The intergenerational effects of war on the health of children

BMC Medicine

Volumn 12, Issue 1, 2014, Pages

  Devakumar, Delan ^a   Birch, Marion ^b   Osrin, David ^a   Sondorp, Egbert ^c   Wells, Jonathan C K ^d  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b Medact   (United Kingdom)

^c ROYAL TROPICAL INSTITUTE   (Netherlands)

^d UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Children; Conflict; Developmental origins; Mental health; War

Indexed keywords

ANXIETY; ARTICLE; BOSNIA AND HERZEGOVINA; CHILD HEALTH; CONFLICT; CONGENITAL MALFORMATION; COPING BEHAVIOR; CROP PRODUCTION; DEPRESSION; DOMESTIC VIOLENCE; ENVIRONMENTAL EXPOSURE; FEEDBACK SYSTEM; FOOD SECURITY; HOSTILITY; HUMAN; LOW BIRTH WEIGHT; MALNUTRITION; MATERNAL MORTALITY; MENTAL HEALTH; MENTAL STRESS; NUTRITIONAL DEFICIENCY; PERINATAL MORTALITY; PHYSICAL VIOLENCE; POSTTRAUMATIC STRESS DISORDER; PREMATURITY; PRENATAL EXPOSURE; PROSTITUTION; PUERPERAL DEPRESSION; SEXUAL ABUSE; SEXUAL BEHAVIOR; SEXUAL VIOLENCE; SEXUALLY TRANSMITTED DISEASE; WAR; WORLD HEALTH ORGANIZATION; CHILD; CULTURAL FACTOR; FAMILY HEALTH; FAMILY SIZE; FEMALE; HUMAN RELATION; INFECTION; PSYCHOLOGY; VIOLENCE; WARFARE;

CHILD; CULTURAL CHARACTERISTICS; FAMILY CHARACTERISTICS; FAMILY HEALTH; FEMALE; HUMANS; INFECTION; INTERGENERATIONAL RELATIONS; MALNUTRITION; MATERNAL EXPOSURE; MENTAL HEALTH; VIOLENCE; WARFARE;

EID: 84897383152     PISSN: None     EISSN: 17417015     Source Type: Journal    
DOI: 10.1186/1741-7015-12-57     Document Type: Article

References (204)

1. Southall D, Carballo M. Can children be protected from the effect of war?. BMJ 1996, 313:1493. 10.1136/bmj.313.7070.1493, 2352967, 8973277.
2. Goldson E. The effect of war on children. Child Abuse Negl 1996, 20:809-819. 10.1016/0145-2134(96)00069-5, 8886465.
3. Jensen PS, Shaw JO. Children as victims of war: current knowledge and future research needs. J Am Acad Child Adolesc Psychiatry 1993, 32:697-708. 10.1097/00004583-199307000-00001, 8340288.
4. Pearn J. Children and war. J Paediatr Child Health 2003, 39:166-172. 10.1046/j.1440-1754.2003.00124.x, 12654137.
5. Levy BS. Health and peace. Croat Med J 2002, 43:114-116.
6. World Health Organization World Report on Violence and Health 2002, Available at: http://www.who.int/violence_injury_prevention/violence/world_report/en/, World Health Organization.
7. Stockholm International Peace Research Institute SIPRI Yearbook 2012 2012, Oxford: Oxford University Press, Stockholm International Peace Research Institute.
8. Southall D. Armed conflict women and girls who are pregnant, infants and children; a neglected public health challenge. What can health professionals do?. Early Hum Dev 2011, 87:735-742. 10.1016/j.earlhumdev.2011.08.020, 21945358.
9. Watchlist on Children and Armed Conflict Caught in the Middle: Mounting Violations Against Children in Nepal's Armed Conflict. 2005, Available at: http://watchlist.org/reports/pdf/nepal.report.20050120.pdf, Watchlist on Children and Armed Conflict.
10. O'Malley B. Education Under Attack. 2007, UNESCO, Available at: http://unesdoc.unesco.org/images/0018/001863/186303e.pdf.
11. Krug EG, Mercy JA, Dahlberg LL, Zwi AB. The world report on violence and health. Lancet 2002, 360:1083-1088. 10.1016/S0140-6736(02)11133-0, 12384003.
12. Bustreo F, Genovese E, Omobono E, Axelsson H, Bannon I. Improving Child Health in Post-Conflict Countries Can the World Bank Contribute?. 2005, Washington, DC: The World Bank.
13. Collier P. On the economic consequences of civil war. Oxford Econ Pap 1999, 51:168-183.
14. Chen S, Loayza NV, Reynal-Querol M. The aftermath of civil war. Post-Conflict Transitions Working Paper Number 4. 2007, Washington, DC: World Bank.
15. Wells JC. Maternal capital and the metabolic ghetto: an evolutionary perspective on the transgenerational basis of health inequalities. Am J Hum Biol 2010, 22:1-17. 10.1002/ajhb.20994, 19844897.
16. Youngson NA, Whitelaw E. Transgenerational epigenetic effects. Annu Rev Genomics Hum Genet 2008, 9:233-257. 10.1146/annurev.genom.9.081307.164445, 18767965.
17. Hackett JA, Sengupta R, Zylicz JJ, Murakami K, Lee C, Down TA, Surani MA. Germline DNA demethylation dynamics and imprint erasure through 5-hydroxymethylcytosine. Science 2013, 339:448-452. 10.1126/science.1229277, 3847602, 23223451.
18. Barker DJ, Osmond C. Infant mortality, childhood nutrition, and ischaemic heart disease in England and Wales. Lancet 1986, 327:1077-1081.
19. Barker DJ, Osmond C, Winter PD, Margetts B, Simmonds SJ. Weight in infancy and death from ischaemic heart disease. Lancet 1989, 334:577-580.
20. Watts C, Zimmerman C. Violence against women: global scope and magnitude. Lancet 2002, 359:1232-1237. 10.1016/S0140-6736(02)08221-1, 11955557.
