Acetylsalicylic acid and ascorbic acid combination improves cognition; Via antioxidant effect or increased expression of NMDARs and nAChRs?

Environmental Toxicology and Pharmacology

Volumn 37, Issue 3, 2014, Pages 916-927

  Kara, Yusuf ^a   Doguc, Duygu Kumbul ^b   Kulac, Esin ^c   Gultekin, Fatih ^b  

^a Serik State Hospital   (Turkey)

^b SULEYMAN DEMIREL UNIVERSITY   (Turkey)

^c KOCAELI UNIVERSITY   (Turkey)

Author keywords

Acetylsalicylic acid; Ageing; NAChRs; NMDARs; Spatial memory

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; ACETYLSALICYLIC ACID; ASCORBIC ACID; BUNGAROTOXIN RECEPTOR; MALONALDEHYDE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2A; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2B; NICOTINIC RECEPTOR ALPHA4; NICOTINIC RECEPTOR BETA2; 8-OXO-7-HYDRODEOXYGUANOSINE; ANTIOXIDANT; ASCORBIC ACID, ASPIRIN DRUG COMBINATION; DEOXYGUANOSINE; DRUG COMBINATION; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N-METHYL D-ASPARTATE RECEPTOR SUBTYPE 2A; NICOTINIC RECEPTOR; NR2B NMDA RECEPTOR;

AGED; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; COGNITION; COMBINATION CHEMOTHERAPY; CONTROLLED STUDY; DRUG EFFECT; HIPPOCAMPUS; MALE; MENTAL PERFORMANCE; MONOTHERAPY; MORRIS WATER MAZE TEST; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SPATIAL LEARNING; WORKING MEMORY; ANALOGS AND DERIVATIVES; ANIMAL; ANIMAL BEHAVIOR; DRUG COMBINATION; DRUG EFFECTS; MAZE TEST; MEMORY; METABOLISM; PHYSIOLOGY; SPRAGUE DAWLEY RAT;

ANIMALS; ANTIOXIDANTS; ASCORBIC ACID; ASPIRIN; BEHAVIOR, ANIMAL; COGNITION; DEOXYGUANOSINE; DRUG COMBINATIONS; HIPPOCAMPUS; MALE; MALONDIALDEHYDE; MAZE LEARNING; MEMORY; OXIDATIVE STRESS; RATS, SPRAGUE-DAWLEY; RECEPTORS, N-METHYL-D-ASPARTATE; RECEPTORS, NICOTINIC;

EID: 84897382845     PISSN: 13826689     EISSN: 18727077     Source Type: Journal    
DOI: 10.1016/j.etap.2014.02.019     Document Type: Article

References (59)

