Fluid-attenuated inversion recovery hyperintensity correlates with matrix metalloproteinase-9 level and hemorrhagic transformation in acute ischemic stroke

Stroke

Volumn 45, Issue 4, 2014, Pages 1040-1045

  Jha, Ruchira ^a   Battey, Thomas W K ^a   Pham, Ly ^a   Lorenzano, Svetlana ^b   Furie, Karen L ^c   Sheth, Kevin N ^d   Kimberly, W Taylor ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

^c BROWN UNIVERSITY   (United States)

^d YALE NEW HAVEN HOSPITAL   (United States)

Author keywords

Brain edema; Brain ischemia; Hemorrhage; Magnetic resonance imaging; Matrix metalloproteinases; Stroke

Indexed keywords

GELATINASE A; GELATINASE B; TISSUE PLASMINOGEN ACTIVATOR;

ADULT; AGED; ARTICLE; BLOOD BRAIN BARRIER; BRAIN HEMORRHAGE; BRAIN ISCHEMIA; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; DIAGNOSTIC TEST ACCURACY STUDY; DIFFUSION WEIGHTED IMAGING; ENZYME BLOOD LEVEL; FEMALE; FIBRINOLYTIC THERAPY; FLUID ATTENUATED INVERSION RECOVERY HYPERINTENSITY; FOLLOW UP; GOLD STANDARD; HEMISPHERE; HEMORRHAGIC TRANSFORMATION; HUMAN; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; NATIONAL INSTITUTES OF HEALTH STROKE SCALE; NERVOUS SYSTEM PARAMETERS; NEUROIMAGING; NUCLEAR MAGNETIC RESONANCE IMAGING; PREDICTIVE VALUE; PRIORITY JOURNAL; PROSPECTIVE STUDY; RECEIVER OPERATING CHARACTERISTIC; RISK FACTOR; SENSITIVITY AND SPECIFICITY; VERY ELDERLY;

BRAIN EDEMA; BRAIN ISCHEMIA; HEMORRHAGE; MAGNETIC RESONANCE IMAGING; MATRIX METALLOPROTEINASES; STROKE;

AGED; AGED, 80 AND OVER; BLOOD-BRAIN BARRIER; BRAIN EDEMA; BRAIN ISCHEMIA; CEREBRAL HEMORRHAGE; FEMALE; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; MATRIX METALLOPROTEINASE 9; MIDDLE AGED; MULTIVARIATE ANALYSIS; PREDICTIVE VALUE OF TESTS; PROSPECTIVE STUDIES; RISK FACTORS; STROKE;

EID: 84897396107     PISSN: 00392499     EISSN: 15244628     Source Type: Journal    
DOI: 10.1161/STROKEAHA.113.004627     Document Type: Article

References (33)