21. Swiss S, Jennings PJ, Aryee GV, Brown GH, Jappah-Samukai RM, Kamara MS, Schaack RDH, Turay-Kanneh RS. Violence against women during the Liberian civil conflict. JAMA 1998, 279:625-629. 10.1001/jama.279.8.625, 9486762.
22. Usta J, Farver JA, Zein L. Women, war, and violence: surviving the experience. J Womens Health (Larchmt) 2008, 17:793-804.
23. Rieder M, Choonara I. Armed conflict and child health. Arch Dis Child 2012, 97:59-62. 10.1136/adc.2009.178186, 3237260, 21393303.
24. International Action Network on Small Arms Gun Violence: The Global Crisis. 2008, Available at: http://www.iansa.org/system/files/GlobalCrisis07.pdf, International Action Network on Small Arms.
25. Albuja S, Anwar A, Birkeland NM, Caterina M, Charron G, Dolores R, Fajans-Turner A, Ginnetti J, Glatz A, Grayson C, Halff K, Jennings E, Jimenez C, Khalil K, Kok F, Leikvang C, Mancini Beck K, McCallin B, Montemurro M, Perez L, Pierre N, Rothing J, Rushing EJ, Shahinian J, Sheekh NM, Schrepfer N, Spence A, Spurrell C, Tengnäs K, Walick N, et al. Global Overview 2011. People Internally Displaced by Conflict and Violence. 2012, Geneva: Norwegian Refugee Council Internal Displacement Monitoring Centre, Birkeland NM, Jennings E, Rushing EJ, Available at: http://www.internal-displacement.org/assets/publications/2012/2012-global-overview-2011-global-en.pdf.
26. Machel G. The impact of war on children. 2001, UK: C. Hurst & Co.
27. Bilukha OO, Brennan M, Anderson M. The lasting legacy of war: epidemiology of injuries from landmines and unexploded ordnance in Afghanistan, 2002-2006. Prehosp Disaster Med 2008, 23:493-499.
28. Cardozo BL, Blanton C, Zalewski T, Tor S, McDonald L, Lavelle J, Brooks R, Anderson M, Mollica R. Mental health survey among landmine survivors in Siem Reap province, Cambodia. Med Confl Surviv 2012, 28:161-181.
29. Lindsey-Curtet C, Holst-Roness FT, Anderson L. Addressing the Needs of Women Affected by Armed Conflict. 2004, Geneva: International Committee of the Red Cross (ICRC, Available at: http://www.icrc.org/eng/assets/files/other/icrc_002_0840_women_guidance.pdf.
30. Wood EJ. Variation in sexual violence during war. Polit Soc 2006, 34:307-342.
31. Marsh M, Purdin S, Navani S. Addressing sexual violence in humanitarian emergencies. Glob Public. Health 2006, 1:133-146. 10.1080/17441690600652787, 19153902.
32. Hynes M, Robertson K, Ward J, Crouse C. A determination of the prevalence of gender-based violence among conflict-affected populations in East Timor. Disasters 2004, 28:294-321. 10.1111/j.0361-3666.2004.00260.x, 15344943.
33. Women's Wellness Center and the Reproductive Health Response in Crises Consortium RHRC 2006, Prevalence of Gender-Based Violence: Preliminary Findings from a Field Assessment in Nine Villages in the Peja Region, Kosovo, Women's Wellness Center and the Reproductive Health Response in Crises Consortium.
34. Martin SL, English KT, Clark KA, Cilenti D, Kupper LL. Violence and substance use among North Carolina pregnant women. Am J Pub Health 1996, 86:991-998.
35. Flynn HA, Walton MA, Chermack ST, Cunningham RM, Marcus SM. Brief detection and co-occurrence of violence, depression and alcohol risk in prenatal care settings. Arch Womens Ment Health 2007, 10:155-161. 10.1007/s00737-007-0188-6, 17594132.
36. O'Connor MJ, Tomlinson M, LeRoux IM, Stewart J, Greco E, Rotheram-Borus MJ. Predictors of alcohol use prior to pregnancy recognition among township women in Cape Town, South Africa. Soc Sci Med 2011, 72:83-90. 10.1016/j.socscimed.2010.09.049, 3023822, 21084142.
37. World Health Organization Interpersonal Violence and Alcohol. http://www.who.int/violence_injury_prevention/violence/world_report/factsheets/pb_violencealcohol.pdf, World Health Organization.
38. Kilpatrick DG, Acierno R, Resnick HS, Saunders BE, Best CL. A 2-year longitudinal analysis of the relationships between violent assault and substance use in women. J Consult Clin Psychol 1997, 65:834-847.
39. Eaton L, Kalichman S, Sikkema K, Skinner D, Watt M, Pieterse D, Pitpitan E. Pregnancy, alcohol intake, and intimate partner violence among men and women attending drinking establishments in a Cape Town, South Africa Township. J Commun Health 2011, 37:208-216.
40. Jejeebhoy SJ. Associations between wife-beating and fetal and infant death: impressions from a survey in rural India. Stud Fam Plann 1998, 29:300-308. 10.2307/172276, 9789323.
41. Campbell JC. Health consequences of intimate partner violence. Lancet 2002, 359:1331-1336. 10.1016/S0140-6736(02)08336-8, 11965295.
42. Simic S, Idrizbegovic S, Jaganjac N, Boloban H, Puvacic J, Gallic A, Dekovic S. Nutritional effects of the siege on new-born babies in Sarajevo. Eur J Clin Nutr 1995, 49:S33-S36.
43. Gazmararian JA, Petersen R, Spitz AM, Goodwin MM, Saltzman LE, Marks JS. Violence and reproductive health: current knowledge and future research directions. Matern Child Health J 2000, 4:79-84. 10.1023/A:1009514119423, 10994575.
44. Kuvacic I, Skrablin S, Hodzic D, Milkovic G. Possible influence of expatriation on perinatal outcome. Acta Obstet Gynecol Scand 1996, 75:367-371. 10.3109/00016349609033333, 8638458.
45. Murphy CC, Schei B, Myhr TL, Du Mont J. Abuse: a risk factor for low birth weight? A systematic review and meta-analysis. CMAJ 2001, 164:1567-1572. 81110, 11402794.