1. AD2000 Collaborative Group, Bentham P., Gray R., Sellwood E., Hills R., Crome P., Raftery J. Aspirin in Alzheimer's disease (AD2000): a randomised open-label trial. Lancet Neurol 2008, 7(1):41-49.
2. Adeneye A.A., Olagunju J.O. Protective effect of oral ascorbic acid (vitamin c) against acetaminophen-induced hepatic injury in rats. AJBR 2008, 11:183-190.
3. Aïd S., Bosetti F. Review: targeting cyclooxygenases-1 and -2 in neuroinflammation: therapeutic implications. Biochimie 2011, 93:46-51.
4. Almeida O.P., Alfonso H., Jamrozik K., Hankey G.J., Flicker L. Aspirin use, depression, and cognitive impairment in later life: the health in men study. J. Am. Geriatr. Soc. 2010, 58(5):990-992.
5. Araujo D.M., Lapchak P.A., Meaney M.J., Collier B., Quirion R. Effects of aging on nicotinic and muscarinic autoreceptors function in the rat brain: relationship to presynaptic cholinergic markers and binding sites. J. Neurosci. 1990, 10:3069-3078.
6. Arkin H., Colton R.R. Tables for Statisticians 1963, Barnes&Noble, New York. 2nd ed.
7. Bai L., Hof P.R., Standaert D.G., Xing Y., Nelson S.E., Young A.B., et al. Changes in the expression of the NR2B subunit during aging in macaque monkeys. Neurobiol. Aging 2004, 25:201-208.
8. Basselin M., Ramadan E., Chen M., Rapoport S.I. Anti-inflammatory effects of chronic aspirin on brain arachidonic acid metabolites. Neurochem. Res. 2011, 36(1):139-145.
9. Bertozzi B., Barbisoni P., Franzoni S., Frisoni G.B., Rozzini R., Trabucchi M. Association of chronic non-steroidal anti-inflammatory drugs use and cognitive decline in non-demented elderly patients admitted to a geriatric evaluation and rehabilitation unit. Arch. Gerontol. Geriatr. 1996, 23:71-79.
10. Broe G.A., Grayson D.A., Creasey H.M., Waite L.M., Casey B.J., Bennett H.P., et al. Anti-inflammatory drugs protect against Alzheimer disease at low doses. Arch. Neurol. 2000, 57:1586-1591.
11. Cady C., Evans M.S., Brewer G.J. Age-related differences in NMDA responses in cultured rat hippocampal neurons. Brain Res. 2001, 921(1-2):1-11.
12. Candelario-Jalil E., Akundi R.S., Bhatia H.S., Lieb K., Appel K., Muñoz E., et al. Ascorbic acid enhances the inhibitory effect of aspirin on neuronal cyclooxygenase-2-mediated prostaglandin E2 production. J. Neuroimmunol. 2006, 174(1-2):39-51.
13. Casolini P., Catalani A., Zuena A.R., Angelucci L. Inhibition of COX-2 reduces the age-dependent increase of hippocampal inflammatory markers, corticosterone secretion, and behavioral impairments in the rat. J. Neurosci. Res. 2002, 68(3):337-343.
14. Changeux J.P., Bertrand D., Corringer P.J., Dehaene S., Edelstein S., Lena C., et al. Brain nicotinic receptors: structure and regulation, role in learning and reinforcement. Brain Res. Rev. 1998, 26:198-216.
15. Chung H.Y., Kim H.J., Kim J.W., Yu B.P. The inflammation hypothesis of aging: molecular modulation by calorie restriction. Ann. N. Y. Acad. Sci. 2001, 928(1). 327-235.
16. Chung H.Y., Sung B., Jung K.J., Zou Y., Yu B.P. The molecular inflammatory process in aging. Antioxid. Redox Signal. 2006, 8:572-581.
17. Clayton D.A., Browning M.D. Deficits in the expression of the NR2B subunit in the hippocampus of aged Fisher 344 rats. Neurobiol. Aging 2001, 22:165-168.
18. Clayton D.A., Grosshans D.R., Browning M.D. Aging and surface expression of hippocampal NMDA receptors. J. Biol. Chem. 2002, 277:14367-14369.
19. Clayton D.A., Mesches M.H., Alvarez E., Bickford P.C., Browning M.D. A hippocampal NR2B deficit can mimic age-related changes in long-term potentiation and spatial learning in the Fischer 344 rat. J. Neurosci. 2002, 22(9):3628-3637.
20. Colantoni A., de Maria N., Caraceni P., Bernardi M., Floyd R.A., Van Thiel D.H. Prevention of reoxygenation injury by sodium salicylate in isolated-perfused rat liver. Free Radic. Biol. Med. 1998, 25:87-94.
