Noncardiovascular mortality in CKD: An epidemiological perspective

Nature Reviews Nephrology

Volumn 10, Issue 4, 2014, Pages 208-214

  De Jager, Dinanda J ^a   Vervloet, Marc G ^b   Dekker, Friedo W ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b VU UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

C REACTIVE PROTEIN; FETUIN A; TROPONIN T; UREMIC TOXIN; VITAMIN D;

CARDIOVASCULAR MORTALITY; CARDIOVASCULAR RISK; CAUSE OF DEATH; CHRONIC KIDNEY DISEASE; END STAGE RENAL DISEASE; HIGH RISK PATIENT; HUMAN; INFECTION; INFLAMMATION; MALIGNANT NEOPLASTIC DISEASE; MORTALITY; NONCARDIOVASCULAR MORTALITY; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEINURIA; REVIEW; RISK FACTOR; VITAMIN BLOOD LEVEL; VITAMIN D DEFICIENCY;

ADULT; ALPHA-2-HS-GLYCOPROTEIN; C-REACTIVE PROTEIN; CARDIOVASCULAR DISEASES; HUMANS; MALE; NEOPLASMS; PROTEINURIA; RENAL INSUFFICIENCY, CHRONIC; RISK FACTORS; TROPONIN T; VITAMIN D DEFICIENCY;

EID: 84897114534     PISSN: 17595061     EISSN: 1759507X     Source Type: Journal    
DOI: 10.1038/nrneph.2014.8     Document Type: Review

References (106)