46. Maman S, Campbell J, Sweat MD, Gielen AC. The intersections of HIV and violence: directions for future research and interventions. Soc Sci Med 2000, 50:459-478. 10.1016/S0277-9536(99)00270-1, 10641800.
47. Heise L, Ellsberg M, Gottemoeller M. Ending violence against women. Population Reports 1999, 13-18. Baltimore: Johns Hopkins University, School of Public Health, Population Information Program, Series L, No. 11.
48. Nowrojee B. Shattered Lives: Sexual Violence during the Rwandan Genocide and its Aftermath. 1996, New York: Human Rights Watch.
49. Kelly JT, Betancourt TS, Mukwege D, Lipton R, Vanrooyen MJ. Experiences of female survivors of sexual violence in eastern Democratic Republic of the Congo: a mixed-methods study. Confl Health 2011, 5:25. 10.1186/1752-1505-5-25, 3271036, 22047181.
50. Nelson BD, Collins L, VanRooyen MJ, Joyce N, Mukwege D, Bartels S. Impact of sexual violence on children in the Eastern Democratic Republic of Congo. Med Confl Surviv 2011, 27:211-225.
51. Mollica RF, McInnes K, Poole C, Tor S. Dose-effect relationships of trauma to symptoms of depression and post-traumatic stress disorder among Cambodian survivors of mass violence. Br J Psychiatry 1998, 173:482-488. 10.1192/bjp.173.6.482, 9926076.
52. Glaser D. Child abuse and neglect and the brain-a review. J Child Psychol Psychiatry 2000, 41:97-116. 10.1017/S0021963099004990, 10763678.
53. Villamor E, Chavarro JE, Caro LE. Growing up under generalized violence: an ecological study of homicide rates and secular trends in age at menarche in Colombia, 1940s-1980s. Econ Hum Biol 2009, 7:238-245. 10.1016/j.ehb.2009.03.002, 19395326.
54. Machel G. Impact of Armed Conflict on Children. 1996, UNICEF, Available at: http://www.unicef.org/graca/a51-306_en.pdf.
55. Morrison AR, Orlando MB, Biehl ML. Social and economic costs of domestic violence: Chile and Nicaragua. Too Close to Home: Domestic Violence in the Americas 1997, 51-80. Washington, D.C: Inter-American Development Bank, Morrison ARaB ML.
56. Sharma M, Prasain D, Hutt M. Gender dimensions of the people's war: some reflections on the experiences of rural women. Himalayan People's War: Nepal's Maoist rebellion 2004, 152-165. London: Hurst & Co.
57. Cahill L, Sherman P. Child abuse and domestic violence. Pediatr Rev 2006, 27:339-345. 10.1542/pir.27-9-339, 16950939.
58. Boothby N, Crawford J, Halperin J. Mozambique child soldier life outcome study: lessons learned in rehabilitation and reintegration efforts. Glob Public Health 2006, 1:87-107. 10.1080/17441690500324347, 19153896.
59. Otake M, Schull WJ. Radiation-related small head sizes among prenatally exposed A-bomb survivors. Int J Radiat Biol 1993, 63:255-270. 10.1080/09553009314550341, 8094424.
60. Otake M, Schull WJ. Radiation-related brain damage and growth retardation among the prenatally exposed atomic bomb survivors. Int J Radiat Biol 1998, 74:159-171. 10.1080/095530098141555, 9712546.
61. Abolghasemi H, Radfar MH, Rambod M, Salehi P, Ghofrani H, Soroush MR, Falahaty F, Tavakolifar Y, Sadaghianifar A, Khademolhosseini SM, Kavehmanesh Z, Joffres M, Burkle FM, Mills EJ. Childhood physical abnormalities following paternal exposure to sulfur mustard gas in Iran: a case-control study. Confl Health 2010, 4:13. 10.1186/1752-1505-4-13, 2917398, 20630096.
62. Alaani S, Tafash M, Busby C, Hamdan M, Blaurock-Busch E. Uranium and other contaminants in hair from the parents of children with congenital anomalies in Fallujah, Iraq. Confl Health 2011, 5:15. 10.1186/1752-1505-5-15, 3177876, 21888647.
63. Murthy RS, Lakshminarayana R. Mental health consequences of war: a brief review of research findings. World Psychiatry 2006, 5:25-30. 1472271, 16757987.
64. Somasundaram D. Child soldiers: understanding the context. BMJ 2002, 324:1268-1271. 10.1136/bmj.324.7348.1268, 1123221, 12028985.
65. Derluyn I, Broekaert E, Schuyten G, De Temmerman E. Post-traumatic stress in former Ugandan child soldiers. Lancet 2004, 363:861-863. 10.1016/S0140-6736(04)15734-6, 15031032.
66. Betancourt TS, Borisova II, Williams TP, Brennan RT, Whitfield TH, de la Soudiere M, Williamson J, Gilman SE. Sierra Leone's former child soldiers: a follow-up study of psychosocial adjustment and community reintegration. Child Dev 2010, 81:1077-1095. 10.1111/j.1467-8624.2010.01455.x, 2921972, 20636683.
67. Moscardino U, Scrimin S, Cadei F, Altoe G. Mental health among former child soldiers and never-abducted children in northern Uganda. Scientific World Journal 2012, 2012:367545. 3361175, 22654596.
68. Levy BS, Sidel VW. Health effects of combat: a life-course perspective. Annu Rev Public Health 2009, 30:123-136. 10.1146/annurev.publhealth.031308.100147, 18925871.
69. Thapa SB, Hauff E. Psychological distress among displaced persons during an armed conflict in Nepal. Soc Psychiatry Psychiatr Epidemiol 2005, 40:672-679. 10.1007/s00127-005-0943-9, 16021344.
70. de Jong JT, Komproe IH, Van Ommeren M. Common mental disorders in postconflict settings. Lancet 2003, 361:2128-2130. 10.1016/S0140-6736(03)13692-6, 12826440.
71. Seino K, Takano T, Mashal T, Hemat S, Nakamura K. Prevalence of and factors influencing posttraumatic stress disorder among mothers of children under five in Kabul, Afghanistan, after decades of armed conflicts. Health Qual Life Out 2008, 6:29.