21. Dani J.A., Bertrand D. Nicotinic acetylcholine receptors and nicotinic cholinergic mechanisms of the central nervous system. Annu. Rev. Pharmacol. Toxicol. 2007, 47:699-729.
22. Delibas N., Doguc D.K., Sutcu R., Eroglu E., Gokalp O. Effect of Nicotine on hippocampal nicotinic acethyl choline alfa7 receptor and NMDA receptor subunits 2A and 2B expression in young and old rats. Int. J. Neurosci. 2005, 115(8):1151-1163.
23. Farooqui T., Farooqui A.A. Aging: an important factor for the pathogenesis of neurodegenerative diseases. Mech. Ageing Dev. 2009, 130(4):203-215.
24. Fiebich B.L., Lieb K., Kammerer N., Hüll M. Synergistic inhibitory effect of ascorbic acid and acetylsalicylic acid on prostaglandin E2 release in primary rat microglia. J. Neurochem. 2003, 86:173-178.
25. Giacobini E. Nicotine acetylcholine receptors in human cortex: aging and Alzheimer's disease. Biology of Nicotine 1992, 183-215. Raven, New York. P.M. Lippiello, A.C. Collins, A.C. Gray, J.H. Robinson (Eds.).
26. Gonzales R.A., Brown L.M., Jones T.W., Trent R.D., Westbrook S.L., Leslie S.W. N-methyl-D-aspartate mediated responses decrease with age in Fischer 344 rat brain. Neurobiol. Aging 1991, 12:219-225.
27. Gould T.J., Feiro O.R. Age-related deficits in the retention of memories for cued fear conditioning are reversed by galantamin treatment. Behav. Brain Res. 2005, 165:160-171.
28. Harris J.R. In vitro fi brillogenesis of the amyloid β1-42 peptide: cholesterol potentiation and aspirin inhibition. Micron 2002, 33(7-8):609-626.
29. Henderson A.S., Jorm A.F., Christensen H., Jacomb P.A., Korten A.E. Aspirin, anti-infl ammatory drugs and risk of dementia. Int. J. Geriatr. Psychiatry 1997, 12:926-930.
30. Ibáñez-Hernández M.G., Macías-Islas M.A., Zavalza-Gómez A.B., Pacheco-Moisés F.P., Ortiz G.G. The effect of ibuprofen and acetylsalicylic acid on cognitive impairment, total antioxidant power and isoprostane serum. Gac. Med. Mex. 2008, 144(6):497-502.
31. In't Veld B.A., Launer L.J., Breteler M.M., Hofman A., Stricker B.H. Pharmacologic agents associated with a preventive effect on Alzheimer's disease: a review of the epidemiologic evidence. Epidemiol. Rev. 2002, 24:248-268.
32. Jung K.J., Kim J.Y., Zou Y., Kim Y.J., Yu B.P., Chung H.Y. Effect of short-term, low dose aspirin supplementation on the activation of pro-inflammatory NF-kappaB in aged rats. Mech. Ageing Dev. 2006, 127(3):223-230.
33. Lawrence, D., 2002. Retrospective data strengthen Alzheimer's link with aspirin and NSAIDs. Lancet, 360 (9338), 959-1030. http://www.thelancet.com/journals/lancet/issue/vol360no9338/PIIS0140-6736(00)X0319-4.
34. Liu L.O., Laabich A., Hardison A., Cooper N.G. Expression of ionotropic glutamate receptors in the retina of the rdta transgenic mouse. BMC Neurosci. 2001, 2:7.
35. Lowry O.H., Rosebrough N.J., Farr A.L., Randall R.J. Protein measurement with the folinphenol reagents. J. Biol. Chem. 1951, 193:265-275.
36. McGahon B.M., Martin D.S., Horrobin D.F., Lynch M.A. Age-related changes in LTP and antioxidant defenses are reversed by an alpha-lipoic acid-enriched diet. Neurobiol. Aging 1999, 20(6):655-664.
37. Mateos R., Lecumberri E., Ramos S., Goya L., Bravo L. Determination of malondialdehyde (MDA) by high-performance liquid chromatography in serum and liver as a biomarker for oxidative stress. Application to a rat model for hypercholesterolemia and evaluation of the effect of diets rich in phenolic antioxidants from fruits. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 2005, 827(1):76-82.
38. Mesches M.H., Gemma C., Veng L.M., Allgeier C., Young D.A., Browning M.D., et al. Sulindac improves memory and increases NMDA receptor subunits in aged Fischer 344 rats. Neurobiol. Aging 2004, 25(3):315-324.
39. Molnar F.J., ManSonHing M., John P.S., Brymer C., Rockwood K., Hachinski V. Subcortical vasculature dementia: survey of treatment patterns and research consideration. Can. J. Neurol. Sci. 1998, 25:320-324.
