MMP9 variation after thrombolysis is associated with hemorrhagic transformation of lesion and death

Stroke

Volumn 44, Issue 10, 2013, Pages 2901-2903

  Inzitari, Domenico ^a   Giusti, Betti ^b   Nencini, Patrizia ^a   Gori, Anna Maria ^b   Nesi, Mascia ^a   Palumbo, Vanessa ^a   Piccardi, Benedetta ^a   Armillis, Alessandra ^b   Pracucci, Giovanni ^a   Bono, Giorgio ^c   Bovi, Paolo ^d   Consoli, Domenico ^e   Guidotti, Mario ^f   Nucera, Antonia ^g   Massaro, Francesca ^h   Micieli, Giuseppe ⁱ   Orlandi, Giovanni ^j   Perini, Francesco ^k   Tassi, Rossana ^l   Tola, Maria Rosaria ^m   Sessa, Maria ⁿ   Toni, Danilo ^o   Abbate, Rosanna ^b   more..

^a CAREGGI UNIVERSITY HOSPITAL   (Italy)

^b UNIVERSITY OF FLORENCE   (Italy)

^c UNIVERSITY OF INSUBRIA   (Italy)

^d UNIVERSITY HOSPITAL OF VERONA   (Italy)

^e G Jazzolino Hospital   (Italy)

^f VALDUCE HOSPITAL   (Italy)

^g S MARIA NUOVA HOSPITAL   (Italy)

^h MISERICORDIA E DOLCE HOSPITAL   (Italy)

ⁱ C MONDINO NATIONAL NEUROLOGICAL INSTITUTE   (Italy)

^j UNIVERSITY OF PISA   (Italy)

^k SAN BORTOLO HOSPITAL   (Italy)

^l UNIVERSITY HOSPITAL OF SIENA   (Italy)

^m UNIVERSITY HOSPITAL OF FERRARA   (Italy)

ⁿ SAN RAFFAELE HOSPITAL   (Italy)

^o SAPIENZA UNIVERSITY OF ROME   (Italy)

more..

Author keywords

Acute stroke; Metalloproteinases; Thrombolytic therapy; Treatment outcome

Indexed keywords

FIBRINOLYTIC AGENT; GELATINASE A; GELATINASE B; INTERSTITIAL COLLAGENASE; MATRILYSIN; MATRIX METALLOPROTEINASE; NEUTROPHIL COLLAGENASE; STROMELYSIN; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TISSUE INHIBITOR OF METALLOPROTEINASE 2; TISSUE INHIBITOR OF METALLOPROTEINASE 4;

AGED; ARTICLE; BLOOD CLOT LYSIS; BRAIN HEMORRHAGE; BRAIN ISCHEMIA; DEATH; FEMALE; FIBRINOLYTIC THERAPY; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; NATIONAL INSTITUTES OF HEALTH STROKE SCALE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RANKIN SCALE; TREATMENT OUTCOME;

ACUTE STROKE; METALLOPROTEINASES; THROMBOLYTIC THERAPY; TREATMENT OUTCOME;

ACUTE DISEASE; ADULT; AGED; AGED, 80 AND OVER; BRAIN ISCHEMIA; CEREBRAL HEMORRHAGE; FEMALE; FIBRINOLYTIC AGENTS; HUMANS; MALE; MATRIX METALLOPROTEINASE 9; MIDDLE AGED; STROKE; THROMBOLYTIC THERAPY; TISSUE INHIBITOR OF METALLOPROTEINASES; TISSUE PLASMINOGEN ACTIVATOR;

EID: 84888310982     PISSN: 00392499     EISSN: 15244628     Source Type: Journal    
DOI: 10.1161/STROKEAHA.113.002274     Document Type: Article

References (8)

1. Romanic AM, White RF, Arleth AJ, Ohlstein EH, Barone FC. Matrix metalloproteinase expression increases after cerebral focal ischemia in rats: inhibition of matrix metalloproteinase-9 reduces infarct size. Stroke. 1998;29:1020-1030.
2. Heo JH, Lucero J, Abumiya T, Koziol JA, Copeland BR, del Zoppo GJ. Matrix metalloproteinases increase very early during experimental focal cerebral ischemia. J Cereb Blood Flow Metab. 1999;19:624-633.
3. Jin R, Yang G, Li G. Molecular insights and therapeutic targets for bloodbrain barrier disruption in ischemic stroke: critical role of matrix metalloproteinases and tissue-type plasminogen activator. Neurobiol Dis. 2010;38:376-385.
4. Mishiro K, Ishiguro M, Suzuki Y, Tsuruma K, Shimazawa M, Hara H. A broad-spectrum matrix metalloproteinase inhibitor prevents hemorrhagic complications induced by tissue plasminogen activator in mice. Neuroscience. 2012;205:39-48.
5. Amantea D, Corasaniti MT, Mercuri NB, Bernardi G, Bagetta G. Brain regional and cellular localization of gelatinase activity in rat that have undergone transient middle cerebral artery occlusion. Neuroscience. 2008;152:8-17.
6. Wahlgren N, Ahmed N, Dàvalos A, Ford GA, Grond M, Hacke W, et al. Thrombolysis with alteplase for acute ischaemic stroke in the Safe Implementation of Thrombolysis in Stroke-Monitoring Study (SITSMOST): An observational study. Lancet. 2007;369:275-282.
7. The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group. Tissue plasminogen activator for acute ischemic stroke. N Engl J Med. 1995;333:1581-1587.
8. Ramos-Fernandez M, Bellolio MF, Stead LG. Matrix metalloproteinase- 9 as a marker for acute ischemic stroke: A systematic review. J Stroke. Cerebrovasc Dis. 2011;20:47-54.