72. Klaric M, Klaric B, Stevanovic A, Grkovic J, Jonovska S. Psychological consequences of war trauma and postwar social stressors in women in Bosnia and Herzegovina. Croat Med J 2007, 48:167-176. 2080525, 17436381.
73. de Jong JT, Komproe IH, Van Ommeren M, El Masri M, Araya M, Khaled N, van de Put W, Somasundaram D. Lifetime events and posttraumatic stress disorder in 4 postconflict settings. JAMA 2001, 286:555-562. 10.1001/jama.286.5.555, 11476657.
74. Dimitry L. A systematic review on the mental health of children and adolescents in areas of armed conflict in the Middle East. Child Care Health Dev 2012, 38:153-161. 10.1111/j.1365-2214.2011.01246.x, 21615769.
75. Ezard N, Oppenheimer E, Burton A, Schilperoord M, Macdonald D, Adelekan M, Sakarati A, van Ommeren M. Six rapid assessments of alcohol and other substance use in populations displaced by conflict. Confl Health 2011, 5:1. 10.1186/1752-1505-5-1, 3050731, 21310092.
76. Bhui K, Warfa N. Drug consumption in conflict zones in Somalia. PLoS Med 2007, 4:e354. 10.1371/journal.pmed.0040354, 2121649, 18076283.
77. Kan PR. Drugs and Contemporary Warfare 2009, Herndon, VA: Potomac Books.
78. Martz E (Ed) Trauma and Rehabilitation after War and Conflict 2010, Springer, Martz E (Ed).
79. Strathdee SA, Zafar T, Brahmbhatt H, Ul Hassan S. Higher level of needle sharing among injection drug users in Lahore, Pakistan, in the aftermath of the US-Afghan war. International Conference on AIDS 2002, Barcelona.
80. Hankins CA, Friedman SR, Zafar T, Strathdee SA. Transmission and prevention of HIV and sexually transmitted infections in war settings: implications for current and future armed conflicts. AIDS 2002, 16:2245-2252. 10.1097/00002030-200211220-00003, 12441795.
81. Bjelosevic E, Hadzikapetanovic H, Loga S, Hodzic M, Skelic D, Savarimooto B. Relation between benzodiazepine abuse and trauma. Med Arh 2003, 57:33-36.
82. Odenwald M, Neuner F, Schauer M, Elbert T, Catani C, Lingenfelder B, Hinkel H, Hafner H, Rockstroh B. Khat use as risk factor for psychotic disorders: a cross-sectional and case-control study in Somalia. BMC Med 2005, 3:5. 10.1186/1741-7015-3-5, 554104, 15707502.
83. Federenko IS, Wadhwa PD. Women's mental health during pregnancy influences fetal and infant developmental and health outcomes. CNS Spectr 2004, 9:198-206.
84. Satyanarayana VA, Lukose A, Srinivasan K. Maternal mental health in pregnancy and child behavior. Indian J Psychiatry 2011, 53:351-361. 10.4103/0019-5545.91911, 3267349, 22303046.
85. Wachs TD, Black MM, Engle PL. Maternal depression: a global threat to children's health, development, and behavior and to human rights. Child Dev Perspect 2009, 3:51-59.
86. Tegethoff M, Greene N, Olsen J, Schaffner E, Meinlschmidt G. Stress during pregnancy and offspring pediatric disease: a National Cohort Study. Environ Health Perspect 2011, 119:1647-1652. 10.1289/ehp.1003253, 3226491, 21775267.
87. Pesonen AK, Raikkonen K, Kajantie E, Heinonen K, Osmond C, Barker DJ, Forsen T, Eriksson JG. Inter-generational social mobility following early life stress. Ann Med 2011, 43:320-328. 10.3109/07853890.2010.549146, 21366512.
88. Feldman R, Vengrober A. Posttraumatic stress disorder in infants and young children exposed to war-related trauma. J Am Acad Child Adolesc Psychiatr 2011, 50:645-658.
89. Siegmund A, Dahlhoff M, Habersetzer U, Mederer A, Wolf E, Holsboer F, Wotjak CT. Maternal inexperience as a risk factor of innate fear and PTSD-like symptoms in mice. J Psychiatr Res 2009, 43:1156-1165. 10.1016/j.jpsychires.2009.02.003, 19304295.
90. Seckl JR, Meaney MJ. Glucocorticoid " Programming" and PTSD Risk. Ann N Y Acad Sci 2006, 1071:351-378. 10.1196/annals.1364.027, 16891583.
91. Radtke KM, Ruf M, Gunter HM, Dohrmann K, Schauer M, Meyer A, Elbert T. Transgenerational impact of intimate partner violence on methylation in the promoter of the glucocorticoid receptor. Transl Psychiatry 2011, 1:e21. 10.1038/tp.2011.21, 3309516, 22832523.
92. Dekel R, Goldblatt H. Is there intergenerational transmission of trauma? The case of combat veterans' children. Am J Orthopsychiatry 2008, 78:281-289.
93. Betancourt TS, Khan KT. The mental health of children affected by armed conflict: protective processes and pathways to resilience. Int Rev Psychiatry 2008, 20:317-328. 10.1080/09540260802090363, 2613765, 18569183.
94. Chu AT, Lieberman AF. Clinical implications of traumatic stress from birth to age five. Annu Rev Clin Psychol 2010, 6:469-494. 10.1146/annurev.clinpsy.121208.131204, 20192799.
95. Australian Institute of Health and Welfare Morbidity of Vietnam Veterans. Suicide in Vietnam Veterans' Children, Supplementary Report 1. 2000, Canberra: Australian Institute of Health and Welfare, 1, Australian Institute of Health and Welfare.
96. Kellerman NP. Psychopathology in children of Holocaust survivors: a review of the research literature. Isr J Psychiatry Relat Sci 2001, 38:36-46.
97. Yehuda R, Bell A, Bierer LM, Schmeidler J. Maternal, not paternal, PTSD is related to increased risk for PTSD in offspring of Holocaust survivors. J Psychiatr Res 2008, 42:1104-1111. 10.1016/j.jpsychires.2008.01.002, 2612639, 18281061.
