. Hill JE, Kelley LC, Langheinrich KA. 1992. Visceral granulomas in chickens infected with a filamentous bacteria. Avian Dis 36:172-176.
35. Hoskins JD, Henk WG, Abdelbaki YZ. 1982. Scanning electronmicroscopic study of the small intestine of dogs from birth to 337 days of age. Am J Vet Res 43:1715-1720.
36. Imaoka A, Okada Y, Matsumoto S, Setoyama H, Umesaki Y. 1997. 16S ribosomal DNA sequence divergence of segmented filamentous bacteria with special reference to inter-species and within-species variation of host animals. Syst Appl Microbiol 20:418-422. (Pubitemid 27374684)
37. Ivanov II, Atarashi K, Manel N, Brodie EL, Shima T, Karaoz U, Wei D, Goldfarb KC, Santee CA, Lynch SV, Tanoue T, Imaoka A, Itoh K, Takeda K, Umesaki Y, Honda K, Littman DR. 2009. Induction of intestinal Th17 cells by segmented filamentous bacteria. Cell 139:485-498.
38. Ivanov II, Frutos Rde L, Manel N, Yoshinaga K, Rifkin DB, Sartor RB, Finlay BB, Littman DR. 2008. Specific microbiota direct the differentiation of IL17-producing T-helper cells in the mucosa of the small intestine. Cell Host Microbe 4:337-349.
39. Jacchieri SG, Torquato R, Brentani RR. 2003. Structural study of binding of flagellin by Toll-like receptor 5. J Bacteriol 185:4243-4247. (Pubitemid 36835265)
40. Jepson MA, Clark MA, Simmons NL, Hirst BH. 1993. Actin accumulation at sites of attachment of indigenous apathogenic segmented filamentous bacteria to mouse ileal epithelial cells. Infect Immun 61:4001-4004. (Pubitemid 23260081)
41. Jergens AE, Dorn A, Wilson J, Dingbaum K, Henderson A, Liu Z, Hostetter J, Evans RB, Wannemuehler MJ. 2006. Induction of differential immune reactivity to members of the flora of gnotobiotic mice following colonization with Helicobacter bilis or Brachyspira hyodysenteriae. Microbes Infect 8:1602-1610. (Pubitemid 43903324)
42. Jergens AE, Wilson-Welder JH, Dorn A, Henderson A, Liu Z, Evans RB, Hostetter J, Wannemuehler MJ. 2007. Helicobacter bilis triggers persistent immune reactivity to antigens derived from the commensal bacteria in gnotobiotic C3H/HeN mice. Gut 56:934-940. (Pubitemid 46999076)
43. Jiang HQ, Bos NA, Cebra JJ. 2001. Timing, localization, and persistence of colonization by segmented filamentous bacteria in the neonatal mouse gut depend on immune status of mothers and pups. Infect Immun 69:3611-3617. (Pubitemid 32493275)
44. Jiang HQ, Kushnir N, Thurnheer MC, Bos NA, Cebra JJ. 2002. Monoassociation of SCID mice with Helicobacter muridarum, but not four other enterics, provokes IBD upon receipt of T cells. Gastroenterology 122:1346-1354. (Pubitemid 34465177)
45. Keilbaugh SA, Shin ME, Banchereau RF, McVay LD, Boyko N, Artis D, Cebra JJ, Wu GD. 2005. Activation of RegIIIβ/γ and interferon γ expression in the intestinal tract of SCID mice: an innate response to bacterial colonisation of the gut. Gut 54:623-629. (Pubitemid 40559244)
46. Klaasen HL, Koopman JP, Poelma FG, Beynen AC. 1992. Intestinal, segmented, filamentous bacteria. FEMS Microbiol Rev 8:165-180.
47. Klaasen HL, Koopman JP, van den Brink ME, Bakker MH, Beynen AC. 1992. Influence of a natural-ingredient diet containing Phaseolus vulgaris on the colonization by segmented, filamentous bacteria of the small bowel of mice. Int J Vitam Nutr Res 62:334-341.
