Preparation of sildenafil citrate microcapsules and in vitro/in vivo evaluation of taste masking efficiency

International Journal of Pharmaceutics

Volumn 466, Issue 1-2, 2014, Pages 286-295

  Yi, Eun Jin ^a   Kim, Ju Young ^a,b   Rhee, Yun Seok ^c   Kim, Su Hyeon ^a   Lee, Hyo Joong ^d   Park, Chun Woong ^d   Park, Eun Seok ^a  

^a Sungkyunkwan University   (South Korea)

^b Woosuk University   (South Korea)

^c Gyeongsang National University   (South Korea)

^d Chungbuk National University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

BUFFER; EUDRAGIT; SILDENAFIL; ACRYLIC ACID DERIVATIVE; MICROCAPSULE; PHOSPHODIESTERASE V INHIBITOR; PIPERAZINE DERIVATIVE; POLYMER; PURINE DERIVATIVE; SULFONE;

ADULT; ARTICLE; BITTER TASTE; CRYSTAL STRUCTURE; DATA ANALYSIS SOFTWARE; DIFFERENTIAL SCANNING CALORIMETRY; DISCRIMINANT ANALYSIS; DRUG DESIGN; DRUG FORMULATION; DRUG RELEASE; DRUG SOLUBILITY; DRUG SYNTHESIS; ELECTRONIC SENSOR; ELECTRONIC TONGUE SYSTEM; EVALUATION STUDY; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; IN VITRO STUDY; IN VIVO STUDY; MALE; MASKING; MEDICATION COMPLIANCE; MICROCAPSULE; MICROENCAPSULATION; NORMAL HUMAN; PARTICLE SIZE; PH; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RAMAN SPECTROMETRY; SCANNING ELECTRON MICROSCOPY; SOLID STATE; SPRAY DRYING; TASTE; TASTE ACUITY; TASTE MASKING EFFICIENCY; X RAY POWDER DIFFRACTION; YOUNG ADULT; CHEMISTRY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFECTS; ELECTRICAL EQUIPMENT; SINGLE BLIND PROCEDURE; SOLUBILITY;

ACRYLATES; ADULT; CAPSULES; DRUG COMPOUNDING; ELECTRICAL EQUIPMENT AND SUPPLIES; FEMALE; HUMANS; HYDROGEN-ION CONCENTRATION; MALE; PHOSPHODIESTERASE 5 INHIBITORS; PIPERAZINES; POLYMERS; PURINES; SINGLE-BLIND METHOD; SOLUBILITY; SULFONES; TASTE; YOUNG ADULT;

EID: 84897376870     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2014.03.001     Document Type: Article

References (41)

