Additive roles of platelets and fibrinogen in whole-blood fibrin clot formation upon dilution as assessed by thromboelastometry

Thrombosis and Haemostasis

Volumn 111, Issue 3, 2013, Pages 447-457

  Ninivaggi, Marisa ^a   Feijge, Marion A H ^a   Baaten, Constance C F M J ^a   Kuiper, Gerhardus J A J M ^a   Marcus, Marco A E ^a   Cate, Hugo Ten ^a   Lancé, Marcus D ^a   Heemskerk, Johan W M ^a   van der Meijden, Paola E J ^a  

^a MAASTRICHT UNIVERSITY   (Netherlands)

Author keywords

Blood dilution; Coagulation; Fibrin clot formation; Platelets; Thrombin generation

Indexed keywords

ANTITHROMBIN; BLOOD CLOTTING FACTOR 10; BLOOD CLOTTING FACTOR 7; BLOOD CLOTTING FACTOR 8; BLOOD CLOTTING FACTOR 9; FIBRINOGEN; HEPARIN; PHOSPHOLIPID; PROTHROMBIN; PROTHROMBIN COMPLEX; VITAMIN K GROUP;

ADULT; AGED; ARTICLE; BLOOD CLOTTING DISORDER; BLOOD CLOTTING TIME; CLINICAL ARTICLE; CONTROLLED STUDY; DILUTION; ERYTHROCYTE; ERYTHROCYTE CONCENTRATE; FIBRIN CLOT; HEMATOLOGICAL PARAMETERS; HEMATOLOGICAL PROCEDURE; HUMAN; HUMAN CELL; MAXIMAL CLOT FIRMNESS; PRIORITY JOURNAL; ROTATIONAL THROMBOELASTOMETRY; THORAX SURGERY; THROMBIN TIME; THROMBOCYTE; THROMBOCYTE COUNT;

BLOOD DILUTION; COAGULATION; FIBRIN CLOT FORMATION; PLATELETS; THROMBIN GENERATION;

AGED; BLOOD COAGULATION; BLOOD PLATELETS; BLOOD TRANSFUSION; CARDIOPULMONARY BYPASS; ERYTHROCYTES; FEMALE; FIBRIN; FIBRINOGEN; HEMODILUTION; HEMORRHAGE; HUMANS; MALE; MIDDLE AGED; PLATELET COUNT; PROTHROMBIN; THROMBELASTOGRAPHY; THROMBIN;

EID: 84897104839     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1160/TH13-06-0493     Document Type: Article

References (30)