1. Wen, C. P. et al. All-cause mortality attributable to chronic kidney disease: A prospective cohort study based on 462,293 adults in Taiwan. Lancet 371, 2173-2182 (2008
2. Chadban, S. J. et al. Prevalence of kidney damage in Australian adults: The AusDiab kidney study. J. Am. Soc. Nephrol. 14 (Suppl. 2), S131-S138 (2003
3. Hallan, S. I. et al. International comparison of the relationship of chronic kidney disease prevalence and ESRD risk. J. Am. Soc. Nephrol. 17, 2275-2284 (2006
4. Coresh, J. et al. Prevalence of chronic kidney disease in the United States. JAMA 298, 2038-2047 (2007
5. United States Renal Data System (National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases). USRDS 2012 Annual Data Report: Atlas of Chronic Kidney Disease and End-Stage Renal Disease in the United States [online], http://www.usrds.org/(2013
6. ERA-EDTA Registry. ERA-EDTA Registry Annual Report 2011 [online], http://www.era-edta-reg.org/(2013
7. Steenkamp, R., Shaw, C. & Feest, T. UK Renal Registry 15th annual report: Chapter 5 survival and causes of death of UK adult patients on renal replacement therapy in 2011: National and centre-specific analyses. Nephron Clin. Pract. 123 (Suppl. 1), 93-123 (2013
8. Australia and New Zealand Dialysis and Transplant Registry. ANZDATA 2012 Annual Report [online], http://www.anzdata.org.au/anzdata/AnzdataReport/ 35thReport/2012-annual-report.pdf (2013
9. de Jager, D. J. et al. Cardiovascular and noncardiovascular mortality among patients starting dialysis. JAMA 302, 1782-1789 (2009
10. Wakasugi, M., Kazama, J. J., Yamamoto, S., Kawamura, K. & Narita, I. Cause-specific excess mortality among dialysis patients: Comparison with the general population in Japan. Ther. Apher. Dial. 17, 298-304 (2013
11. Raymond, N. T. et al. Elevated relative mortality risk with mild-to-moderate chronic kidney disease decreases with age. Nephrol. Dial. Transplant. 22, 3214-3220 (2007
12. Marks, A. et al. Chronic kidney disease, a useful trigger for proactive primary care Mortality results from a large UK cohort. Fam. Pract. 30, 282-289 (2013
13. Matsushita, K. et al. Association of estimated glomerular filtration rate and albuminuria with all-cause and cardiovascular mortality in general population cohorts: A collaborative meta-analysis. Lancet 375, 2073-2081 (2010
14. Foley, R. N., Parfrey, P. S. & Sarnak, M. J. Clinical epidemiology of cardiovascular disease in chronic renal disease. Am. J. Kidney Dis. 32 (Suppl. 3), S112-S119 (1998
15. Genovesi, S. et al. Sudden death and associated factors in a historical cohort of chronic haemodialysis patients. Nephrol. Dial. Transplant. 24, 2529-2536 (2009
16. Foley, R. N., Parfrey, P. S. & Sarnak, M. J. Epidemiology of cardiovascular disease in chronic renal disease. J. Am. Soc. Nephrol. 9 (Suppl.), S16-S23 (1998
17. Levin, A. Clinical epidemiology of cardiovascular disease in chronic kidney disease prior to dialysis. Semin. Dial. 16, 101-105 (2003
18. Go, A. S., Chertow, G. M., Fan, D., McCulloch, C. E. & Hsu, C. Y. Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization. N. Engl. J. Med. 351, 1296-1305 (2004
19. Weiner, D. E. et al. Chronic kidney disease as a risk factor for cardiovascular disease and all-cause mortality: A pooled analysis of community-based studies. J. Am. Soc. Nephrol. 15, 1307-1315 (2004
20. Jager, K. J. et al. Cardiovascular and non-cardiovascular mortality in dialysis patients: where is the link Kidney Int. Suppl. 1, 21-23 (2011
21. Blacher, J. et al. Carotid arterial stiffness as a predictor of cardiovascular and all-cause mortality in end-stage renal disease. Hypertension 32, 570-574 (1998
22. Collins, A. J. Cardiovascular mortality in end-stage renal disease. Am. J. Med. Sci. 325, 163-167 (2003
23. Gansevoort, R. T. et al. Chronic kidney disease and cardiovascular risk: Epidemiology, mechanisms, and prevention. Lancet 382, 339-352 (2013
24. Hackett, A. S. & Watnick, S. G. Withdrawal from dialysis in end-stage renal disease: Medical, social, and psychological issues. Semin. Dial. 20, 86-90 (2007
25. Chan, H. W., Clayton, P. A., McDonald, S. P., Agar, J. W. M. & Jose, M. D. Risk factors for dialysis withdrawal: An analysis of the Australia and New Zealand Dialysis and Transplant (ANZDATA) Registry, 1999-2008 Clin. J. Am. Soc. Nephrol. 7, 775-781 (2012
26. Fried, L. F. et al. Kidney function as a predictor of noncardiovascular mortality. J. Am. Soc. Nephrol. 16, 3728-3735 (2005