48. Klaasen HL, Koopman JP, Van den Brink ME, Bakker MH, Poelma FG, Beynen AC. 1993. Intestinal, segmented, filamentous bacteria in a wide range of vertebrate species. Lab Anim 27:141-150. (Pubitemid 23104423)
49. Klaasen HL, Koopman JP, Van den Brink ME, Van Wezel HP, Beynen AC. 1991. Mono-association of mice with noncultivable, intestinal, segmented, filamentous bacteria. Arch Microbiol 156:148-151.
50. Klaasen HL, Van der Heijden PJ, Stok W, Poelma FG, Koopman JP, Van den Brink ME, Bakker MH, Eling WM, Beynen AC. 1993. Apathogenic, intestinal, segmented, filamentous bacteria stimulate the mucosal immune system of mice. Infect Immun 61:303-306. (Pubitemid 23015431)
51. Koopman JP, Stadhouders AM, Kennis HM, De Boer H. 1987. The attachment of filamentous segmented microorganisms to the distal ileum wall of the mouse: a scanning- and transmission-electron-microscopy study. Lab Anim 21:48-52. (Pubitemid 17235247)
52. Koopman JP, van den Brink ME, Scholten PM, van der Heyden M, van Schie FW, Hectors MP, Nagengast F. 1989. The influence of stress and cheese whey on intestinal parameters in mice. Vet Q 11:24-29.
53. Kriegel MA, Sefik E, Hill JA, Wu HJ, Benoist C, Mathis D. 2011. Naturally transmitted segmented filamentous bacteria segregate with diabetes protection in nonobese diabetic mice. Proc Natl Acad Sci USA 108:11548-11553.
54. Kuwahara T, Ogura Y, Oshima K, Kurokawa K, Ooka T, Hirakawa H, Itoh T, Nakayama-Imaohji H, Ichimura M, Itoh K, Ishifune C, Maekawa Y, Yasutomo K, Hattori M, Hayashi T. 2011. The lifestyle of the segmented filamentous bacterium: a nonculturable gutassociated immunostimulating microbe inferred by whole-genome sequencing. DNA Res 18:291-303.
55. Lee YK, Menezes JS, Umesaki Y, Mazmanian SK. 2011. Proinflammatory T-cell responses to gut microbiota promote experimental autoimmune encephalomyelitis. Proc Natl Acad Sci USA 108 Suppl 1:4615-4622.
56. Leidy J. 1881. The parasites of termites. J Acad Nat Sci (Phila) 8:425-447.
57. Ley RE, Hamady M, Lozupone C, Turnbaugh PJ, Ramey RR, Bircher JS, Schlegel ML, Tucker TA, Schrenzel MD, Knight R, Gordon JI. 2008. Evolution of mammals and their gut microbes. Science 320:1647-1651. (Pubitemid 351931256)
58. Lowden S, Heath T. 1995. Segmented filamentous bacteria associated with lymphoid tissues in the ileum of horses. Res Vet Sci 59:272-274.
59. Maggio- Price L, Treuting P, Zeng W, Tsang M, Bielefeldt- Ohmann H, Iritani BM. 2006. Helicobacter infection is required for inflammation and colon cancer in SMAD3-deficient mice. Cancer Res 66: 828-838.
60. Marraffini LA, Sontheimer EJ. 2010. CRISPR interference: RNA-directed adaptive immunity in bacteria and archaea. Nat Rev Genet 11:181-190.
61. Mattick JS. 2002. Type IV pili and twitching motility. Annu Rev Microbiol 56:289-314. (Pubitemid 35217457)
62. McFall-Ngai M, Hadfield MG, Bosch TC, Carey HV, Domazet-Loso T, Douglas AE, Dubilier N, Eberl G, Fukami T, Gilbert SF, Hentschel U, King N, Kjelleberg S, Knoll AH, Kremer N, Mazmanian SK, Metcalf JL, Nealson K, Pierce NE, Rawls JF, Reid A, Ruby EG, Rumpho M, Sanders JG, Tautz D, Wernegreen JJ. 2013. Animals in a bacterial world, a new imperative for the life sciences. Proc Natl Acad Sci USA 110:3229-3236.
63. Meyerholz DK, Stabel TJ, Cheville NF. 2002. Segmented filamentous bacteria interact with intraepithelial mononuclear cells. Infect Immun 70:3277-3280. (Pubitemid 34564193)
64. Ohashi Y, Hiraguchi M, Sunaba C, Tanaka C, Fujisawa T, Ushida K. 2010. Colonization of segmented filamentous bacteria and its interaction with the luminal IgA level in conventional mice. Anaerobe 16:543-546.