98. Scharf M, Mayseless O. Disorganizing experiences in second- and third-generation holocaust survivors. Qual Health Res 2011, 21:1539-1553. 10.1177/1049732310393747, 21189333.
99. Gangi S, Talamo A, Ferracuti S. The long-term effects of extreme war-related trauma on the second generation of Holocaust survivors. Violence Vict 2009, 24:687-700. 10.1891/0886-6708.24.5.687, 19852407.
100. Summerfield D. The psychological legacy of war and atrocity: the question of long-term and transgenerational effects and the need for a broad view. J Nerv Ment Dis 1996, 184:375-377. 10.1097/00005053-199606000-00008, 8642388.
101. Scharf M. Long-term effects of trauma: psychosocial functioning of the second and third generation of Holocaust survivors. Dev Psychopathol 2007, 19:603-622.
102. Patel V, Rahman A, Jacob KS, Hughes M. Effect of maternal mental health on infant growth in low income countries: new evidence from South Asia. BMJ 2004, 328:820-823. 10.1136/bmj.328.7443.820, 383383, 15070641.
103. Galler JR, Harrison RH, Biggs MA, Ramsey F, Forde V. Maternal moods predict breastfeeding in Barbados. J Dev Behav Pediatr 1999, 20:80-87. 10.1097/00004703-199904000-00002, 10219685.
104. Falceto OG, Giugliani ER, Fernandes CL. Influence of parental mental health on early termination of breast-feeding: a case-control study. J Am Board Fam Pract 2004, 17:173-183. 10.3122/jabfm.17.3.173, 15226281.
105. Murray L, Cooper P. Effects of postnatal depression on infant development. Arch Dis Child 1997, 77:99-101. 10.1136/adc.77.2.99, 1717268, 9301345.
106. Patel V, DeSouza N, Rodrigues M. Postnatal depression and infant growth and development in low income countries: a cohort study from Goa, India. Arch Dis Child 2003, 88:34-37. 10.1136/adc.88.1.34, 1719257, 12495957.
107. Galler JR, Harrison RH, Ramsey F, Forde V, Butler SC. Maternal depressive symptoms affect infant cognitive development in Barbados. J Child Psychol Psychiatry 2000, 41:747-757. 10.1111/1469-7610.00662, 11039687.
108. Galler JR, Ramsey FC, Harrison RH, Taylor J, Cumberbatch G, Forde V. Postpartum maternal moods and infant size predict performance on a national high school entrance examination. J Child Psychol Psychiatry 2004, 45:1064-1075. 10.1111/j.1469-7610.2004.t01-1-00299.x, 15257663.
109. Osborn DA, Jeffery HE, Cole MJ. Opiate treatment for opiate withdrawal in newborn infants. Cochrane Database Syst Rev 2010, (10). CD002059.
110. Shankaran S, Lester BM, Das A, Bauer CR, Bada HS, Lagasse L, Higgins R. Impact of maternal substance use during pregnancy on childhood outcome. Semin Fetal Neonatal Med 2007, 12:143-150. 10.1016/j.siny.2007.01.002, 3717561, 17317350.
111. Mwenda JM, Arimi MM, Kyama MC, Langat DK. Effects of khat (Catha edulis) consumption on reproductive functions: a review. East Afr Med J 2003, 80:318-323.
112. Strand RT, Fernandes Dias L, Bergstrom S, Andersson S. Unexpected low prevalence of HIV among fertile women in Luanda, Angola. Does war prevent the spread of HIV?. Int J STD AIDS 2007, 18:467-471. 10.1258/095646207781147300, 17623504.
113. Guerin PJ, Brasher C, Baron E, Mic D, Grimont F, Ryan M, Aavitsland P, Legros D. Shigella dysenteriae serotype 1 in west Africa: intervention strategy for an outbreak in Sierra Leone. Lancet 2003, 362:705-706. 10.1016/S0140-6736(03)14227-4, 12957094.
114. Griffith DC, Kelly-Hope LA, Miller MA. Review of reported cholera outbreaks worldwide, 1995-2005. Am J Trop Med Hyg 2006, 75:973-977.
115. Gayer M, Legros D, Formenty P, Connolly MA. Conflict and emerging infectious diseases. Emer Infect Dis 2007, 13:1625-1631.
116. United Nations High Commissioner for Refugees. [http://www.unhcr.org/].
117. Shears P, Berry AM, Murphy R, Nabil MA. Epidemiological assessment of the health and nutrition of Ethiopian refugees in emergency camps in Sudan, 1985. Med J (Clin Res Ed) 1987, 295:314-318.
118. Brewer IW. The control of communicable diseases in camps. Am J Pub Health 1918, 8:121-124.
119. Connolly MA, Heymann DL. Deadly comrades: war and infectious diseases. Lancet 2002, 360:s23-s24.
120. Fair J, Jentes E, Inapogui A, Kourouma K, Goba A, Bah A, Tounkara M, Coulibaly M, Garry RF, Bausch DG. Lassa virus-infected rodents in refugee camps in Guinea: a looming threat to public health in a politically unstable region. Vector Borne Zoonotic Dis 2007, 7:167-171. 10.1089/vbz.2006.0581, 17627434.
121. Bonner PC, Schmidt WP, Belmain SR, Oshin B, Baglole D, Borchert M. Poor housing quality increases risk of rodent infestation and Lassa fever in refugee camps of Sierra Leone. Am J Trop Med Hyg 2007, 77:169-175.
122. Rowland M, Rab MA, Freeman T, Durrani N, Rehman N. Afghan refugees and the temporal and spatial distribution of malaria in Pakistan. Soc Sci Med 2002, 55:2061-2072. 10.1016/S0277-9536(01)00341-0, 12406471.
123. Singh S, Bohler E, Dahal K, Mills E. The state of child health and human rights in Nepal. PLoS Med 2006, 3:e203. 10.1371/journal.pmed.0030203, 1483907, 16792433.