27. Yeun, J. Y., Levine, R. A., Mantadilok, V. & Kaysen, G. A. C-reactive protein predicts all-cause and cardiovascular mortality in hemodialysis patients. Am. J. Kidney Dis. 35, 469-476 (2000
28. Owen, W. F. & Lowrie, E. G. C-reactive protein as an outcome predictor for maintenance hemodialysis patients. Kidney Int. 54, 627-636 (1998
29. Zimmermann, J., Herrlinger, S., Pruy, A., Metzger, T. & Wanner, C. Inflammation enhances cardiovascular risk and mortality in hemodialysis patients. Kidney Int. 55, 648-658 (1999
30. Zoccali, C. et al. Inflammation is associated with carotid atherosclerosis in dialysis patients. Creed Investigators. Cardiovascular Risk Extended Evaluation in Dialysis Patients. J. Hypertens. 18, 1207-1213 (2000
31. Iseki, K., Tozawa, M., Yoshi, S. & Fukiyama, K. Serum C-reactive protein (CRP) and risk of death in chronic dialysis patients. Nephrol. Dial. Transplant. 14, 1956-1960 (1999
32. Noh, H. et al. Serum C-reactive protein: A predictor of mortality in continuous ambulatory peritoneal dialysis patients. Perit. Dial. Int. 18, 387-394 (1998
33. Wanner, C., Drechsler, C. & Krane, V. C-reactive protein and uremia. Semin. Dial. 22, 438-441 (2009
34. Dellinger, R. P. et al. Surviving Sepsis Campaign: International guidelines for management of severe sepsis and septic shock, 2012. Intensive Care Med. 39, 165-228 (2013
35. Wakasugi, M., Kawamura, K., Yamamoto, S., Kazama, J. J. & Narita, I. High mortality rate of infectious diseases in dialysis patients: A comparison with the general population in Japan. Ther. Apher. Dial. 16, 226-231 (2012
36. Sarnak, M. J. & Jaber, B. L. Mortality caused by sepsis in patients with end-stage renal disease compared with the general population. Kidney Int. 58, 1758-1764 (2000
37. Powe, N. R., Jaar, B., Furth, S. L., Hermann, J. & Briggs, W. Septicemia in dialysis patients: Incidence, risk factors, and prognosis. Kidney Int. 55, 1081-1090 (1999
38. Wang, H. E., Gamboa, C., Warnock, D. G. & Muntner, P. Chronic kidney disease and risk of death from infection. Am. J. Nephrol. 34, 330-336 (2011
39. Sarnak, M. J. & Jaber, B. L. Pulmonary infectious mortality among patients with end-stage renal disease. Chest 120, 1883-1887 (2001
40. Inamoto, H. et al. Incidence and mortality patterns of malignancy and factors affecting the risk of malignancy in dialysis patients. Nephron 59, 611-617 (1991
41. Birkeland, S. A., Lokkegaard, H. & Storm, H. H. Cancer risk in patients on dialysis and after renal transplantation. Lancet 355, 1886-1887 (2000
42. Iseki, K., Osawa, A. & Fukiyama, K. Evidence for increased cancer deaths in chronic dialysis patients. Am. J. Kidney Dis. 22, 308-313 (1993
43. Maisonneuve, P. et al. Cancer in patients on dialysis for end-stage renal disease: An international collaborative study. Lancet 354, 93-99 (1999
44. Weng, P. H. et al. Cancer-specific mortality in chronic kidney disease: Longitudinal follow-up of a large cohort. Clin. J. Am. Soc. Nephrol. 6, 1121-1128 (2011
45. Stewart, J. H. et al. Cancers of the kidney and urinary tract in patients on dialysis for end-stage renal disease: Analysis of data from the United States, Europe, and Australia and New Zealand. J. Am. Soc. Nephrol. 14, 197-207 (2003
46. Buccianti, G. et al. Cancer among patients on renal replacement therapy: A population-based survey in Lombardy, Italy. Int. J. Cancer 66, 591-593 (1996
47. Wong, G. et al. Association of CKD and cancer risk in older people. J. Am. Soc. Nephrol. 20, 1341-1350 (2009
48. Wong, G. et al. The risk of cancer in people with diabetes and chronic kidney disease. Nephrol. Dial. Transplant. 27, 3337-3344 (2012
49. Christensson, A. et al. Association of cancer with moderately impaired renal function at baseline in a large, representative, population-based cohort followed for up to 30 years. Int. J. Cancer 133, 1452-1458 (2013
50. Kantor, A. F., Hoover, R. N., Kinlen, L. J., McMullan, M. R. & Fraumenti, J. F. Jr. Cancer in patients receiving long-term dialysis treatment. Am. J. Epidemiol. 126, 370-376 (1987
51. Vajdic, C. M. et al. Cancer incidence before and after kidney transplantation. JAMA 296, 2823-2831 (2006
52. Newstead, C. G. Cancer risk in patients on dialysis. Lancet 354, 90-91 (1999
53. Iff, S. et al. Reduced Estimated GFR and Cancer Mortality. Am. J. Kidney Dis. 63, 23-30 (2014
54. Vamvakas, S., Bahner, U. & Heidland, A. Increased cancer incidence in terminal kidney failure: Potential pathogenetic mechanisms [German]. Schweiz. Med. Wochenschr. 127, 597-604 (1997
55. Larsson, T. E. et al. Conjoint effects of serum calcium and phosphate on risk of total, cardiovascular, and noncardiovascular mortality in the community. Arterioscler. Thromb. Vasc. Biol. 30, 333-339 (2010