1. R. Agarwal, R. Mittal, and A. Singh Studies of ion-exchange resin complex of chloroquine phosphate Drug Development and Industrial Pharmacy 26 2000 773 776 (Pubitemid 30397333)
2. M. Al-Omran, S. Al-Suwayeh, A. El- Helw, and S. Saleh Taste masking of diclofenac sodium using microencapsulation Journal of Microencapsulation 19 2002 45 52 (Pubitemid 34083461)
3. M. Ameri, and Y.-F. Maa Spray drying of biopharmaceuticals: stability and process considerations Drying Technology 24 2006 763 768 (Pubitemid 43820928)
4. Asaka, T.; Misawa, Y.; Kashimura, M.; Morimoto, S.; Watantabe, Y.; Hatayama, K.; 1992. 2′-Modified erythromycin or derivatives thereof. WO Patent 1992006991.
5. D. Bora, P. Borude, and K. Bhise Taste masking by spray-drying technique AAPS PharmSciTech 9 2008 1159 1164
6. J. Breitkreutz, and J. Boos Paediatric and geriatric drug delivery Expert Opinion on Drug Delivery 4 2007 37 45 (Pubitemid 46117485)
7. H.G. Brittain Analytical profiles of drug substances and excipients 2001 Academic Press Waltham
8. G. Carnaby-Mann, and M. Crary Pill swallowing by adults with dysphagia Archives of Otolaryngology-Head & Neck Surgery 131 2005 970
9. ® with Raman spectroscopy Journal of Pharmaceutical and Biomedical Analysis 46 2008 303 309
10. M. De Veij, P. Vandenabeele, T. De Beer, J.P. Remon, and L. Moens Reference database of Raman spectra of pharmaceutical excipients Journal of Raman Spectroscopy 40 2009 297 307
11. Depalmo, G.A.; 1999. Composition based on ibuprofen, for oral usage. EP Patent 0560207.
12. D. Douroumis Orally disintegrating dosage forms and taste-masking technologies; 2010 Expert Opinion on Drug Delivery 8 2011 665 675
13. E. Esposito, R. Roncarati, R. Cortesi, F. Cervellati, and C. Nastruzzi Production of Eudragit microparticles by spray-drying technique: influence of experimental parameters on morphological and dimensional characteristics Pharmaceutical Development and Technology 5 2000 267 278 (Pubitemid 30247107)
14. N. Galiè, H.A. Ghofrani, A. Torbicki, R.J. Barst, L.J. Rubin, D. Badesch, T. Fleming, T. Parpia, G. Burgess, and A. Branzi Sildenafil citrate therapy for pulmonary arterial hypertension New England Journal of Medicine 353 2005 2148 2157 (Pubitemid 41653106)
15. Y. Gao, F.-d. Cui, Y. Guan, L. Yang, Y.-s. Wang, and L.-n. Zhang Preparation of roxithromycin-polymeric microspheres by the emulsion solvent diffusion method for taste masking International Journal of Pharmaceutics 318 2006 62 69 (Pubitemid 43983049)
16. H.A. Ghofrani, I.H. Osterloh, and F. Grimminger Sildenafil: from angina to erectile dysfunction to pulmonary hypertension and beyond Nature Reviews Drug Discovery 5 2006 689 702 (Pubitemid 44151606)
17. M.M. Goldenberg Safety and efficacy of sildenafil citrate in the treatment of male erectile dysfunction Clinical Therapeutics 20 1998 1033
18. M. Guhmann, M. Preis, F. Gerber, N. Pöllinger, J. Breitkreutz, and W. Weitschies Development of oral taste masked diclofenac formulations using a taste sensing system International Journal of Pharmaceutics 438 2012 81 90
19. L. Hughes, and A. Gehris A New Method of Characterizing the Buccal Dissolution of Drugs 2002 Rohm and Haas Research Laboratory Spring House Philadelphia http://www.rohmhaas.com/ionexchange/pharmaceuticals/Formulations- doc/buccal-dissolution.pdf
20. M.A. Hussain, B.J. Aungst, C.A. Koval, and E. Shefter Improved buccal delivery of opioid analgesics and antagonists with bitterless prodrugs Pharmaceutical Research 5 1988 615 618
21. Itoh, A.; Niwa, T.; 2001. Rapidly releasing and taste-masking pharmaceutical dosage form. WO Patent 1998030209.
22. T.A. Júlio, I.F. Zâmara, J.S. Garcia, and M.G. Trevisan Compatibility of sildenafil citrate and pharmaceutical excipients by thermal analysis and LC-UV Journal of Thermal Analysis and Calorimetry 111 2013 1 8