124. Health care in danger. http://www.icrc.org/eng/what-we-do/safeguarding-health-care/index.jsp.
125. Mann J, Drucker E, Tarantola D. Bosnia: the war against public health. Med Global Survival 1994, 1:130-144.
126. Nathanson V. Delivering healthcare in situations of conflict or violence. BMJ 2011, 343:d4671. 10.1136/bmj.d4671, 21831934.
127. ICRC Iraq: Civilians without Protection: the Ever-Worsening Humanitarian Crisis. 2007, Available at: http://www.icrc.org/eng/assets/files/other/iraq-report-icrc.pdf, ICRC.
128. Msuya C, Sondorp E. Interagency Health Evaluation Liberia. 2005, Available at: http://www.alnap.org/resource/3392.aspx.
129. De Schryver A, Meheus A. Epidemiology of sexually transmitted diseases: the global picture. Bull World Health Organ 1990, 68:639-654. 2393188, 2289300.
130. Ward J, Vann B. Gender-based violence in refugee settings. Lancet 2002, 360:s13-s14.
131. Kinyanda E, Weiss HA, Mungherera M, Onyango-Mangen P, Ngabirano E, Kajungu R, Kagugube J, Muhwezi W, Muron J, Patel V. Psychiatric disorders and psychosocial correlates of high HIV risk sexual behaviour in war-affected Eastern Uganda. AIDS Care 2012, 24:1323-1332. 10.1080/09540121.2011.647676, 22272693.
132. Cossa HA, Gloyd S, Vaz RG, Folgosa E, Simbine E, Diniz M, Kreiss JK. Syphilis and HIV infection among displaced pregnant women in rural Mozambique. Int J STD AIDS 1994, 5:117-123.
133. Civilians in war zones; women and children worst. Economist 2009, Available at: http://www.economist.com/node/13145799.
134. Oxford JS, Sefton A, Jackson R, Innes W, Daniels RS, Johnson NP. World War I may have allowed the emergence of " Spanish" influenza. Lancet Infect Dis 2002, 2:111-114. 10.1016/S1473-3099(02)00185-8, 11901642.
135. Erkoreka A. Origins of the Spanish Influenza pandemic (1918-1920) and its relation to the First World War. J Mol Genet Med 2009, 3:190-194. 2805838, 20076789.
136. Mazumder B, Almond D, Park K, Crimmins EM, Finch CE. Lingering prenatal effects of the 1918 influenza pandemic on cardiovascular disease. J Dev Orig Health Dis 2010, 1:26-34. 10.1017/S2040174409990031, 2826837, 20198106.
137. Almond D. Is the 1918 influenza pandemic over? Long-term effects of in utero influenza exposure in the post-1940 U.S. population. J Polit Econ 2006 1918, 114:672-712.
138. Novo A, Huebschen JM, Muller CP, Tesanovic M, Bojanic J. Ongoing rubella outbreak in Bosnia and Herzegovina, March-July 2009--preliminary report. Euro Surveill 2009, 14. pii: 19343.
139. Saigal S, Doyle LW. An overview of mortality and sequelae of preterm birth from infancy to adulthood. Lancet 2008, 371:261-269. 10.1016/S0140-6736(08)60136-1, 18207020.
140. Le Doare K, Bland R, Newell ML. Neurodevelopment in children born to HIV-infected mothers by infection and treatment status. Pediatrics 2012, 130:e1326-e1344. 10.1542/peds.2012-0405, 23118140.
141. Fernando D, Wickremasinghe R, Mendis KN, Wickremasinghe AR. Cognitive performance at school entry of children living in malaria-endemic areas of Sri Lanka. Trans R Soc Trop Med Hyg 2003, 97:161-165. 10.1016/S0035-9203(03)90107-6, 14584369.
142. Clarke SE, Jukes MC, Njagi JK, Khasakhala L, Cundill B, Otido J, Crudder C, Estambale BB, Brooker S. Effect of intermittent preventive treatment of malaria on health and education in schoolchildren: a cluster-randomised, double-blind, placebo-controlled trial. Lancet 2008, 372:127-138. 10.1016/S0140-6736(08)61034-X, 2495044, 18620950.
143. Kihara M, Carter JA, Newton CR. The effect of Plasmodium falciparum on cognition: a systematic review. Trop Med Int Health 2006, 11:386-397. 10.1111/j.1365-3156.2006.01579.x, 16553922.
144. Simetka O, Reilley B, Joseph M, Collie M, Leidinger J. Obstetrics during civil war: six months on a maternity ward in Mallavi, northern Sri Lanka. Med Confl Surviv 2002, 18:258-270.
145. Childbirth at checkpoints in the occupied Palestinian territory. Abstract available at: http://download.thelancet.com/flatcontentassets/pdfs/palestine/palestine2011-4.pdf.
146. Hudic I, Radoncic F, Fatusic Z. Incidence and causes of maternal death during 20-year period (1986-2005) in Tuzla Canton, Bosnia and Herzegovina. J Matern Fetal Neonatal Med 2011, 24:1286-1288. 10.3109/14767058.2011.557105, 21417593.
147. Strong MA. The health of adults in the developing world: the view from Bangladesh. Health Transit Rev 1992, 2:215-224.
148. Anderson FW, Morton SU, Naik S, Gebrian B. Maternal mortality and the consequences on infant and child survival in rural Haiti. Matern Child Health J 2007, 11:395-401. 10.1007/s10995-006-0173-0, 17265193.
149. Complex Emergency Database. [http://www.cedat.be/].
150. World Health Organization Public Health Risk Assessment and Interventions. The Horn of Africa: Drought and Famine Crisis 2011, Geneva, World Health Organization.
151. Egal F. Nutrition in conflict situations. Br J Nutr 2006, 96:S17-19. 10.1079/BJN20061692, 16923242.
152. Hendrie B. Relief aid behind the lines: the cross-border operation in Tigray. War and Hunger Rethinking International Responses to Complex Emergencies 1994, 125-139. London: Zed Books, Macrae J, Zwi A, Duffield M, Slim M.
153. Baten J, Wagner A. Autarchy, market disintegration, and health: the mortality and nutritional crisis in Nazi Germany, 1933-1937. Econ Hum Biol 2002, 1:1-28.