1. Cho AH, Kim JS, Kim SJ, Yun SC, Choi CG, Kim HR, et al. Focal fluid-Attenuated inversion recovery hyperintensity within acute diffusion-weighted imaging lesions is associated with symptomatic intracerebral hemorrhage after thrombolysis. Stroke. 2008;39:3424-3426.
2. Chung JW, Kim KJ, Noh WY, Jang MS, Yang MH, Han MK, et al. Validation of FLAIR hyperintense lesions as imaging biomarkers to predict the outcome of acute stroke after intra-Arterial thrombolysis following intravenous tissue plasminogen activator. Cerebrovasc Dis. 2013;35:461-468.
3. Kufner A, Galinovic I, Brunecker P, Cheng B, Thomalla G, Gerloff C, et al. Early infarct FLAIR hyperintensity is associated with increased hemorrhagic transformation after thrombolysis. Eur J Neurol. 2013;20:281-285.
4. Campbell BC, Costello C, Christensen S, Ebinger M, Parsons MW, Desmond PM, et al EPITHET-DEFUSE Investigators. Fluid-Attenuated inversion recovery hyperintensity in acute ischemic stroke may not predict hemorrhagic transformation. Cerebrovasc Dis. 2011;32:401-405.
5. Ayata C, Ropper AH. Ischaemic brain oedema. J Clin Neurosci. 2002;9:113-124.
6. Lapchak PA, Chapman DF, Zivin JA. Metalloproteinase inhibition reduces thrombolytic (tissue plasminogen activator)-induced hemorrhage after thromboembolic stroke. Stroke. 2000;31:3034-3040.
7. Wang X, Tsuji K, Lee SR, Ning M, Furie KL, Buchan AM, et al. Mechanisms of hemorrhagic transformation after tissue plasminogen activator reperfusion therapy for ischemic stroke. Stroke. 2004;35(11 suppl 1):2726-2730.
8. Ning M, Furie KL, Koroshetz WJ, Lee H, Barron M, Lederer M, et al. Association between tPA therapy and raised early matrix metalloproteinase-9 in acute stroke. Neurology. 2006;66:1550-1555.
9. Inzitari D, Giusti B, Nencini P, Gori AM, Nesi M, Palumbo V, et al MAGIC Study Group. MMP9 variation after thrombolysis is associated with hemorrhagic transformation of lesion and death. Stroke. 2013;44:2901-2903.
10. Montaner J, Alvarez-Sabín J, Molina CA, Anglés A, Abilleira S, Arenillas J, et al. Matrix metalloproteinase expression is related to hemorrhagic transformation after cardioembolic stroke. Stroke. 2001;32:2762-2767.
11. Kimberly WT, Battey TW, Pham L, Wu O, Yoo AJ, Furie KL, et al. Glyburide is associated with attenuated vasogenic edema in stroke patients. Neurocrit Care. September 26, 2013. doi:10.1007/s12028-013-9917-z.: Http://link. springer.com/article/10.1007/s12028-013-9917-z. Accessed February 24, 2014.
12. Hacke W, Kaste M, Bluhmki E, Brozman M, Dávalos A, Guidetti D, et al ECASS Investigators. Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke. N Engl J Med. 2008;359:1317-1329.
13. Schellinger PD, Jansen O, Fiebach JB, Hacke W, Sartor K. A standardized MRI stroke protocol: Comparison with CT in hyperacute intracerebral hemorrhage. Stroke. 1999;30:765-768.
14. Montaner J, Molina CA, Monasterio J, Abilleira S, Arenillas JF, Ribó M, et al. Matrix metalloproteinase-9 pretreatment level predicts intracranial hemorrhagic complications after thrombolysis in human stroke. Circulation. 2003;107:598-603.
15. Horstmann S, Kalb P, Koziol J, Gardner H, Wagner S. Profiles of matrix metalloproteinases, their inhibitors, and laminin in stroke patients: Influence of different therapies. Stroke. 2003;34:2165-2170.
16. Asahi M, Asahi K, Jung JC, del Zoppo GJ, Fini ME, Lo EH. Role for matrix metalloproteinase 9 after focal cerebral ischemia: Effects of gene knockout and enzyme inhibition with BB-94. J Cereb Blood Flow Metab. 2000;20:1681-1689.
17. Heo JH, Lucero J, Abumiya T, Koziol JA, Copeland BR, del Zoppo GJ. Matrix metalloproteinases increase very early during experimental focal cerebral ischemia. J Cereb Blood Flow Metab. 1999;19:624-633.
18. Castellanos M, Leira R, Serena J, Blanco M, Pedraza S, Castillo J, et al. Plasma cellular-fibronectin concentration predicts hemorrhagic transformation after thrombolytic therapy in acute ischemic stroke. Stroke. 2004;35:1671-1676.
19. Trouillas P, von Kummer R. Classification and pathogenesis of cerebral hemorrhages after thrombolysis in ischemic stroke. Stroke. 2006;37:556-561.
20. Lansberg MG, Albers GW, Wijman CA. Symptomatic intracerebral hemorrhage following thrombolytic therapy for acute ischemic stroke: A review of the risk factors. Cerebrovasc Dis. 2007;24:1-10.
21. Simard JM, Woo SK, Schwartzbauer GT, Gerzanich V. Sulfonylurea receptor 1 in central nervous system injury: A focused review. J Cereb Blood Flow Metab. 2012;32:1699-1717.
22. Yang Y, Rosenberg GA. Blood-brain barrier breakdown in acute and chronic cerebrovascular disease. Stroke. 2011;42:3323-3328.
23. Gröhn OH, Kettunen MI, Penttonen M, Oja JM, van Zijl PC, Kauppinen RA. Graded reduction of cerebral blood flow in rat as detected by the nuclear magnetic resonance relaxation time T2: A theoretical and experimental approach. J Cereb Blood Flow Metab. 2000;20:316-326.
24. Bottomley PA, Foster TH, Argersinger RE, Pfeifer LM. A review of normal tissue hydrogen NMR relaxation times and relaxation mechanisms from 1-100 MHz: Dependence on tissue type, NMR frequency, temperature, species, excision, and age. Med Phys. 1984;11:425-448.
25. Neumann-Haefelin T, Kastrup A, de Crespigny A, Yenari MA, Ringer T, Sun GH, et al. Serial MRI after transient focal cerebral ischemia in rats: Dynamics of tissue injury, blood-brain barrier damage, and edema formation. Stroke. 2000;31:1965-1972.
26. Singer OC, Humpich MC, Fiehler J, Albers GW, Lansberg MG, Kastrup A, et al; MR Stroke Study Group Investigators. Risk for symptomatic intracerebral hemorrhage after thrombolysis assessed by diffusion-weighted magnetic resonance imaging. Ann Neurol. 2008;63:52-60.
27. Simard JM, Geng Z, Silver FL, Sheth KN, Kimberly WT, Stern BJ, et al. Does inhibiting Sur1 complement rt-PA in cerebral ischemia? Ann N Y Acad Sci. 2012;1268:95-107.
28. Kunte H, Busch MA, Trostdorf K, Vollnberg B, Harms L, Mehta RI, et al. Hemorrhagic transformation of ischemic stroke in diabetics on sulfonylureas. Ann Neurol. 2012;72:799-806.
29. Ziegler A, Ebinger M, Fiebach JB, Audebert HJ, Leistner S. Judgment of FLAIR signal change in DWI-FLAIR mismatch determination is a challenge to clinicians. J Neurol. 2012;259:971-973.
30. Thomalla G, Rossbach P, Rosenkranz M, Siemonsen S, Krützelmann A, Fiehler J, et al. Negative fluid-Attenuated inversion recovery imaging identifies acute ischemic stroke at 3 hours or less. Ann Neurol. 2009;65:724-732.
31. Cho AH, Sohn SI, Han MK, Lee DH, Kim JS, Choi CG, et al. Safety and efficacy of MRI-based thrombolysis in unclear-onset stroke. A preliminary report. Cerebrovasc Dis. 2008;25:572-579.
32. Ebinger M, Ostwaldt AC, Galinovic I, Rozanski M, Brunecker P, Nolte CH, et al. Clinical and radiological courses do not differ between fluid-Attenuated inversion recovery-positive and negative patients with stroke after thrombolysis. Stroke. 2010;41:1823-1825.
33. Warach S, Latour LL. Evidence of reperfusion injury, exacerbated by thrombolytic therapy, in human focal brain ischemia using a novel imaging marker of early blood-brain barrier disruption. Stroke. 2004;35(11 suppl 1):2659-2661.