The haematocrit - An important factor causing impaired haemostasis in patients with cyanotic congenital heart disease

International Journal of Cardiology

Volumn 167, Issue 4, 2013, Pages 1317-1321

  Jensen, A S ^a   Johansson, P I ^a   Idorn, L ^a   Sorensen K E ^b   Thilen U ^c   Nagy, E ^d   Furenas E ^e   Sondergaard L ^a  

^a Rigshospitalet   (Denmark)

^b AARHUS UNIVERSITY HOSPITAL   (Denmark)

^c LUND UNIVERSITY HOSPITAL   (Sweden)

^d KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^e SAHLGRENSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Cyanotic congenital heart disease; Haematocrit; Haemoptysis; Haemostasis; Thrombelastography

Indexed keywords

FERROUS FUMARATE;

ADULT; AGED; ARTICLE; BLOOD CLOTTING; CYANOTIC HEART DISEASE; FEMALE; HEMATOCRIT; HEMOPTYSIS; HEMOSTASIS; HUMAN; HYPOCOAGULABILITY; IRON DEFICIENCY; MAJOR CLINICAL STUDY; MALE; PHLEBOTOMY; PRIORITY JOURNAL; PROSPECTIVE STUDY;

CYANOTIC CONGENITAL HEART DISEASE; HAEMATOCRIT; HAEMOPTYSIS; HAEMOSTASIS; THROMBELASTOGRAPHY;

ADULT; CYANOSIS; FEMALE; HEART DEFECTS, CONGENITAL; HEMATOCRIT; HEMOSTASIS; HUMANS; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; THROMBELASTOGRAPHY;

EID: 84881476952     PISSN: 01675273     EISSN: 18741754     Source Type: Journal    
DOI: 10.1016/j.ijcard.2012.03.181     Document Type: Article

References (23)

1. Gatzoulis MA, Webb GD, Daubeney PEF. Eisenmenger's Syndrome. In: Diagnosis and management of adult congenital heart disease. Churchill Livingstone. Edinburgh: Elsevier Limited,2006: 363-377.
2. D.K. Tempe, and S. Virmani Coagulation abnormalities in patients with cyanotic congenital heart disease J Cardiothorac Vasc Anesth 16 2002 752 765
3. M.A. Mamas, B. Clarke, and V.S. Mahadevan Embolisation of systemic-to-pulmonary collaterals in patients with the Eisenmenger reaction presenting with haemoptysis Cardiol Young 18 2008 528 531
4. M.C. Territo, and M.H. Rosove Cyanotic congenital heart disease: Hematologic management J Am Coll Cardiol 18 1991 320 322
5. W.A. Osthaus, D. Boethig, and K. Johanning Whole blood coagulation measured by modified thrombelastography (ROTEM) is impaired in infants with congenital heart diseases Blood Coagul Fibrinolysis 19 2008 220 225
6. M.C. Lill, J.K. Perloff, and J.S. Child Pathogenesis of thrombocytopenia in cyanotic congenital heart disease Am J Cardiol 98 2006 254 258
7. A.M. Peters, A. Rozkovec, R.N. Bell, K.A. Hallidie-Smith, J.F. Goodwin, and J.P. Lavender Platelet kinetics in congenital heart disease Cardiovasc Res 16 1982 391 397
8. H. Horigome, Y. Hiramatsu, O. Shigeta, T. Nagasawa, and A. Matsui Overproduction of platelet microparticles in cyanotic congenital heart disease with polycythemia J Am Coll Cardiol 39 2002 1072 1077
9. H. Horigome, T. Murakami, T. Isobe, T. Nagasawa, and A. Matsui Soluble P-selectin and thrombomodulin-protein C-Protein S pathway in cyanotic congenital heart disease with secondary erythrocytosis Thromb Res 112 2003 223 227
10. H. Kajimoto, M. Nakazawa, and K. Murasaki Increased thrombogenesity in patients with cyanotic congenital heart disease Circ J 71 2007 948 953
11. L.H. Caramuru, N.Y. Maeda, S.P. Bydlowski, and A.A. Lopes Age-dependent likelihood of in situ thrombosis in secondary pulmonary hypertension Clin Appl Thromb Hemost 10 2004 217 223
12. J. Shibata, J. Hasegawa, and H. Siemens Hemostasis and coagulation at a hematocrit level of 0.85: functional consequences of erythrocytosis Blood 101 2003 4416 4422
13. Y. Cui, F. Hei, and C. Long Perioperative Monitoring of Thromboelastograph on Hemostasis and Therapy for Cyanotic Infants Undergoing Complex Cardiac Surgery Artif Organs 33 2009 909 914
14. A.A. Lopes, N.Y. Maeda, M. Ebaid, D.F. Chamone, and F. Pileggi Effect of intentional hemodilution on platelet survival in secondary pulmonary hypertension Chest 95 1989 1207 1210
15. T.K. Sahoo, S. Chauhan, M. Sahu, A. Bisoi, and U. Kiran Effects of Hemodilution on Outcome After Modified Blalock-Taussig Shunt Operation in Children With Cyanotic Congenital Heart Disease J Cardiothorac Vasc Anesth 21 2007 179 183
16. M. Terai, M. Nakazawa, A. Takao, and Y. Imai Thrombocytopenia in patients with aortopulmonary transposition and an intact ventricular septum Br Heart J 57 1987 371 374
17. K.C. Gersh, C. Nagaswami, and J.W. Weisel Fibrin network structure and clot mechanical properties are altered by incorporation of erythrocytes Thromb Haemost 102 2009 1169 1175
18. J.K. Perloff, A.J. Marelli, and P.D. Miner Risk of stroke in adults with cyanotic congenital heart disease Circulation 87 1993 1954 1959
19. E.L. Tay, A. Peset, and M. Papaphylactou Replacement therapy for iron deficiency improves exercise capacity and quality of life in patients with cyanotic congenital heart disease and/or the Eisenmenger syndrome Int J Cardiol 151 2011 307 312
20. H.M. Maurer, C.M. McCue, L.W. Robertson, and J.C. Haggins Correction of platelet dysfunction and bleeding in cyanotic congenital heart disease by simple red cell volume reduction Am J Cardiol 35 1975 831 835
21. C. Broberg, M. Ujita, and S. Babu-Narayan Massive pulmonary artery thrombosis with haemoptysis in adults with Eisenmenger's syndrome: a clinical dilemma Heart 90 2004 e63
22. A.S. Jensen, K. Iversen, N.G. Vejlstrup, and L. Sondergaard Images in cardiovascular medicine. Pulmonary artery thrombosis and hemoptysis in Eisenmenger syndrome Circulation 115 2007 e632 e634
23. P. Wood The Eisenmenger syndrome or pulmonary hypertension with reversed central shunt. I Br Med J 2 1958 701 709