The telomere lengthening conundrum - Artifact or biology?

Nucleic Acids Research

Volumn 41, Issue 13, 2013, Pages

  Steenstrup, Troels ^a,b   Hjelmborg, Jacob V B ^a,b   Kark, Jeremy D ^c   Christensen, Kaare ^a,b   Aviv, Abraham ^d  

^a UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

^b ODENSE UNIVERSITY HOSPITAL   (Denmark)

^c HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^d University of Medicine and Dentistry of New Jersey Medical School   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACCURACY; AGE; ARTICLE; ARTIFACT; FOLLOW UP; INTERMETHOD COMPARISON; LEUKOCYTE; LEUKOCYTE TELOMERE LENGTH; LONGITUDINAL STUDY; MEASUREMENT ERROR; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SOUTHERN BLOTTING; TELOMERE HOMEOSTASIS;

ARTIFACTS; BLOTTING, SOUTHERN; HUMANS; LEUKOCYTES; POLYMERASE CHAIN REACTION; TELOMERE HOMEOSTASIS;

EID: 84880518638     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gkt370     Document Type: Article

References (22)

1. Gardner, J.P., Li, S., Srinivasan, S.R., Chen, W., Kimura, M., Lu, X., Berenson, G.S. and Aviv, A. (2005) Rise in insulin resistance is associated with escalated telomere attrition. Circulation, 111, 2171-2177. (Pubitemid 40632431)
2. Aviv, A., Chen, W., Gardner, J.P., Kimura, M., Brimacombe, M., Cao, X., Srinivasan, S.R. and Berenson, G.S. (2009) Leukocyte telomere dynamics: longitudinal findings among young adults in the Bogalusa Heart Study. Am. J. Epidemiol., 69, 323-329.
3. Martin-Ruiz, C.M., Gussekloo, J., van Heemst, D., von Zglinicki, T. and Westendorp, R.G. (2005) Telomere length in white blood cells is not associated with morbidity or mortality in the oldest old: a population-based study. Aging Cell, 4, 287-290.
4. Ehrlenbach, S., Willeit, P., Kiechl, S., Willeit, J., Reindl, M., Schanda, K., Kronenberg, F. and Brandstatter, A. (2009) Influences on the reduction of relative telomere length over 10 years in the population-based Bruneck Study: introduction of a well-controlled high-throughput assay. Int. J. Epidemiol., 38, 1725-1734.
5. Nordfjall, K., Svenson, U., Norrback, K.F., Adolfsson, R., Lenner, P. and Roos, G. (2009) The individual blood cell telomere attrition rate is telomere length dependent. PLoS Genet., 5, e1000375.
6. Epel, E.S., Merkin, S.S., Cawthon, R., Blackburn, E.H., Adler, N.E., Pletcher, M.J. and Seeman, T.E. (2009) The rate of leukocyte telomere shortening predicts mortality from cardiovascular disease in elderly men. Aging, 1, 81-88.
7. Farzaneh-Far, R., Lin, J., Epel, E., Lapham, K., Blackburn, E. and Whooley, M.A. (2010) Telomere length trajectory and its determinants in persons with coronary artery disease: longitudinal findings from the heart and soul study. PLoS One, 5, e8612.
8. Chen, W., Kimura, M., Kim, S., Cao, X., Srinivasan, S.R., Berenson, G.S., Kark, J.D. and Aviv, A. (2011) Longitudinal versus cross-sectional evaluations of leukocyte telomere length dynamics: age-dependent telomere shortening is the rule. Gerontol. A Biol. Sci. Med. Sci., 66, 312-319.
9. Svenson, U., Nordfjall, K., Baird, D., Roger, L., Osterman, P., Hellenius, M.L. and Roos, G. (2011) Blood cell telomere length is a dynamic feature. PLoS One, 6, e21485.
10. Kark, J.D., Goldberger, N., Kimura, M., Sinnreich, R. and Aviv, A. (2012) Energy intake and leukocyte telomere length in young adults. Am. J. Clin. Nutr., 95, 479-487.
11. Shalev, I., Moffitt, T.E., Sugden, K., Williams, B., Houts, R.M., Danese, A., Mill, J., Arseneault, L. and Caspi, A. (2012) Exposure to violence during childhood is associated with telomere erosion from 5 to 10 years of age: a longitudinal study. Mol. Psychiatry, Apr 24 (doi: 10.1038/mp.2012.32; epub ahead of print).
12. Steenstrup, T., Hjelmborg, J.V., Mortensen, L.H., Kimura, M., Christensen, K. and Aviv, A. (2013) Leukocyte telomere dynamics in the elderly. Eur J Epidemiol., 28, 181-187.
13. Kirkwood, T.B. (2012) Commentary: ageing-what's all the noise about? Developments after gartner. Int. J. Epidemiol., 41, 351-352.
14. Kimura, M., Gazitt, Y., Cao, X., Zhao, X., Lansdorp, P.M. and Aviv, A. (2010) Synchrony of telomere length among hematopoietic cells. Exp. Hematol., 38, 854-859.
15. Frenck, R.W. Jr, Blackburn, E.H. and Shannon, K.M. (1998) The rate of telomere sequence loss in human leukocytes varies with age. Proc. Natl Acad. Sci. USA., 95, 5607-5610. (Pubitemid 28224142)
16. Nordfjall, K., Larefalk, A., Lindgren, P., Holmberg, D. and Roos, G. (2005) Telomere length and heredity: indications of paternal inheritance. Proc. Natl Acad. Sci. USA., 102, 16374-1678.
17. Aviv, A., Valdes, A.M. and Spector, T.D. (2005) Human telomere biology: pitfalls of moving from the laboratory to epidemiology. Int. J. Epidemiol., 35, 1424-1429. (Pubitemid 46178916)
18. Rufer, N., Brummendorf, T.H., Kolvraa, S., Bischoff, C., Christensen, K., Wadsworth, L., Schulzer, M. and Lansdorp, P.M. (1999) Telomere fluorescence measurements in granulocytes and T lymphocyte subsets point to a high turnover of hematopoietic stem cells and memory T cells in early childhood. J. Exp. Med., 190, 157-167. (Pubitemid 29354909)
19. Aubert, G., Baerlocher, G.M., Vulto, I., Poon, S.S. and Lansdorp, P.M. (2012) Collapse of telomere homeostasis in hematopoietic cells caused by heterozygous mutations in telomerase genes. PLoS Genet., 8, e1002696.
20. Aviv, A. (2008) The epidemiology of human telomeres: faults and promises. J. Gerontol. A Biol. Sci. Med. Sci., 63, 979-983.
21. Aviv, A., Hunt, S.C., Lin, J., Cao, X., Kimura, M. and Blackburn, E. (2011) Impartial comparative analysis of measurement of leukocyte telomere length/DNA content by Southern blots and qPCR. Nucleic Acids Res., 39, e134.
22. Needham, T. (1993) A visual explanation of Jensen's inequality. Am. Math. Mon., 100, 768-771.