40. Morris R. Developments of a water-maze procedure for studying spatial learning in the rat. J. Neurosci. Methods 1984, 11:47-60.
41. Murray C.A., Lynch M.A. Dietary supplementation with Vitamin E reverses the age-related deficit in long term potentiation in dentate gyrus. J. Biol. Chem. 1998, 273(20):12161-12168.
42. McGeer P.L., McGeer E.G. Inflammation and degenerative diseases of aging. Ann. N. Y. Acad. Sci. 2004, 1035:104-116.
43. O'Donnell E., Lynch M.A. Dietary antioxidant supplementation reverses age-related neuronal changes. Neurobiol. Aging 1998, 19(5):461-467.
44. O'Neill M.J., Murray T.K., Lakics V., Visanji N.P., Duty S. The role of neuronal nicotinic acetylcholine receptors in acute and chronic neurodegeneration. Curr. Drug Targets CNS Neurol. Disord. 2002, 1(4):399-411.
45. Peacock J.M., Folsom A.R., Knopman D.S., Mosley T.H., Goff D.C., Szklo M. Association of nonsteroidal anti-inflammatory drugs and aspirin with cognitive performance in middle-aged adults. Neuroepidemiology 1999, 18:134-143.
46. Pittaluga A., Fedele E., Risiglione C., Raiteri M. Age-related decrease of the NMDA receptor-mediated noradrenaline release in rat hippocampus and partial restoration by D-cycloserine. Eur. J. Pharmacol. 1993, 231:129-134.
47. Price J.F., Stewart M.C., Deary I.J., Murray G.D., Sandercock P., Butcher I., et al. AAA Trialists. Low dose aspirin and cognitive function in middle aged to elderly adults: randomised controlled trial. BMJ 2008, 337.
48. Rice M.E., Russo-Menna I. Differential compartmentalization of brain ascorbate and glutathione between neurons and glia. Neuroscience 1998, 82:1213-1223.
49. Riedel G., Platt B., Micheau J. Review; Glutamate receptor function in learning and memory. Behav. Brain Res. 2003, 18, 140(1-2):1-47.
50. Rosenzweig E.S., Barnes C.A. Review; Impact of aging on hippocampal function: plasticity, network dynamics, and cognition. Prog. Neurobiol. 2003, 69(3):143-179.
51. Smith J.W., Al-Khamees O., Costall B., Naylor R.J., Smythe J.W. Chronic aspirin ingestion improves spatial learning in adult and aged rats. Pharmacol. Biochem. Behav. 2002, 71(1-2):233-238.
52. So A., Revaz S., Dudler J., Brune K. Pain: Mechanisms and Management. Eular On-line Course on Rheumatic Diseases - Module no.39 2009, P24. 2007-2009.
53. Stamford J.A., Isaac D., Hicks C.A., Ward M.A., Osborne D.J., O'Neill M.J. Ascorbic acid is neuroprotective against global ischaemia in striatum but not hippocampus: histological and voltammetric data. Brain Res. 1999, 835(2):229-240.
54. Stitik T.P., Klecz R., Greenwald B., Tran J.J. Pharmacotherapy of disability. DeLisa's Physical Medicine and Rehabilitation: Principles and Practice 2010, 1743-1803. Lippincott Willliams & Wilkins, Philadelphia. 5th ed. W.R. Frontera, J.A. Delisa, B.M. Gans, N.E. Walsh, L.R. Robindon (Eds.).
55. Tang Y.P., Shimizu E., Dube G.R., Rampon C., Kerchner G.A., Zhuo M., et al. Genetic enhancement of learning and memory in mice. Nature 1999, 401(6748):63-69.
56. Thomas T., Nadackal T.G., Thomas K. Aspirin and non-steroidal anti-inflammatory drugs inhibit amyloid-beta aggregation. Neuroreport 2001, 12(15):3263-3267.
57. Waldstein S.R., Wendell C.R., Seliger S.L., Ferrucci L., Metter E.J., Zonderman A.B. Nonsteroidal anti-inflammatory drugs, aspirin, and cognitive function in the Baltimore longitudinal study of aging. J. Am. Geriatr. Soc. 2010, 58(1):38-43.
58. Woodruff-Pak D.S., Lehr M.A., Li J.G., Liu-Chen L.Y. Young and older good learners have higher levels of brain nicotinic receptor binding. Neurobiol. Aging 2010, 31(6):1032-1043.
59. Zhang X., Wahlstrom G., Nordberg A. Influence of development and aging on nicotinic receptor subtypes in rodent brain. Int. J. Dev. Neurosci. 1990, 8:715-721.