154. Ali MM, Shah IH. Sanctions and childhood mortality in Iraq. Lancet 2000, 355:1851-1857. 10.1016/S0140-6736(00)02289-3, 10866440.
155. Zakanj Z, Armano G, Grguric J, Herceg-Cavrak V. Influence of 1991-1995 war on breast-feeding in Croatia: questionnaire study. Croat Med J 2000, 41:186-190.
156. Jakobsen M, Sodemann M, Nylen G, Bale C, Nielsen J, Lisse I, Aaby P. Breastfeeding status as a predictor of mortality among refugee children in an emergency situation in Guinea-Bissau. Trop Med Int Health 2003, 8:992-996. 10.1046/j.1360-2276.2003.01122.x, 14629765.
157. Andersson N, Paredes-Solis S, Legorreta-Soberanis J, Cockcroft A, Sherr L. Breast-feeding in a complex emergency: four linked cross-sectional studies during the Bosnian conflict. Public Health Rep 2010, 13:2097-2104.
158. Victora CG, Adair L, Fall C, Hallal PC, Martorell R, Richter L, Sachdev HS. Maternal and child undernutrition: consequences for adult health and human capital. Lancet 2008, 371:340-357. 10.1016/S0140-6736(07)61692-4, 2258311, 18206223.
159. Cheung E, Mutahar R, Assefa F, Ververs MT, Nasiri SM, Borrel A, Salama P. An epidemic of scurvy in Afghanistan: assessment and response. Food Nutr Bull 2003, 24:247-255.
160. Seal AJ, Creeke PI, Dibari F, Cheung E, Kyroussis E, Semedo P, van den Briel T. Low and deficient niacin status and pellagra are endemic in postwar Angola. Am J Clin Nutr 2007, 85:218-224.
161. Lumey LH. Decreased birthweights in infants after maternal in utero exposure to the Dutch famine of 1944-1945. Paediatr Perinat Epidemiol 1992, 6:240-253. 10.1111/j.1365-3016.1992.tb00764.x, 1584725.
162. Brialic I, Rodin U, Vrdoljak J, Plavec D, Capkun V. Secular birth weight changes in liveborn infants before, during, and after 1991-1995 homeland war in Croatia. Croat Med J 2006, 47:452-458. 2080423, 16758524.
163. Hogue CJ, Buehler JW, Strauss LT, Smith JC. Overview of the national infant mortality surveillance (NIMS) project-design, methods, results. Public Health Rep 1987, 102:126-138. 1477827, 3104969.
164. Pena-Rosas JP, Viteri FE. Effects and safety of preventive oral iron or iron+folic acid supplementation for women during pregnancy. Cochrane Database Syst Rev 2009, 4. CD004736.
165. De-Regil LM, Fernandez-Gaxiola AC, Dowswell T, Pena-Rosas JP. Effects and safety of periconceptional folate supplementation for preventing birth defects. Cochrane Database Syst Rev 2010, 10. CD007950.
166. Wells JC, Chomtho S, Fewtrell MS. Programming of body composition by early growth and nutrition. Proc Nutr Soc 2007, 66:423-434. 10.1017/S0029665107005691, 17637095.
167. Gudmundsson S, Henningsson AC, Lindqvist P. Correlation of birth injury with maternal height and birthweight. BJOG 2005, 112:764-767. 10.1111/j.1471-0528.2004.00545.x, 15924534.
168. Moses RG, Mackay MT. Gestational diabetes: is there a relationship between leg length and glucose tolerance?. Diab Care 2004, 27:1033-1035.
169. Myklestad K, Vatten LJ, Magnussen EB, Salvesen KA, Romundstad PR. Do parental heights influence pregnancy length? A population-based prospective study, HUNT 2. BMC Pregnancy Childbirth 2013, 13:33. 10.1186/1471-2393-13-33, 3608172, 23383756.
170. Clarkin PF. Adiposity and height of adult Hmong refugees: relationship with war-related early malnutrition and later migration. Am J Hum Biol 2008, 20:174-184. 10.1002/ajhb.20711, 18172871.
171. Fishman SM, Caulfield L, de Onis M. Childhood and maternal underweight. Comparative Quantification of Health Risks: Global and Regional Burden of Disease Attributable to Selected Major Risk Factors 2004, 39-161. Geneva: World Health Organization, Ezzati M, Lopez AD, Rodgers A, Murray CLJ.
172. Maternal anthropometry and pregnancy outcomes. A WHO collaborative study. Bull World Health Organ 1995, 73:1-98. 2486652, 20604475.
173. Horta BL, Gigante DP, Osmond C, Barros FC, Victora CG. Intergenerational effect of weight gain in childhood on offspring birthweight. Int J Epidemiol 2009, 38:724-732. 10.1093/ije/dyp168, 2689398, 19376883.
174. Greenfeld C, Flaws JA. Renewed debate over postnatal oogenesis in the mammalian ovary. BioEssays 2004, 26:829-832. 10.1002/bies.20094, 15273985.
175. Bukovsky A, Caudle MR, Svetlikova M, Wimalasena J, Ayala ME, Dominguez R. Oogenesis in adult mammals, including humans: a review. Endocrine 2005, 26:301-316. 10.1385/ENDO:26:3:301, 16034186.
176. Ravelli G-P, Stein ZA, Susser MW. Obesity in young men after famine exposure in utero and early infancy. N Engl J Med 1976, 295:349-353. 10.1056/NEJM197608122950701, 934222.
177. Roseboom TJ, van der Meulen JH, Ravelli AC, Osmond C, Barker DJ, Bleker OP. Effects of prenatal exposure to the Dutch famine on adult disease in later life: an overview. Mol Cell Endocrinol 2001, 185:93-98. 10.1016/S0303-7207(01)00721-3, 11738798.
178. Stein AD, Zybert PA, van der Pal-de Bruin K, Lumey LH. Exposure to famine during gestation, size at birth, and blood pressure at age 59 Y: evidence from the Dutch famine. Eur J Epidemiol 2006, 21:759-765. 10.1007/s10654-006-9065-2, 17082900.
