Maternal inexperience as a risk factor of innate fear and PTSD-like symptoms in mice

Journal of Psychiatric Research

Volumn 43, Issue 14, 2009, Pages 1156-1165

  Siegmund, Anja ^a   Dahlhoff, Maik ^a,b   Habersetzer, Ursula ^a   Mederer, Anna ^a   Wolf, Eckhard ^b   Holsboer, Florian ^a   Wotjak, Carsten T ^a  

^a MAX PLANCK INSTITUTE OF PSYCHIATRY   (Germany)

^b UNIVERSITY OF MUNICH   (Germany)

Author keywords

Animal model; Anxiety; Conditioning; Contextual; Hippocampus; PTSD; Sensitization; Trauma

Indexed keywords

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANXIETY; ARTICLE; CONTROLLED STUDY; DISEASE PREDISPOSITION; EPIGENETICS; EXPERIMENTAL TEST; FACTORIAL ANALYSIS; FEAR; FEMALE; FOOTSHOCK; INBRED STRAIN; LITTER SIZE; MALE; MATERNAL BEHAVIOR; MATERNAL CARE; MOUSE; NONHUMAN; PATHOPHYSIOLOGY; POSTTRAUMATIC STRESS DISORDER; PRIORITY JOURNAL; RISK FACTOR; STRESS;

ANIMALS; BEHAVIOR, ANIMAL; BREEDING; CONDITIONING, CLASSICAL; DISEASE MODELS, ANIMAL; ELECTROSHOCK; EXPLORATORY BEHAVIOR; FEAR; FEMALE; INSTINCT; LOCOMOTION; MALE; MATERNAL BEHAVIOR; MICE; MICE, INBRED C57BL; PREGNANCY; PRINCIPAL COMPONENT ANALYSIS; RISK FACTORS; STRESS DISORDERS, POST-TRAUMATIC;

EID: 70149110431     PISSN: 00223956     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpsychires.2009.02.003     Document Type: Article

References (36)

