SCFß-TRCP-mediated degradation of NEDD4 inhibits tumorigenesis through modulating the PTEN/Akt signaling pathway

Oncotarget

Volumn 5, Issue 4, 2014, Pages 1026-1037

  Liu, Jia ^a,b   Wan, Lixin ^b   Liu, Pengda ^b   Inuzuka, Hiroyuki ^b   Liu, Jiankang ^a   Wang, Zhiwei ^c   Wei, Wenyi ^b  

^a XI'AN JIAOTONG UNIVERSITY   (China)

^b HARVARD MEDICAL SCHOOL   (United States)

^c SOOCHOW UNIVERSITY   (China)

Author keywords

Akt; Cancer; Degradation; NEDD4; Phosphorylation; PTEN; Therapy; Ubiquitination; TRCP

Indexed keywords

BETA TRANSDUCIN REPEAT CONTAINING PROTEIN; CASEIN KINASE I; MAMMALIAN TARGET OF RAPAMYCIN; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; STEM CELL FACTOR; UBIQUITIN PROTEIN LIGASE NEDD4; ESCRT PROTEIN; NEDD4 UBIQUITIN PROTEIN LIGASES; PTEN PROTEIN, HUMAN; UBIQUITIN PROTEIN LIGASE;

ARTICLE; CANCER GROWTH; CARCINOGENESIS; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVATION; ENZYME INACTIVATION; ENZYME INHIBITION; ENZYME REGULATION; HUMAN; HUMAN CELL; PROTEIN DEGRADATION; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN PHOSPHORYLATION; PROTEIN TARGETING; SIGNAL TRANSDUCTION; UBIQUITINATION; UPREGULATION; AMINO ACID SEQUENCE; CELL MOTION; GENETIC TRANSFECTION; GENETICS; HEK293 CELL LINE; HELA CELL LINE; MCF 7 CELL LINE; METABOLISM; MOLECULAR GENETICS; PHOSPHORYLATION; PROTEIN PROCESSING; TUMOR CELL LINE;

AMINO ACID SEQUENCE; CARCINOGENESIS; CELL LINE, TUMOR; CELL MOVEMENT; ENDOSOMAL SORTING COMPLEXES REQUIRED FOR TRANSPORT; HEK293 CELLS; HELA CELLS; HUMANS; MCF-7 CELLS; MOLECULAR SEQUENCE DATA; PHOSPHORYLATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTO-ONCOGENE PROTEINS C-AKT; PTEN PHOSPHOHYDROLASE; SIGNAL TRANSDUCTION; SKP CULLIN F-BOX PROTEIN LIGASES; TRANSFECTION; UBIQUITIN-PROTEIN LIGASES; UBIQUITINATION;

EID: 84897405021     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.1675     Document Type: Article

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