179. Ravelli AC, van Der Meulen JH, Osmond C, Barker DJ, Bleker OP. Obesity at the age of 50 y in men and women exposed to famine prenatally. Am J Clin Nutr 1999, 70:811-816.
180. Stein AD, Kahn HS, Rundle A, Zybert PA, van der Pal-de Bruin K, Lumey LH. Anthropometric measures in middle age after exposure to famine during gestation: evidence from the Dutch famine. Am J Clin Nutr 2007, 85:869-876.
181. Stein AD, Lumey LH. The relationship between maternal and offspring birth weights after maternal prenatal famine exposure: the Dutch famine birth cohort study. Hum Biol 2000, 72:641-654.
182. Hult M, Tornhammar P, Ueda P, Chima C, Edstedt Bonamy AK, Ozumba B, Norman M. Hypertension, diabetes and overweight: looming legacies of the Biafran famine. PloS One 2010, 5:e13582. 10.1371/journal.pone.0013582, 2962634, 21042579.
183. Zheng X, Wang Y, Ren W, Luo R, Zhang S, Zhang JH, Zeng Q. Risk of metabolic syndrome in adults exposed to the great Chinese famine during the fetal life and early childhood. Eur J Clin Nutr 2012, 66:231-236. 10.1038/ejcn.2011.161, 21970943.
184. Yang Z, Zhao W, Zhang X, Mu R, Zhai Y, Kong L, Chen C. Impact of famine during pregnancy and infancy on health in adulthood. Obes Rev 2008, 9:95-99. 10.1111/j.1467-789X.2007.00447.x, 18307708.
185. Li Y, Jaddoe VW, Qi L, He Y, Wang D, Lai J, Zhang J, Fu P, Yang X, Hu FB. Exposure to the Chinese famine in early life and the risk of metabolic syndrome in adulthood. Diab Care 2011, 34:1014-1018.
186. Huang C, Li Z, Wang M, Martorell R. Early life exposure to the 1959-1961 Chinese famine has long-term health consequences. J Nutr 2010, 140:1874-1878. 10.3945/jn.110.121293, 20702751.
187. St Clair D, Xu M, Wang P, Yu Y, Fang Y, Zhang F, Zheng X, Gu N, Feng G, Sham P, He L. Rates of adult schizophrenia following prenatal exposure to the Chinese famine of 1959-1961. JAMA 2005, 294:557-562. 10.1001/jama.294.5.557, 16077049.
188. Xu MQ, Sun WS, Liu BX, Feng GY, Yu L, Yang L, He G, Sham P, Susser E, St Clair D, He L. Prenatal malnutrition and adult schizophrenia: further evidence from the 1959-1961 Chinese famine. Schizophr Bull 2009, 35:568-576. 10.1093/schbul/sbn168, 2669578, 19155344.
189. Westing AH. Warfare in a fragile world: military impacts on the human environment. 1980, London: Taylor and Francis.
190. World Health Organization Dioxins and their effects on human health. Fact Sheet No 225, May 2010. Available at: http://www.who.int/mediacentre/factsheets/fs225/en/, World Health Organization.
191. Martin M. Vietnamese victims of Agent Orange and US-Vietnam relations. 2009, Congressional Research Service 7-5700 CRS Report for Congress May 28 2009 (re level of Agent Orange used).
192. United Nations Convention on the Rights of the Child. Available at: [http://www.unicef.org/crc].
193. Osmani S, Sen A. The hidden penalties of gender inequality: fetal origins of ill-health. Econ Hum Biol 2003, 1:105-121. 10.1016/S1570-677X(02)00006-0, 15463967.
194. Holsboer F. The corticosteroid receptor hypothesis of depression. Neuropsychopharmacol 2000, 23:477-501.
195. Schmidt U, Holsboer F, Rein T. Epigenetic aspects of posttraumatic stress disorder. Dis Markers 2011, 30:77-87. 10.1155/2011/343616, 3825244, 21508512.
196. Francis D, Diorio J, Liu D, Meaney MJ. Nongenomic transmission across generations of maternal behavior and stress responses in the rat. Science 1999, 286:1155-1158. 10.1126/science.286.5442.1155, 10550053.
197. Liu D, Diorio J, Tannenbaum B, Caldji C, Francis D, Freedman A, Sharma S, Pearson D, Plotsky PM, Meaney MJ. Maternal care, hippocampal glucocorticoid receptors, and hypothalamic-pituitary-adrenal responses to stress. Science 1997, 277:1659-1662. 10.1126/science.277.5332.1659, 9287218.
198. Weaver IC, Champagne FA, Brown SE, Dymov S, Sharma S, Meaney MJ, Szyf M. Reversal of maternal programming of stress responses in adult offspring through methyl supplementation: altering epigenetic marking later in life. J Neurosci 2005, 25:11045-11054. 10.1523/JNEUROSCI.3652-05.2005, 16306417.
199. Weaver IC, Meaney MJ, Szyf M. Maternal care effects on the hippocampal transcriptome and anxiety-mediated behaviors in the offspring that are reversible in adulthood. Proc Natl Acad Sci U S A 2006, 103:3480-3485. 10.1073/pnas.0507526103, 1413873, 16484373.
200. Gardner H, Kobtzeff O {Eds) The Ashgate Research Companion to War: Origins and Prevention. 2012, Ashgate: Farnham, Gardner H, Kobtzeff O {Eds).
201. ICRC/IFRC Guidelines for Assessment in Emergencies. 2008, Geneva, Switzerland: ICRC and the IFRCRC, Available at: http://psychosocial.actalliance.org/default.aspx?di=66841, ICRC/IFRC.
202. The Sphere Project The Sphere Handbook: Humanitarian Charter and Minimum Standards in Humanitarian Response. 2011, The Sphere Project.
203. World Health Organization Integrating Sexual and Reproductive Health into Health Emergency and Disaster Risk Management. 2012, Geneva, World Health Organization.
204. Office of the Special Representative of the Secretary-General for Children and Armed Conflict The Six Grave Violations Against Children During Armed Conflict: The Legal Foundation Working Paper 1. 2009, New York, Office of the Special Representative of the Secretary-General for Children and Armed Conflict.