1. Beane M.L., Cole M.A., Spencer R.L., and Rudy J.W. Neonatal handling enhances contextual fear conditioning and alters corticosterone stress responses in young rats. Hormones and Behavior 41 (2002) 33-40
2. Bond T.L., Neumann P.E., Mathieson W.B., and Brown R.E. Nest building in nulligravid, primigravid and primiparous C57BL/6J and DBA/2J mice (Mus musculus). Physiology and Behavior 75 (2002) 551-555
3. Bredy T.W., Humpartzoomian R.A., Cain D.P., and Meaney M.J. Partial reversal of the effect of maternal care on cognitive function through environmental enrichment. Neuroscience 118 (2003) 571-576
4. Bredy T.W., Lee A.W., Meaney M.J., and Brown R.E. Effect of neonatal handling and paternal care on offspring cognitive development in the monogamous California mouse (Peromyscus californicus). Hormones and Behavior 46 (2004) 30-38
5. Caldji C., Tannenbaum B., Sharma S., Francis D., Plotsky P.M., and Meaney M.J. Maternal care during infancy regulates the development of neural systems mediating the expression of fearfulness in the rat. Proceedings of the National Academy of Sciences USA 95 (1998) 5335-5340
6. Champagne F.A., Francis D.D., Mar A., and Meaney M.J. Variations in maternal care in the rat as a mediating influence for the effects of environment on development. Physiology and Behavior 79 (2003) 359-371
7. Cohen H., Geva A.B., Matar M.A., Zohar J., and Kaplan Z. Post-traumatic stress behavioural responses in inbred mouse strains: can genetic predisposition explain phenotypic vulnerability?. International Journal of Neuropsychopharmacology (2007) 1-19
8. Cohen-Salmon C. Differences in patterns of pup care in Mus musculus domesticus. VIII. Effects of previous experience and parity in XLII inbred mice. Physiology and Behavior 40 (1987) 177-180
9. Featherstone R.E., Fleming A.S., and Ivy G.O. Plasticity in the maternal circuit: effects of experience and partum condition on brain astrocyte number in female rats. Behavioral Neuroscience 114 (2000) 158-172
10. Fleming A.S., O'Day D.H., and Kraemer G.W. Neurobiology of mother-infant interactions: experience and central nervous system plasticity across development and generations. Neuroscience and Biobehavioral Reviews 23 (1999) 673-685
11. Francis D., Diorio J., Liu D., and Meaney M.J. Nongenomic transmission across generations of maternal behavior and stress responses in the rat. Science 286 (1999) 1155-1158
12. Gilbertson M.W., Shenton M.E., Ciszewski A., Kasai K., Lasko N.B., Orr S.P., et al. Smaller hippocampal volume predicts pathologic vulnerability to psychological trauma. Nature Neuroscience 5 (2002) 1242-1247
13. Gilbertson M.W., Williston S.K., Paulus L.A., Lasko N.B., Gurvits T.V., Shanton M.E., et al. Configural cue performance in identical twins discordant for posttraumatic stress disorder: theoretical implications for the role of the hippocampal function. Biological Psychiatry 62 5 (2007) 513-520
14. Kaffman A., and Meaney M.J. Neurodevelopmental sequelae of postnatal maternal care in rodents: clinical and research implications of molecular insights. Journal of Child Psychology and Psychiatry 48 (2007) 224-244
15. Kamprath K., and Wotjak C.T. Nonassociative learning processes determine expression and extinction of conditioned fear in mice. Learning and Memory 11 (2004) 770-786
16. Krishnan V., Han M.H., Graham D.L., Berton O., Renthal W., Russo S.J.., et al. Molecular adaptations underlying susceptibility and resistance to social defeat in brain reward regions. Cell 131 (2007) 391-404
17. Liu D., Diorio J., Day J.C., Francis D.D., and Meaney M.J. Maternal care, hippocampal synaptogenesis and cognitive development in rats. Nature Neuroscience 3 (2000) 799-806
18. Liu D., Diorio J., Tannenbaum B., Caldji C., Francis D., Freedman A., et al. Maternal care, hippocampal glucocorticoid receptors, and hypothalamic-pituitary-adrenal responses to stress. Science 277 (1997) 1659-1662
19. Millstein R.A., and Holmes A. Effects of repeated maternal separation on anxiety - and depression - related phenotypes in different mouse strains. Neuroscience and Biobehavioral Reviews 31 1 (2007) 3-17
20. Ohl F., Sillaber I., Binder E., Keck M.E., and Holsboer F. Differential analysis of behavior and diazepam-induced alterations in C57BL/6N and BALB/c mice using the modified hole board test. Journal of Psychiatric Research 35 (2001) 147-154
21. Parfitt D.B., Levin J.K., Saltstein K.P., Klayman A.S., Greer L.M., and Helmreich D.L. Differential early rearing environments can accentuate or attenuate the responses to stress in male C57BL/6 mice. Brain Research 1016 (2004) 111-118
22. Ronca A.E., Baer L.A., Daunton N.G., and Wade C.E. Maternal reproductive experience enhances early postnatal outcome following gestation and birth of rats in hypergravity. Biology of Reproduction 65 (2001) 805-813
23. Siegmund A., Langnaese K., and Wotjak C.T. Differences in extinction of conditioned fear in C57BL/6 substrains are unrelated to expression of alpha-synuclein. Behavioral Brain Research 157 (2005) 291-298
24. Siegmund A., and Wotjak C.T. Toward an animal model of posttraumatic stress disorder. Annals of the New York Academy of Sciences 1071 (2006) 324-334
25. Siegmund A., and Wotjak C.T. A mouse model of posttraumatic stress disorder that distinguishes between conditioned and sensitised fear. Journal of Psychiatric Research 41 (2007) 848-860
26. Siegmund A., and Wotjak C.T. Hyperarousal does not depend on trauma-related contextual memory in an animal model of posttraumatic stress disorder. Physiology and Behavior 90 (2007) 103-107
27. Siegmund A., Kaltwasser S.F., Holsboer F., Czisch M., and Wotjak C.T. Hippocampal N-acetylaspartate levels before trauma predict the development of long-lasting posttraumatic stress disorder-like symptoms in mice. Biological Psychiatry 65 3 (2009) 258-262 [Epub 2008 Oct 8]
28. Solomon Z., Mikulincer M., and Avitzur E. Coping, locus of control, social support, and combat-related posttraumatic stress disorder: a prospective study. Journal of Personality and Social Psychology 55 (1988) 279-285
29. Strekalova T., Spanagel R., Bartsch D., Henn F.A., and Gass P. Stress-induced anhedonia in mice is associated with deficits in forced swimming and exploration. Neuropsychopharmacology 29 (2004) 2007-2017
30. van Gaalen M.M., and Steckler T. Behavioural analysis of four mouse strains in an anxiety test battery. Behavioral Brain Research 115 (2000) 95-106
31. Vasterling J.J., Duke L.M., Brailey K., Constans J.I., Allain Jr. A.N., and Sutker P.B. Attention, learning, and memory performances and intellectual resources in Vietnam veterans: PTSD and no disorder comparisons. Neuropsychology 16 (2002) 5-14
32. Yehuda R., and Bierer L.M. Transgenerational transmission of cortisol and PTSD risk. Progress in Brain Research 167 (2008) 121-135
33. Yehuda R., and LeDoux J. Response variation following trauma: a translational neuroscience approach to understanding PTSD. Neuron 56 (2007) 19-32
34. Yehuda R., Schmeidler J., Giller Jr. E.L., Siever L.J., and Binder-Brynes K. Relationship between posttraumatic stress disorder characteristics of holocaust survivors and their adult offspring. American Journal of Psychiatry 155 (1998) 841-843
35. Yehuda R., Schmeidler J., Wainberg M., Binder-Brynes K., and Duvdevani T. Vulnerability to posttraumatic stress disorder in adult offspring of Holocaust survivors. American Journal of Psychiatry 155 (1998) 1163-1171
36. Yehuda R., Teicher M.H., Seckl J.R., Grossman R.A., Morris A., and Bierer L.M. Parental posttraumatic stress disorder as a vulnerability factor for low cortisol trait in offspring of holocaust survivors. Archives of General Psychiatry 64 (2007) 1040-1048