23. M. Jańczyk, A. Kutyła, K. Sollohub, H. Wosicka, K. Cal, and P. Ciosek Electronic tongue for the detection of taste-masking microencapsulation of active pharmaceutical substances Bioelectrochemistry 80 2010 94 98
24. Kirk-Othmer Encyclopedia of Chemical Technology 2005 John Wiley & Sons Ltd. New York
25. J.-H. Lee, G. Choi, Y.-J. Oh, J.W. Park, Y.B. Choy, M.C. Park, Y.J. Yoon, H.J. Lee, H.C. Chang, and J.-H. Choy A nanohybrid system for taste masking of sildenafil International Journal of Nanomedicine 7 2012 1635
26. M. Maniruzzaman, J.S. Boateng, M. Bonnefille, A. Aranyos, J.C. Mitchell, and D. Douroumis Taste masking of paracetamol by hot-melt extrusion: an in vitro and in vivo evaluation European Journal of Pharmaceutics and Biopharmaceutics 80 2012 433 442
27. M. Maniruzzaman, M. Bonnefille, A. Aranyos, M.J. Snowden, and D. Douroumis An in-vivo and in-vitro taste masking evaluation of bitter melt-extruded drugs Journal of Pharmacy and Pharmacology 2013
28. E. Michelakis, W. Tymchak, D. Lien, L. Webster, K. Hashimoto, and S. Archer Oral sildenafil is an effective and specific pulmonary vasodilator in patients with pulmonary arterial hypertension comparison with inhaled nitric oxide Circulation 105 2002 2398 2403 (Pubitemid 34556392)
29. R.B. Moreland, I. Goldstein, N.N. Kim, and A. Traish Sildenafil citrate, a selective phosphodiesterase type 5 inhibitor:: research and clinical implications in erectile dysfunction Trends in Endocrinology & Metabolism 10 1999 97 104 (Pubitemid 29283892)
30. Motola, S.; Agisim, G.R.; Mogavero, A.; 1991. Palatable ibuprofen solutions. US 5024997.
31. Singh, S.; Amin, D.; Goud, M.; 2009. Taste masked chewable compositions of sildenafil citrate. WO Patent 2009074995.
32. H. Sohi, Y. Sultana, and R.K. Khar Taste masking technologies in oral pharmaceuticals: recent developments and approaches Drug Development and Industrial Pharmacy 30 2004 429 448 (Pubitemid 38821855)
33. M. Ueda, Y. Nakamura, H. Makita, and Y. Kawashima Preparation of microcapsules masking the bitter taste of enoxacin by using one continuous process technique of agglomeration and microencapsulation Journal of Microencapsulation 10 1993 461 473 (Pubitemid 23297060)
34. K. Vithani, Y. Cuppok, S. Mostafa, I.J. Slipper, M.J. Snowden, and D. Douroumis Diclofenac sodium sustained release hot melt extruded lipid matrices Pharmaceutical Development and Technology 19 2014 531 538
35. K. Vithani, M. Maniruzzaman, I.J. Slipper, S. Mostafa, C. Miolane, Y. Cuppok, D. Marchaud, and D. Douroumis Sustained release solid lipid matrices processed by hot-melt extrusion (HME) Colloids and Surfaces B: Biointerfaces 110 2013 403 410
36. D. Walton The morphology of spray-dried particles a qualitative view Drying Technology 18 2000 1943 1986
37. Wehling, F.; Schuehle, S.; Madamala, N.; 1993. Effervescent dosage form with microparticles. US Patent 5178878.
38. Winter, S.; Scheiwe, M.-W.; 2010. Melting tablet containing a sildenafil salt. EP Patent 2416755.
39. K. Woertz, C. Tissen, P. Kleinebudde, and J. Breitkreutz Taste sensing systems (electronic tongues) for pharmaceutical applications International Journal of Pharmaceutics 417 2011 256 271
40. T. Yajima, A. Nogata, M. Demachi, N. Umeki, S. Itai, N. Yunoki, and M. Nemoto Particle design for taste-masking using a spray-congealing technique Chemical and Pharmaceutical Bulletin 44 1996 187 191 (Pubitemid 26053955)
41. S. Zgoulli, V. Grek, G. Barre, G. Goffinet, P. Thonart, and S. Zinner Microencapsulation of erythromycin and clarithromycin using a spray-drying technique Journal of Microencapsulation 16 1999 565 571 (Pubitemid 29403554)