56. Di Iorio, B. et al. Sevelamer versus calcium carbonate in incident hemodialysis patients: Results of an open-label 24-month randomized clinical trial. Am. J. Kidney Dis. 62, 771-778 (2013
57. Wang, A. Y. et al. Associations of serum fetuin-A with malnutrition, inflammation, atherosclerosis and valvular calcification syndrome and outcome in peritoneal dialysis patients. Nephrol. Dial. Transplant. 20, 1676-1685 (2005
58. Ooi, D. S., Veinot, J. P., Wells, G. A. & House, A. A. Increased mortality in hemodialyzed patients with elevated serum troponin T: A one-year outcome study. Clin. Biochem. 32, 647-652 (1999
59. Mehrotra, R. et al. Chronic kidney disease, hypovitaminosis D, and mortality in the United States. Kidney Int. 76, 977-983 (2009
60. den Elzen, W. P., van Manen, J. G., Boeschoten, E. W., Krediet, R. T. & Dekker, F. W. The effect of single and repeatedly high concentrations of C-reactive protein on cardiovascular and non-cardiovascular mortality in patients starting with dialysis. Nephrol. Dial. Transplant. 21, 1588-1595 (2006
61. Westenfeld, R. et al. Fetuin-A protects against atherosclerotic calcification in CKD. J. Am. Soc. Nephrol. 20, 1264-1274 (2009
62. Moe, S. M. et al. Role of calcification inhibitors in the pathogenesis of vascular calcification in chronic kidney disease (CKD). Kidney Int. 67, 2295-2304 (2005
63. Ketteler, M. et al. Association of low fetuin-A (AHSG) concentrations in serum with cardiovascular mortality in patients on dialysis: A cross-sectional study. Lancet 361, 827-833 (2003
64. Hermans, M. M. et al. Association of serum fetuin-A levels with mortality in dialysis patients. Kidney Int. 72, 202-207 (2007
65. Johnson, P. A. et al. Cardiac troponin T as a marker for myocardial ischemia in patients seen at the emergency department for acute chest pain. Am. Heart J. 137, 1137-1144 (1999
66. Havekes, B. et al. Serum troponin T concentration as a predictor of mortality in hemodialysis and peritoneal dialysis patients. Am. J. Kidney Dis. 47, 823-829 (2006
67. Wang, A. Y. et al. Prognostic value of cardiac troponin T is independent of inflammation, residual renal function, and cardiac hypertrophy and dysfunction in peritoneal dialysis patients. Clin. Chem. 53, 882-889 (2007
68. Brandenburg, V. M., Vervloet, M. G. & Marx, N. The role of vitamin D in cardiovascular disease: From present evidence to future perspectives. Atherosclerosis 225, 253-263 (2012
69. Drechsler, C. et al. Vitamin D deficiency is associated with sudden cardiac death, combined cardiovascular events, and mortality in haemodialysis patients. Eur. Heart J. 31, 2253-2261 (2010
70. Dusso, A. S. Kidney disease and vitamin D levels: 25-hydroxyvitamin D, 1,25-dihydroxyvitamin D, and VDR activation. Kidney Int. Suppl. 1, 136-141 (2011
71. Murr, C. et al. Vitamin D deficiency parallels inflammation and immune activation, the Ludwigshafen Risk and Cardiovascular Health (LURIC) study. Clin. Chem. Lab. Med. 50, 2205-2212 (2012
72. Lange, N., Litonjua, A. A., Gibbons, F. K., Giovannucci, E. & Christopher, K. B. Pre-hospital vitamin D concentration, mortality, and bloodstream infection in a hospitalized patient population. Am. J. Med. 126, 640.e19-640.e27 (2013
73. Ginde, A. A., Camargo, C. A. Jr & Shapiro, N. I. Vitamin D insufficiency and sepsis severity in emergency department patients with suspected infection. Acad. Emerg. Med. 18, 551-554 (2011
74. Venkatram, S. et al. Vitamin D deficiency is associated with mortality in the medical intensive care unit. Crit. Care 15, R292 (2011
75. Bell, D. S. Protean manifestations of vitamin D deficiency, part 2: Deficiency and its association with autoimmune disease, cancer, infection, asthma, dermopathies, insulin resistance, and type 2 diabetes. South. Med. J. 104, 335-339 (2011
76. Fiscella, K., Winters, P., Tancredi, D., Hendren, S. & Franks, P. Racial disparity in death from colorectal cancer: Does vitamin D deficiency contribute Cancer 117, 1061-1069 (2011
77. Yao, S. & Ambrosone, C. B. Associations between vitamin D deficiency and risk of aggressive breast cancer in African-American women. J. Steroid Biochem. Mol. Biol. 136, 337-341 (2013
78. Kim, H. J. et al. Vitamin D deficiency is correlated with poor outcomes in patients with luminal-type breast cancer. Ann. Surg. Oncol. 18, 1830-1836 (2011