65. Pamp SJ, Harrington ED, Quake SR, Relman DA, Blainey PC. 2012. Single-cell sequencing provides clues about the host interactions of segmented filamentous bacteria (SFB). Genome Res 22:1107-1119.
66. Powrie F, Leach MW, Mauze S, Caddle LB, Coffman RL. 1993. Phenotypically distinct subsets of CD4+ T cells induce or protect from chronic intestinal inflammation in C. B-17 scid mice. Int Immunol 5:1461-1471. (Pubitemid 23325202)
67. Prakash T, Oshima K, Morita H, Fukuda S, Imaoka A, Kumar N, Sharma VK, Kim SW, Takahashi M, Saitou N, Taylor TD, Ohno H, Umesaki Y, Hattori M. 2011. Complete genome sequences of rat and mouse segmented filamentous bacteria, a potent inducer of Th17 cell differentiation. Cell Host Microbe 10:273-284.
68. Rahimi S, Grimes JL, Fletcher O, Oviedo E, Sheldon BW. 2009. Effect of a direct-fed microbial (Primalac) on structure and ultrastructure of small intestine in turkey poults. Poult Sci 88:491-503.
69. Reimann HA. 1965. Microbic phagocytosis by enteric epithelial cells. JAMA 192:1130-1132.
70. Sanford SE. 1991. Light- and electron-microscopic observations of a segmented filamentous bacterium attached to the mucosa of the terminal ileum of pigs. J Vet Diagn Invest 3:328-333.
71. Savage DC. 1969. Localization of certain indigenous microorganisms on the ileal villi of rats. J Bacteriol 97:1505-1506.
72. Savage DC, Dubos R, Schaedler RW. 1968. The gastrointestinal epithelium and its autochthonous bacterial flora. J Exp Med 127:67-76.
73. Sczesnak A, Segata N, Qin X, Gevers D, Petrosino JF, Huttenhower C, Littman DR, Ivanov II. 2011. The genome of Th17 cell-inducing segmented filamentous bacteria reveals extensive auxotrophy and adaptations to the intestinal environment. Cell Host Microbe 10:260-272.
74. Sears CL, Pardoll DM. 2011. Perspective: α-bugs, their microbial partners, and the link to colon cancer. J Infect Dis 203:306-311.
75. Smith TM. 1997. Segmented filamentous bacteria in the bovine small intestine. J Comp Pathol 117:185-190. (Pubitemid 27466432)
76. Snel J, Blok HJ, Kengen HMP, Ludwig FGJ, Poelma FGJ, Koopman JP, Akkermans ADL. 1994. Phylogenetic characterization of Clostridium related segmented filamentous bacteria in mice based on 16S ribosomal RNA analysis. Syst Appl Microbiol 17:172-179. (Pubitemid 24285682)
77. Snel J, Heinen PP, Blok HJ, Carman RJ, Duncan AJ, Allen PC, Collins MD. 1995. Comparison of 16S rRNA sequences of segmented filamentous bacteria isolated from mice, rats, and chickens and proposal of Candidatus arthromitus. Int J Syst Bacteriol 45:780-782.
78. Snel J, Hermsen CC, Smits HJ, Bos NA, Eling WM, Cebra JJ. 1998. Interactions between gut-associated lymphoid tissue and colonization levels of indigenous, segmented, filamentous bacteria in the small intestine of mice. Can J Microbiol 44:1177-1182.
79. Snellen JE, Savage DC. 1978. Freeze-fracture study of the filamentous, segmented microorganism attached to the murine small bowel. J Bacteriol 134:1099-1107. (Pubitemid 8354533)
80. Stepankova R, Powrie F, Kofronova O, Kozakova H, Hudcovic T, Hrncir T, Uhlig H, Read S, Rehakova Z, Benada O, Heczko P, Strus M, Bland P, Tlaskalova-Hogenova H. 2007. Segmented filamentous bacteria in a defined bacterial cocktail induce intestinal inflammation in SCID mice reconstituted with CD45RBhighCD4+ T cells. Inflamm Bowel Dis 13:1202-1211. (Pubitemid 47597767)
81. Suchodolski JS, Camacho J, Steiner JM. 2008. Analysis of bacterial diversity in the canine duodenum, jejunum, ileum, and colon by comparative 16S rRNA gene analysis. FEMS Microbiol Ecol 66:567-578.