1. Brenni M, Worn M, Bruesch M, et al. Successful rotational thromboelastometry-guided treatment of traumatic haemorrhage, hyperfibrinolysis and coagulopathy. Acta Anaesthesiol Scand 2010; 54: 111-117.
2. Tirosh-Wagner T, Strauss T, Rubinshtein M, et al. Point of care testing in children undergoing cardiopulmonary bypass. Pediatr Blood Cancer 2011; 56: 794-798.
3. Wegner J, Popovsky MA. Clinical utility of thromboelastography: one size does not fit all. Semin Thromb Haemost 2010; 36: 699-706.
4. Schochl H, Nienaber U, Hofer G, et al. Goal-directed coagulation management of major trauma patients using thromboelastometry (ROTEM)-guided administration of fibrinogen concentrate and prothrombin complex concentrate. Crit Care 2010; 14: R55.
5. Schols SE, Lance MD, Feijge MA, et al. Impaired thrombin generation and fibrin clot formation in patients with dilutional coagulopathy during major surgery. Thromb Haemost 2010; 103: 318-328.
6. Hemker HC, Giesen P, Al Dieri R, et al. Calibrated automated thrombin generation measurement in clotting plasma. Pathophysiol Haemost Thromb 2003; 33: 4-15.
7. Baglin T. The measurement and application of thrombin generation. Br J Haematol 2005; 130: 653-661.
8. Schols SE, Heemskerk JW, van Pampus EC. Correction of coagulation in dilutional coagulopathy: use of kinetic and capacitive coagulation assays to improve haemostasis. Transfus Med Rev 2010; 24: 44-52.
9. Callow CR, Swindell R, Randall W, et al. The frequency of bleeding complications in patients with haematological malignancy following the introduction of a stringent prophylactic platelet transfusion policy. Br J Haematol 2002; 118: 677-682.
10. Fenger-Eriksen C, Lindberg-Larsen M, Christensen AQ, et al. Fibrinogen concentrate substitution therapy in patients with massive haemorrhage and low plasma fibrinogen concentrations. Br J Anaesth 2008; 101: 769-773.
11. Thorarinsdottir HR, Sigurbjornsson FT, Hreinsson K, et al. Effects of fibrinogen concentrate administration during severe haemorrhage. Acta Anaesthesiol Scand 2010; 54: 1077-1082.
12. Lance MD, Ninivaggi M, Schols SE, et al. Perioperative dilutional coagulopathy treated with fresh frozen plasma and fibrinogen concentrate: a prospective randomized intervention trial. Vox Sang 2012; 103: 25-34.
13. Demeyere R, Gillardin S, Arnout J, et al. Comparison of fresh frozen plasma and prothrombin complex concentrate for the reversal of oral anticoagulants in patients undergoing cardiopulmonary bypass surgery: a randomized study. Vox Sang 2010; 99: 251-260.
14. Rahe-Meyer N, Sorensen B. For: Fibrinogen concentrate for management of bleeding. J Thromb Haemost 2011; 9: 1-5.
15. Dickneite G, Doerr B, Kaspereit F. Characterisation of the coagulation deficit in porcine dilutional coagulopathy and substitution with a prothrombin complex concentrate. Anesth Analg 2008; 106: 1070-1077.
16. Dickneite G, Pragst I. Prothrombin complex concentrate vs fresh frozen plasma for reversal of dilutional coagulopathy in a porcine trauma model. Br J Anaesth 2009; 102: 345-354.
17. Fries D, Haas T, Klingler A, et al. Efficacy of fibrinogen and prothrombin complex concentrate used to reverse dilutional coagulopathy--a porcine model. Br J Anaesth 2006; 97: 460-467.
18. Rosing J, Tans G, Govers-Riemslag JW, et al. The role of phospholipids and factor Va in the prothrombinase complex. J Biol Chem 1980; 255: 274-283.
19. Schols SE, Feijge MA, Lance MD, et al. Effects of plasma dilution on tissue-factor-induced thrombin generation and thromboelastography: partly compensating role of platelets. Transfusion 2008; 48: 2384-2394.
20. Vanschoonbeek K, Feijge MA, Van Kampen RJ, et al. Initiating and potentiating role of platelets in tissue factor-induced thrombin generation in the presence of plasma: subject-dependent variation in thrombogram characteristics. J Thromb Haemost 2004; 2: 476-484.
21. Schols SE, van der Meijden PE, van Oerle R, et al. Increased thrombin generation and fibrinogen level after therapeutic plasma transfusion: relation to bleeding. Thromb Haemost 2008; 99: 64-70.
22. Bochsen L, Johansson PI, Kristensen AT, et al. The influence of platelets, plasma and red blood cells on functional haemostatic assays. Blood Coagul Fibrinolysis 2011; 22: 167-175.
23. Jensen AS, Johansson PI, Idorn L, et al. The haematocrit-an important factor causing impaired haemostasis in patients with cyanotic congenital heart disease. Int J Cardiol 2013; 167: 1317-1321.
24. Nagler M, Kathriner S, Bachmann LM, et al. Impact of changes in haematocrit level and platelet count on thromboelastometry parameters. Thromb Res 2013; 131: 249-253.
25. Heemskerk JW, Mattheij NJ, Cosemans JM. Platelet-based coagulation: different populations, different functions. J Thromb Haemost 2013; 11: 2-16.
26. Weiss G, Lison S, Spannagl M, et al. Expressiveness of global coagulation parameters in dilutional coagulopathy. Br J Anaesth 2010; 105: 429-436.
27. Dickneite G, Pragst I, Joch C, et al. Animal model and clinical evidence indicating low thrombogenic potential of fibrinogen concentrate (Haemocomplettan P). Blood Coagul Fibrinolysis 2009; 20: 535-540.
28. Grottke O, Braunschweig T, Spronk HM, et al. Increasing concentrations of prothrombin complex concentrate induce disseminated intravascular coagulation in a pig model of coagulopathy with blunt liver injury. Blood 2011; 118: 1943-1951.
29. Grottke O, Rossaint R, Henskens Y, et al. Thrombin generation capacity of prothrombin complex concentrate in an in vitro dilutional model. PLoS One 2013; 8: e64100.
30. Castoldi E, Rosing J. Thrombin generation tests. Thromb Res 2011; 127 (Suppl 3): S21-25.