79. Churilla, T. M., Brereton, H. D., Klem, M. & Peters, C. A. Vitamin D deficiency is widespread in cancer patients and correlates with advanced stage disease: A community oncology experience. Nutr. Cancer 64, 521-525 (2012
80. Drechsler, C. et al. Vitamin D status and clinical outcomes in incident dialysis patients: Results from the NECOSAD study. Nephrol. Dial. Transplant. 26, 1024-1032 (2011
81. Nagata, M. et al. Prediction of cardiovascular disease mortality by proteinuria and reduced kidney function: Pooled analysis of 39,000 individuals from 7 cohort studies in Japan. Am. J. Epidemiol. 178, 1-11 (2013
82. Bello, A. K. et al. Associations among estimated glomerular filtration rate, proteinuria, and adverse cardiovascular outcomes. Clin. J. Am. Soc. Nephrol. 6, 1418-1426 (2011
83. Kidney Diseases: Improving Global Outcomes (KDIGO) CKD Work Group. KDIGO clinical practice guideline for the evaluation and management of chronic kidney disease. Kidney Int. Suppl. 3, 1-150 (2013
84. Wu, H. M., Tang, J. L., Cao, L., Sha, Z. H. & Li, Y. Interventions for preventing infection in nephrotic syndrome. Cochrane Database of Systematic Reviews, Issue 4, Art. No.: CD003964 http://dx.doi.org/10.1002/14651858CD003964. pub2.
85. Cambier, J. F. & Ronco, P. Onco-nephrology: Glomerular diseases with cancer. Clin. J. Am. Soc. Nephrol. 7, 1701-1712 (2012
86. Lagrand, W. K. et al. C-reactive protein as a cardiovascular risk factor: More than an epiphenomenon Circulation 100, 96-102 (1999
87. Stenvinkel, P. et al. Strong association between malnutrition, inflammation, and atherosclerosis in chronic renal failure. Kidney Int. 55, 1899-1911 (1999
88. Kaysen, G. A. The microinflammatory state in uremia: Causes and potential consequences. J. Am. Soc. Nephrol. 12, 1549-1557 (2001
89. Pupim, L. B., Himmelfarb, J., McMonagle, E., Shyr, Y. & Ikizler, T. A. Influence of initiation of maintenance hemodialysis on biomarkers of inflammation and oxidative stress. Kidney Int. 65, 2371-2379 (2004
90. Wu, C. C., Sytwu, H. K. & Lin, Y. F. Cytokines in diabetic nephropathy. Adv. Clin. Chem. 56, 55-74 (2012
91. Bloembergen, W. E. & Port, F. K. Epidemiological perspective on infections in chronic dialysis patients. Adv. Ren. Replace. Ther. 3, 201-207 (1996
92. Tiwari, S. et al. Prevalence and severity of vitamin D deficiency in patients with diabetic foot infection. Br. J. Nutr. 109, 99-102 (2013
93. Mora, J. R., Iwata, M. & von Andrian, U. H. Vitamin effects on the immune system: Vitamins A and D take centre stage. Nat. Rev. Immunol. 8, 685-698 (2008
94. Liu, P. T. et al. Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response. Science 311, 1770-1773 (2006
95. Smeeth, L. et al. Risk of myocardial infarction and stroke after acute infection or vaccination. N. Engl. J. Med. 351, 2611-2618 (2004
96. Badiou, S. et al. Fine-tuning of the prediction of mortality in hemodialysis patients by use of cytokine proteomic determination. Clin. J. Am. Soc. Nephrol. 3, 423-430 (2008
97. Cohen, G. & Horl, W. H. Immune dysfunction in uremia-an update. Toxins (Basel) 4, 962-990 (2012
98. Mansouri, L., Paulsson, J. M., Moshfegh, A., Jacobson, S. H. & Lundahl, J. Leukocyte proliferation and immune modulator production in patients with chronic kidney disease. PLoS ONE 8, e73141 (2013
99. Adesso, S. et al. The uremic toxin indoxyl sulphate enhances macrophage response to LPS. PLoS ONE 8, e76778 (2013
100. Soubrane, C. et al. Influence of the uremic state on the development of malignancy. An experimental study in the rat. Am. J. Nephrol. 6, 363-368 (1986
101. Zaoui, P. & Hakim, R. M. Natural killer-cell function in hemodialysis patients: Effect of the dialysis membrane. Kidney Int. 43, 1298-1305 (1993
102. Sun, C. Y., Chang, S. C. & Wu, M. S. Suppression of Klotho expression by protein-bound uremic toxins is associated with increased DNA methyltransferase expression and DNA hypermethylation. Kidney Int. 81, 640-650 (2012
103. Abramovitz, L. et al. KL1 internal repeat mediates klotho tumor suppressor activities and inhibits bFGF and IGF-I signaling in pancreatic cancer. Clin. Cancer Res. 17, 4254-4266 (2011
104. Wolf, I. et al. Functional variant of KLOTHO: A breast cancer risk modifier among BRCA1 mutation carriers of Ashkenazi origin. Oncogene 29, 26-33 (2010
105. Katneni, R. & Hedayati, S. S. Central venous catheter-related bacteremia in chronic hemodialysis patients: Epidemiology and evidence-based management. Nat. Clin. Pract. Nephrol. 3, 256-266 (2007
106. Janus, N., Vacher, L. V., Karie, S., Ledneva, E. & Deray, G. Vaccination and chronic kidney disease. Nephrol. Dial. Transplant. 23, 800-807 (2008