82. Suzuki K, Meek B, Doi Y, Muramatsu M, Chiba T, Honjo T, Fagarasan S. 2004. Aberrant expansion of segmented filamentous bacteria in IgA-deficient gut. Proc Natl Acad Sci USA 101: 1981-1986. (Pubitemid 38229001)
83. Talham GL, Jiang HQ, Bos NA, Cebra JJ. 1999. Segmented filamentous bacteria are potent stimuli of a physiologically normal state of the murine gut mucosal immune system. Infect Immun 67:1992-2000. (Pubitemid 29144426)
84. Tannock GW, Miller JR, Savage DC. 1984. Host specificity of filamentous, segmented microorganisms adherent to the small bowel epithelium in mice and rats. Appl Environ Microbiol 47:441-442. (Pubitemid 14185010)
85. Thompson CL, Mikaelyan A, Brune A. 2013. Immune-modulating gut symbionts are not 'Candidatus arthromitus.' Mucosal Immunol 6:200-201.
86. Thompson CL, Vier R, Mikaelyan A, Wienemann T, Brune A. 2012. 'Candidatus arthromitus' revised: segmented filamentous bacteria in arthropod guts are members of Lachnospiraceae. Environ Microbiol 14:1454-1465.
87. Tjalsma H, Boleij A, Marchesi JR, Dutilh BE. 2012. A bacterial driver-passenger model for colorectal cancer: beyond the usual suspects. Nat Rev Microbiol 10:575-582.
88. + lamina propria dendritic cells in enterobacterial infection. J Gastroenterol 44:803-811.
89. Uematsu S, Fujimoto K, Jang MH, Yang BG, Jung YJ, Nishiyama M, Sato S, Tsujimura T, Yamamoto M, Yokota Y, Kiyono H, Miyasaka M, Ishii KJ, Akira S. 2008. Regulation of humoral and cellular gut immunity by lamina propria dendritic cells expressing Toll-like receptor 5. Nat Immunol 9:769-776. (Pubitemid 351859160)
90. Umesaki Y, Okada Y, Matsumoto S, Imaoka A, Setoyama H. 1995. Segmented filamentous bacteria are indigenous intestinal bacteria that activate intraepithelial lymphocytes and induce MHC class II molecules and fucosyl asialo GM1 glycolipids on the small intestinal epithelial cells in the ex-germ-free mouse. Microbiol Immunol 39:555-562.
91. Umesaki Y, Setoyama H, Matsumoto S, Imaoka A, Itoh K. 1999. Differential roles of segmented filamentous bacteria and clostridia in development of the intestinal immune system. Infect Immun 67:3504-3511. (Pubitemid 29291522)
92. Urdaci MC, Regnault B, Grimont PA. 2001. Identification by in situ hybridization of segmented filamentous bacteria in the intestine of diarrheic rainbow trout (Oncorhynchus mykiss). Res Microbiol 152:67-73. (Pubitemid 32168119)
93. Wu HJ, Ivanov II, Darce J, Hattori K, Shima T, Umesaki Y, Littman DR, Benoist C, Mathis D. 2010. Gut-residing segmented filamentous bacteria drive autoimmune arthritis via T helper 17 cells. Immunity 32:815-827.
94. Yamauchi KE, Snel J. 2000. Transmission-electron-microscopic demonstration of phagocytosis and intracellular processing of segmented filamentous bacteria by intestinal epithelial cells of the chick ileum. Infect Immun 68:6496-6504.
95. Yin Y, Wang Y, Zhu L, Liu W, Liao N, Jiang M, Zhu B, Yu HD, Xiang C, Wang X. 2013. Comparative analysis of the distribution of segmented filamentous bacteria in humans, mice, and chickens. ISME J 7:615-621.
96. Zheng Y, Valdez PA, Danilenko DM, Hu Y, Sa SM, Gong Q, Abbas AR, Modrusan Z, Ghilardi N, de Sauvage FJ, Ouyang W. 2008. Interleukin 22 mediates early host defense against attaching and effacing bacterial pathogens. Nat Med 14:282-289. (Pubitemid 351347912)